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| 1 | Starch grain evidence reveals early pottery function cooking plant foods in North China显示文摘Early pottery sherds excavated in northern China date back to more than 11,000 cal a BP,and are presumed to have been used as cooking vessels.There has been,however,no direct evidence to demonstrate this function.Here we report ancient starch grains recovered from carbonized residues adhering to the bases of flatbottomed vessels excavated from the Zhuannian site dating more than 10,000 cal a BP in the North China Plain.This evidence demonstrates that early pottery was being used to cook cereal grains,particularly millets,and acorns.Because millets were in the process of domestication at thistime,we propose that pottery invention in northern China may have been related to early farming activities. | Xiaoyan Yang Zhikun Ma Tao Wang Linda Perry Quan Li Xiujia Huan Jincheng Yu | 2014 | Chinese Science Bulletin2014，59，32： | 10 |
| 2 | Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia显示文摘Resveratrol possesses beneficial biological effects,which include anti-oxidant,anti-inflammatory and anti-carcinogenic properties.Recently,resveratrol has been shown to exhibit neuroprotective effects in models of Parkinson's disease,cerebral ischemia and Alzheimer's disease.However,its effects on vascular dementia remain unclear.The present study established a rat model of vascular dementia using permanent bilateral common carotid artery occlusion.At 8-12 weeks after model induction,rats were intragastrically administered 25 mg/kg resveratrol daily.Our results found that resveratrol shortened the escape latency and escape distances in the Morris water maze,and prolonged the time spent percentage and swimming distance percentage in the target quadrant during the probe test,indicating that resveratrol improved learning and memory ability in vascular dementia rats.Further experiments found that resveratrol decreased malonyldialdehyde levels,and increased superoxide dismutase activity and glutathione levels in the hippocampus and cerebral cortex of vascular dementia rats.These results confirmed that the neuroprotective effects of resveratrol on vascular dementia were associated with its anti-oxidant properties. | Xingrong Ma Zhikun Sun Yanru Liu Yanjie Jia Boai Zhang Jiewen Zhang | 2013 | Neural Regeneration Research2013，8，22： | 7 |
| 3 | A Novel Parallel Scheme for Fast Similarity Search in Large Time Series显示文摘The similarity search is one of the fundamental components in time series data mining,e.g.clustering,classification,association rules mining.Many methods have been proposed to measure the similarity between time series,including Euclidean distance,Manhattan distance,and dynamic time warping(DTW).In contrast,DTW has been suggested to allow more robust similarity measure and be able to find the optimal alignment in time series.However,due to its quadratic time and space complexity,DTW is not suitable for large time series datasets.Many improving algorithms have been proposed for DTW search in large databases,such as approximate search or exact indexed search.Unlike the previous modified algorithm,this paper presents a novel parallel scheme for fast similarity search based on DTW,which is called MRDTW(MapRedcuebased DTW).The experimental results show that our approach not only retained the original accuracy as DTW,but also greatly improved the efficiency of similarity measure in large time series. | YIN Hong YANG Shuqiang MA Shaodong LIU Fei CHEN Zhikun | 2015 | China Communications2015，12，2： | 6 |
| 4 | Plant microremains provide direct evidence for the functions of stone knives from the Lajia site, northwestern China显示文摘A large number of stone knives have been recovered from Neolithic archaeological sites in East Asia.However, direct evidence regarding the functions of the stone knives has been scarce, and hence, their functions have remained controversial. In this study, we recovered and analysed ancient starch grains and phytoliths from residues adhering to stone knives excavated from the Lajia site, Qinghai Province, northwest China, thus providing direct evidence for the functions of the knives. Our analyses were based on the following:(1) an assemblage of 278identifiable starch grains, representing grains from the stems of foxtail millet(Setaria italica) and broomcorn millet(Panicum miliaceum)(65.1 % of the total) and the stems of Hordeum and Triticum species(3.6 % of the total), and(2) an assemblage of 361 identifiable phytoliths,the majority of which were from the stems and leaves of plants such as Panicoideae and related taxa(96 % of the total). Our study demonstrates that one of the functions of the stone knives was the harvesting crops. In addition, a few starch grains from food legumes and roots(3.4 % of the total) indicate that the stone knives were also likely used to process, peel and cut some foods. | Zhikun Ma Quan Li Xiujia Huan Xiaoyan Yang Jingyun Zheng Maolin Ye | 2014 | Chinese Science Bulletin2014，59，11： | 5 |
| 5 | Early millet use in West Liaohe area during early-middle Holocene显示文摘It is generally recognized that millet agriculture originated in northern China. However, the domestication process of foxtail millet(Setaria italica) and broomcorn millet(Panicum miliaceum) is still poorly understood. Based on statistical and morphological analyses of ancient millet starch grains, a tangible hypothesis has been proposed for the long-term domestication of green foxtail millet(S. viridis). However, the hypothesis requires validation by evidence from more regions and more archaeological finds. The West Liaohe region is one of the earliest regions of millet cultivation. Here, we report ancient starch grains recovered from 12 stone grinding tools from eight sites of the Xiaohexi culture(before 8.5 ka BP), Xinglongwa culture(8.2–7.4 ka BP), Zhaobaogou culture(7.0–6.4 ka BP), and Hongshan culture(6.5–5.0 ka BP) in the West Liaohe region of China. Our results indicate that the proportion of millet starch grains with wrinkled surfaces and rough edges, which are diagnostic of wild millet grasses, decreased from 13.0% to 3.4% from the Xiaohexi culture to the Hongshan culture. Millet starch grains measuring >16.8 ?m, a size class recorded only in domesticated foxtail millet, increased from 55.0% to 62.1%. These millet data imply that the process of millet domestication in the West Liaohe region began in the Xiaohexi period and continued up to the Hongshan period. | MA ZhiKun YANG XiaoYan ZHANG Chi SUN YongGang JIA Xin | 2016 | Science China Earth Sciences2016，59，8： | 5 |
| 6 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 7 | Brain-derived neurotrophic factor prevents beta-amyloid-induced apoptosis of pheochromocytoma cells by regulating Bax/Bcl-2 expression显示文摘Brain-derived neurotrophic factor was utilized in the present study to treat cell injury models induced by aggregated β-amyloid(25-35).Methylthiazolyldiphenyl-tetrazolium bromide assay and western blot analysis showed that brain-derived neurotrophic factor provided neuroprotection against cellular apoptosis by suppressing the decline in β-amyloid(25-35)-induced cell activity and the increasing ratio of Bax/Bcl-2.After treating pheochromocytoma cells with tyrosine kinase receptor B receptor inhibitor K252a,brain-derived neurotrophic factor reverses the above-mentioned changes.The experimental findings suggested that brain-derived neurotrophic factor prevented β-amyloid peptide-induced cellular apoptosis by modulating Bax/Bcl-2 expression,and this effect was associated with binding to the specific tyrosine kinase receptor B receptor. | Zhikun Sun Xingrong Ma Hongqi Yang Jiahua Zhao Jiewen Zhang | 2012 | Neural Regeneration Research2012，7，5： | 2 |
| 8 | Nano silica aerogel-induced formation of an organic/alloy biphasic interfacial layer enables construction of stable high-energy lithium metal batteries显示文摘Lithium metal batteries represent promising candidates for high-energy-density batteries, however, many challenges must still be overcome,e.g., interface instability and dendrite growth. In this work, nano silica aerogel was employed to generate a hybrid film with high lithium ion conductivity(0.6 mS cm^(-1)at room temperature) via an in situ crosslinking reaction. TOF-SIMS profile analysis has revealed conversion mechanism of hybrid film to Li–Si alloy/Li F biphasic interface layer, suggesting that the Li–Si alloy and Li F-rich interface layer promoted rapid Li+transport and shielded the Li anodes from corrosive reactions with electrolyte-derived products. When coupled with nickel-cobalt-manganese-based cathodes, the batteries achieve outstanding capacity retention over 1000 cycles at 1 C. Additionally the developed film coated on Li enabled high coulombic efficiency(99.5%) after long-term cycling when coupled with S cathodes. Overall, the results presented herein confirm an effective strategy for the development of high-energy batteries. | Chengwei Ma Xinyu Zhang Chengcai Liu Yuanxing Zhang Yuanshen Wang Ling Liu Zhikun Zhao Borong Wu Daobin Mu | 2023 | Green Energy & Environment2023，8，4： | 1 |
| 9 | Phase Selection and Microhardness of Directionally Solidified AlCoCrFeNi_(2.1) Eutectic High-Entropy Alloy显示文摘In the present work,the solidification behaviors and microhardness of directionally solidified AlCoCrFeNi_(2.1) eutectic highentropy alloy(EHEA)obtained at different growth velocities are investigated.The microstructure of the as-cast AlCoCrFeNi_(2.1) EHEA is composed of bulky dendrites(NiAl phase)and lamellar eutectic structures,indicating that the actual composition of the alloy slightly deviates from the eutectic point.However,it is interesting to observe that the full lamellar structure of this alloy is obtained through directional solidification.In order to explain this phenomenon,the maximum interface temperature criterion and the interface response function(IRF)theory are applied to calculate the velocity range of the transition from the primary phase to the eutectic,which is 1.2–2×10^(4)μm/s.Furthermore,microhardness is one of the important parameters to measure the mechanical properties of materials.Therefore,the microhardness test is performed,and the test result indicates that the microhardness(HV)increased with increasing growth velocity(V)or decreased with increasing lamellar spacing(λ).The dependences ofλand HV on V are determined by using a linear regression analysis.The relationships between theλ,V and HV are given as:λ=11.62V^(-0.48),HV=305.5V 0.02 and HV=328.1λ^(0.04),respectively.The microhardness of the AlCoCrFeNi_(2.1) EHEA increases from 312.38 HV to 329.54 HV with the increase in growth velocity(5–200μm/s).Thus,directional solidification is an effective method to improve the mechanical properties of alloys. | Peng Peng Shengyuan Li Weiqi Chen Yuanli Xu Xudong Zhang Zhikun Ma Jiatai Wang | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，8： | 1 |
| 10 | Indica rice spread to the Tibetan Plateau in the 700s CE显示文摘Asian cultivated rice(Oryza sativa)has two main subspecies,indica(O.sativa sub.indica)and japonica(O.sativa sub.japonica).Japonica rice was domesticated in the middle and lower reaches of the Yangtze River in China,while indica appeared around 4000 a BP in northern south Asia after hybridization between introduced japonica and indigenous proto-indica.When and how indica rice spread into China is still barely understood,although it is cultivated widely in southern China today.Here we report on the earliest,definite indica rice remains in China,including charred seeds,phytoliths,and ancient DNA,from the newly investigated Kongsangqiao site at an elevation of 2676 m above sea level in Tibet,along with a charcoal study that reveals the vegetation and climate during of human occupation.AMS radiocarbon dating of charred indica rice grains suggests the remains are from the 8th century(700s CE).The dominant identified charcoal fragments are Himalayan pine(Pinus wallichiana),from which a rather cold climate is inferred where indica rice could not be grown in situ,suggesting it was likely brought to the site.Both archaeological and literature records thus support that indica rice,fully domesticated in northern south Asia,had spread to the southern margin of the Tibetan Plateau via parts of the ancient Tang-Tubo Road,Tubo-Nepal Road,by at least the 8th century CE. | Qingli SUN Qi YANG Yu GAO Zhengquan GU Jishuai YANG Shuzhi WANG Zhikun MA Yan TONG Xiaoyan YANG | 2022 | Science China Earth Sciences2022，65，12： | 0 |
| 11 | Generation of in situ CRISPR-mediated primary and metastatic cancer from monkey liver显示文摘Non-human primates(NHPs)represent the most valuable animals for drug discovery.However,the current main challenge remains that the NHP has not yet been used to develop an efficient translational medicine platform simulating human diseases,such as cancer.This study gen erated an in situ gen e-editi ng approach to in duce efficie nt loss-of-function mutations of Pten and p53 genes for rapid modeling primary and metastatic liver tumors using the CRISPR/Cas9 in the adult cyno molgus mon key.Un der ultraso und guida nee,the CRISPR/Cas9 was injected into the cyno molgus mon key liver through the in trahepatic portal vein.The results showed that the ultraso un d-guided CRISPR/Cas9 resulted in in dels of the Pten and p53 genes in seve n out of eight monkeys.The best mutation efficiencies for Pten and p53 were up to 74.71%and 74.68%,respectively.Furthermore,the morbidity of primary and exte nsively metastatic(lung,splee n,lymph nodes)hepatoma in CRISPR-treated mon keys was 87.5%.The ultraso un d-guided CRISPR system could have great potential to successfully pursue the desired target genes,thereby reducing possible side effects associated with hitting no n-specific off-target genes,and sign ifica ntly in creasing more efficie ncy as well as higher specificity of in situ gene editi ng in vivo,which holds promise as a powerful,yet feasible tool,to edit disease genes to build corresp on ding huma n disease models in adult NHPs and to greatly accelerate the discovery of new drugs and save economic costs. | Liping Zhong Yong Huang Jian He Nuo Yang Banghao Xu Yun Ma Junjie Liu Chao Tang Chengpiao Luo Pan Wu Zongqiang Lai Yu Huo Tao Lu Dongni Huang Wenlin Gong Lu Gan Yiqun Luo Zhikun Zhang Xiyu Liu Yongxiang Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 12 | ZnO Films on Transferable and Low Thermal Resistance Graphite Substrate Grown by Ultrasonic Spray Pyrolysis显示文摘ZnO thin films were deposited on graphite substrates by ultrasonic spray pyrolysis method with Zn(CH 3 COO) 2 ·2H 2 O aqueous solution as precursor. The crystalline structure, morphology, and optical properties of the as-grown ZnO films were investigated systematically as a function of deposition temperature and growth time. Near-band edge ultraviolet(UV) emission was observed in room temperature photoluminescence spectra for the optimized samples, yet the usually observed defect related deep level emissions were nearly undetectable, indicating that high optical quality ZnO thin fi lms could be achieved via this ultrasonic spray pyrolysis method. Considering the features of transferable and low thermal resistance of the graphite substrates, the achievement will be of special interest for the development of high-power semiconductor devices with suffi cient power durability. | 边继明 MA Xiaowen SUN Jingchang ZHANG Zhikun WANG Yuxin QIN Fuwen LUO Yingmin ZHANG Yuzhi FU Xianping | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，3： | 0 |
| 13 | Breeding and Cultivation Techniques of a New Spring Wheat Variety Kechun 140103显示文摘Kechun 140103 is a new spring wheat variety with high and stable yield bred by Keshan Branch of Heilongjiang Academy of Agricultural Sciences.This paper summarizes the breeding process,characteristics,yield performance and cultivation techniques of Kechun 140103,in order to promote the popularization and application of the variety. | Chao TIAN Ligang SHAO Jingyu CHE Yong MA Qichang ZHANG Ningtao LIU Zhikun WANG Xuewei YIN Liting DAI | 2023 | Plant Diseases and Pests2023，14，3： | 0 |
| 14 | Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution显示文摘Dear Editor,The placenta connecting the fetus to the matermal uterus provides material exchange and an immune-tolerant environment for the embryo in all eutherian mammals(Shao et al.,2022).The representative mouse placenta displays a multilayered structure with distinct characteristics and functions,including the matermal decidua,junctional zone,and labyrinth layer(Marsh and Blelloch,2020).The decidua,which is thought to be derived from the matermal endometrium(and further undergoes decidualization),provides an anchor for fetal trophoblast invasion.The junctional zone predominantly contains spongiotrophoblasts(SpT),glycogen trophoblasts(GlyT),and trophoblast giant cells(TGCs).The labyrinth is the innermost two-layer structure,which mainly consists of syncytiotrophoblast cells(SynTI and SynTII),sinusoidal TGCs(S-TGCs),and fetal endothelial cells(Simmons and Cross,2005). | Liyuan Jiang Xin Wang Leyun Wang Sinan Ma Yali Ding Chao Liu Siqi Wang Xuan Sha Ying Zhang Zhikun Li Wei Li Guihai Feng Qi Zhou | 2023 | Protein & Cell2023，14，12： | 0 |
| 15 | Brain-derived neurotrophic factor protects PC12 cells from beta-amyloid-induced neurotoxicity through the tropomyosin-related kinase B receptor pathway显示文摘The present study utilized beta amyloid (Aβ)-induced cell apoptosis in PC12 cells as a cell model of Alzheimer's disease to investigate the interaction between brain-derived neurotrophic factor (BDNF) and the tropomyosin-related kinase B receptor. Results showed that Aβ(25-35) can reduce survival of PC12 cells and increase cleaved caspase-3 expression in PC12 cells. However, BDNF inhibited Aβ(25-35)-induced cytotoxicity and cleaved casapase-3 expression. Interestingly, pretreatment with the tropomyosin-related kinase receptor inhibitor K252a for 20 minutes prior to BDNF blocked the neuroprotective effect of BDNF on PC12 cells. | Zhikun Sun Xingrong Ma Hongqi Yang Jiahua Zhao Jiewen Zhang | 2011 | Neural Regeneration Research2011，6，32： | 0 |
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