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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Direct generation of an ultrafast vortex beam in a CVD-graphene-based passively mode-locked Pr:LiYF4 visible laser显示文摘We report on the direct generation of passively mode-locked vortex lasers in the visible spectral region, for the first time to the best of our knowledge, using a Pr :Li YF4(Pr:YLF) crystal as the gain medium. A stable mode-locked TEM00 mode has been achieved with a maximum average output power of 75 m W using a graphene saturable absorber mirror. The mode-locked pulse width is measured to be as short as about 73.4 ps at a repetition rate of about 140 MHz, and the laser wavelength is at about 721 nm with spectral width of about 0.5 nm. By slightly misaligning the laser resonator, a first-order Laguerre-Gaussian mode(LG0,1) has also been obtained with output power reduced to about 22 m W. The achieved LG0,1 mode has been verified via a home made improved Fizeau interferometer. This work provides a simple and universal method for direct generation of an ultrafast vortex laser,which can be readily extended to other spectral regions by using different laser gain mediums. | Nan Li Junjie Huang Bin Xu Yaqi Cai Jie Lu Linjie Zhan Zhengqian Luo Huiying Xu Zhiping Cai Weiwei Cai | 2019 | Photonics Research2019，7，11： | 9 |
| 3 | Physics-informed neural networks(PINNs)for fluidmechanics:a review显示文摘Despite the significant progress over the last 50 years in simulating flow problems using numerical discretization of the Navier–Stokes equations(NSE),we still cannot incorporate seamlessly noisy data into existing algorithms,mesh-generation is complex,and we cannot tackle high-dimensional problems governed by parametrized NSE.Moreover,solving inverse flow problems is often prohibitively expensive and requires complex and expensive formulations and new computer codes.Here,we review flow physics-informed learning,integrating seamlessly data and mathematical models,and implement them using physics-informed neural networks(PINNs).We demonstrate the effectiveness of PINNs for inverse problems related to three-dimensional wake flows,supersonic flows,and biomedical flows. | Shengze Cai Zhiping Mao Zhicheng Wang Minglang Yin George Em Karniadakis | 2021 | Acta Mechanica Sinica2021，37，12： | 7 |
| 4 | Self-Q-switched and wavelength-tunable tungsten disulfide-based passively Q-switched Er:Y2O3 ceramic lasers显示文摘We report on diode-pumped Er:Y_2O_3 ceramic lasers at about 2.7 μm in the tunable continuous-wave, selfQ-switching and tungsten disulfide(WS2)-based passively Q-switching regimes. For stable self-Q-switched operation, the maximum output power reaches 106.6 m W under an absorbed power of 2.71 W. The shortest pulse width is measured to be about 1.39 μs at a repetition rate of 26.7 kHz at maximum output. Using a spin-coated WS2 as a saturable absorber, a passively Q-switched Er:Y_2O_3 ceramic laser is also realized with a maximum average output power of 233.5 m W(for the first time, to the best of our knowledge). The shortest pulse width decreases to 0.72 μs at a corresponding repetition rate of 29.4 kHz, which leads to a pulse energy of 7.92 μJ and a peak power of 11.0 W. By inserting an undoped YAG thin plate as a Fabry–Perot etalon, for the passive Q switching, wavelength tunings are also demonstrated at around 2710, 2717, 2727, and 2740 nm. | XIAOFENG GUAN JIAWEI WANG YUZHAO ZHANG BIN XU ZHENGQIAN LUO HUIYING XU ZHIPING CAI XIAODONG XU JIAN ZHANG JUN XU | 2018 | Photonics Research2018，6，9： | 6 |
| 5 | An Active Defense Solution for ARP Spoofing in OpenFlow Network显示文摘As an emerging network technology,Software-defined network(SDN), has been rapidly developing for recent years due to its advantage in network management and updating. There are still a lot of open problems while applying this novel technology in reality,especially for meeting security demands. The Address resolution protocol(ARP) spoofing, a representative network attack in traditional networks is investigated.We implement the ARP spoofing in SDN network firstly and find that the threat of ARP attack still exists and has big impact on the network. We propose a novel mechanism as defense solution for ARP spoofing oriented to OpenFlow platform. Theoretical analyzation is given, and the mechanism is implemented as a module of POX controller. Experiment results and performance evaluations show that our solution can reduce the security threat of ARP spoofing remarkably on OpenFlow platform and related SDN platforms. | XIA Jing CAI Zhiping HU Gang XU Ming | 2019 | Chinese Journal of Electronics2019，28，1： | 6 |
| 6 | A validated UPLC–MS/MS method for simultaneous determination of imatinib, dasatinib and nilotinib in human plasma显示文摘sensitive, rapid, simple and economical ultra-performance liquid chromatography–tandem mass spectrometric method(UPLC–MS/MS) was developed and validated for simultaneous determination of imatinib,dasatinib and nilotinib in human plasma using gliquidone as internal standard(IS). Liquid-liquid extraction method with ethyl acetate was used for sample pre-treatment. The separation was performed on an Xtimate Phenyl column using isocratic mobile phase consisting of A(aqueous phase: 0.15% formic acid and 0.05% ammonium acetate) and B(organic phase: acetonitrile)(A:B=40:60, v/v). The flow rate was 0.25 mL/min and the total run time was 6 min. The multiple reaction monitoring(MRM) transitions, m/z 494.5→394.5 for imatinib, 488.7→401.5 for dasatinib, 530.7→289.5 for nilotinib and 528.5→403.4 for IS, were chosen to achieve high selectivity in the simultaneous analyses. The method exhibited great improvement in sensitivity and good linearity over the concentration range of 2.6–5250.0 ng/mL for imatinib, 2.0–490.0 ng/mL for dasatinib, and 2.4–4700.0 ng/mL for nilotinib. The method showed acceptable results on sensitivity, specificity,recovery, precision, accuracy and stability tests. This UPLC–MS/MS assay was successfully used for human plasma samples analysis and no significant differences were found in imatinib steady-state trough concentrations among the SLC22A5-1889T > C or SLCO1B3 699G > A genotypes(P > 0.05). This validated method can provide support for clinical therapeutic drug monitoring and pharmacokinetic investigations of these three tyrosine kinase inhibitors(TKIs). | Jing Zeng Hualin Cai Zhiping Jiang Qing Wang Yan Zhu Ping Xu Xielan Zhao | 2017 | Journal of Pharmaceutical Analysis2017，7，6： | 6 |
| 7 | CsPbBr_3 perovskite quantum dots: saturable absorption properties and passively Q-switched visible lasers显示文摘This work presents the saturable absorption(SA) properties of CsPbBr_3 perovskite quantum dots(QDs). The perovskite QDs show excellent SA performance with a nonlinear absorption coefficient of-35 × 10^(-2) cm∕GW and a figure of merit of 3.7 × 10^(-14) esu cm. Further, their use as saturable absorbers in a passively Q-switched visible solid-state laser for the generation of soliton pulses is demonstrated. These results demonstrate thepotential for the perovskite QDs to act as saturable absorbers. | JINGZHOU LI HONGXING DONG BIN XU SAIFENG ZHANG ZHIPING CAI JUN WANG LONG ZHANG | 2017 | Photonics Research2017，5，5： | 5 |
| 8 | Feature Selection Method Based on Class Discriminative Degree for Intelligent Medical Diagnosis显示文摘By using efficient and timely medical diagnostic decision making,clinicians can positively impact the quality and cost of medical care.However,the high similarity of clinical manifestations between diseases and the limitation of clinicians’knowledge both bring much difficulty to decision making in diagnosis.Therefore,building a decision support system that can assist medical staff in diagnosing and treating diseases has lately received growing attentions in the medical domain.In this paper,we employ a multi-label classification framework to classify the Chinese electronic medical records to establish corresponding relation between the medical records and disease categories,and compare this method with the traditional medical expert system to verify the performance.To select the best subset of patient features,we propose a feature selection method based on the composition and distribution of symptoms in electronic medical records and compare it with the traditional feature selection methods such as chi-square test.We evaluate the feature selection methods and diagnostic models from two aspects,false negative rate(FNR)and accuracy.Extensive experiments have conducted on a real-world Chinese electronic medical record database.The evaluation results demonstrate that our proposed feature selection method can improve the accuracy and reduce the FNR compare to the traditional feature selection methods,and the multi-label classification framework have better accuracy and lower FNR than the traditional expert system. | Shengqun Fang Zhiping Cai Wencheng Sun Anfeng Liu Fang Liu Zhiyao Liang Guoyan Wang | 2018 | Computers, Materials & Continua2018，，6： | 5 |
| 9 | Oxidative damage of primary cultured hippocampal neurons Does androgen have an antagonistic effect?显示文摘BACKGROUND: Evidence illustrates that androgen has a neuroprotective role.However,whether androgen also has the protective effect on hippocampal neurons during free radical mediated injury remains unclear.OBJECTIVE: To investigate the neuroprotective effect of androgen on hippocampal neurons during free radical damage.DESIGN,TIME AND SETTING: A controlled in vitro experiment was performed at the Department of Human Anatomy,Cell Culture Lab,and Neuroendocrinology Lab,Basic Medical School,Hebei Medical University from February to June 2009.MATERIALS: Testosterone was provided by Tianjin Jinyao Amino Acid Company,China.METHODS: Primary cultured neurons from 24 Sprague Dawley rats were randomly assigned into four groups: control,H2O2,testosterone,and testosterone (pre-added) plus H2O2 groups.MAIN OUTCOME MEASURES: The positive cell ratio of microtubule associated protein-II and neuron specific enolase was determined by immunocytochemistry.Neuronal morphology was observed by hematoxylin-eosin staining and Nissl staining.Cell vitality and viability were determined using an inverted phase contrast microscope.The content of nitric oxide synthase,malondialdehyde,and superoxide dismutase were measured with a spectrophotometer.RESULTS: As compared with the control group,cell vitality and viability,and superoxide dismutase level were significantly decreased in the H2O2 group (P < 0.05),while nitric oxide synthase and malondialdehyde levels were significantly increased (P < 0.05).Neuronal vitality and viability as well as superoxide dismutase level in the testosterone plus H2O2 group were significantly greater than in the H2O2 group (P < 0.05),and nitric oxide synthase and malondialdehyde levels were significantly less than in the H2O2 group (P < 0.05).CONCLUSION: Androgen partially reversed H2O2-induced neuronal damage and protected neurons. | Zhaohui Li Zhiping Cai Huixian Cui Jinsong Zhu Sha Li Guosheng Xie Lei Xue | 2010 | Neural Regeneration Research2010，5，5： | 4 |
| 10 | Using Imbalanced Triangle Synthetic Data for Machine Learning Anomaly Detection显示文摘The extreme imbalanced data problem is the core issue in anomaly detection.The amount of abnormal data is so small that we cannot get adequate information to analyze it.The mainstream methods focus on taking fully advantages of the normal data,of which the discrimination method is that the data not belonging to normal data distribution is the anomaly.From the view of data science,we concentrate on the abnormal data and generate artificial abnormal samples by machine learning method.In this kind of technologies,Synthetic Minority Over-sampling Technique and its improved algorithms are representative milestones,which generate synthetic examples randomly in selected line segments.In our work,we break the limitation of line segment and propose an Imbalanced Triangle Synthetic Data method.In theory,our method covers a wider range.In experiment with real world data,our method performs better than the SMOTE and its meliorations. | Menghua Luo Ke Wang Zhiping Cai Anfeng Liu Yangyang Li Chak Fong Cheang | 2019 | Computers, Materials & Continua2019，，1： | 4 |
| 11 | Diode-pumped wavelength-switchable visible Pr^(3+):YLF laser and vortex laser around 670 nm显示文摘Here we developed a novel wavelength-switchable visible continuous-wave(CW)Pr^(3+):YLF laser around 670 nm.In single-wavelength laser operations,the maximum output powers of 2.60 W,1.26 W,and 0.21 W,the maximum slope efficiencies of 34.7%,27.3%,and 12.3%were achieved with good beam qualities(M^(2)<1.6)at 670.4 nm,674.2 nm,and 678.9 nm,respectively.Record-high output power(2.6 W)and record-high slope efficiency(34.7%)were achieved for the Pr^(3+):YLF laser operation at 670.4 nm.This is also the first demonstration of longer-wavelength peaks beyond 670 nm in the^(3)P_(1)→^(3)F_(3)transition of Pr^(3+):YLF.In multi-wavelength laser operations,the dual-wavelength lasings,including 670.1/674.8 nm,670.1/679.1 nm,and 675.0/679.4 nm,were obtained by fine adjustment of one/two etalons within the cavity.Furthermore,the triple-wavelength lasings,e.g.672.2/674.2/678.6 nm and 670.4/674.8/679.4 nm,were successfully demonstrated.Moreover,both the first-order vortex lasers(LG_(0)^(+1)and LG_(0)^(-1)modes)at 670.4 nm were obtained by off-axis pumping. | Xiuji Lin Qichen Feng Yao Zhu Shuaihao Ji Bo Xiao Huiying Xu Wensong Li Zhiping Cai | 2021 | Opto-Electronic Advances2021，4，4： | 4 |
| 12 | Mid‐infrared all‐fiber gain‐switched pulsed laser at 3μm显示文摘Mid-infrared(MIR)fiber pulsed lasers are of tremendous application interest in eye-safe LIDAR,spectroscopy,chemical detection and medicine.So far,these MIR lasers largely required bulk optical elements,complex free-space light alignment and large footprint,precluding compact all-fiber structure.Here,we proposed and demonstrated an all-fiberized structured gain-switched Ho3+-doped ZBLAN fiber laser operating around 2.9μm.A home-made 1146 nm Raman fiber pulsed laser was utilized to pump highly concentrated single-cladding Ho3+-doped ZBLAN fiber with different lengths of 2 m or 0.25 m.A home-made MIR fiber mirror and a perpendicular-polished ZBLAN fiber end construct the all-fiberized MIR cavity.Stable gain-switched multiple states with a sub-pulse number tuned from 1 to 8 were observed.The effects of gain fiber length,pump power,pump repetition rate and output coupling ratio on performance of gain-switched pulses were further investigated in detail.The shortest pulse duration of 283 ns was attained with 10 kHz repetition rate.The pulsed laser,centered at 2.92μm,had a maximum average output power of 54.2 mW and a slope efficiency of 10.12%.It is,to the best of our knowledge,the first time to demonstrate a mid-infrared gain-switched Ho3+:ZBLAN fiber laser with compact all-fiber structure. | Xiaojin Zhang Weiwei Li Jin Li Huiying Xu Zhiping Cai Zhengqian Luo | 2020 | Opto-Electronic Advances2020，3，5： | 4 |
| 13 | Organic–inorganic hybrid perovskite scintillators for mixed field radiation detection显示文摘Sensitive and fast detection of neutrons and gamma rays is vital for homeland security,high-energy physics,and proton therapy.Fast-neutron detectors rely on light organic scintillators,andγ-ray detectors use heavy inorganic scintillators and semiconductors.Efficient mixed-field detection using a single material is highly challenging due to their contradictory requirements.Here we report hybrid perovskites(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)that combine light organic cations and heavy inorganic skeletons at a molecular level to achieve unprecedented performance for mixed-field radiation detection.High neutron absorption due to a high density of hydrogen,strong radiative recombination within the highly confined[PbX_(6)]^(4-)layer,and sub-nanometer distance between absorption sites and radiative centers,enable a light yield of 41000 photons/MeV,detection pulse width of 2.97 ns and extraordinary linearity response toward both fast neutrons andγ-rays,outperforming commonly used fast-neutron scintillators.Neutron energy spectrum,time-of-flight based fast-neutron/γ-ray discrimination and neutron yield monitoring were all successfully achieved using(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)detectors.We further demonstrate the monitoring of reaction kinetics and total power of a nuclear fusion reaction.We envision that molecular hybridized scintillators open a new avenue for mixed-field radiation detection and imaging. | Mengling Xia Guangda Niu Linyue Liu Runlong Gao Tong Jin Pengying Wan Weicheng Pan Xianpeng Zhang Zuoxiang Xie Sam Teale Zenghua Cai Jiajun Luo Shan Zhao Haodi Wu Shiyou Chen Zhiping Zheng Qingguo Xie Xiaoping Ouyang Edward HSargent Jiang Tang | 2022 | InfoMat2022，4，9： | 2 |
| 14 | A METHOD OF TASK ALLOCATION AND AUTOMATED NEGOTIATION FOR MULTI ROBOTS显示文摘A method of task allocation and automated negotiation for multi robots was proposed. Firstly, the principles of task allocation were described based on the real capability of robot. Secondly, the model of automated negotiation was constructed, in which Least-Squares Support Vector Regression (LSSVR) was improved to estimate the opponent's negotiation utility and the robust controller of output feedback was employed to optimize the utility performance indicators. Thirdly, the protocol of negotiation and reallocation was proposed to improve the real-time capability and task allocation. Finally, the validity of method was proved through experiments. | Ke Wende Peng Zhiping Yuan Quande Hong Bingrong Chen Ke Cai Zesu | 2012 | Journal of Electronics(China)2012，29，6： | 2 |
| 15 | Wind Tunnel Experiments and Numerical Study on Performance Characteristics of an H-type Vertical Axis Wind Turbine in the Spanwise Direction显示文摘The aerodynamic forces and vortex characteristics of an H-type Vertical Axis Wind Turbine(VAWT)become complicated because of dynamic stall,particularly in the three-dimensional impact on the blade spanwise direction.This study focused on the evaluation of the aerodynamic performance and vortex characteristics of an H-type VAWT in the spanwise direction by numerical simulations and wind tunnel experiments.Pressure acting on the blade surface was obtained from multiport pressure measurement devices by wind tunnel.Meanwhile,the vortex field around different blade sections was investigated through numerical simulations.The stall behavior was analysed by comparing the results of numerical simulations and experiments.As a result,the tangential force of single blade was mainly contributed at the chordwise position of x/c≤0.4 c and the power of single blade was mainly contributed at the azimuthal angle range of 60°≤θ≤150°in the blade section position region of 0≤z/(H/2)≤0.7.At the section position of z/(H/2)=0.5,the initial flow separation was found at the suction side and progressed forward to the leading edge.With the increase of the tip speed ratios,the decreasing position of the averaged local power coefficient of each section was closer to the middle section of z/(H/2)=0,and the attenuation speed became faster.The power coefficient reductions at the blade section position of z/(H/2)=0.9 were 38.29%,46.78%and 56.42%when the tip speed ratios were 1.38,2.19 and 2.58,respectively.The results of this study provided a better understanding of the development of the performance characteristics and vortex characteristics of H-type VAWT. | ZHANG Yanfeng LI Qing’an ZHU Xinyu SONG Xiaowen CAI Chang GUO Zhiping | 2021 | Journal of Thermal Science2021，30，3： | 2 |
| 16 | Effect of chlorine dioxide on avian influenza A(H7N9)virus显示文摘Avian influenza remains a threat to human wellbeing.Hypochlorite derivatives are commonly used as disinfectants to prevent the spread of the disease.The World Health Organization(WHO)has listed chlorine dioxide(ClO_(2))as an A1‐level,safe,and efficient disinfectant.In this study,we tested the efficacy of ClO_(2),in aqueous solution and gas forms,against avian influenza A(H7N9)virus.The virus suspension was mixed with ClO_(2) aqueous solutions of various concentrations and for various time intervals.Aliquots of the mixture were then serially diluted,and the 50%tissue culture infective dose(TCID50)was measured with a hemagglutination test on MDCK cells.ClO_(2) gas produced from generators was introduced in a chamber containing the virus suspension in a Petri dish.The infective activity of the surviving virus was measured by the hemagglutination test.An aqueous solution of ClO_(2) at 126μg/mL for 15 s was effective given that no surviving virus was detected with the hemagglutination test.ClO_(2) gas at>5μL/L sustained for 1 h inactivated the virus effectively,while at 2.5μL/L for 1 h,it only partially inactivated the virus.ClO_(2) as gas or aqueous solution at a certain concentration is effective in inactivating the H7N9 virus,and can be applied for the decontamination and disinfection of environments. | Zhiping Sun Yun Qian Norio Ogata Xia Cai Wendong Han Youhua Xie Hirofumi Morino Koushirou Sogawa Takashi Shibata Di Qu | 2022 | Biosafety and Health2022，4，1： | 2 |
| 17 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 18 | Visible Raman and Brillouin lasers from a microresonator/ZBLAN-fiber hybrid system显示文摘Raman and Brillouin lasers based on a high-quality(high-Q) whispering gallery mode microresonator(WGMR)are usually achieved by employing a tunable single-frequency laser as a pump source. Here, we experimentally demonstrate visible Raman and Brillouin lasers using a compact microresonator/ZrF4-BaF2-LaF3-AlF3-NaF(ZBLAN)-fiber hybrid system by incorporating a WGMR with a fiber-compatible distributed Bragg reflector/fiber Bragg grating to form a Fabry–Perot(F-P) fiber cavity and using a piece of Pr:ZBLAN fiber as gain medium.The high-Q silica-microsphere not only offers a Rayleigh-scattering-induced backreflection to form the ~635 nm red laser oscillation in the F-P fiber cavity, but also provides a nonlinear gain in the WGMR itself to generate either stimulated Raman scattering or stimulated Brillouin scattering. Up to six-order cascaded Raman lasers at0.65 μm, 0.67 μm, 0.69 μm, 0.71 μm, 0.73 μm, and 0.76 μm are achieved, respectively. Moreover, a Brillouin laser at 635.54 nm is clearly observed. This is, to the best of our knowledge, the first demonstration of visible microresonator-based lasers created by combining a Pr:ZBLAN fiber. This structure can effectively extend the laser wavelength in the WGMR to the visible waveband and may find potential applications in underwater communication, biomedical diagnosis, microwave generation, and spectroscopy. | SHUISEN JIANG CHANGLEI GUO KAIJUN CHE ZHENGQIAN LUO TUANJIE DU HONGYAN FU HUIYING XU ZHIPING CAI | 2019 | Photonics Research2019，7，5： | 1 |
| 19 | Synthesis of high rubber styrene-EPDM-acrylonitrile graft copolymer and its toughening effect on SAN显示文摘 | Zhiping Zeng Lianshi Wang Tongmin Cai | 2004 | Journal of Applied Polymer Science2004，94，2： | 1 |
| 20 | Synthesis of high rubber styrene-EPDM-acrylonitrile graft copolymer and its toughening effect on SAN 显示文摘 | ZENG Zhiping WANG Lianshi CAI Tongmin | 2004 | J Appl Polym Sci2004，94，2： | 1 |
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