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| 1 | The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis显示文摘Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,'Huang Qin,' are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants. | Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin | 2019 | Molecular Plant2019，12，7： | 23 |
| 2 | The Antagonistic Action of Abscisic Acid and Cytokinin Signaling Mediates Drought Stress Response in Arabidopsis显示文摘 | Xiaozhen Huang Lingyan Hou Jingjing Meng Huiwen You Zhen Li Zhizhong Gong Shuhua Yang Yiting Shi | 2018 | Molecular Plant2018，11，7： | 15 |
| 3 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 4 | Discrimination of Motor Imagery Patterns by Electroencephalogram Phase Synchronization Combined With Frequency Band Energy显示文摘Central nerve signal evoked by thoughts can be directly used to control a robot or prosthetic devices without the involvement of the peripheral nerve and muscles.This is a new strategy of human-computer interaction.A method of electroencephalogram(EEG) phase synchronization combined with band energy was proposed to construct a feature vector for pattern recognition of brain-computer interaction based on EEG induced by motor imagery in this paper,rhythm and beta rhythm were first extracted from EEG by band pass filter and then the frequency band energy was calculated by the sliding time window;the instantaneous phase values were obtained using Hilbert transform and then the phase synchronization feature was calculated by the phase locking value(PLV) and the best time interval for extracting the phase synchronization feature was searched by the distribution of the PLV value in the time domain.Finally,discrimination of motor imagery patterns was performed by the support vector machine(SVM).The results showed that the phase synchronization feature more effective in4s-7s and the correct classification rate was 91.4%.Compared with the results achieved by a single EEG feature related to motor imagery,the correct classification rate was improved by 3.5 and4.3 percentage points by combining phase synchronization with band energy.These indicate that the proposed method is effective and it is expected that the study provides a way to improve the performance of the online real-time brain-computer interaction control system based on EEG related to motor imagery. | Chuanwei Liu Yunfa Fu Jun Yang Xin Xiong Huiwen Sun Zhengtao Yu | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，3： | 3 |
| 5 | GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation显示文摘 | Yuting Guo Huiwen Wang Yinglong Tang Yue Wang Mengqi Zhang Zhiguang Yang Eric Nyirimigabo Bin Wei Zhongbing Lu Guangju Ji | 2018 | Protein & Cell2018，9，11： | 3 |
| 6 | Postharvest BTH treatment induced disease resistance and enhanced reactive oxygen species metabolism in muskmelon (Cucumis melo L.) fruit显示文摘 | Yalin Ren Yunfei Wang Yang Bi Yonghong Ge Yi Wang Cunfei Fan Daqiang Li Huiwen Deng | 2012 | European Food Research and Technology2012，，6： | 2 |
| 7 | Indifference pricing and hedging in a multiple-priors model with trading constraints显示文摘This paper considers utility indifference valuation of derivatives under model uncertainty and trading constraints, where the utility is formulated as an additive stochastic differential utility of both intertemporal consumption and terminal wealth, and the uncertain prospects are ranked according to a multiple-priors model of Chen and Epstein(2002). The price is determined by two optimal stochastic control problems(mixed with optimal stopping time in the case of American option) of forward-backward stochastic differential equations.By means of backward stochastic differential equation and partial differential equation methods, we show that both bid and ask prices are closely related to the Black-Scholes risk-neutral price with modified dividend rates.The two prices will actually coincide with each other if there is no trading constraint or the model uncertainty disappears. Finally, two applications to European option and American option are discussed. | YAN HuiWen LIANG GeChun YANG Zhou | 2015 | Science China Mathematics2015，58，4： | 2 |
| 8 | Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes mellitus:a cross-sectional cohort study显示文摘This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinine ratio(UACR)in patients with type 2 diabetes mellitus(T2DM)and the association with biomarkers of inflammation and fibrosis in diabetic kidney disease(DKD).A total of 390 patients with T2DM were divided into three groups:normal albuminuria(UACR<30 mg/g,n=136,NA),microalbuminuria(UACR at 30-300 mg/g,n=132,MA),and clinical albuminuria(UACR>300 mg/g,n=122,CA).Circulating miR-154-5p,inflammatory(C-reactive protein(CRP);erythrocyte sedimentation rate(ESR);and tumor necrosis factor-a(TNF-α)and fibrotic markers(vascular endothelial growth factor(VEGF);transforming growth factor-β1(TGF-β1);and fibronectin(FN),and other biochemical indicators were assessed via real-time PCR,enzyme-linked immunosorbent assay,and chemiluminescence assay in patients with T2DM and 138 control subjects(NC).UACR,miR-154-5p,glycated hemoglobin(HbA1c),serum creatinine(sCr),blood urea nitrogen(BUN),ESR,CRP,VEGF,TNF-α,TGF-β1,and FN were significantly higher and the estimated glomerular filtration rate(eGFR)was significantly lower in NA,MA,and CA groups than in NC subjects(P<0.05).Elevated levels of UACR and miR-154-5p were directly correlated with HbA1c,sCr,BUN,ESR,CRP,VEGF,TNF-α,TGF-β1,and FN and negatively correlated with eGFR(P<0.05).miR-154-5p,HbA1c,sCr,BUN,eGFR,ESR,CRP,VEGF,TNF-α,TGF-β1,and FN were important factors affecting UACR.These findings indicated that elevated serum miR-154-5p is significantly correlated with high UACR in patients with T2DM and may offer a novel reference for the early diagnosis of DKD. | Huiwen Ren Can Wu Ying Shao Shuang Liu Yang Zhou Qiuyue Wan | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 9 | Effects of Thioether Content on Thermal and Optical Properties of Polyam- ides显示文摘 | Zhang Gang Hu Jiangjun Yang Huiwen | 2012 | Polymer International2012，61，： | 1 |
| 10 | CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis显示文摘 | Tianxia Jiang Jie Zhuang Hongxia Duan Yongting Luo Qiqun Zeng Kelong Fan Huiwen Yan Di Lu Zhongde Ye Junfeng Hao Jing Feng Dongling Yang Xiyun Yan | 2012 | Blood2012，，11： | 1 |
| 11 | Integrative method in lithofacies characteristics and 3D velocity volume of the Permian igneous rocks in H area, Tarim Basin显示文摘This paper introduces horizon control, seismic control, logging control and facies control methods through the application of the least squares fitting of logging curves, seismic inversion and facies-controlled techniques. Based on the microgeology and thin section analyses, the lithology, lithofacies and periods of the Permian igneous rocks are described in detail. The seismic inversion and facies-controlled techniques were used to find the distribution characteristics of the igneous rocks and the 3D velocity volume. The least squares fitting of the logging curves overcome the problem that the work area is short of density logging data. Through analysis of thin sections, the lithofacies can be classified into eruption airfall subfacies, eruption pyroclastic flow subfacies and eruption facies. | Yang Haijun Liu Yongfu Xie Huiwen Xu Yongzhong Sun Qi Wang Shuangshuang | 2013 | International Journal of Mining Science and Technology2013，23，2： | 1 |
| 12 | A novel solid-state electrochemil quenching sensor for detection of ani- line based on luminescent composite nanofibers 显示文摘 | Wang Xiaoying Yang Yu Gao Huiwen | 2014 | J Lumi- nesc2014，156，： | 1 |
| 13 | Electrohydrogenation of 4-amino-5-nitrosodimethyl uracil with a foamed nickel cathode显示文摘 | HU Xien YANG Huiwen WANG Xuejun | 2002 | J Applied Electrochemistry2002，32，3： | 1 |
| 14 | Electrohydrogenation of 4 -amino- 5-nitrosodimethyl-uracil with a foamed nickel cathode 显示文摘 | HU Xien YANG Huiwen WANG Xuejun | 2002 | Journal of Applied Electrochemistry2002，32，： | 1 |
| 15 | Insulin therapy restores impaired function and expression of P-glycoprotein in blood–brain barrier of experimental diabetes显示文摘 | Haiyan Liu Xiaodong Liu Lee Jia Yuchun Liu Huiwen Yang Guangji Wang Lin Xie | 2008 | Biochemical Pharmacology2008，，8： | 1 |
| 16 | Analysis of gene mutations in Chinese patients with maple syrup urine disease显示文摘 | Nan Yang Lianshu Han Xuefan Gu Jun Ye Wenjuan Qiu Huiwen Zhang Zhuwen Gong Yafen Zhang | 2012 | Molecular Genetics and Metabolism2012，，4： | 1 |
| 17 | Effect of postharvest acibenzolar-S-methyl dipping on phenylpropanoid pathway metabolism in muskmelon ( Cucumis melo L.) fruits显示文摘 | Yaoyao Liu Yonghong Ge Yang Bi Canying Li Huiwen Deng Lingang Hu Boyu Dong | 2014 | Scientia Horticulturae2014，，： | 1 |
| 18 | Low back pain and osteoarthritis pain:a perspective of estrogen显示文摘Low back pain(LBP)is the world's leading cause of disability and is increasing in prevalence more rapidly than any other pain condition.Intervertebral disc(IVD)degeneration and facet joint osteoarthritis(FJOA)are two common causes of LBP,and both occur more frequently in elderly women than in other populations.Moreover,osteoarthritis(OA)and OA pain,regardless of the joint,are experienced by up to twice as many women as men,and this difference is amplified during menopause.Changes in estrogen may be an important contributor to these pain states.Receptors for estrogen have been found within IVD tissue and nearby joints,highlighting the potential roles of estrogen within and surrounding the IVDs and joints.In addition,estrogen supplementation has been shown to be effective at ameliorating IVD degeneration and OA progression,indicating its potential use as a therapeutic agent for people with LBP and OA pain.This review comprehensively examines the relationship between estrogen and these pain conditions by summarizing recent preclinical and clinical findings.The potential molecular mechanisms by which estrogen may relieve LBP associated with IVD degeneration and FJOA and OA pain are discussed. | Huiwen Pang Shihui Chen David M.Klyne David Harrich Wenyuan Ding Sidong Yang Felicity Y.Han | 2023 | Bone Research2023，11，3： | 0 |
| 19 | Operating pesticide use reduction within the boundary of food security in peri-urban settings显示文摘Pesticide use in peri-urban areas afects the urban enviroment and public health,and reducing the use may present food security isues for urban dwellers.In this study,we explore how a muiallyadopted goal of a 20%reduetion in pesticide use could be achieved,along with local food security and environmental implica-tions,for Shanghai located in the densely populated East China.A regional Shanghai Agricultural Sector Model inorporating district-and technology-varying crop budgets,was developed to simulate the efects of pesticide reduction policy.Here we find that achieving the reduction goal had the largest implications in districts with high pesticide use totals and intensities,potentially reducing pesticide non point source pollution in the Yangtze River Estuary and Dianshan Lake;the production levels of rice and leafy vegetables would be most afected;and adopting machinery that allows more precise pesticide application modulates these results.Moreover,imposing the requlrements at the district-level caused more severe local food security concerns,and less environmental benefits.Furthermore,a closed Shanghai's agricultural economy would subtantally enlarge the regional het-erogeneity in the above-mentioaned outcomes.Exploring the ffects of a quantity control policy on current-use pesticides at diferent aggregation levels has important implications for regulating the use of agrochemicals. | Yuquan W.Zhang Bruce A.McCarl Zhengwei Cao Qiang Li Shaohua Yang Huiwen Liu | 2022 | Fundamental Research2022，2，4： | 0 |
| 20 | Electrocatalytic CO_(2) reduction to C_(2)H_(4): From lab to fab显示文摘The global concerns of energy crisis and climate change,primarily caused by carbon dioxide(CO_(2)),are of utmost importance.Recently,the electrocatalytic CO_(2) reduction reaction(CO_(2)RR) to high value-added multi-carbon(C_(2+)) products driven by renewable electricity has emerged as a highly promising solution to alleviate energy shortages and achieve carbon neutrality.Among these C_(2+) products,ethylene(C_(2)H_(4))holds particular importance in the petrochemical industry.Accordingly,this review aims to establish a connection between the fundamentals of electrocatalytic CO_(2) reduction reaction to ethylene(CO_(2)RRto-C_(2)H_(4)) in laboratory-scale research(lab) and its potential applications in industrial-level fabrication(fab).The review begins by summarizing the fundamental aspects,including the design strategies of high-performance Cu-based electrocatalysts and advanced electrolyzer devices.Subsequently,innovative and value-added techniques are presented to address the inherent challenges encountered during the implementations of CO_(2)RR-to-C_(2)H_(4) in industrial scenarios.Additionally,case studies of the technoeconomic analysis of the CO_(2)RR-to-C_(2)H_(4) process are discussed,taking into factors such as costeffectiveness,scalability,and market potential.The review concludes by outlining the perspectives and challenges associated with scaling up the CO_(2)RR-to-C_(2)H_(4) process.The insights presented in this review are expected to make a valuable contribution in advancing the CO_(2)RR-to-C_(2)H_(4) process from lab to fab. | Zeyu Guo Fabao Yang Xiaotong Li Huiwen Zhu Hainam Do Kam Loon Fow Jonathan D.Hirst Tao Wu Qiulin Ye Yaqi Peng Hao Bin Wu Angjian Wu Mengxia Xu | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
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