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| 1 | Self-Navigated 3D Acoustic Tweezers in Complex Media Based on Time Reversal显示文摘Acoustic tweezers have great application prospects because they allow noncontact and noninvasive manipulation of microparticles in a wide range of media.However,the nontransparency and heterogeneity of media in practical applications complicate particle trapping and manipulation.In this study,we designed a 1.04 MHz 256-element 2D matrix array for 3D acoustic tweezers to guide and monitor the entire process using real-time 3D ultrasonic images,thereby enabling acoustic manipulation in nontransparent media.Furthermore,we successfully performed dynamic 3D manipulations on multiple microparticles using multifoci and vortex traps.We achieved 3D particle manipulation in heterogeneous media(through resin baffle and ex vivo macaque and human skulls)by introducing a method based on the time reversal principle to correct the phase and amplitude distortions of the acoustic waves.Our results suggest cutting-edge applications of acoustic tweezers such as acoustical drug delivery,controlled micromachine transfer,and precise treatment. | Ye Yang Teng Ma Sinan Li Qi Zhang Jiqing Huang Yifei Liu Jianwei Zhuang Yongchuan Li Xuemin Du Lili Niu Yang Xiao Congzhi Wang Feiyan Cai Hairong Zheng | 2021 | Research2021，，1： | 1 |
| 2 | Non-small molecule PROTACs(NSM-PROTACs):Protein degradation kaleidoscope显示文摘The proteolysis targeting chimeras(PROTACs)technology has been rapidly developed since its birth in 2001,attracting rapidly growing attention of scientific institutes and pharmaceutical companies.At present,a variety of small molecule PROTACs have entered the clinical trial.However,as small molecule PROTACs flourish,non-small molecule PROTACs(NSM-PROTACs)such as peptide PROTACs,nucleic acid PROTACs and antibody PROTACs have also advanced considerably over recent years,exhibiting the unique characters beyond the small molecule PROTACs.Here,we briefly introduce the types of NSM-PROTACs,describe the advantages of NSM-PROTACs,and summarize the development of NSM-PROTACs so far in detail.We hope this article could not only provide useful insights into NSM-PROTACs,but also expand the research interest of NSM-PROTACs. | Sinan Ma Jianai Ji Yuanyuan Tong Yuxuan Zhu Junwei Dou Xian Zhang Shicheng Xu Tianbao Zhu Xiaoli Xu Qidong You Zhengyu Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 1 |
| 3 | In Situ Scattering Studies of Crystallization Kinetics in a Phase-Separated Zr-Cu-Fe-Al Bulk Metallic Glass显示文摘Thermal stability and the crystallization kinetics of a phase-separated Zr-Cu-Fe-Al bulk metallic glass were investigated using in situ high-energy synchrotron X-ray and neutron diffraction,as well as small-angle synchrotron X-ray scattering.It was revealed that this glass with excellent glass-forming ability possesses a two-step crystallization behavior.The crystalline products and their evolution sequence are more complicated than a homogeneous Zr-Cu-Al glass with average glass-forming ability.The experimental results indicate that a finely distributed nanometer-sized cubic Zr_(2)Cu phase forms first and then transforms to a tetragonal Zr_(2)Cu phase,while the matrix transforms to an orthorhombic Zr_(3)Fe phase.The strength of the Zr-Cu-Fe-Al composite containing cubic Zr_(2)Cu phase and glass matrix increases,and the plasticity also improves compared to the as-cast Zr-Cu-Fe-Al bulk metallic glass.Our results suggest that the formation of multiple and complex crystalline products would be the characteristics of the Zr-Cu-Fe-Al glass with better glass-forming ability.Our study may shed light on the synthesis of bulk-sized glass-nanocrystals composites of high strength and good plasticity. | Sinan Liu Jiacheng Ge Huiqaing Ying Chenyu Lu Dong Ma Xun-Li Wang Xiaobing Zuo Yang Ren Tao Feng Jun Shen Horst Hahn Si Lan | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，1： | 0 |
| 4 | Microcarriers promote the through interface movement of mouse trophoblast stem cells by regulating stiffness显示文摘Mechanical force is crucial in the whole process of embryonic development.However,the role of trophoblast mechanics during embryo implantation has rarely been studied.In this study,we constructed a model to explore the effect of stiffness changes in mouse trophoblast stem cells(mTSCs)on implantation:microcarrier was prepared by sodium alginate using a droplet microfluidics system,and mTSCs were attached to the microcarrier surface with laminin modifications,called T(micro).Compared with the spheroid,formed by the self-assembly of mTSCs(T(sph)),we could regulate the stiffness of the microcarrier,making the Young’s modulus of mTSCs(367.70±79.81 Pa)similar to that of the blastocyst trophoblast ectoderm(432.49±151.90 Pa).Moreover,T(micro)contributes to improve the adhesion rate,expansion area and invasion depth of mTSCs.Further,T(micro)was highly expressed in tissue migration-related genes due to the activation of the Rho-associated coiled-coil containing protein kinase(ROCK)pathway at relatively similar modulus of trophoblast.Overall,our study explores the embryo implantation process with a new perspective,and provides theoretical support for understanding the effect of mechanics on embryo implantation. | Zili Gao Jia Guo Bo Gou Zhen Gu Tan Jia Sinan Ma Liyuan Jiang Wenli Liu Lixun Zhou Qi Gu | 2023 | Bioactive Materials2023，，10： | 0 |
| 5 | Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution显示文摘Dear Editor,The placenta connecting the fetus to the matermal uterus provides material exchange and an immune-tolerant environment for the embryo in all eutherian mammals(Shao et al.,2022).The representative mouse placenta displays a multilayered structure with distinct characteristics and functions,including the matermal decidua,junctional zone,and labyrinth layer(Marsh and Blelloch,2020).The decidua,which is thought to be derived from the matermal endometrium(and further undergoes decidualization),provides an anchor for fetal trophoblast invasion.The junctional zone predominantly contains spongiotrophoblasts(SpT),glycogen trophoblasts(GlyT),and trophoblast giant cells(TGCs).The labyrinth is the innermost two-layer structure,which mainly consists of syncytiotrophoblast cells(SynTI and SynTII),sinusoidal TGCs(S-TGCs),and fetal endothelial cells(Simmons and Cross,2005). | Liyuan Jiang Xin Wang Leyun Wang Sinan Ma Yali Ding Chao Liu Siqi Wang Xuan Sha Ying Zhang Zhikun Li Wei Li Guihai Feng Qi Zhou | 2023 | Protein & Cell2023，14，12： | 0 |
| 6 | The scattering mechanism of squall lines with C-Band dual polarization radar.Part Ⅰ:echo characteristics and particles phase recognition显示文摘Squall line is a kind of common mesoscale disaster weather.At present,there are few studies on the elaborate detection of squall line by dual polarization radar.With the dual polarization upgrade of weather radar network,we need to study the relationship between squall line echoes of base data and polarization data to reveal new echo phenomena and formation mechanisms.The relationship between radar parameters and atmospheric physical processes also need to be examined.Based on the NUIST CDP radar,a squall line in the Yangtze and Huaihe River basin that occurred from July 30 to 31,2014 is analyzed.The results show that polarization parameters have obvious advantages in the characteristics analysis of size,phase state,shape and orientation of the water condensate particles.The phase states of water condensate particles in convection cell can be distinguished through comparative discussion.Several phase states exist in the squall line,including small,medium and large raindrops,melting hails,dry hails and ice crystal particles and the Z_(DR)column can be used to identify the location of the main updraft.In addition,the polarization parameters are more sensitive to the melting layer.The gust front is presented as a narrow linear echo in Z affected by strong turbulence.It is an obvious velocity convergence line in V and approximately 0.70 inρ_(HV).The Z_(DR)can be used as a criterion to distinguish the horizontal and vertical scale of turbulence.The deforming turbulence,which is affected by environmental airflow,will cause an abnormally high Z_(DR)in the gust front and a negative Z_(DR)before and after the gust front.The variation of Z_(DR)depends on the turbulence arrangement,orientation and relative position between turbulence and radar.These dual polarization parameter characteristics offer insights into understanding the structure and evolution of the squall line. | Jiashan ZHU Ming WEI Sinan GAO Hanfeng HU Lei MA | 2022 | Frontiers of Earth Science2022，16，2： | 0 |
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