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| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 3 | Epidemiology of fungal infections in China显示文摘与 immunocompromised 主人的增加的数字,真菌的感染的流行病学的特征经历了世界范围的庞大的变化,在中国包括。在这份报纸,我们越过中国在真菌病上考察了存在数据总结可得到的流行病学的侧面。我们发现在中国的表面的真菌的感染的一般发生是稳定的,但是癣 capitis 的发生减少了,传播线路变化了。由对比,侵略真菌的感染的全面发生继续升起了。candidemia 的出现由除 C 以外的 Candida 种类引起了。albicans 和不平常的 Candida 种类最近在中国增加了的包括的一些。曲霉属菌引起的感染也在最近的年里宣传了,特别地与 azole 抵抗的曲霉属菌 fumigatus 的出现。cryptococcosis 的一个增加的趋势在中国被注意了,与 Cryptococcus neoformans var。grubii 圣 5 遗传型作为占优势的病原体孤立。回顾的研究建议了在中国的 Pneumocystis 肺病的流行病学的特征可能类似于在另外的发展中的国家的那些。地方性的真菌的感染例如在东北中国的 sporotrichosis,必须引起研究,诊断,并且处理警戒。当前,在中国的真菌病上的流行病学的数据可变、碎片。因此,关于在中国的真菌的感染的全国流行病学的研究是对改进国家健康的重要需要。 | Min Chen Yuan Xu Nan Hong Yali Yang Wenzhi Lei Lin Du Jingjun Zhao Xia Lei Lin Xiong Langqi Cai Hui Xu Weihua Pan Wanqing Liao | 2018 | Frontiers of Medicine2018，12，1： | 49 |
| 4 | A randomized controlled clinical trial: Interruption of intrauterine transmission of hepatitis B virus infection with HBIG显示文摘瞄准:与积极 HBeAg 和 HBsAg 在怀孕女人与 HBIG 评估 HBV 的子宫内的感染的打断的功效。方法:未来的使随机化的控制试用被采用。有积极 HBeAg 和 HBsAg 的六十个盒子与包括的标准是重合的,并且 8 个盒子被排除。52 个盒子被分析(在试用的 28 个盒子组织, 24 在控制组织) 。在审判组的所有情况静脉内地收到了 200 IU HBIG 在 3 次从的每 4 wk 28 (th ) wk。控制的盒子以一样的方法组织收到的安慰剂。所有怀孕女人在试用的开始和试用(交货) 的结束为 HBeAg 和 HBV-DNA 被检测。所有新生儿的脐带血为同时检测 HBeAg 和 HBV-DNA 被收集。结果:为在试用组的新生儿的 HBeAg 的调查,新生儿的 28 个盒子中的 6 个有积极 HBeAg,是的 HBeAg 积极的率 21.4% , 95% CI being 的全部的率 8%-41% 。在控制组,新生儿的 24 个盒子中的 19 个有积极 HBeAg, HBeAg 积极的率是 79.2% , 95%CI 的率 5%-93% 。由统计分析, chi (2 )= 17.26, P <
0.01, RR = 0.27, 95% CI (6.3 乘 10 (8.6 乘的 -6), 10 (-5)) 。为在审判组的新生儿的 HBV-DNA 的调查,新生儿的 28 诉讼中的 7 个有积极 HBV-DNA,是的 HBV-DNA 积极的率 25% , 95% CI being 的全部的率 11%-45% 。在控制组,新生儿的 24 个盒子中的 20 个有积极 HBV-DNA, HBV-DNA 积极的率是 83.3% , 95% CI being 的全部的率 63%-95% 。由统计分析, chi (2 )= 17.62, P <
0.01, RR = 0.30, 95% CI (1.5 乘 10 (1.7 乘的 -5), 10 (-4) 。结果显示处于 HBeAg 积极的率和在二个组之间的新生儿的 HBV-DNA 积极的率有有效差量。在试用组, 28 个新生儿中的 7 个有 HBV-DNA 积极,但是新生儿的 HBV-DNA 负担比他们的母亲的低。在控制组, 24 个新生儿中的 20 个仍然有 HBV-DNA 积极,并且新生儿的 HBV-DNA 负担他们的母亲接近了那些。统计分析显示没有 HBIG 干预和他们的子代,在在出生后的女人之间的 HBV-DNA 负担没有有效差量(T = 81.5, P >
0.1 ) 。结论:与 HBIG 阻止 HBV 的子宫内的感染有效、安全 28 (th ) 在有积极 HBeAg 和 HBsAg 的怀孕女人的 wk。在临床的申请,有否定 HBeAg 和积极 HBV-DNA 的那些怀孕女人也需要被 HBIG 打断。 | Qin XH Lin Xi-ao Xiao-Bo Lu Yue-Xin Zhang Xia Cai | 2006 | World Journal of Gastroenterology2006，12，21： | 25 |
| 5 | NRS2002 assesses nutritional status of leukemia patients undergoing hematopoietic stem cell transplantation显示文摘Objective:To discuss whether nutritional risk screening 2002(NRS2002) is appropriate for nutritional risk screening for leukemia patients before and after hematopoietic stem cell transplantation(HSCT),and whether there are risk differences in other conditions,such as age,gender and matching degree;to find the methods and indicators of nutritional risk screening for these patients before and after HSCT,in order to give timely intervention to guarantee the successful completion of the entire transplantation process.Methods:Nutritional risk of 99 leukemia patients was screened with NRS2002 before and after HSCT.The χ2 test was applied to compare the risk differences between groups such as age,gender and matching degree,while the differences of other enumeration data,such as recent(1-3 months) weight loss,reduced food intake within one week and BMI,were compared by continuity correction.Results:Of the 99 leukemia patients,22 cases(22.2%) had nutritional risk before HSCT,while all patients had nutritional risk after HSCT;there is no significant difference in nutritional risk between male and female,and patients of less than 30 years old,not-full matched,recent(1-3 months) weight loss,reduced food intake within a week or BMI <18.5 were more likely to have nutritional risk;and 77 cases(77.8%) had weight loss,among which 49 patients(63.6%) had more than 5% weight loss within one month.Conclusions:This study showed that leukemia patients should receive the nutritional risk screening conventionally before and after HSCT,and NRS2002 was only appropriate for nutritional risk screening before HSCT.More attention should be paid to the patients less than 30 years old or not-full matched.Weight change was one of the important nutritional indicators for patients after HSCT. | Peng Liu Zhao-Feng Zhang Jing-Jing Cai Bo-Shi Wang Xia Yan | 2012 | Chinese Journal of Cancer Research2012，24，4： | 25 |
| 6 | Localization and Dynamic Change of Saikosaponin in Root of Bupleurum chinense显示文摘Anatomical, histochemical and phytochemical methods were used to investigate the structure, the localization and content changes of total saikosaponin and saikosaponin-a of the roots of Bupleurum chinense DC. at different developmental stages. Results showed that saikosaponin was mainly distributed in pericycle and primary phloem in the young root; but in the mature root, it was mainly distributed in vascular cambium and secondary phloem. During the whole growth period from the pre-blossom, blossom, fruit, and fruit mature periods until the pre-withering period, it was in the fruit mature period that both the total saikosaponin content and the saikosaponin-a content reached the highest level. So the last 20 d of October was considered as the right collecting season for the drug of B. chinense. In addition, the quality of 1-year-old drug was better than that of 2-year-old drug due to its higher saikosaponin content. On the other hand, judging from the external characteristics of the drug, the one with an acerose taproot and more lateral roots was of better quality. The results offered theoretical bases for selecting medicinal material of high quality and determining the most appropriate harvesting stage and part of B. chinense. | Ling-Ling Tan Xia Cai Zheng-Hai Hu Xi-Lu Ni | 2008 | Journal of Integrative Plant Biology2008，50，8： | 21 |
| 7 | Effects of process parameters on pore structure of semi-coke prepared by solid heat carrier with dry distillation显示文摘The semi-coke was prepared by solid heat carrier with dry distillation in single factor method. The pore structures of raw coal and semi-coke were characterized by Brunauer-Emmett-Teller (BET) and scanning electron microscope (SEM). The results show that the adsorption and desorption isotherm of semi-coke are not coincident. There was a wide pore distribution on the semi-coke, in which mesopores and micropores account for a considerable proportion. Also there are many more secondary pores. With the increase of the final temperature of heat carrier and constant temperature, as well as the decrease of volume ratio of coal and hot carrier reactor, specific surface area and pore volume of semi-coke increased rapidly first and then decreased and finally increased, along with the rapidly reduction of average pore size. SEM photos show that the surface of semi-coke becomes increasingly rough and glossy. | Zhou, Guoli Wu, Jianjun Miao, Zhenyong Hu, Xuelian Li, Xia Shi, Xin Cai, Zhidan Shang, Yukun | 2013 | International Journal of Mining Science and Technology2013，23，3： | 20 |
| 8 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 9 | Association between Ambient Air Pollution and Hospital Emergency Admissions for Respiratory and Cardiovascular Diseases in Beijing: a Time Series Study显示文摘Objective To investigate the association between ambient air pollution and hospital emergency admissions in Beijing. Methods In this study, a semi-parametric generalized additive model(GAM) was used to evaluate the specific influences of air pollutants(PM10, SO2, and NO2) on hospital emergency admissions with different lag structures from 2009 to 2011, the sex and age specific influences of air pollution and the modifying effect of seasons on air pollution to analyze the possible interaction. Results It was found that a 10 μg/m3 increase in concentration of PM10 at lag 03 day, SO2 and NO2 at lag 0 day were associated with an increase of 0.88%, 0.76%, and 1.82% respectively in overall emergency admissions. A 10 μg/m3 increase in concentration of PM10, SO2 and NO2 at lag 5 day were associated with an increase of 1.39%, 1.56%, and 1.18% respectively in cardiovascular disease emergency admissions. For lag 02, a 10 μg/m3 increase in concentration of PM10, SO2 and NO2 were associated with 1.72%, 1.34%, and 2.57% increases respectively in respiratory disease emergency admissions. Conclusion This study further confirmed that short-term exposure to ambient air pollution was associated with increased risk of hospital emergency admissions in Beijing. | ZHANG Ying WANG Shi Gong MA Yu Xia SHANG Ke Zheng CHENG Yi Fan LI Xu NING Gui Cai ZHAO Wen Jing LI Nai Rong | 2015 | Biomedical and Environmental Sciences2015，28，5： | 18 |
| 10 | Tectonic Evolution of the Meso-Tethys in the Western Segment of Bangonghu-Nujiang Suture Zone: Insights from Geochemistry and Geochronology of the Lagkor Tso Ophiolite显示文摘The subduction of the Bangonghu-Nujiang Meso-Tethys and the collision between the Lhasa and Qiangtang blocks were important events in the growth of the Tibetan crust. However,the timing of collision initiation and closure timing,as well as nature and structure of the Bangonghu ocean basin,are still poorly constrained. The Lagkor Tso ophiolite,located in the south of Gerze County,Tibet,is one of the most completed ophiolites preserved in the southern side of the BangonghuNujiang suture zone. This study discussed the tectonic evolution of the Bangonghu-Nujiang suture zone as revealed by the Lagkor Tso ophiolite investigated by field investigations,petrology,geochemistry,geochronology and tectonic analysis methods. We present new LA-ICP-MS zircon U-Pb and 39Ar/40 Ar ages for the Lagkor Tso ophiolite,in addition to geochemical and platinum-group element(PGE) data presented for the Lagkor Tso ophiolite in Tibet. It is suggested that the ancient Lagkor Tso oceanic basin split in Middle Jurassic(161.2 ± 2.7 Ma – 165.4 ± 3.5 Ma),and experienced a second tectonic emplacement during the Early Cretaceous(137.90 ± 6.39 Ma). The Lagkor Tso ophiolite likely developed in an independent suture zone. The Bangonghu-Nujiang ocean subducted southwards,and the dehydration of the subducting oceanic crust materials caused partial melting of the continental mantle wedge,which formed the second-order expanding center of the obduction dish. This led to inter-arc expansion,followed by the formation of inter-arc and back-arc basins with island arc features,which are represented by ophiolites around the Shiquanhe-Lagkor Tso-Yongzhu region. The tectonic environment presently can be considered to be similar to that of the current Western Pacific,in which a large number of island arc-ocean basin systems are developed. | YUAN Yajuan YIN Zhengxin LIU Weiliang HUANG Qiangtai LI Jianfeng LIU Hongfei WAN Zhifeng CAI Zhourong XIA Bin | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 17 |
| 11 | A Review on Metal-Organic Framework-Derived Porous Carbon-Based Novel Microwave Absorption Materials显示文摘The development of microwave absorption materials(MAMs) is a considerable important topic because our living space is crowed with electromagnetic wave which threatens human’s health.And MAMs are also used in radar stealth for protecting the weapons from being detected.Many nanomaterials were studied as MAMs,but not all of them have the satisfactory performance.Recently,metal-organic frameworks(MOFs) have attracted tremendous attention owing to their tunable chemical structures,diverse properties,large specific surface area and uniform pore distribution.MOF can transform to porous carbon(PC) which is decorated with metal species at appropriate pyrolysis temperature.However,the loss mechanism of pure MOF-derived PC is often relatively simple.In order to further improve the MA performance,the MOFs coupled with other loss materials are a widely studied method.In this review,we summarize the theories of MA,the progress of different MOF-derived PC-based MAMs,tunable chemical structures incorporated with dielectric loss or magnetic loss materials.The different MA performance and mechanisms are discussed in detail.Finally,the shortcomings,challenges and perspectives of MOF-derived PC-based MAMs are also presented.We hope this review could provide a new insight to design and fabricate MOF-derived PC-based MAMs with better fundamental understanding and practical application. | Zhiwei Zhang Zhihao Cai Ziyuan Wang Yaling Peng Lun Xia Suping Ma Zhanzhao Yin Yi Huang | 2021 | Nano-Micro Letters2021，13，4： | 17 |
| 12 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 13 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 14 | Effects of land uses on soil physic-chemical properties and erodibility in collapsing-gully alluvial fan of Anxi County,China显示文摘As a special kind of soil erosion that severely deteriorates the qualities of soil in granite regions,collapsing gully is widely distributed in the tropical and subtropical areas of South China.In particular,collapsing-gully erosion produces a large amount of sediment deposited on the plough layer of alluvial fan farmland and causes increase of desertification,great reduction of nutrients and rapid enhancement of erodibility in the soil.This study was designed to evaluate the effects of different land uses on the soil physic-chemical properties and erodibility of collapsing-gully alluvial fan.Our results show that the physical properties of soil in alluvial fan were greatly improved with smaller bulk density,increased soil porosity,strengthened water holding capacity and a higher particulate matter content.The chemical properties of soil were also significantly improved,including pH,cation exchange capacity,and the contents of organic matter,total and available nitrogen,potassium and phosphorus.All the land uses were proved to improve the soil properties,especially in the tea garden,vegetable land and paddy field.The results of correlation analyses among the properties demonstrate that the physical and chemical properties were significantly correlated,indicating that improving the soil physical properties is an effective method to increase the soil nutrient in the farmland of collapsing-gully alluvial fan.In addition,the application of land uses included grass land,eucalyptus forest land,vegetable land,tea garden,sweet potato land,and paddy field reduced the erodibility of the soil compare to bare land.The erodibility K values of soils in grass land,eucalyptus forest land,vegetable land,tea garden,sweet potato land,and paddy field were 14.43,16.97,45.45,33.12,18.94,and 34.01%lowerthan those of bare land,respectively.The results of multiple linear regression analysis show that the soil erodibility had a significant correlation with the physic-chemical properties,especially the soil texture and the content of organic matter.In conclusion,our results demonstrate that different land use patterns are effective to improve the quality of the soil in collapsing-gully alluvial fan,including the improvements of the soil structure,nutrients and anti-erosion ability.Ourfindings provide important implications for the soil improvement in the farmland of collapsing-gully alluvial fan. | DENG Yu-song XIA Dong CAI Chong-fa DING Shu-wen | 2016 | Journal of Integrative Agriculture2016，15，8： | 15 |
| 15 | USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy显示文摘Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is critical to mount a host defense or repair tissue.The exact molecular mechanisms controlling this process are still elusive.Here,we report that ubiquitin-specific protease 19(USP19)acts as an anti-inflammatory switch that inhibits inflammatory responses and promotes M2-like macrophage polarization.USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species.In addition,USP19 inhibited the proteasomal degradation of inflammasome-independent NLRP3 by cleaving its polyubiquitin chains.USP19-stabilized NLRP3 promoted M2-like macrophage polarization by direct association with interferon regulatory factor 4,thereby preventing its p62-mediated selective autophagic degradation.Consistent with these observations,compared to wild-type mice,Usp19−/−mice had decreased M2-like macrophage polarization and increased interleukin-1βsecretion,in response to alum and chitin injections.Thus,we have uncovered an unexpected mechanism by which USP19 switches the proinflammatory function of NLRP3 into an anti-inflammatory function,and suggest that USP19 is a potential therapeutic target for inflammatory interventions. | Tao Liu Liqiu Wang Puping Liang Xiaojuan Wang Yukun Liu Jing Cai Yuanchu She Dan Wang Zhi Wang Zhiyong Guo Samuel Bates Xiaojun Xia Junjiu Huang Jun Cui | 2021 | Cellular & Molecular Immunology2021，18，10： | 15 |
| 16 | Constrained large-eddy simulation and detached eddy simulation of flow past a commercial aircraft at 14 degrees angle of attack显示文摘With the development of computational power and numerical algorithms,computational fluid dynamics(CFD) has become an important strategy for the design of aircraft,which significantly reduces the reliance on wind-tunnel and flight tests.In this paper,we conducted a numerical investigation on the flow past a full commercial aircraft at Mach number 0.2 and 14 degrees angle of attack by means of Reynolds-averaged Navier-Stokes(RANS),detached-eddy simulation(DES) and our newly developed constrained large-eddy simulation(CLES).The objective of this paper is to study the capability of these models in simulating turbulent flows.To our knowledge,this is the first large-eddy simulation method for full commercial aircraft simulation.The results show that the CLES can predict the mean statistical quantities well,qualitatively consistent with traditional methods,and can capture more small-scale structures near the surface of the aircraft with massive separations.Our study demonstrates that CLES is a promising alternative for simulating real engineering turbulent flows. | CHEN ShiYi CHEN YingChun XIA ZhenHua QU Kun SHI YiPeng XIAO ZuoLi LIU QiuHong CAI QingDong LIU Feng LEE Cunbiao ZHANG RiKui CAI JinSheng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 14 |
| 17 | Nutritional assessment with different tools in leukemia patients after hematopoietic stem cell transplantation显示文摘Objective:Correct nutritional assessment is essential for leukemia patients after hematopoietic stem cell transplantation(HSCT).This study aimed to investigate the best nutritional assessment method for leukemia patients after HSCT,and find the possible nutritional risk of the patients during the transplantation process in order to intervene in the patients with nutritional risks and undernourished patients timely,so that the entire transplantation process could be successfully completed.Methods:A prospective study was performed in 108 leukemia patients after HSCT,and different nutritional assessment methods,including nutritional risk screening 2002(NRS2002),mini nutritional assessment(MNA),subjective globe assessment(SGA)and malnutritional universal screening tools(MUST),were used.The associations between nutritional status of these patients and nutritional assessment methods were analyzed.Results:A total of 108 patients completed SGA,and 99 patients completed NRS2002,MNA and MUST.During the treatment process,85.2%of the patients lost weight,wherein,50%lost weight greater than5%,and 42.6%had significantly reduced food intake.For nutritional risk assessment,the positive rates of NRS2002,MNA and MUST were 100%,74.7%and 63.6%,respectively.There was a significant difference(P<0.05)among the positive rates of NRS2002,MNA and MUST.In undernutrition assessment,the positive rate of SGA(83.3%)was significantly higher than that of MNA(17.2%)(P<0.05),and the incidence rate of nutritional risk among leukemia patients≤30 years old was greater than that of patients>30 years old(P<0.05).Conclusions:Patients with leukemia were in poor nutritional status during and after HSCT.The leukemia patients≤30 years old had a greater incidence rate of nutritional risk.As nutritional risk screening tool,the specificity of NRS2002 is not high,but it can be used for evaluating nutritional deficiencies.MNA is a good nutritional risk screening tool,but not an adequate tool for nutritional assessment.If assessment of undernutrition is necessary,the combination of all these screening tools and clinical laboratory indicators should be applied to improve accuracy. | Boshi Wang Xia Yan Jingjing Cai Yu Wang Peng Liu | 2013 | Chinese Journal of Cancer Research2013，25，6： | 14 |
| 18 | Changes in China’s lakes: climate and human impacts显示文摘Lakes have played a critical role in providing water and ecosystem services for people and other organisms in China for millennia.However,accelerating climate change and economic boom have resulted in unprecedented changes in these valuable lakes.Using Landsat images covering the entity of the country,we explored the changes in China’s lakes and the associated driving forces over the last 30 years(i.e.mid-1980 s to 2015).We discovered that China’s lakes have changed with divergent regional trends:in the sparsely populated Tibetan Plateau,lakes are abundant and the lake area has increased dramatically from 38596 to46831 km^2(i.e.increased by 8235 km^2,or 21.3%),whereas,in the densely populated northern and eastern regions,lakes are relatively scarce and the lake area has decreased from 36659 to 33657 km^2(i.e.decreased by 3002 km^2,or 8.2%).In particular,severe lake decreases occurred in the Mongolia-Xinjiang Plateau and the Eastern Plain(-2151 km^2).Statistical analyses indicated that climate was the most important factor controlling lake changes in the Tibetan Plateau,the Yun-Gui Plateau and the Northeast Plain.However,the strength of climatic control on lake changes was low in the Eastern Plain and the Mongolia-Xinjiang Plateau,where human activities,e.g.impoldering,irrigation and mining,have caused serious impacts on lakes.Further lake changes will exacerbate regional imbalances between lake resources and population distribution,and thus may increase the risk of water-resource crises in China. | Shengli Tao Jingyun Fang Suhui Ma Qiong Cai Xinyu Xiong Di Tian Xia Zhao Leqi Fang Heng Zhang Jiangling Zhu Shuqing Zhao | 2020 | National Science Review2020，7，1： | 14 |
| 19 | Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer显示文摘AIM:To investigate the utility of Beclin-1 and LC3,two autophagy-related proteins,in predicting the cetuximab efficacy in advanced colorectal cancer(ACRC) . METHODS:The data of 85 patients with ACRC treated at the Sun Yat-sen University Cancer Center from March 1,2005 to December 31,2008 were studied,including 45 cases treated with cetuximab-containing chemotherapy and 40 cases treated with non-cetuximab-containing chemotherapy.Beclin-1 and LC3 expression was evaluated by immunohistochemistry,and KRAS status was evaluated by polymerase chain reaction. RESULTS:Beclin-1 and LC3 expression in ACRC wassignificantly correlated(r=0.44,P<0.01);however,LC3 was more highly expressed in cancerous tissues than in normal tissues(Z=-2.63,P<0.01) .In the cetuximab-containing chemotherapy group,patients with low LC3 expression had higher objective response rates(ORRs) than those with high LC3 expression(52.9%vs 17.9%,P=0.01) ,and patients with low Beclin-1 expression had a longer median progressionfree survival(PFS) than their counterparts with higher Beclin-1 expression(9.0 mo vs 3.0 mo,P=0.01) . However,neither of these predictive relationships was detected in the group treated with non-cetuximabcontaining chemotherapy.Patients with wild-type KRAS had higher ORRs(42.3%vs 9.1%,P=0.049) and disease control rates(DCRs)(73.1%vs 36.4%,P= 0.035) ,and longer median PFS(5.5 mo vs 2.5 mo,P= 0.02) than those with mutant KRAS in the cetuximabcontaining chemotherapy group.Neither Beclin-1(P= 0.52) nor LC3(P=0.32) expression was significantly correlated with KRAS status. CONCLUSION:Patients with low Beclin-1 expression had a longer PFS than those with high Beclin-1 expression,and patients with low LC3 expression had a higher ORR in ACRC patients treated with cetuximab-containing chemotherapy. | Gui-Fang Guo Wen-Qi Jiang Bei Zhang Yu-Chen Cai Rui-Hua Xu Xu-Xian Chen Fang Wang Liang-Ping Xia | 2011 | World Journal of Gastroenterology2011，17，43： | 14 |
| 20 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
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