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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | The complete mitochondrial genome of the Chinese oak silkmoth, Antheraea pernyi (Lepidoptera: Saturniidae)显示文摘我们从中国橡树丝绸蛾决定了 mitogenome 的完全的核苷酸顺序, Antheraea pernyi (鳞翅目:Saturniidae ) 。15,566 bp 通报染色体为鳞翅类的 mitogenomes 包含不正常的基因组织和顺序。mitogenome 在已知的鳞翅类的 mitogenome 序列之中包含最低 A+T 内容(80.16%) 。一个不平常的特征比作为是更多的 T 的出现,与一在偏斜度(−0.021 ) 稍微否定,在主要染色体海滨的作文。所有编码蛋白质的基因被 ATN 鳕鱼 ons 开始,除了细胞色素 oxidase 子单元我,它被在另外的 lepidopterans 观察了的 TTAG 顺序建议。所有转移 RNA (tRNAs ) 有 mitochondrial tRNA 的典型四叶苜蓿形的立体道路交叉点结构,除了 tRNA 重量的单位 (AGN), 哪个不能形成稳定的茎环结构的 DHU 手臂。二与一段超过 50 bp 排列了顺序块, 90% 顺序身份在 Saturniidae 和 Bombycoidae 种类的 A+T 富有的区域被识别。 | Yanqun Liu Yuping Li Minhui Pan Fangyin Dai Xuwei Zhu Cheng Lu Zhonghuai Xiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 21 |
| 3 | Eu^(3+)-doped LaPO_4 and LaAlO_3 nanosystems and their luminescence properties显示文摘Eu3+ ion-doped LaPO4 nanowires or nanorods have been successfully synthesized by a simple hydrothermal method.The influence of varying the hydrothermal and subsequent sintering conditions on the morphology and structure of the LaPO4 host has been investigated by scanning electron microscopy(SEM) and X-ray diffraction(XRD).For comparison,the Eu3+ ions were also doped into monoclinic monazite LaPO4 nanoparticles and perovskite LaAlO3 nanoparticles.The relative intensities of the emission lines of the LaPO4:Eu3+ nanosystems were essentially independent of their shape.The optimal doping concentrations in the monoclinic LaPO4 and perovskite LaAlO3 nanosystems were determined to be about 5.0 and 3.5 mol%,respectively.Under appropriate UV-radiation,the red light emitted from LaAlO3:Eu3+(3.5 mol%) was brighter than that from LaPO4:Eu3+(5.0 mol%) nanomaterial,resulting from differences in their spin-orbit couplings and covalence,which indicates that the nanoscale LaAlO3 is a promising host material for rare earth ions. | WAN Qiang,HE YuPing,DAI Ning & ZOU BingSuo State Key Laboratory of State Key Laboratory of Chemo/Biosensing and Chemometrics and Key Laboratory for Micro-Nano Opto-Electronic Devices of Ministry of Education,Hunan University,Changsha 410082,China | 2009 | Science China Chemistry2009，52，8： | 6 |
| 4 | The electromagnetic response of composition-regulated honeycomb structural materials used for broadband microwave absorption显示文摘The undesirable absorption bandwidth is the main limitation for the application of microwave absorbing materials.Noting that the design of structure and composition of absorbing coating allows it to obtain a satisfying absorption bandwidth and to avoid weight increasing,honeycomb and its sandwich structures coated by various absorbant have been developed and measured using an arch measurement system over2-18 GHz.To further understand the absorption mechanisms of honeycomb structural materials,simulation based on finite element method and transmission line theory is performed to analyze the different responses to the applied microwave between honeycomb structural materials and uniform-medium slab materials.The proper composition design allows control over the microwave loss mechanisms,which optimize the coating to possess both of the dielectric and magnetic advantages.For the honeycomb structural materials,the magnetic resonation is found for the first time,which is resulting from the periodic honeycomb walls on both sides of the dielectric cavity(consisting of the aramid paper interlayer and vacuum hexagonal prisms).In addition,the conversion of structure from solid to honeycomb brings about changes in impedance,propagating path,effective wavelength,effective attenuation area,microwave phases,and inductive coupling effect,etc.,which result in a better microwave absorbing performance.The honeycomb sandwich structure coated by CIP/CB/EP with the weight ratio of 4:0.03:1 shows the absorption bandwidth of~9.8 GHz for reflection loss(RL)lower than-10 dB which covers part of the S and C bands and almost the whole X and Ku bands. | Huifang Pang Yuping Duan Xuhao Dai Lingxi Huang Xuan Yang Tuo Zhang Xiaoji Liu | 2021 | Journal of Materials Science & Technology2021，，29： | 4 |
| 5 | Magnetic and microwave absorption properties of Ni_(1-x)Zn_xFe_2O_4 nanocrystalline synthesized by sol-gel method显示文摘Ni1-xZnxFe2O4(0≤x≤1,in steps of 0.1) nanocrystallines were synthesized by sol-gel route.The doping effects of zinc on structural,magnetic and microwave absorption properties were investigated in detail.X-ray diffraction(XRD) results show that all the samples are single-phase spinel structure.The magnetic and microwave absorption properties are strongly dependent on the zinc content,which can be understood in terms of the cations redistribution in spinel tetrahedral and octahedral sites with the increase of zinc content.The magnetic measurement shows the antiferromagnetic nature of the samples for x=0.9 and x=1.0.The saturation magnetization reaches the maximum of 3.35μB/f.u.at x=0.5.The optimal reflection loss(RL) of-29.6 dB is found at 6.5 GHz for an absorber thickness of 5 mm.The RL values exceeding 10 dB are obtained for the absorber in the range of 3.9-8.9 GHz.These Ni1-xZnxFe2O4 nanocrystallines may be attractive candidates for electromagnetic wave absorption materials. | ZHANG Min LIU QiangChun ZI ZhenFa DAI YuQiang ZHU XueBin SUN YuPing DAI JianMing | 2013 | Science China(Technological Sciences)2013，56，1： | 4 |
| 6 | Research on DC Protection Strategy in Multi-Terminal Hybrid HVDC System显示文摘Multi-terminal hybrid high-voltage direct current(HVDC)systems have been developed quickly in recent years in power transmission area.However,for voltage-source converter(VSC)stations in hybrid HVDC systems,no direct current(DC)filters are required.In addition,the DC reactor is also not installed at the line end because the DC fault can be limited by the converter itself.This means that the boundary element at the line end is absent,and the single-ended protections used in line commutated converter(LCC)based HVDC(LCC-HVDC)systems or VSC-HVDC systems cannot distinguish the fault line in multi-terminal hybrid HVDC systems.This paper proposes a novel singleended DC protection strategy suitable for the multi-terminal hybrid HVDC system,which mainly applies the transient information and active injection concept to detect and distinguish the fault line.Compared with the single-ended protections used in LCC-HVDC and VSC-HVDC systems,the proposed protection strategy is not dependent on the line boundary element and is thus suitable for the multiterminal hybrid HVDC system.The corresponding simulation cases based on power systems computer aided design(PSCAD)/electromagnetic transients including DC(EMTDC)are carried out to verify the superiority of the proposed protection. | Yuping Zheng Jiawei He Bin Li Tonghua Wua Wei Dai Ye Li | 2021 | Engineering2021，7，8： | 4 |
| 7 | Red-Emissive Organic Room-Temperature Phosphorescence Material for Time-Resolved Luminescence Bioimaging显示文摘Organic room-temperature phosphorescence(RTP)materials have been used in high-resolution imaging.However,the development of long-wavelength-emis sion RTP materials in aqueous solution remains a challenge.Here,we report red-emissive RTP materials via integration of the ring-fusing effect and host–guest interaction. | Wenbo Dai Yahui Zhang Xinghui Wu Shuai Guo Jieran Ma Jianbing Shi Bin Tong Zhengxu Cai Haiyan Xie Yuping Dong | 2022 | CCS Chemistry2022，4，8： | 2 |
| 8 | Fast Distance Protection Scheme for Wind Farm Transmission Lines Considering R-L and Bergeron Models显示文摘The distributed capacitance of the line becomes larger as the scale of wind farms,the transmission voltage level,and the transmission distance increase.Hence,the error of the traditional time-domain distance protection scheme based on the R-L model,which ignores the distributed capacitance of the line,becomes unacceptable.Therefore,the error of the time-domain fault location method based on the R-L model,especially the maximum error range,is theoretically analyzed in this paper.On this basis,a novel fault location method based on the RL and Bergeron models is proposed.Then,a fast time-domain distance protection scheme is designed.In the proposed scheme,the error in the fitting calculation is used to construct a weight matrix,and an algorithm for solving the time-domain differential equations is designed to improve the calculation speed and stability.Compared with the traditional frequency-domain distance protection scheme,the proposed scheme is independent of the power supply characteristics;thus,it is suitable for wind farm transmission lines.In addition,compared with the traditional method based on the R-L model,the proposed scheme effectively avoids the negative influence of the distributed capacitance of the line,which significantly improves the operating speed.Different types of faults are simulated by PSCAD/EMTDC to verify the effectiveness and superiority of the proposed scheme. | Zepeng Hu Bin Li Yuping Zheng Tonghua Wu Jiawei He Bin Yao Yaru Sheng Wei Dai Xindong Li | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，3： | 2 |
| 9 | Research Progress of Value, Extraction and Applicationof Silkworm Chrysalis Protein显示文摘Silkworm chrysalis protein is a high quality pure natural complete animal protein with high utilization value, and it has been widely used in many industries in recent years. The nutrition, health care and medicinal value of silkworm chrysalis protein, the degreasing, deodorization and decoloration extraction process, and its application in food, medicine, feed, etc. are summarized, in order to provide the reference for further development and industrial production of silkworm chrysalis protein. | zhang yuping zhang lili chen ming dai junjun wu chuanhua liu jian fan tao yin jianli | 2018 | Animal Husbandry and Feed Science2018，10，4： | 2 |
| 10 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 11 | Chromosome-level Genomes Reveal the Genetic Basis of Descending Dysploidy and Sex Determination in Morus Plants显示文摘Multiple plant lineages have independently evolved sex chromosomes and variable karyotypes to maintain their sessile lifestyles through constant biological innovation.Morus notabilis,a dioecious mulberry species,has the fewest chromosomes among Morus spp.,but the genetic basis of sex determination and karyotype evolution in this species has not been identified.In this study,three high-quality genome assemblies were generated for Morus spp.[including dioecious M.notabilis(male and female)and Morus yunnanensis(female)]with genome sizes of 301–329 Mb and were grouped into six pseudochromosomes.Using a combination of genomic approaches,we found that the putative ancestral karyotype of Morus species was close to 14 protochromosomes,and that several chromosome fusion events resulted in descending dysploidy(2n=2x=12).We also characterized a~6.2-Mb sex-determining region on chromosome 3.Four potential male-specific genes,a partially duplicated DNA helicase gene(named MSDH)and three Ty3_Gypsy long terminal repeat retrotransposons(named MSTG1/2/3),were identified in the Y-linked area and considered to be strong candidate genes for sex determination or differentiation.Population genomic analysis showed that Guangdong accessions in China were genetically similar to Japanese accessions of mulberry.In addition,genomic areas containing selective sweeps that distinguish domesticated mulberry from wild populations in terms of flowering and disease resistance were identified.Our study provides an important genetic resource for sex identification research and molecular breeding in mulberry. | Zhongqiang Xia Xuelei Dai Wei Fan Changying Liu Meirong Zhang Peipei Bian Yuping Zhou Liang Li Baozhong Zhu Shuman Liu Zhengang Li Xiling Wang Maode Yu Zhonghuai Xiang Yu Jiang Aichun Zhao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 12 | Organic Host-Guest Materials with Bright Red Room-Temperature Phosphorescence for Persistent Bioimaging显示文摘Organic room-temperature phosphorescence(RTP)materials have attracted immense attention in bioimaging due to their long emission lifetime and large Stokes shift.RTP materials with long emission wavelength can improve the penetration depth for bioimaging.However,the design of red persistent RTP materials is still challenging.In this study,a fused-ring structure has been proposed to effectively decrease the triplet energy level,thus extending the emission wavelength of phosphorescence.In addition,the fused-ring structure exhibits a high molar extinction coefficient(ɛ)and high luminescence efficiency due to the rigid structure.A new class of crystalline hosts(iminodibenzyl,IDB)are developed to stabilize the triplet excitons that are generated from the fused-ring molecules.The maximum RTP wavelength of doping materials can reach 635 nm with a lifetime of 9.35 ms.Water-disperse nanoparticles are successfully prepared for in vivo time-resolved bioimaging,which eliminates the background fluorescence interference from biological tissues.These reveal a delicate design strategy for the construction of long-wavelength emissive RTP materials for high-resolution bioimaging. | Yueyue Si Yeyun Zhao Wenbo Dai Shisheng Cui Peng Sun Jianbing Shi Bin Tong Zhengxu Cai Yuping Dong | 2023 | Chinese Journal of Chemistry2023，41，13： | 1 |
| 13 | Simultaneous Determination of Amoxicillin and Ampicillin in Eggs by Reversed-Phase High-Performance Liquid Chromatography with Fluorescence Detection using Pre-Column Derivatization显示文摘 | Kaizhou Xie Longfei Jia Dong Xu Huisheng Guo Xing Xie Yuping Huang Xuesen Chen Wenbin Bao Guojun Dai Jinyu Wang | 2012 | Journal of Chromatographic Science2012，，7： | 1 |
| 14 | Experimental study on the vitrification and xenotransplantation of human ovarian tissue显示文摘Background:Cryopreservation of ovarian tissue is a promising method for preserving fertility.Transmission electron microscopy(TEM)is an evaluation system for cryo-injury during the cooling and warming process which is very laborious and needs to be optimized.Objective:In this study,we evaluated that serum 17β-oestradiol(E2)may be used as an indicator of vitrified ovarian tissue.Methods:Immunodeficient nude mice were used as hosts for xenografting of vitrified-warmed human ovarian tissues.A total of 54 mice were divided into two group:vitrified ovarian xenotransplant(VOX)group(n?45)and non-transplant control group(n?9).The transplanted mice were grouped into vitrified/warmed grafted-4 weeks(VOX-4w,n?15),vitrified/warmed grafted-6weeks(VOX-6w n?15)and vitrified/warmed grafted-12 weeks(VOX-12w n?15)according to the time after transplantation.The viable and functional recovery of grafted ovarian tissue was assessed by light microscopy,transmission electron microscopy,and hormone(E2)assays.Results:Serum E2 concentration was significantly higher in VOX-6w(group(21.07 pg/ml)than that of VOX-12w group(15.59 pg/ml).VOX-12w group showed a lower value(12.61 pg/ml)for E2 concentration.The trend for E2 concentration was consistent with the morphological identification of the grafts.Conclusion:In vivo serum hormone E2 released by cortical biopsies can be used as a functional marker for xenotransplanted vitrified-warmed human ovarian tissue reserve. | Jinghui Zhao Yuping Ge Jingyi Li Yucui Zeng Guoyi Dong Liping Zeng Juanjuan Dai Hui Du Mumin Shao Xuewen Yu Huan Li Fang He Zhouchun Shang Chun Wang Gabor Vajt Huiru Tang Ruifang Wu Yutao Du | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，1： | 1 |
| 15 | A new decomposition based evolutionaryalgorithm with uniform designs for many-objectiveoptimization显示文摘 | Dai Cai Wang Yuping | 2015 | Applied Soft Computing2015，30，1： | 1 |
| 16 | A new uniform evolutionaryalgorithm based on decomposition and CDAS for manyobjectiveoptimization显示文摘 | Dai Cai Wang Yuping | 2015 | Knowledge-Based Systems2015，85，1： | 1 |
| 17 | Controlling for outer -diameter of superconducting cable for PF Cable - In - Conduit Conductor of ITER显示文摘 | Yuping Teng Shaotao Dai Zhourong Wei | 2012 | Cryogenics2012，52，12： | 1 |
| 18 | Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells显示文摘 | Yuping Luo Volkan Coskun Aibing Liang Juehua Yu Liming Cheng Weihong Ge Zhanping Shi Kunshan Zhang Chun Li Yaru Cui Haijun Lin Dandan Luo Junbang Wang Connie Lin Zachary Dai Hongwen Zhu Jun Zhang Jie Liu Hailiang Liu Jean deVellis Steve Horvath Yi Eve Sun | 2015 | Cell2015，，5： | 1 |
| 19 | Corrigendum to“Research on DC Protection Strategy in Multi-Terminal Hybrid HVDC System”[Engineering 7(2021)1064-1075]显示文摘This work was supported by the Headquarter Science and Technology Project of State Grid Corporation of China(Research on the transient protection for AC/DC hybrid grid with high-proportion renewable energy,SGAH0000TKJS1900278).We are very sorry for missing the description of the project funding information. | Yuping Zheng Jiawei He Bin Li Tonghua Wu Wei Dai Ye Li | 2022 | Engineering2022，8，3： | 0 |
| 20 | Progress and Challenges Toward Effective Flexible Perovskite Solar Cells显示文摘The demand for building-integrated photovoltaics and portable energy systems based on flexible photovoltaic technology such as perovskite embedded with exceptional flexibility and a superior power-to-mass ratio is enormous.The photoactive layer,i.e.,the perovskite thin film,as a critical component of flexible perovskite solar cells(F-PSCs),still faces long-term stability issues when deformation occurs due to encountering temperature changes that also affect intrinsic rigidity.This literature investigation summarizes the main factors responsible for the rapid destruction of F-PSCs.We focus on long-term mechanical stability of F-PSCs together with the recent research protocols for improving this performance.Furthermore,we specify the progress in F-PSCs concerning precise design strategies of the functional layer to enhance the flexural endurance of perovskite films,such as internal stress engineering,grain boundary modification,self-healing strategy,and crystallization regulation.The existing challenges of oxygen-moisture stability and advanced encapsulation technologies of F-PSCs are also discussed.As concluding remarks,we propose our viewpoints on the large-scale commercial application of F-PSCs. | Xiongjie Li Haixuan Yu Zhirong Liu Junyi Huang Xiaoting Ma Yuping Liu Qiang Sun Letian Dai Shahzada Ahmad Yan Shen Mingkui Wang | 2023 | Nano-Micro Letters2023，15，11： | 0 |
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