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| 1 | Aerosol and boundary-layer interactions and impact on air quality显示文摘Air quality is concerned with pollutants in both the gas phase and solid or liquid phases. The latter are referred to as aerosols, which are multifaceted agents affecting air quality, weather and climate through many mechanisms. Unlike gas pollutants, aerosols interact strongly with meteorological variables with the strongest interactions taking place in the planetary boundary layer(PBL). The PBL hosting the bulk of aerosols in the lower atmosphere is affected by aerosol radiative effects. Both aerosol scattering and absorption reduce the amount of solar radiation reaching the ground and thus reduce the sensible heat fluxes that drive the diurnal evolution of the PBL. Moreover, aerosols can increase atmospheric stability by inducing a temperature inversion as a result of both scattering and absorption of solar radiation, which suppresses dispersion of pollutants and leads to further increases in aerosol concentration in the lower PBL.Such positive feedback is especially strong during severe pollution events. Knowledge of the PBL is thus crucial for understanding the interactions between air pollution and meteorology. A key question is how the diurnal evolution of the PBL interacts with aerosols, especially in vertical directions, and affects air quality.We review the major advances in aerosol measurements, PBL processes and their interactions with each other through complex feedback mechanisms, and highlight the priorities for future studies. | Zhanqing Li Jianping Guo Aijun Ding Hong Liao Jianjun Liu Yele Sun Tijian Wang Huiwen Xue Hongsheng Zhang Bin Zhu | 2017 | National Science Review2017，4，6： | 37 |
| 2 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 3 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 4 | Effect of methamidophos on soil fungi community in microcosms by plate count,DGGE and clone library analysis显示文摘Methamidophos 广泛地被使用在北中国的杀虫剂。在黑色的真菌的社区玷污的土壤上的 methamidophos 的潜在的影响被板计数, 28S rDNA-PCR-DGGE,和克隆图书馆分析估计。三个 methamidophos 层次(50,150,和 250 mg/kg ) 在土壤缩影被测试。从板计数的结果在一个 60-d 缩影实验期间证明 methamidophos ( 250 mg/kg )的高集中能显著地刺激采指纹显示出的模式的真菌的 populations.DGGE (使中毒的坡度胶化电气泳动)在 methamidophos.Shannon 差异索引的压力下面的 culturable 和全部的真菌社区的回答之间的重要差别从 DGGE 计算了侧面显示在有 methamidophos 处理的所有缩影的 culturable 真菌在 1 星期孵化以后增加了。然而,全部的真菌的差异索引在第一个星期内减少了,作为与 culturable 真菌的刺激相比。然而,在第 8 星期, methamidophos 对待的所有缩影类似于在由香农建议差异为 culturable 和总数索引真菌的社区结构的控制缩影。相反,在 1 个星期以后, culturable 和 unculturable 的真菌的结构被聚类分析两个都在 methamidophos 的压力下面扰乱到不同程度。克隆定序分析显示了刺激病原并且 unculturable 由 methamidophos 处理的真菌的人口,植物病爆发的 suggetsing 潜力风险。 | LI Xinyu ZHANG Huiwen WU Minna ZHANG Yan ZHANG Chenggang | 2008 | Journal of Environmental Sciences2008，20，5： | 11 |
| 5 | A seed-specific AP2-domain transcription factor from soybean plays a certain role in regulation of seed ger-mination显示文摘Plant seed development and germination are under strict temporal and spatial regulation, and tran-scription factors play important roles in this regulation. In the present study we identified an EST ex-pressed specifically in the developing soybean seeds. The full length of the gene was obtained through further RACE analysis and the gene was named GmSGR. Sequence analysis revealed that this gene belonged to the AP2/ERF transcription factor family. Its AP2 domain had the highest similarity with that of the A-3 member AtABI4 of DREB subgroup in the AP2/ERF family in Arabidopsis. GmSGR did not exhibit transcriptional activation activity in the yeast assay system. GmSGR was overexpressed in Arabidopsis and the germination rates of the transgenic seeds were significantly higher than that of the wild type seeds under higher concentrations of ABA and glucose respectively. However, the germina-tion rates of the transgenic seeds were lower than that of control under salt stress. The expression of AtEm6 and AtRD29B was higher in the seedlings of the transgenic plants than that in the wild-type seedlings. These results suggest that GmSGR may confer reduced ABA sensitivity and enhanced salt sensitivity to the transgenic seeds through regulating the expression of AtEm6 and AtRD29B genes. | WANG ChunMei, WANG HuiWen, ZHANG JinSong & CHEN ShouYi National Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Bei-jing 100101, China | 2008 | Science China(Life Sciences)2008，51，4： | 11 |
| 6 | Isolation and characterization of Sporobolomyces sp. LF1 capable of degrading chlorimuron-ethyl显示文摘A yeast strain which was capable of degrading sulfonylurea herbicide chlorimuron-ethyl named as LF1 was isolated from a chlorimuron-ethyl contaminated soil near the warehouse of the factory producing chlorimuron-ethyl in Shenyang City,Northeast China. The strain was identified as Sporobolomyces sp.,based on its morphological and physiological characteristics and the phylogenetic analysis of 18S rRNA gene sequence.So far,this is the only yeast strain of Sporobolomyces sp.which is able to degrade chlorimuron-ethyl.Incubation tests showed that when the initial concentration of chlorimuron-ethyl in culture was 5 mg/L,LF1 could degrade more than 77%of the herbicide after incubation for 4 d at 30°C.The possible mechanism of chlorimuron-ethyl degradation by LF1 could be the acidic hydrolysis caused by the acids from the metabolism of the yeast strain.Further study should be conducted to examine the pathways of chlorimuron-ethyl degradation by LF1 and to approach the feasibility of using LF1 to degrade the chlorimuron-ethyl in soil system. | ZHANG Xiaoli ZHANG Huiwen LI Xu SU Zhencheng WANG Jingjing ZHANG Chenggang | 2009 | Journal of Environmental Sciences2009，21，9： | 10 |
| 7 | Ectopic expression of soybean GmKNT1 in Arabidopsis results in altered leaf morphology and flower identity显示文摘Plant morphology is specified by leaves and flowers, and the shoot apical meristem (SAM) defines the architecture of plant leaves and flowers. Here, we reported the characterization of a soybean KNOX gene GmKNT1, which was highly homologous to Arabidopsis STM. The GmKNT1 was strongly expressed in roots, flowers and developing seeds. Its expression could be induced by IAA, ABA and JA, but inhibited by GA or cytokinin. Staining of the transgenic plants overexpressing GmKNT1-GUS fusion protein revealed that the GmKNT1 was mainly expressed at lobe region, SAM of young leaves, sepal and carpel, not in seed and mature leaves. Scanning electron micros-copy (SEM) disclosed multiple changes in morphology of the epidermal cells and stigma. The transgenic Arabidopsis plants overexpress-ing the GmKNT1 showed small and lobed leaves, shortened internodes and small clustered inflorescence. The lobed leaves might result from the function of the meristems located at the boundary of the leaf. Compared with wild type plants, transgenic plants had higher ex-pression of the SAM-related genes including the CUP, WUS, CUC1, KNAT2 and KNAT6. These results indicated that the GmKNT1 could affect multiple aspects of plant growth and development by regulation of downstream genes expression. | Jun Liu Da Ha Zongming Xie Chunmei Wang Huiwen Wang Wanke Zhang Jinsong Zhang Shouyi Chen | 2008 | Journal of Genetics and Genomics2008，35，7： | 8 |
| 8 | Impact of acetochlor on ammonia-oxidizing bacteria in microcosm soils显示文摘Acetochlor is an increasingly used herbicide on corn in North China. Currently, the effect of acetochlor on soil ammonia-oxidizing bacteria (AOB) communities is not well documented. Here, we studied the diversity and community composition of AOB in soil amended with three concentrations of acetochlor (50, 150, 250 mg/kg) and the control (0 mg acetochlor/kg soil) in a microcosm experiment by PCR-DGGE (polymerase chain reaction-denaturing gradient gel electrophoresis) and the phylogenetic analysis of excised DGGE bands. DGGE profiles showed that acetochlor had a stimulating effect on AOB at the early stage after acetochlor amended, and the order of intensity and duration is medium-acetochlor amended samples (AM) > low-acetochlor amended samples (AL) > high-acetochlor amended samples (AH). At the end of 60 d microcosm, acetochlor had a negative effect on the diversity of AOB. Cluster analysis of DGGE profiles showed that acetochlor had a greater effect on the community structure of AOB on day 60 than on day 1. The phylogenetic analysis revealed that all the sequences of excised DGGE bands were closely related to members of the genus Nitrosospira and formed two separate subclusters designated as subcluster 1 and subcluster 2 affiliated respectively with clusters 3 and 4 in Nitrosospira as defined by Stephen. Some dominant AOB had a change from subcluster 2 to subcluster 1 with the incubation. The results showed that acetochlor had an effect on the AOB on a long-term basis and the chronic effect of acetochlor should be paid more attention in future. | Xinyu LI Chenggang ZHANG | 2008 | Journal of Environmental Sciences2008，20，9： | 7 |
| 9 | Soil fungistasis and its relations to soil microbial composition and diversity:A case study of a series of soils with different fungistasis显示文摘Fungistasis is one of the important approaches to control soil-borne plant pathogens.Some hypotheses about the mechanisms for soil fungistasis had been established,which mainly focused on the soil bacterial community composition,structure,diversity as well as function.In this study,the bacterial community composition and diversity of a series of soils treated by autoclaving,which coming from the same original soil sample and showing gradient fungistasis to the target soil-borne pathogen fungi Fusarium gr... | Wu Minna Zhang Huiwen Ll Xinyu Zhang Yan Su Zhencheng Zhang Chenggang | 2008 | Journal of Environmental Sciences2008，20，7： | 7 |
| 10 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 11 | Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a major pest native to the Americas that has recently invaded the Old World.Point mutations in the target-site proteins acetylcholinesterase-1(ace-1),voltage-gated sodium channel(VGSC)and ryanodine receptor(RyR)have been identified in S.frugiperda as major resistance mechanisms to organophosphate,pyrethroid and diamide insecticides respectively.Mutations in the adenosine triphosphate-binding cassette transporter C2 gene(ABCC2)have also been identified to confer resistance to Cry IF protein.In this study,we applied a whole-genome sequencing(WGS)approach to identify point mutations in the target-site genes in 150 FAW individuals collected from China,Malawi,Uganda and Brazil.This approach revealed three amino acid substitutions(A201S,G227A and F290V)of S.frugiperda ace-1,which are known to be associated with organophosphate resistance.The Brazilian population had all three ace-1 point mutations and the 227A allele(mean frequency=0.54)was the most common.Populations from China,Malawi and Uganda harbored two of the three ace-1 point mutations(A201S and F290V)with the 290V allele(0.47-0.58)as the dominant allele.Point mutations in VGSC(T929I,L932F and L1014F)and RyR(I4790M and G4946E)were not detected in any of the 150 individuals.A novel 12-bp insertion mutation in exon 15 of the ABCC2 gene was identified in some of the Brazilian individuals but absent in the invasive populations.Our results not only demonstrate robustness of the WGS-based genomic approach for detection of resistance mutations,but also provide insights for improvement of resistance management tactics in S.frugiperda. | Fang Guan Jianpeng Zhang Huiwen Shen Xingliang Wang Amanda Padovan Tom K.Walsh Wee Tek Tay Karl H.J.Gordon William James Cecilia Czepak Michael Hilary Otim Donald Kachigamba Yidong Wu | 2021 | Insect Science2021，28，3： | 6 |
| 12 | The Role of Initial Cloud Condensation Nuclei Concentration in Hail Using the WRF NSSL 2-moment Microphysics Scheme显示文摘The effects of the initial cloud condensation nuclei(CCN) concentrations(100–3000 mg^(-1)) on hail properties were investigated in an idealized non-severe hail storm experiment using the Weather Research and Forecasting(WRF) model, with the National Severe Storms Laboratory 2-moment microphysics scheme. The initial CCN concentration(CCNC) had obvious non-monotonic effects on the mixing ratio, number concentrations, and radius of hail, both in clouds and at the surface, with a CCNC threshold between 300 and 500 mg^(-1). An increasing CCNC is conducive(suppressive) to the amount of surface hail precipitation below(above) the CCNC threshold. The non-monotonic effects were due to both the thermodynamics and microphysics. Below the CCNC threshold, the mixing ratios of cloud droplets and ice crystals increased dramatically with the increasing CCNC, resulting in more latent heat released from condensation and frozen between 4 and 8 km and intensified updraft volume. The extent of the riming process, which is the primary process for hail production, increased dramatically. Above the CCNC threshold, the mixing ratio of cloud droplets and ice crystals increased continuously, but the maximum updraft volume was weakened because of reduced frozen latent heating at low level. The smaller ice crystals reduced the formation of hail and smaller clouds, with decreased rain water reducing riming efficiency so that graupel and hail also decreased with increasing CCNC, which is unfavorable for hail growth. | Xiaofei LI Qinghong ZHANG Huiwen XUE | 2017 | Advances in Atmospheric Sciences2017，34，9： | 4 |
| 13 | GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation显示文摘 | Yuting Guo Huiwen Wang Yinglong Tang Yue Wang Mengqi Zhang Zhiguang Yang Eric Nyirimigabo Bin Wei Zhongbing Lu Guangju Ji | 2018 | Protein & Cell2018，9，11： | 3 |
| 14 | Mechanisms of abnormal overpressure generation in Kuqa foreland thrust belt and their impacts on oil and gas reservoir formation显示文摘Based on overview for mechanism of abnormaloverpressure generation in sedimentary basins, an insightdiscussion is made by the authors for the distribution, fea-tures and generation mechanisms of abnormal overpressurein the Kuqa foreland thrust belt. The abnormal overpressurein the Kelasu structure zone west to the Kuqa forelandthrust belt was primarily distributed in Eogene to lowerCretaceous formations; structural compression and struc-tural emplacement as well as the containment of Eogenegyps-salt formation constituted the main mechanisms for thegeneration of abnormal overpressure. The abnormal over-pressure zone in the eastern Yiqikelike structure zone wasdistributed primarily in lower Jurassic Ahe Group, resultingfrom hydrocarbon generation as well as structural stressother than from under-compaction. Various distributionsand generating mechanisms have different impacts upon theformation of oil and gas reservoirs. K-E reservoir in the Ke-lasu zone is an allochthonous abnormal overpressure system.One of the conditions for reservoir accumulation is the mi-gration of hydrocarbon (T-J hydrocarbon source rock) alongthe fault up to K-E reservoir and accumulated into reservoir.And this migration process was controlled by the abnormaloverpressure system in K-E reservoir. The confined abnor-mal overpressure system in the Yiqikelike structure zoneconstituted the main cause for the poor developing of dis-solved porosity in T-J reservoir, resulting in poor physicalproperty of reservoir. The poor physical property of T-J res-ervoir of Yinan 2 structure was the main cause for the ab-sence of oil accumulation, but the presence of natural gasreservoir in the structure. | PI Xuejun XIE Huiwen ZHANG Cun TIAN Zuoji | 2002 | Chinese Science Bulletin2002，47，S1： | 3 |
| 15 | Environmental Conditions of Barchan Dune and Barchan Chain-A Case Study from the Hexi Desert Area of Gansu显示文摘[Objective] The paper was to discuss why the top of tall barchan dunes and barchan chains widespread in single prevailing wind area had not been leveled by wind erosion. [Method] Based on the preliminary survey of distribution status,the morphological characteristics and environmental conditions of barchan dunes and barchan chains in Hexi desert area of Gansu were investigated in details. The significance of difference between samples and significance of correlation between indicators were examined via variance test. [Result] Barchan dunes and barchan chains in Hexi desert area of Gansu distributed at the leeward direction of desert fringe,generally in patch distribution. The distribution area was gravelly beach or cohesive gravel beach,with broader dune slack; winds in distribution area of barchan dunes and barchan chains blew obviously from one direction,while winds at other directions were light or occasionally strong but with low frequency;the barchan dune in the desert fringe of Hexi desert area of Gansu was relatively tall,while barchan chain was even more taller and larger. Coincidence or separation of the dune peak and the sand ridge might be related to distribution frequency of dominant prevailing wind or wind at opposite direction and the observation seasons.[Conclusion]Studying top stability of barchan dune has an important academic value in revealing blowing sand movement rule at desert fringe,invasion of sand flow,and expansion of desert. | Chang Zhaofeng Wang Qiangqiang Zhang Jianhui Xi Junqiang Wang Qi Zhang Dekui Tang Jinnian Zhang Huiwen | 2015 | Animal Husbandry and Feed Science2015，7，6： | 2 |
| 16 | Spatial variation and driving mechanism of soil organic carbon components in the alluvial/sedimentary zone of the Yellow River显示文摘Alluviation and sedimentation of the Yellow River are important factors influencing the surface soil structure and organic carbon content in its lower reaches.Selecting Kaifeng and Zhoukou as typical cases of the Yellow River flooding area,the field survey,soil sample collection,laboratory experiment and Geographic Information System(GIS)spatial analysis methods were applied to study the spatial distribution characteristics and change mechanism of organic carbon components at different soil depths.The results revealed that the soil total organic carbon(TOC),active organic carbon(AOC)and nonactive organic carbon(NOC)contents ranged from 0.05–30.03 g/kg,0.01–8.86 g/kg and 0.02–23.36 g/kg,respectively.The TOC,AOC and NOC contents in the surface soil layer were obviously higher than those in the lower soil layer,and the sequence of the content and change range within a single layer was TOC>NOC>AOC.Geostatistical analysis indicated that the TOC,AOC and NOC contents were commonly influenced by structural and random factors,and the influence magnitudes of these two factors were similar.The overall spatial trends of TOC,AOC and NOC remained relatively consistent from the 0–20 cm layer to the 20–100 cm layer,and the transition between high-and low-value areas was obvious,while the spatial variance was high.The AOC and NOC contents and spatial distribution better reflected TOC spatial variation and carbon accumulation areas.The distribution and depth of the sediment,agricultural land-use type,cropping system,fertilization method,tillage process and cultivation history were the main factors impacting the spatial variation in the soil organic carbon(SOC)components.Therefore,increasing the organic matter content,straw return,applying organic manure,adding exogenous particulate matter and conservation tillage are effective measures to improve the soil quality and attain sustainable agricultural development in the alluvial/sedimentary zone of the Yellow River. | LI Guodong ZHANG Junhua ZHU Lianqi TIAN Huiwen SHI Jiaqi REN Xiaojuan | 2021 | Journal of Geographical Sciences2021，31，4： | 2 |
| 17 | A Comparison of Shale Gas Fracturing Based on Deep and Shallow Shale Reservoirs in the United States and China显示文摘China began to build its national shale gas demonstration area in 2012.The central exploration,drilling,and development technologies for medium and shallow marine shale reservoirs with less than 3,500m of buried depth in Changning-Weiyuan,Zhaotong,and other regions had matured.In this study,we macroscopically investigated the development history of shale gas in the United States and China and compared the physical and mechanical conditions of deep and shallow reservoirs.The comparative results revealed that themain reasons for the order-ofmagnitude difference between China’s annual shale gas output and the United States could be attributed to three aspects:reservoir buried depth,reservoir physical and mechanical properties,and engineering technology level.The current engineering technology level of China could not meet the requirements of increasing production and reducing costs for deep shale gas reservoirs;they had reached the beneficial threshold development stage and lacked the capacity for large-scale commercial production.We identified several physical and mechanical reasons for this threshold development stage.Deep shale reservoirs were affected by the bedding fracture,low brittleness index,low clay mineral content,and significant areal differences,as well as by the transformation from elasticity to plasticity,difficulty in sanding,and high mechanical and strength parameters.Simultaneously,they were accompanied by six high values of formation temperature,horizontal principal stress difference,pore pressure,fracture pressure,extension pressure,and closure pressure.The key to deep shale gas horizontal well fracturing was to improve the complexity of the hydraulic fracture network,formadequate proppant support of fracture surface,and increase the practical stimulated reservoir volume(SRV),which accompanied visual hydraulic discrete network monitoring.On this basis,we proposed several ideas to improve China’s deep shale gas development involving advanced technology systems,developing tools,and supporting technologies in shale gas exploration and development in the United States.These ideas primarily involved stimulation technologies,such as vertically integrated dessert identification and optimization,horizontal well multistage/multicluster fracturing,staged tools development for horizontal wells,fractures network morphology monitoring by microseismic and distributed optical fiber,shale hydration expansion,soak well,and fracturing fluid flow back.China initially developed the critical technology of horizontal well large-scale and high-strength volume fracturing with a core of“staged fracturing with dense cutting+shorter cluster spacing+fracture reorientation by pitching+forced-sand addition+increasing diameter perforating+proppant combination by high strength and small particle size particles”.We concluded that China should continue to conduct critical research on theories and technical methods of horizontal well fracturing,suitable for domestic deep and ultra-deep marine and marine-continental sedimentary shale,to support and promote the efficient development of shale gas in China in the future.It is essential to balance the relationship between the overall utilization degree of the gas reservoir and associated economic benefits and to localize some essential tools and supporting technologies.These findings can contribute to the flourishing developments of China’s deep shale gas. | Qixing Zhang Bing Hou Huiwen Pang Shan Liu Yue Zeng | 2022 | Computer Modeling in Engineering & Sciences2022，，12： | 2 |
| 18 | Cytokine nanosponges suppressing overactive macrophages and dampening systematic cytokine storm for the treatment of hemophagocytic lymphohistiocytosis显示文摘Hemophagocytic lymphohistiocytosis(HLH)is a highly fatal condition with the positive feedback loop between continued immune cell activation and cytokine storm as the core mechanism to mediate multiple organ dysfunction.Inspired by macrophage membranes harbor the receptors with special high affinity for proin-flammation cytokines,lipopolysaccharide(LPS)-stimulated macrophage membrane-coated nanoparticles(LMNP)were developed to show strong sponge ability to both IFN-γand IL-6 and suppressed overactivation of macrophages by inhibiting JAK/STAT signaling pathway both in vitro and in vivo.Besides,LMNP also efficiently alleviated HLH-related symptoms including cytopenia,hepatosplenomegaly and hepatorenal dysfunction and save the life of mouse models.Furthermore,its sponge effect also worked well for five human HLH samples in vitro.Altogether,it’s firstly demonstrated that biocompatible LMNP could dampen HLH with high potential for clinical transformation,which also provided alternative insights for the treatment of other cytokine storm-mediated pathologic conditions such as COVID-19 infection and cytokine releasing syndrome during CAR-T therapy. | Honglan Wang Huiwen Liu Jia Li Chunying Liu Hui Chen Junying Li Chunyan Sun Tao Guo Zhiqing Pang Bo Zhang Yu Hu | 2023 | Bioactive Materials2023，，3： | 1 |
| 19 | Effects of Thioether Content on Thermal and Optical Properties of Polyam- ides显示文摘 | Zhang Gang Hu Jiangjun Yang Huiwen | 2012 | Polymer International2012，61，： | 1 |
| 20 | Thermochemical Study on Ternary Complexes of Dysprosium with Aromatic Acid and Phenanthroline显示文摘 | Xiao Shengxiong Gu Huiwen LI Xu Zhang Jianjun Ren Ning | 2010 | J Chem Eng Data2010，55，9： | 1 |
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