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| 1 | P wave velocity structure of upper and middle crust beneath the Three Gorges reservoir dam and adjacent regions显示文摘The three-dimensional P wave velocity structures of upper and middle crust beneath the Three Gorges reservoir dam and adjacent regions were reconstructed by means of the seismic tomography, using the absolute P-arrivals from the events observed by the Three Gorges seismic network. Our preliminary study of the deep structure shows: (1) the lithology of the Huangling anticline, integral and highly so-lidified, exhibits a uniformity. Down to a depth of 20 km, the Huangling anticline still shows high- velocity anomalies. Note that the characteristics of the velocity images with the different depths are not the same; (2) the depth of the sedimentary rocks beneath the entire Zigui basin is not constant, which is less than 6 km; (3) the top boundary of the crystalline basement varies from 0 to 7 km, whereas the bottom one between 14 and 16 km; (4) the partially molten substances of the upper mantle are located in the Badong-Zigui and its adjacent regions as well as nearby Peishi area. The development and evo-lution of the current tectonics are associated with the cooling and solidifying process of the molten substances within the upper mantle; (5) the different velocity structures of the deep crust in both east and west side of the Jiuwanxi fault are to be investigated in order to understand the origin of gravita-tional gradient zone in the Three Gorge areas; and (6) the velocities within the upper crust would be affected by reservoir water permeability. | LI Qiang ZHAO Xu CAI JinAn LIU RuiFeng LONG GuiHua AN YanRu | 2009 | Science China Earth Sciences2009，52，4： | 11 |
| 2 | Lignin biosynthesis by suppression of two O-methyl-transferases显示文摘Caffeic acid O-methyltransferase (COMT) and caffeoyl-CoA-3-O-methyltransferase (CCoAOMT) genes encode two methyltransferases at different substrate levels in lignin biosynthesis. We constructed two single antisense expression vectors containing the cDNA of COMT or CCoAOMT genes and one dual antisense expression vector containing cDNAs of both OMTs genes. The antisense constructs were transferred into tobacco mediated by Agrobac-terium tumefacience. PCR-Southern analysis indicated that antisense cDNAs had been integrated into the genome of the transgenic tobacco. The antisense genes were also expressed at transcriptional level displayed by Northern dot analysis. Klason lignin assay of 3-month-old transgenic tobaccos showed that repression in COMT or CCoAOMT alone could result in reduction of lignin content, more reduction was caused by suppression in CCoAOMT than in COMT. Furthermore, simultaneous suppression of both COMT and CCoAOMT resulted in more reduction than that of single gene, which indicated | ZHAO Huayan WEI Jianhua ZHANG Jinyu LIU Huirong WANG Tai SONG Yanru | 2002 | Chinese Science Bulletin2002，47，13： | 7 |
| 3 | Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia显示文摘Resveratrol possesses beneficial biological effects,which include anti-oxidant,anti-inflammatory and anti-carcinogenic properties.Recently,resveratrol has been shown to exhibit neuroprotective effects in models of Parkinson's disease,cerebral ischemia and Alzheimer's disease.However,its effects on vascular dementia remain unclear.The present study established a rat model of vascular dementia using permanent bilateral common carotid artery occlusion.At 8-12 weeks after model induction,rats were intragastrically administered 25 mg/kg resveratrol daily.Our results found that resveratrol shortened the escape latency and escape distances in the Morris water maze,and prolonged the time spent percentage and swimming distance percentage in the target quadrant during the probe test,indicating that resveratrol improved learning and memory ability in vascular dementia rats.Further experiments found that resveratrol decreased malonyldialdehyde levels,and increased superoxide dismutase activity and glutathione levels in the hippocampus and cerebral cortex of vascular dementia rats.These results confirmed that the neuroprotective effects of resveratrol on vascular dementia were associated with its anti-oxidant properties. | Xingrong Ma Zhikun Sun Yanru Liu Yanjie Jia Boai Zhang Jiewen Zhang | 2013 | Neural Regeneration Research2013，8，22： | 7 |
| 4 | Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer:a subpopulation analysis of the JACOB trial显示文摘Background:The JACOB trial(NCT01774786)was a double-blinded,placebo-controlled,randomized,multicenter,international,phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemo-therapy in first-line treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer(GEJC).The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial.Methods:This post hoc subpopulation analysis included all patients recruited in China's Mainland(n=163;20.9%)between June 2013 and January 2016.The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy(pertuzumab group;n=82)or placebo plus trastuzumab and chemotherapy(con-trol group;n=81).Intravenous pertuzumab(840 mg)and trastuzumab(8 mg/kg loading and 6 mg/kg maintenance doses)were given every 3 weeks until disease progression or unacceptable toxicity.Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin.The primary endpoint was overall survival(OS);secondary efficacy endpoints included progression-free survival(PFS),and overall objective response rate(ORR).Results:The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group(hazard ratio[HR]0.75;95%confidence interval[CI]0.49 to 1.14).The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups,respectively(HR 0.85;95%CI 0.60 to 1.21),and the median ORRs were 68.9%and 55.7%,respectively.The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group.The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable.The most common grade 3-5adverse events were neutropenia,anemia,and leukopenia.However,due to the nature of being a post hoc subgroup analysis,the results presented here are descriptive only and need to be interpreted with caution.Conclusions:OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients,and this regimen demonstrated an acceptable safety profile. | Tianshu Liu Yanru Qin Jin Li Ruihua Xu Jianming Xu Shujun Yang Shukui Qin Yuxian Bai Changping Wu Yixiang Mao Haiyan Wu Yilin Ge Lin Shen | 2019 | Cancer Communications2019，39，1： | 6 |
| 5 | Preparation of Aminated Lignin through Etherification and Amination显示文摘A new method for the preparation of aminated lignin(AEL) through etherification and amination reaction was presented. Chlorine atoms were firstly introduced into lignin through its etherification with epichlorohydrin. Then, hydrophilic amine groups were grafted to the modified lignin structure through amination with ethylenediamine to obtain AEL. Subsequent acidification of AEL led to the ionized aminated lignin(IAEL). The results of our analyses showed that the nitrogen content of AEL was 6.9%. Foaming and emulsifying experiments indicated that AEL had better foamability and emulsifying properties than IAEL. Surface tension tests showed that AEL and IAEL had similar critical micelle concentration(CMC). However, IAEL had lower surface tension(36.33 mN/m) than AEL(42.89 mN/m) at CMC. These results demonstrate the promising applicability of AEL as an emulsifier and that of IAEL as feedstock in the production of detergent and dispersant. | ChangZhou Chen BingXin Wang YanRu Zhang Ting Shi Jun Liu XiLuan Wang YongMing Fan | 2018 | Paper And Biomaterials2018，3，2： | 4 |
| 6 | Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid显示文摘Kainic acid can simulate excitatory amino acids in vitro.Neural stem cells,isolated from newborn Wistar rats,were cultured in vitro and exposed to 100-4 000 μM kainic acid for 7 days to induce neuronal cell differentiation,causing the number of astrocytes to be significantly increased.Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone.Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons. | Guifang Sun Zhihao Yuan Boai Zhang Yanjie Jia Yangfei Ji Xingrong Ma Yu Liu Yanru Liu Quanqing Wen Yanling Zhao | 2012 | Neural Regeneration Research2012，7，12： | 4 |
| 7 | The effect of serum luteinizing hormone on trigger day with a GnRH antagonist protocol in IVF/ICSI treatment显示文摘Objective:To investigate the effect of serum luteinizing hormone(LH)on trigger day with a Gonadotrophinreleasing hormone(GnRH)antagonist protocol in patients receiving in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)treatment for pregnancy outcomes.Methods:We retrospectively reviewed the medical documents of patients receiving IVF/ICSI with fresh embryo transfers from the Reproductive Medicine Center of Peking University People's Hospital between January 2016 and December 2018.730 patients were included and divided into three groups by their serum LH level determined on trigger day.All patients were categorized into Group A,Group B,and Group C based on LH concentrations<1.0 IU/L,1.0–5.0 IU/L,and from 5.0 to 10.0 IU/L on trigger day during the cycle,respectively.Comparisons were made between the three groups.Results:There was a significant difference in implantation rates between Group A and Group C(24.8%versus 40.1%,respectively,P<0.05).The clinical pregnancy rates(39.3%versus 54.3%,respectively,P=0.078)and live birth rate(LBR)(32.1%versus 46.5%,respectively,P=0.116),though the differences were not significant.Multivariate logistic regression analysis showed that the OR of Group C for clinical pregnancy(OR=1.849,P=0.040)and for LBR(OR=1.915,P=0.034)were significant using Group A as the base level.Conclusions:Our study has demonstrated that patients with higher serum LH levels(5.0–10.0 IU/L)on trigger day in the GnRH antagonist protocol may confer better clinical outcomes than those with lower LH levels(<1.0 IU/L). | Yanru Hou Li Tian Huixin Liu Jiajia Ai Yanbin Wang Huan Shen | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，4： | 2 |
| 8 | Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘H3K9me2 和 H3K27me2 是与抄写压抑联系的重要 epigenetic 标记,当 H3K4me3 与抄写激活被联系时。活跃、压抑的 histone methylations 以一种互相独占的方式散布,这被显示出,但是内在的机制糟糕被理解。这里,我们识别了 ceKDM7A,一个哲学博士(植物 homeodomain )- 并且 JmjC 包含域的蛋白质,为 H3K9me2 和 H3K27me2 特定的 histone demethylase。我们进一步证明 ceKDM7A 的 PHD 领域在染色体宽的水平绑了 H3K4me3 和与 ceKDM7A co 局部性的 H3K4me3。到 H3K4me3 的 PHD 域绑定的混乱在 vivo 减少了 demethylase 活动,并且 ceKDM7A 的损失减少了它的联系目标基因的表达式。这些结果显示 ceKDM7A 被招募到倡导者到 demethylate H3K9me2 和 H3K27me2 并且通过 PHD 领域的绑定激活基因表示到 H3K4me3。因此,我们的学习识别双特性的 histone demethylase 并且提供新奇卓见进 histone methylation 的规定。 | Hanqing Lin Yiqin Wang Yanru Wang Feng Tian Pu Pu Yi Yu Hailei Mao Ying Yang Ping Wang Lulu Hu Yan Lin Yi Liu Yanhui Xu Charlie Degui Chen | 2010 | Cell Research2010，20，8： | 2 |
| 9 | Efficacy of intrapleural instillation of fibrinolytics for treating pleural empyema and parapneumonic effusion: a meta‐analysis of randomized control trials显示文摘 | Wencheng Nie Yanru Liu Jian Ye Liuhong Shi Fangchun Shao Kejing Ying Ruifeng Zhang | 2014 | The Clinical Respiratory Journal2014，，3： | 1 |
| 10 | Screening of High Temperature Resistant Fodder Yeast Strains显示文摘[Objective] This study aimed to screen yeast strains suitable for high temperature processing of formulated biological feed. [Method] High temperature resistance and culture conditions of six yeast strains were investigated. [Result] Two yeast strains resistant to high temperature( 45 ℃) with high viable cell number( 108 cells / ml) were screened,including DQFC2117-1 and DQFC2122-2. [Conclusion] Strains DQFC2117-1 and DQFC2122-2 could be used as high temperature resistant yeast strains for processing of formulated biological feed. | Yufeng LIU Yueming WANG Qingli YANG Yanru JI Yan DONG Jie SHI | 2015 | Agricultural Biotechnology2015，4，4： | 1 |
| 11 | Chlorinated Conjugated Polymer Based on Chlorine- and Cyano-substituted (E)-1,2-Di(thiophen-2-yl)ethane for Ambipolar and n-Type Organic Thin-film Transistors显示文摘Chlorinated conjugated polymers are rarely reported in ambipolar and n-type organic thin-film transistors(OTFTs),mainly due to the lack of chlorinated strong electron-deficient building blocks.Herein,we report three new chlorine(Cl)-and cyano(CN)-substituted(E)-1,2-di(thiophen-2-yl)ethane building blocks and their copolymers P2Cl1CNTVT-DPP,P4Cl1CNTVT-DPP and P2Cl2CNTVT-DPP. | Yulong Zhang Chan Zhang Yunran Su Weijia Dong Yanru Li Zhongwei Liu Xiang Yao Yang Han Zhuping Fei | 2022 | Chinese Journal of Chemistry2022，40，16： | 1 |
| 12 | Anchoring Active Sites by Pt_(2)FeNi Alloy Nanoparticles on NiFe Layered Double Hydroxides for Efficient Electrocatalytic Oxygen Evolution Reaction显示文摘Strategy of anchoring alloy nanoparticles made up of the efficient catalytic element(e.g.,Ni,Fe)on dodecyl sulfate(DS^(-))-intercalated NiFe layered double hydroxides(DS^(-)-NiFe LDH)obtained by a convenient one-step hydrothermal coprecipitation method for essentially enhancing oxygen evolution reaction(OER)performance was proposed.The results of structural characterization indicate Pt_(2)FeNi alloy nanoparticles evenly distribute on the surface of DS^(-)-NiFe LDH.The sizes of the Pt_(2)FeNi nanoparticles,closely related to their OER performance,could be wellcontrolled by adjusting the amount of H;PtCl;addition.The composite structure of as-prepared product was stable during processes of synthesis,exfoliation,self-assembly,and subsequent electrocatalytic OER.Rigorous electrochemical test proving the contributing catalytic active sites was located at the interface between Pt_(2)FeNi and DS^(-)-NiFe LDH,and the Ni and Fe were the major active elements while O atoms are adsorption sites.The formation of Pt_(2)FeNi nanoparticles could greatly prompt the reduction of Tafel slope.The best-performing Pt_(2)FeNi/DS^(-)-NiFe LDH with a Pt content of 0.98 wt%achieved low overpotential of 204 mV at 10 mA cm^(-2)and 262 mV at 50 mA cm^(-2).This work provides a convenient and effective strategy to create additional active sites for enhancing OER performance of NiFe LDH and make contribution to its wide application. | Zhicheng Zheng Yanru Guo Hao Wan Gen Chen Ning Zhang Wei Ma Xiaohe Liu Shuquan Liang Renzhi Ma | 2022 | Energy & Environmental Materials2022，5，1： | 1 |
| 13 | Study and control of three-phase PWM rectifier based on dual single-input single-out- put model 显示文摘 | YIN Zhonggang LIU Jing ZHONG Yanru | 2013 | IEEE Transactions on Industrial Informatics2013，9，2： | 1 |
| 14 | Macrophage polarization is involved in liver fibrosis induced byβ_(1)-adrenoceptor autoantibody显示文摘Accumulating evidence suggests that liver injury can be induced by the over-expression ofβ_(1)-adrenergic receptors(β_(1)-ARs).High titers of autoantibodies specific toβ_(1)-adrenergic receptors(β_(1)-AA)are detected in the sera of heart failure patients,potentially playing agonist-like roles.However,the role ofβ_(1)-AA in liver function has not been characterized.In this study,we collect the sera of primary biliary cholangitis(PBC)patients,a condition which easily develops into liver fibrosis,and analyze the relationship between PBC andβ_(1)-AA.A passive immunization model is established to assess the effect ofβ_(1)-AA on the liver.Subsequently,the effect ofβ_(1)-AA on macrophages is investigated in vitro.Results show that PBC patients have a high titer and ratio ofβ_(1)-AA,compared to controls.Liver injury and fibrosis are induced byβ_(1)-AA.In vitro experiments with ROS probe demonstrate thatβ_(1)-AA induces macrophages to produce ROS and secrete TNFα.These effects can be partially reversed by metoprolol,a blocker forβ_(1)-AR.Results from the transwell and phagocytosis assays show thatβ_(1)-AA promotes macrophage migration and phagocytosis.FCM tests suggest thatβ_(1)-AA induces the alteration of M1 rather than M2 markers in macrophages.Finally,the Annexin V/PI assay indicates that macrophage culture supernatants stimulated byβ_(1)-AA cause hepatocyte apoptosis.Overall,these results suggest thatβ_(1)-AA is involved in PBC.Theβ_(1)-AA-induced activation,phagocytosis and phenotypic modification of macrophages may play an important role in the development of hepatic fibrosis and injury. | Ye Wu Xiongxiong Fan Haicun Yu Jingyi Liu Yanru Duan Suli Zhang Li Yan Yunhui Du Huirong Liu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 1 |
| 15 | Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO显示文摘 | Yuhan Tang Hongtao Tian Yanru Shi Chao Gao Mingyou Xing Wei Yang Wei Bao Di Wang Liegang Liu Ping Yao | 2013 | Phytomedicine (-)2013，，8： | 1 |
| 16 | Halloysite nanotubes loaded with nano silver for the sustained-release of antibacterial polymer nanocomposite scaffolds显示文摘It is challenging for antibacterial polymer scaffolds to achieve the drug sustained-release through directly coating or blending.In this work,halloysite nanotubes(HNTs),a natural aluminosilicate nanotube,were utilized as a nano container to load nano silver(Ag)into the lumen through vacuum negativepressure suction&injection and thermal decomposition of silver acetate.Then,the nano Ag loaded HNTs(HNTs@Ag)were introduced to poly-l-lactic acidide)(PLLA)scaffolds prepared by additive manufacturing for the sustained-release of Ag^+.Acting like a’shield’,the tube walls of HNTs not only retarded the erosion of external aqueous solution on internal nano Ag to generate Ag^+but also postponed the generated Ag^+to diffuse outward.The results indicated the PLLA-HNTs@Ag nanocomposite scaffolds achieved a sustained-release of Ag^+over 28 days without obvious initial burst release.Moreover,the scaffolds exhibited a long-lasting antibacterial property without compromising the cytocompatibility.Besides,the degradation properties,biomineralization ability and mechanical properties of the scaffolds were increased.This study suggests the potential application of inorganic nanotubes as drug carrier for the sustained-release of functional polymer nanocomposite scaffolds. | Wang Guo Wei Liu Li Xu Pei Feng Yanru Zhang Wenjing Yang Cijun Shuai | 2020 | Journal of Materials Science & Technology2020，42，11： | 1 |
| 17 | Polydatin modulates Ca 2<ce:hsp sp='0.10'/>+ handling, excitation–contraction coupling and β-adrenergic signaling in rat ventricular myocytes显示文摘 | Jianxin Deng Wenjuan Liu Yanru Wang Ming Dong Ming Zheng Jie Liu | 2012 | Journal of Molecular and Cellular Cardiology2012，，5： | 1 |
| 18 | Preliminary report of the September 5,2022 M_(S) 6.8 Luding earthquake,Sichuan,China显示文摘The 2022 M_(S)6.8 Luding earthquake is the strongest earthquake in Sichuan Province, Western China, since the 2017 M_(S)7.0 Jiuzhaigou earthquake. It occurred on the Moxi fault in the southeastern segment of the Xianshuihe fault, a tectonically active and mountainous region with severe secondary earthquake disasters. To better understand the seismogenic mechanism and provide scientific support for future hazard mitigation, we summarize the preliminary results of the Luding earthquake, including seismotectonic background, seismicity and mainshock source characteristics and aftershock properties, and direct and secondary damage associated with the mainshock.The peak ground displacements in the NS and EW directions observed by the nearest GNSS station SCCM are ~35 mm and ~55 mm, respectively, resulting in the maximum coseismic dislocation of 20 mm along the NWW direction, which is consistent with the sinistral slip on the Xianshuihe fault. Back-projection of teleseismic P waves suggest that the mainshock rupture propagated toward south-southeast. The seismic intensity of the mainshock estimated from the back-projection results indicates a Mercalli scale of Ⅷ or above near the ruptured area,consistent with the results from instrumental measurements and field surveys. Numerous aftershocks were reported, with the largest being M_(S)4.5. Aftershock locations(up to September 18, 2022) exhibit 3 clusters spanning an area of 100 km long and 30 km wide. The magnitude and rate of aftershocks decreased as expected, and the depths became shallower with time. The mainshock and two aftershocks show left-lateral strike-slip focal mechanisms. For the aftershock sequence, the b-value from the Gutenberg-Richter frequency-magnitude relationship, h-value, and p-value for Omori’s law for aftershock decay are 0.81, 1.4, and 1.21, respectively, indicating that this is a typical mainshock-aftershock sequence. The low b-value implies high background stress in the hypocenter region. Analysis from remote sensing satellite images and UAV data shows that the distribution of earthquake-triggered landslides was consistent with the aftershock area. Numerous small-size landslides with limited volumes were revealed, which damaged or buried the roads and severely hindered the rescue process. | Yanru An Dun Wang Qiang Ma Yueren Xu Yu Li Yingying Zhang Zhumei Liu Chunmei Huang Jinrong Su Jilong Li Mingxiao Li Wenkai Chen Zhifan Wan Dengjie Kang Baoshan Wang | 2023 | Earthquake Research Advances2023，3，1： | 1 |
| 19 | Study on the equilibrium, kinetics and isotherm of biosorption of lead ions onto pretreated chemically modified orange peel显示文摘 | Zhexian Xuan Yanru Tang Xiaomin Li Yinghui Liu Fang Luo | 2006 | Biochemical Engineering Journal2006，，2： | 1 |
| 20 | Study and control of three-phase PWM rectifier based on dual single-input single-output model显示文摘 | Yin Zhonggang Liu Jing Zhong Yanru | 2013 | IEEE Trans on Industrial Informat- ics2013，9，2： | 1 |
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