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| 1 | GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation显示文摘 | Yuting Guo Huiwen Wang Yinglong Tang Yue Wang Mengqi Zhang Zhiguang Yang Eric Nyirimigabo Bin Wei Zhongbing Lu Guangju Ji | 2018 | Protein & Cell2018，9，11： | 3 |
| 2 | Recent advances in hollow metal-organic frameworks and their composites for heterogeneous thermal catalysis显示文摘Hollow metal-organic frameworks(Ho MOFs)as emerging materials have been arousing great interest in heterogeneous catalysis with respect to the solid counterparts,mainly because of their unique and intriguing features such as high surface to volume ratio,large void space,short channel length,and more exposed active sites.To achieve diverse catalysis,it is of great importance to combine Ho MOFs with other active components for constructing smart composites.In this review,the recent advances in Ho MOFs and their composites for heterogeneous catalysis are summarized.Firstly,the synthetic strategies for various Ho MOFs with single shell,double shells or multiple shells are summarized,while their composites with yolk-shell,hollow sandwich and hollow satellite structures are described.Secondly,various catalytic reactions over Ho MOFs and their composites are discussed,and moreover,the relationships among the active components,structures and their performances are illustrated.Thirdly,the potential challenges and future development on Ho MOFs-based nanocatalysts are proposed.This review will bring some insights for better design and fabrication of heterogeneous nanocatalysts with the well-defined hollow structures. | Haowu Wang Fengbin Zheng Guangxin Xue Yinglong Wang Guodong Li Zhiyong Tang | 2021 | Science China Chemistry2021，64，11： | 2 |
| 3 | Comparative proteomic analysis provides insight into a complex regulatory network of taproot formation in radish (Raphanus sativus L.)显示文摘The fleshy taproot of radish is an important storage organ determining its yield and quality.Taproot thickening is a complex developmental process in radish.However,the molecular mechanisms governing this process remain unclear at the proteome level.In this study,a comparative proteomic analysis was performed to analyze the proteome changes at three developmental stages of taproot thickening using iTRAQ approach.In total,1862 differentially expressed proteins(DEPs)were identified from 6342 high-confidence proteins,among which 256 up-regulated proteins displayed overlapped accumulation in S1(pre-cortex splitting stage)vs.S2(cortex splitting stage)and S1 vs.S3(expanding stage)pairs,whereas 122 up-regulated proteins displayed overlapped accumulation in S1 vs.S3 and S2 vs.S3 pairs.Gene Ontology(GO)and pathway enrichment analysis showed that these DEPs were mainly involved in several processes such as“starch and sucrose metabolism”,“plant hormone signal transduction”,and“biosynthesis of secondary metabolites”.A high concordance existed between iTRAQ and RT-qPCR at the mRNA expression levels.Furthermore,association analysis showed that 187,181,and 96 DEPs were matched with their corresponding differentially expressed genes(DEGs)in S1 vs.S2,S1 vs.S3,and S2 vs.S3 comparison,respectively.Notably,several functional proteins including cell division cycle 5-like protein(CDC5),expansin B1(EXPB1),and xyloglucan endotransglucosylase/hydrolase protein 24(XTH24)were responsible for cell division and expansion during radish taproot thickening process.These results could facilitate a better understanding of the molecular mechanism underlying taproot thickening,and provide valuable information for the identification of critical genes/proteins responsible for taproot thickening in root vegetable crops. | Yang Xie Liang Xu Yan Wang Lianxue Fan Yinglong Chen Mingjia Tang Xiaobo Luo Liwang Liu | 2018 | Horticulture Research2018，5，1： | 1 |
| 4 | Effect of Antibacterial Enoxacin on the Properties of Injectable Nano-hydroxyapatite/Polyurethane Cement for Bone Repairing显示文摘Biomaterial-associated infection(BAI)is a kind of serious post-operative complication in orthopaedic surgery.Antibiotic-loaded bone cement shines a light on BAI prevention for convenient manipulation and complex filling.To this aim,we designed an antibacterial bone cement based on Nano-hydroxyapatite/Polyurethane(PUHA)loading with antibiotic Enoxacin(EN).The distinct shear-thinning behavior of the prepolymers was observed,indicating a good injectability.The PUHA bone cement possessed a suitable curing speed,and the addition of EN might slightly expedite the curing process and enhance the mechanical properties.The EN release profile indicated that the EN-loaded bone cement could reach the minimum inhibitory concentration in 2 h,and sustainedly released EN for almost 8 days,exhibiting an antibacterial delivery potential.Antibacterial test further confirmed the antibacterial ability of EN-loaded bone cement is in a dose-dependent manner.However,the osteogenic performance of drug-loaded bone cement with high dosage is not as good as antibacterial activity.When the EN concentration of antibacterial cement was lower than 32μg·mL^(-1),the proliferation and osteogenic differentiation of rat mesenchymal stem cells could be significantly promoted.Overall,this study verified the potential of the EN-loaded PUHA bone cement in anti-infection and osteogenesis for bone repairing. | Jinzheng Zhang Xiaoyu Lei Jiajing Tang Jie Chen Qing Zhao Wei Fang Yinglong Zhang Yubao Li Yi Zuo | 2022 | Journal of Bionic Engineering2022，19，2： | 0 |
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