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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Drag models for simulating gas–solid flow in the turbulent fluidization of FCC particles显示文摘This paper examines the suitability of various drag models for predicting the hydrodynamics of the turbulent fluidization of FCC particles on the Fluent V6.2 platform.The drag models included those of Syamlal–O’Brien,Gidaspow,modified Syamlal–O’Brien,and McKeen.Comparison between experimental data and simulated results showed that the Syamlal–O’Brien,Gidaspow,and modified Syamlal–O’Brien drag models highly overestimated gas–solid momentum exchange and could not predict the formation of dense phase in the fluidized bed,while the McKeen drag model could not capture the dilute charac- teristics due to underestimation of drag force.The standard Gidaspow drag model was then modified by adopting the effective particle cluster diameter to account for particle clusters,which was,however, proved inapplicable for FCC particle turbulent fluidization.A four-zone drag model(dense phase,subdense phase,sub-dilute phase and dilute phase)was finally proposed to calculate the gas–solid exchange coefficient in the turbulent fluidization of FCC particles,and was validated by satisfactory agreement between prediction and experiment. | Peng Li Xingying Lan Chunming Xu Gang Wang Chunxi Lu Jinsen Gao | 2009 | Particuology2009，7，4： | 13 |
| 3 | Effect of static bed height in the upper fluidized bed on flow behavior in the lower riser section of a coupled reactor显示文摘To study olefin reduction by using an auxiliary reactor for FCC naphtha upgrading, a large-scale cold model of a riser-bed coupled to an upper fluidized bed was established. The effect of static bed height in the upper fluidized bed on particle flow behavior in the lower riser was investigated experimentally. A restriction index of solids holdup was used to evaluate quantitatively the restrictive effect of the upper fluidized bed. Experimental results show that, under the restrictive effect of the upper fluidized bed, the riser could be divided into three regions in the longitudinal direction: accelerating, fully developed and restriction. The axial distribution of solids holdup in the riser is characterized by large solids holdup in the top and bottom sections and small solids holdup in the middle section. Overall solids holdup increased with increasing static bed height in the upper fluidized bed, while particle velocity decreased. Such restrictive effect of the upper fluidized bed could extend from the middle and top sections to the whole riser volume when riser outlet resistance is increased, which increases with increasing static bed height in the upper fluidized bed. The upper bed exerts the strongest restriction on the area close to the riser outlet. | Dewu Wang Chunxi Lu Chaoyu Yan | 2009 | Particuology2009，7，1： | 9 |
| 4 | Superhydrophobic modification of ceramic membranes for vacuum membrane distillation显示文摘The hydrophobically modi fied ceramic membranes have great potential for energy-ef ficient membrane distillation.In this work,flat-sheet ceramic membranes with a superhydrophobic surface were fabricated by grafting 1H,1H,2H,2H-per fluorooctyltrichlorosilane or 1H,1H,2H,2H-per fluorodecyltriethoxysilane and followed by ultraviolet irradiation.The surface water contact angle was improved from 46° of original ceramic membrane to 159°,which exhibited a stable and excellent superhydrophobic effect.The modi fied membranes showed a high flux of 27.28 kg·m^(-2)·h^(-1) and simultaneously maintained an excellent retention rate of 99.99%,when used in vacuum membrane distillation process for treatment of a 1 wt% NaCl(75 °C) aqueous solution.These results suggested that superhydrophobic modi fication of ceramic surface is a facile and cost-effective way to achieve higher membrane distillation performance.The superhydrophobically-modi fied ceramic membrane with an excellent desalination capacity would show considerable potential in practical membrane distillation utilizations. | Yanhui Yang Qianqian Liu Haizhi Wang Fusheng Ding Guoshan Jin Chunxi Li Hong Meng | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 9 |
| 5 | C/EBPα regulates SIRT1 expression during adipogenesis显示文摘SIRT1 在 adipogenesis 起一个重要作用,但是 SIRT1 怎么在 adipogenesis 被调整,大部分是未知的。在这研究,我们证明 SIRT1 蛋白质和 mRNA 层次与 CCAAT/enhancer-binding 蛋白质伪一起被增加(C/EBP 伪) 在 adipocyte 区别期间。C/EBP 伪,然而并非 C/EBP 伪 p 30,在 HeLa 房间和 3T3-L1 的激活的 SIRT1 倡导者 preadipocytes。而且, C/EBP 伪 upregulated SIRT1 mRNA 和蛋白质在 Soas2 房间以一种 p53 独立的方式在 HeLa 铺平房间和增加的 SIRT1 表示。在 preadipocytes, C/EBP 伪 upregulated SIRT1 蛋白质水平的宫外的表示并且导致的 C/EBP 伪击倒 SIRT1 的减少蛋白质水平。而且由倡导者删除分析,胶化移动试金和染色质 immunoprecipitation,我们发现了那 C/EBP,伪在一个一致 C/EBP 伪绑定地点跳了到 SIRT1 倡导者。这些数据证明那 C/EBP 伪在 adipogenesis 期间调整 SIRT1 表示由对 SIRT1 倡导者直接有约束力。 | Qihuang Jin Fang Zhang Tingting Yan Zhen Liu Chunxi Wang Xinjian Ge Qiwei Zhai | 2010 | Cell Research2010，20，4： | 8 |
| 6 | Effect of ^(60)Co-gamma radiation on the random walk error of interferometric fiber optic gyroscopes显示文摘Two ^(60)Co-gamma radiation experiments were launched to explore the radiation effect on optical components and interferometric fiber optic gyroscope (IFOG). In optical components radiation experiment, the result showed that polarization-maintaining (PM) fiber coil loss was the most affected parameter in all the RWC (random walk coefficient) related parameters, compared with the weak sensitivity of other components parameters. In the IFOG radiation experiment, the RWC performance degradation was found to be almost due to an increase of the PM fiber attenuation. Based on the experiment result, a RWC prediction model in radiation, which is obtained by embedding PM fiber loss expression into the RWC model, was built following a power law of dose and dose rate. An IFOG RWC in space radiation environment was predicted from radiation dose and dose rate by the RWC prediction model. This RWC value calculated from test data is fully accorded to the RWC value predicted from radiation dose. | JIN Jing*, WANG XueQin, SONG NingFang & ZHANG ChunXi School of Instrument Science and Optic-electronics Engineering, Beihang University, Beijing 100191, China | 2010 | Science China(Technological Sciences)2010，53，11： | 4 |
| 7 | Polymer nanoparticles as adjuvants in cancer immunotherapy显示文摘Immunotherapy is a promising strategy to inhibit cancer progression viaactivation of the immune system. In immunotherapy, adjuvants as immunologicstimulants or delivery systems play a critical role in inducing the antitumorimmune response and decreasing the side effects of immune stimulants. Polymernanoparticles have attracted increasing attention as an indispensable componentof immunotherapy, owing to their favorable properties, such as excellentbiocompatibility and biodegradability, flexible size, high activity as immunestimulants, large surface area for binding multivalent immune ligands, and highloading capacity for immune-related components. In cancer immunotherap^polymer nanoparticles can protect cargo from the surrounding milieu, deliverthe antigens and immunostimulatory molecules to antigen-presenting cells,or stimulate robust T cell response. This review summarizes the currentadvancements in polymer nanopartide adjuvants for cancer immunotherapyand predicts their prospects in fundamental and clinical studies. | Shengxian Li Xiangru Feng Jixue Wang Liang He Chunxi Wang Jianxun Ding Xuesi Chen | 2018 | Nano Research2018，11，11： | 3 |
| 8 | Effect of extracellular signal-regulated kinase and nitric oxide on compressive neuralgia formation and maintenance显示文摘BACKGROUND:Previous studies have shown that extracellular signal-regulated kinase 1/2(ERK1/2) and nitric oxide activation play a pivotal role in central sensitization and long-term neuronal plasticity induced by noxious stimulation.However,their effects on compressive neuralg formation and maintenance remain poorly understood.OBJECTIVE:To investigate effects of the specific inhibitor of ERK1/2 signal pathway U0126 on neuronal nitric oxide synthase(nNOS) expression in the dorsal horn of the spinal cord in a compressive neuralgia rat model.DESIGN,TIME AND SETTING:A randomized,controlled experiment was performed at the Institu of Otolaryngology,Head and Neck Surgery,First Hospital of Jilin University from July 2008 to Marc 2009.MATERIALS:U0126(Bio-Mol,USA) was used in this study.METHODS:A total of 84 rats were randomly assigned to two groups.In the first part of the experiment,24 rats were used for behavioral testing,and they were randomly assigned to three sub-groups(n = 8):U0126,dimethyl sulfoxide(DMSO) and model control.In the second part of th experiment,60 rats were used for immunofluorescence and Western blot analysis,and they were randomly assigned to six sub-groups(n = 10):sham surgery,model control,U0126 post-injection 0.5,2,12 and 24 hours.Neuropathic pain was produced by chronic compression to the dorsal roo ganglion in rats from each sub-group.Rats in the U0126 group were administered a 5-μg U0126 intrathecal injection,and rats in the DMSO group were administered a 10-μL 5% DMSO intratheca injection.MAIN OUTCOME MEASURES:Changes in mechanical and thermal hyperalgesia were observed using von Frey filaments and thermalqia stimular.Thermal and mechanical hyperalgesia were stimulated at different time points following intrathecal injection of U0126.nNOS activation and expression in the spinal cord dorsal horn were determined by immunofluorescence and Western blot analysis.RESULTS:Intrathecal injection of U0126 significantly attenuated chronic compression of dorsal root ganglion-induced mechanical and thermal hyperalgesia.Immunofluorescence staining results demonstrated that,compared to the sham surgery group,the number of nNOS-positive neurons was significantly increased in the injured spinal dorsal horn in the model control group(P < 0.01).However,compared to the model control group,there were significantly decreasing numbers of nNOS-positive neurons in the U0126 post-injection groups at 0.5-hour,2-hour,and 12-hour(P < 0.05).Western blot analysis revealed similar results.CONCLUSION:Decreased activity in the ERK signal pathway resulted in down regulated nNOS expression in the dorsal horn of the spinal cord.These results suggested that ERK is involved in nitric oxide reaction to neuropathic pain. | Tongwei Yang Xuesong Song Ping Wang Chunxi Wang Baoshun Lu | 2010 | Neural Regeneration Research2010，5，10： | 3 |
| 9 | C/EBPαp30 plays transcriptional regulatory roles distinct from C/EBPαp42显示文摘CCAAT/enhancer 有约束力的蛋白质α(C/EBP α) 是 transcriptional 禁止细胞增殖的规章的因素,和其他的翻译开始生产二多肽, C/EBP α p 30 并且 C/EBP α p 42。由表示介绍, C/EBP α p 30specifically 禁止了基因的一个唯一的集合,这被揭示,包括 MPP11, p84N5 和 SMYD2,它没被 C/EBP α p 影响 42 在两根 QSG-7701 hepatocyte 房间线和 QGY-7703 hepatoma, cells.Semi 量的 RT-PCR 分析独立地证实了这些结果。Chromatinimmunoprecipitation 试金显示出 30 比 C/EBP α p 更强烈绑了在这些基因的倡导者的那 C/EBP α p 42。在 C/EBP α是调整的 down 的临床的 hepatoma 在样品,所有三基因明确地由 30 在上面的 C/EBP α p 禁止了调整。然而, MPP11, p84N5 和 SMYD2genes 的压抑可能直接不涉及 C/EBP α p 30-mediated 生长抑制。我们的数据建议 30 调整的那 C/EBP α p 目标基因的一个唯一的集合并且多于 C/EBP α p 的 dominant-negativeregulator 42。 | Chunxi Wang~1 Xiaotao Chen~1 Yanping Wang~1 Jialei Gong~1 Gengxi Hu ~1State Key Laboratory of Molecular Biology institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China | 2007 | Cell Research2007，17，4： | 2 |
| 10 | NMR Studies on the Interaction between Oncogene RET G-Quadruplex and Berberine显示文摘of main observation and conclusion RET G-quadruplex DNA(G4-DNA)is formed in the promoter region of RET protein,which is involved in the initiation and progression of human cancers.Berberine inhibits cancer cell growth through interactions with RET G4-DNA,but how it binds to RET G4-DNA remains unknown.Previously,we reported that colchicine selectively bound to RET G4-DNA,but the structural basis of its binding selectivity is still unclear.Here,mainly by NMR,we demonstrated how berberine bound to RET G4-DNA in a means different from colchicine,and implied several key determinants for small molecules specifically binding to one G4-DNA. | Fei Wang Chunxi Wang Yaping Liu Wenxian Lan Renxiao Wang Shaohua Huang Chunyang Cao | 2020 | Chinese Journal of Chemistry2020，38，12： | 2 |
| 11 | The performance of a centrifugal fan with enlarged impeller显示文摘 | Li Chunxi Wang Song Ling Jia Yakui | 2011 | Energy Conversion and Management2011，，8： | 1 |
| 12 | Climatology of Hail in China: 1961 - 2005 显示文摘 | Zhang Chunxi Zhang Qinghong and Wang Yuqing | 2007 | Journal Of Applied Meteorology and Climatology2007，，： | 1 |
| 13 | The performance of a centrifugal fan with enlarged impeller显示文摘 | Li Chunxi Wang Song Ling Jia Yakui | 2011 | Energy Conversion and Management2011，，8： | 1 |
| 14 | Design principle for sensing coil of fiber-optic cur- rent sensor based on geometric rotation effect显示文摘 | Chunxi Zhang Chuansheng l i Xiaxiao Wang Lijing Li Jia Yu and Xiujuan Feng | 2012 | APPLIED OPTICS2012，51，18： | 1 |
| 15 | Molecular and Clinical Characterization of a Novel SCN5A Mutation Associated With Atrioventricular Block and Dilated Cardiomyopathy显示文摘 | Junbo Ge Aijun Sun Vesa Paajanen Shijun Wang Chunxi Su Zhiyin Yang Ying Li Shaochun Wang Jianguo Jia Keqiang Wang Yunzeng Zou Lizhi Gao Kun Wang Zheng Fan | 2008 | Circulation: Arrhythmia and Electrophysiology2008，，2： | 1 |
| 16 | Climatology of Hail in China:1961--2005显示文摘 | Zhang Chunxi Zhang Qinghong Wang Yuqing | 2008 | Appl Meteor & Climat2008，47，： | 1 |
| 17 | In- ternal flow characteristics of a variable pitch axial fan under abnormal installation angles of single blade 显示文摘 | YE Xuemin LI Chunxi WANG Songling | 2011 | Advanced Science Letters2011，4，67： | 1 |
| 18 | Molecular and Clinical Characterization of a Novel SCN5A Mutation Associated With Atrioventricular Block and Dilated Cardiomyopathy显示文摘 | Junbo Ge Aijun Sun Vesa Paajanen Shijun Wang Chunxi Su Zhiyin Yang Ying Li Shaochun Wang Jianguo Jia Keqiang Wang Yunzeng Zou Lizhi Gao Kun Wang Zheng Fan | 2008 | Circulation: Arrhythmia and Electrophysiology2008，，2： | 1 |
| 19 | Climatology of hail in China: 1961 -2005显示文摘 | Zhang Chunxi Zhang Qinghong Wang Yuqing | 2007 | Journal of Applied Meteorol- ogy and Climatology2007，，： | 1 |
| 20 | The per formance of a centrifugal fan with enlarged impeller 显示文摘 | LI Chunxi WANG Songling J1A Yakui | 2011 | Energy Conversion and Management2011，52，89： | 1 |
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