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| 1 | The Oral Microbiome Bank of China显示文摘The human microbiome project(HMP) promoted further understanding of human oral microbes. However, research on the human oral microbiota has not made as much progress as research on the gut microbiota. Currently, the causal relationship between the oral microbiota and oral diseases remains unclear, and little is known about the link between the oral microbiota and human systemic diseases. To further understand the contribution of the oral microbiota in oral diseases and systemic diseases, a Human Oral Microbiome Database(HOMD) was established in the US. The HOMD includes 619 taxa in 13 phyla, and most of the microorganisms are from American populations. Due to individual differences in the microbiome, the HOMD does not reflect the Chinese oral microbial status. Herein, we established a new oral microbiome database—the Oral Microbiome Bank of China(OMBC,http://gffzz1f92d53390b34408hbof9oqxwocqv69k0.ffgz.tsg.suse.edu.cn/ombc). Currently, the OMBC includes information on 289 bacterial strains and 720 clinical samples from the Chinese population, along with lab and clinical information. The OMBC is the first curated description of a Chinese-associated microbiome; it provides tools for use in investigating the role of the oral microbiome in health and diseases, and will give the community abundant data and strain information for future oral microbial studies. | Xian Peng Xuedong Zhou Xin Xu Yuqing Li Yan Li Jiyao Li Xiaoquan Su Shi Huang Jian Xu Ga Liao | 2018 | International Journal of Oral Science2018，10，2： | 8 |
| 2 | A Collision Arbitration Protocol Based on Specific Selection Function显示文摘Fast and effective identifications of a large number of items are required in many Radio-frequency identification(RFID) applications. Simultaneous responses from multiple tags are corrupted by collisions and thus result in low identification efficiency. To address the problem of low identification efficiency, many existing tag anticollision algorithms try to schedule the identification process to avoid collisions. A novel anti-collision scheme based on specific selection function is presented, in which tags pick a slot according to a selection function instead of being randomly assigned to slots within a frame. If collision occurs, the reader sends the custom command SETBM according to the collision information. When probed by the SETBM, the tags apply the selection function to its partial ID and send the mapped result to the reader. According to the mapped result, the reader assigns the time slot to the tags. All tags collided in the same slot will be identified by the tree traversal scheme. Compared to the most of existing anti-collision algorithms, simulation results show that our proposed algorithm can achieve better performance in terms of identification efficiency, time efficiency, and energy consumption. | SU Jian REN Yuqing YANG Ying HAN Yu WEN Guangjun | 2017 | Chinese Journal of Electronics2017，26，4： | 5 |
| 3 | Accurate assessment of antibiotic susceptibility and screening resistant strains of a bacterial population by linear gradient plate显示文摘The dynamics of a bacterial population exposed to theminimum inhibitory concentration (MIC) of an antibiotic is an important issue in pharmacological research.Therefore,a novel antibiotic susceptibility test is urgently needed that can both precisely determine the MIC and accurately select antibiotic-resistant strains from clinical bacterial populations.For this purpose,we developed a method based on Fick's laws of diffusion using agar plates containing a linear gradient of antibiotic.The gradient plate contained two layers.The bottom layer consisted of 15 mL agar containing the appropriate concentration of enrofloxacin and allowed to harden in the form of a wedge with the plate slanted such that the entire bottom was just covered.The upper layer consisted of 15 mL plain nutrient agar added with the plate held in the horizontal position.After allowing vertical diffusion of the drug from the bottom agar layer for 12 h,the enrofloxacin concentration was diluted in proportion to the ratio of the agar layer thicknesses.The uniform linear concentration gradient was verified by measuring the enrofloxacin concentration on the agar surface.When heavy bacterial suspensions were spread on the agar surface and incubated for more than 12 h,only resistant cells were able to form colonies beyond the boundary of confluent growth of susceptible cells.In this way,the true MIC of enrofloxacin was determined.The MICs obtained using this linear gradient plate were consistent with those obtained using conventional antibiotic susceptibility tests.Discrete colonies were then spread onto a gradient plate with higher antibiotic concentrations;the boundary line increased significantly,and gene mutations conferring resistance were identified.This new method enables the rapid identification of resistant strains in the bacterial population.Use of the linear gradient plate can easily identify the precise MIC and reveal the dynamic differentiation of bacteria near the MIC.This method allows the study of genetic and physiological characteristics of individual strains,and may be useful for early warning of antibiotic resistance that may occur after use of certain antimicrobial agents,and guide clinical treatment. | LIU YuQing LI JingRan DU JiaFa HU Ming BAI Hua QI Jing GAO Chao WEI TianTian SU Hong JIN JianLing GAO PeiJi | 2011 | Science China(Life Sciences)2011，54，10： | 4 |
| 4 | Extraordinary Floods of 4100?4000<ce:hsp sp='0.25'/>a BP recorded at the Late Neolithic Ruins in the Jinghe River Gorges, Middle Reach of the Yellow River, China显示文摘 | Chun Chang Huang Jiangli Pang Xiaochun Zha Yali Zhou Hongxia Su Yuqing Li | 2010 | Palaeogeography Palaeoclimatology Palaeoecology2010，，1： | 4 |
| 5 | Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock显示文摘Post-translational modifications play essential roles in finely modulating eukaryotic circadian clock systems.In plants,the effects of O-glycosylation on the circadian clock and the underlying mechanisms remain largely unknown.The O-fucosyltransferase SPINDLY(SPY)and the O-GIcNAc transferase SECRET AGENT(SEC)are two prominent O-glycosylation enzymes in higher plants,with both overlapped and unique functions in plant growth and development.Unlike the critical role of O-GIcNAc in regulating the animal circadian clock,here we report that nuclear-localized SPY,but not SEC,specifically modulates the pace of the Arabidopsis circadian clock.By identifying the interactome of SPY,we identified PSEUDORESPONSE REGULATOR 5(PRR5),one of the core circadian clock components,as a new SPY-interacting protein.PRR5 can be O-fucosylated by SPY in pianta,while point mutation in the catalytic domain of SPY abolishes the O-fucosylation of PRR5.The protein abundance of PRR5 is strongly increased in spy mutants,while the degradation rate of PRR5 is much reduced,suggesting that PRR5 proteolysis is promoted by SPY-mediated O-fucosylation.Moreover,multiple lines of genetic evidence indicate that PRR5 is a major downstream target of SPY to specifically mediate its modulation of the circadian clock.Collectively,our findings provide novel insights into the specific role of the O-fucosyltransferase activity of SPY in modulating the circadian clock and implicate that O-glycosylation might play an evolutionarily conserved role in modulating the circadian clock system,via O-GIcNAcylation in mammals,but via O-fuco-sylation in higher plants. | Yan Wang Yuqing He Chen Su Rodolfo Zentella Tai-ping Sun Lei Wang | 2020 | Molecular Plant2020，13，3： | 4 |
| 6 | Effects of complement inhibition on the ABC phenomenon in rats显示文摘Researchers reported that intravenously injected PEGylated colloidal drug carriers lose their long-circulating characteristic and accumulated extensively in liver when they are administrated twice in the same animal with certain intervals. This phenomenon was referred to as the 'accelerated blood clearance(ABC) phenomenon'. Some former studies had found that complement-mediated phagocytosis, activated by antigen–antibody complex, was responsible for inducing the phenomenon. According to the theory, we have used cobra venom factor to deplete complement in vivo and to investigate the effect of complement inhibition on the ABC phenomenon. Rats were administered by injection of cobra venom factor solution to build up the model of complement exhaustion/inhibition, and the effect of the inhibition of complement on ABC phenomenon was carried out. It seemed that inhibition of complement didn’t affect the pharmacokinetic of the first infection. By contrast, in rats of which complement had been depleted, the second dose of PEGylated nanoemulsions showed enhanced circulation time compared with normal rats in a complement inhibition-independent manner, but the ABC phenomenon was not completely eliminated. It indicated that complement inhibition could certainly weaken the accelerated clearance;meanwhile, there were other factors causing the ABC effect.These findings provide novel insights into the attenuating of ABC phenomenon and lay foundation for further study of immune mechanism. | Lirong Wang Yuqing Su Xuling Wang Kaifan Liang Mengyang Liu Wenya Tang Yanzhi Song Xinrong Liu Yihui Deng | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，3： | 2 |
| 7 | Scalable manufacture of vertical p-GaN/n-SnO_(2) heterostructure for self-powered ultraviolet photodetector, solar cell and dual-color light emitting diode显示文摘Vertical SnO_(2)based p-n junctions are pivotal since they built the core components in photoelectronic systems.Nevertheless,preparation of high-quality p-SnO_(2)with controllable hole mobility and concentration is still a great challenge owing to the self-compensating effect and lattice distortion caused by the radius discrepancy between host and doped atoms.Herein,p type GaN:Mg grown by metal organic chemical vapor deposition is employed as hole transportation layer to construct p-n heterojunction with intrinsic n-SnO_(2)prepared by atomic layer deposition.Both material preparation techniques are compatible with current industrial mass production processes.The p-GaN/n-SnO_(2)heterojunction can be developed as solar cell,dual-color light emitting diode and self-powered,high speed ultraviolet(UV)photodetector with external quantum efficiency of 74%at 0 V bias voltage.In addition,direct recombination of donor bound excitons(D0 X)and UV emission red shifts caused by quantum confinement Stack effect are observed in SnO_(2).Since our device fabrication technique is a standard craft in photoelectronics,the study of p-GaN/n-SnO_(2)heterojunction suggests a simple and effective strategy for large scale device integration in next generation high performance photoelectronic devices. | Longxing Su Yuqing Zuo Jin Xie | 2021 | InfoMat2021，3，5： | 2 |
| 8 | 调强适形放疗在乳腺癌保乳术后应用的系统评价(英文)显示文摘Objective:The aim of this study was to assess the long-term effect of breast conservation with breast intensitymodulated radiotherapy (IMRT) for early-stage breast cancers.Methods:Pub Med,EMBASE,Cochrane Library,Chinese Biomedical Literature Database were searched to identify relevant original published trails,and the references of eligible studies were manually screened.Randomized controlled trails reported in any language,comparing breast IMRT with conventional radiotherapy (RT) in patients with early-stage breast cancer were eligible for inclusion.Two investigators independently assessed the quality of included trials and extracted data.The RevMan 5.0 software was used for statistical analysis.Results:Four trials involving 1440 patients were included.The results showed that in the IMRT group,the occurrence of acute moist dermatitis,the edema of the mammary gland and the occurrence of hyperpigmentation were lower than those of RT group,the pooled risk ratio value and 95% confidence interval were 0.28 (0.17-0.48),0.03 (0.00-0.21) and 0.06 (0.02-0.15) respectively.The use of IMRT did not correlate with pain and quality of life,but the presence of moist desquamation did significantly correlate with pain and reduced quality of life.Conclusion:The currently available evidence showed that IMRT significantly reduces the occurrence of moist acute dermatitis anywhere in the breast and alleviates the suffering of patients and improves the quality of life of patients.Future large-scale,high-quality,double-blind trials are needed. | Xiupeng Ye Ling Su Xiaohu Wang Kehu Yang inhui Tian Qiuning Zhang Qiang Wang Xiaojun Li Yuqing Kang Liyun Guo Ruifeng Liu Shifang Feng | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，12： | 2 |
| 9 | Ferric nanoparticle-based resonance light scattering determination of DNA at nanogram levels显示文摘 | CHENG Yongqiang LI Zhengping SU Yuqing | 2007 | Talanta2007，71，4： | 1 |
| 10 | Effect of Oral Atorvastatin on CD4+CD25+ Regulatory T Cells, FoxP3 Expression, and Prognosis in Patients With ST-Segment Elevated Myocardial Infarction Before Primary Percutaneous Coronary Intervention显示文摘 | Dan Zhang Shaoqin Wang Yuqing Guan Lei Wang Wenzhi Xie Nan Li Peng Zhao Guohai Su | 2011 | Journal of Cardiovascular Pharmacology2011，，5： | 1 |
| 11 | Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority Phase III trail显示文摘Background:Erythropoietin is a glycoprotein that mainly regulates erythropoiesis.In patients with chronic renal failure with anemia,darbepoetin alfa can stimulate erythropoiesis,correct anemia,and maintain hemoglobin levels.This study was designed to demonstrate the efficacy and safety of darbepoetin alfa injections as being not inferior to epoetin alfa injections(Recombinant Human Erythropoietin injection,rHuEPO)when maintaining hemoglobin(Hb)levels within the target range(10.0-12.0 g/dL)for the treatment of renal anemia.Methods:Ninety-five patients were enrolled in this study from April 15,2013 to April 10,2014 at 25 sites.In this study,patients(n=95)aged 18-70 years were randomized into a once per week intravenous darbepoetin alfa group(n=56)and a twice or three times per week intravenous epoetin alfa group(n=39)for 28 weeks,who had anemia with hemoglobin levels between 6 g/dL and 10 g/dL due to chronic kidney disease(CKD)and were undergoing hemodialysis or hemofiltration with ESA-naive(erythropoiesis stimulating agent-naive).The primary efficacy profile was the mean Hb level(the non-inferiority margin was-1.0 g/dL,week 21-28);the secondary efficacy profiles were the Hb increase rate(week 0-4),the target Hb achievement cumulative rate and time,the change trends of the Hb levels,and the target Hb maintenance ratio.Adverse events(AEs)were observed and compared,and the efficacy and safety were analyzed between the two treatment groups.Additionally,the frequencies of dose adjustments between the darbepoetin alfa and epoetin alfa groups were compared during the treatment period.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:The mean Hb level was 11.3 g/dL in the darbepoetin alfa group and 10.7 g/dL in the epoetin alfa group,respectively;the difference of the lower limits of the 95%confidence intervals(CI)between the two groups was 0.1 g/dL(>-1.0 g/dL),and non-inferiority was proven;the Hb levels started to increase in the first four weeks at a similar increase rate;no obvious differences were observed between the groups in the target Hb achievement cumulative rates,and the Hb levels as well as the target Hb level maintenance rate changed over time.The incidence of AEs was 62.5%in the darbepoetin alfa group and 76.9%in the epoetin alfa group.All the adverse events observed in the study were those commonly associated with hemodialysis.Conclusion:Darbepoetin alfa intravenously once per week can effectively increase Hb levels and maintain the target Hb levels well,which makes it not inferior to epoetin alfa intravenously twice or three times per week.Darbepoetin alfa shows an efficacy and safety comparable to epoetin alfa for the treatment of renal anemia. | Nan Chen Changying Xing Jianying Niu Bicheng Liu Junzhou Fu Jiuyang Zhao Zhaohui Ni Mei Wang Wenhu Liu Jinghong Zhao Ling Zhong Xiongfei Wu Wenge Li Yuqing Chen Wei Shi Jianghua Chen Aiping Yin Ping Fu Rong Wang Gengru Jiang Fanfan Hou Guohua Ding Jing Chen Gang Xu Yuichiro Kondo Yuliang Su Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，1： | 1 |
| 12 | Delay - constrained transmission of fine scalable coded content over P2P networks显示文摘 | Xiao Su Yi Shang Tao Wang Yuqing Mai | 2005 | Signal Processing: Image Communication2005，，20： | 1 |
| 13 | 与膝关节疼痛相关的功能障碍及常规治疗措施的调查显示文摘目的 调查膝关节疼痛给农民带来的功能障碍负担和当地医疗诊治情况.方法 自2005年10月至12月,采用横断面研究利用扩大免疫规划整体抽样的方法,以内蒙古武川县当地50岁以上农业人口1030名为对象.参与调查者在完成已设计好的骨关节炎问卷后接受双膝负重半屈曲后前位X线检查.结果 在接受膝关节X线检查的1027名中,513名(50%)反映其膝关节在过去的12个月中至少有1个月出现过疼痛,其中109名(21%)患者有骨关节炎影像学表现(Kellgren/Lawrence分度≥2).通过对年龄、性别、体重指数、受教育程度及腰疼情况的校正,可以看出膝关节疼痛与完成行走、爬10层楼、弯腰、做保洁工作和下厨等活动的困难程度关系密切.在513名有膝关节疼痛的参与者中,在影像学上是否出现疾病改变与有无无法忍受的疼痛(36%相对于59%),是否活动受限(39%相对于64%),是否使用过非甾体类抗炎药(78%相对于88%)以及在过去的12个月中是否就医(33%相对于59%)有着密切的联系.结论 农业人口重体力劳动者的膝关节疼痛与功能障碍明显相关.有疼痛症状者十分依赖非甾体类抗炎药而较少诉求外科手术治疗. | 林剑浩 康晓征 Marlene Fransen 李虎 柯岩 王志强 Yuqing Zhang Steve Su | 2010 | 中华医学杂志2010，90，21： | 1 |
| 14 | Coordinative regulation of plants growth and development by light and circadian clock显示文摘The circadian clock,known as an endogenous timekeeping system,can integrate various cues to regulate plant physiological functions for adapting to the changing environment and thus ensure optimal plant growth.The synchronization of internal clock with external environmental information needs a process termed entrainment,and light is one of the predominant entraining signals for the plant circadian clock.Photoreceptors can detect and transmit light information to the clock core oscillator through transcriptional or post-transcriptional interactions with core-clock components to sustain circadian rhythms and regulate a myriad of downstream responses,including photomorphogenesis and photoperiodic flowering which are key links in the process of growth and development.Here we summarize the current understanding of the molecular network of the circadian clock and how light information is integrated into the circadian system,especially focus on how the circadian clock and light signals coordinately regulate the common downstream outputs.We discuss the functions of the clock and light signals in regulating photoperiodic flowering among various crop species. | Chen Su Yan Wang Yingjun Yu Yuqing He Lei Wang | 2021 | aBIOTECH2021，2，2： | 1 |
| 15 | Extraordinary Floods of 4100?4000a BP recorded at the Late Neolithic Ruins in the Jinghe River Gorges, Middle Reach of the Yellow River, China显示文摘 | Chun Chang Huang Jiangli Pang Xiaochun Zha Yali Zhou Hongxia Su Yuqing Li | 2010 | Palaeogeography, Palaeoclimatology, Palaeoecology2010，，1： | 1 |
| 16 | The accelerated blood clearance phenomenon of PEGylated nanoemulsion upon cross administration with nanoemulsions modified with polyglycerin显示文摘For investigating the accelerated blood clearance(ABC) phenomenon of polyglycerin modified nanoemulsions upon cross administration with polyethylene glycol(PEG) covered nanoemulsion, we used the 1,2-distea-royl-sn-glycero-3-phosphoethanolamine-npolyglycerine-610 and the 1,2-distearoyl-n-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000] as modify materials, the dialkylcarbocyanines as fluorescence indicator. Exhausted macrophages rat model was established and new material containing polycarboxyl structure was synthesized. The microplate reader and the in vivo optical imaging system were applied to measure the concentration of nanoemulsions in tissues.The results show that the first dose of polyglycerin modified nanoemulsion can induce the ABC phenomenon of the second dose of PEGylated nanoemulsion. With the increase in the amount of the surface polyglycerin, the extent of the ABC phenomenon decreases. Liver accumulation has positive relationship with the ABC phenomenon. Furthermore, kupffer cells in liver can get more immune information from polyhydroxy structure than polycarboxyl group in the modify compound. The results of our work imply that the polycarboxyl structure has advantages to eliminate the ABC phenomenon. | Yuqing Su Lirong Wang Kaifan Liang Mengyang Liu Xinrong Liu Yanzhi Song Yihui Deng | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，1： | 1 |
| 17 | Single-Cell Microwell Platform Reveals Circulating Neural Cells as a Clinical Indicator for Patients with Blood-Brain Barrier Breakdown显示文摘Central nervous system diseases commonly occur with the destruction of the blood-brain barrier.As a primary cause of morbidity and mortality,stroke remains unpredictable and lacks cellular biomarkers that accurately quantify its occurrence and development.Here,we identify NeuN^(+)/CD45^(−)/DAPI^(+)phenotype nonblood cells in the peripheral blood of mice subjected to middle cerebral artery occlusion(MCAO)and stroke patients.Since NeuN is a specific marker of neural cells,we term these newly identified cells as circulating neural cells(CNCs).We find that the enumeration of CNCs in the blood is significantly associated with the severity of brain damage in MCAO mice(p<0:05).Meanwhile,the number of CNCs is significantly higher in stroke patients than in negative subjects(p<0:0001).These findings suggest that the amount of CNCs in circulation may serve as a clinical indicator for the real-time prognosis and progression monitor of the occurrence and development of ischemic stroke and other nervous system disease. | Yu Zhang Antony R.Warden Khan Zara Ahmad Yanlei Liu Xijun He Minqiao Zheng Xinlong Huo Xiao Zhi Yuqing Ke Hongxia Li Sijia Yan Wenqiong Su Deng Cai Xianting Ding | 2021 | Research2021，，1： | 0 |
| 18 | Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure显示文摘Clinically,a large proportion of glaucoma patients undergo repeated intraocular pressure(IOP)spike(Spike IOP)attacks during their sleep,which may facilitate retinopathy.In this study,we established a mouse model of repeated transient Spike IOP to investigate the direct damage to the retina following Spike IOP attacks,and elucidated the underlying molecular mechanism.We analyzed the changes in the number of retinal ganglion cells(RGCs)via immunofluorescence.Thereafter,we detected retinal cell apoptosis via terminal deoxynucleotidyl transferase deoxyuridine triphosphate(d UTP)nick-end labeling(TUNEL)staining,and performed RNA sequencing(RNA-seq)to reveal the underlying molecular mechanism.Finally,we validated the expression of key molecules in the endoplasmic reticulum(ER)stress pathway using quantitative real-time polymerase chain reaction(q RT-PCR)and western blot analysis.Results revealed a time-dependent RGC loss in Spike IOP,evidenced by a reduction in the number of Brn3 a-positive RGCs in experimental eyes following a 7-d continuous treatment with Spike IOP.In addition,TUNEL staining indicated that apoptosis of retinal cells started in the outer nuclear layer(ONL),and then spread to the ganglion cell layer(GCL)with time.RNA-seq analysis revealed that ER stress might be involved in Spike IOP-induced retinal injury.This result was corroborated by western blot,which revealed upregulation of ER stress-related proteins including binding immunoglobulin protein/glucose-regulated protein 78(Bi P/GRP78),phosphorylated inositolrequiring enzyme 1(p-IRE1),unspliced X-box-binding protein 1(XBP1-u),spliced X-box-binding protein 1(XBP1-s),phosphorylated c-Jun N-terminal kinase(p-JNK),C/EBP-homologous protein(CHOP),and B-cell lymphoma 2(Bcl-2)-associated X protein(Bax).These findings indicate that repeated IOP transients are detrimental to the retina,while ER stress plays an important role in retinal cell apoptosis in this situation.Notably,repeated Spike IOP among glaucoma patients is a crucial factor for progressive retinopathy. | Xue YANG Xiaowei YU Zhenni ZHAO Yuqing HE Jiamin ZHANG Xiaoqian SU Nannan SUN Zhigang FAN | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，9： | 0 |
| 19 | Transient Stability Analysis of Large-scale Power Systems:A Survey显示文摘Transient stability analysis is a key problem in power system operation and planning.This paper aims at giving a comprehensive review on the modeling ideas and analysis methods for transient stability of large-scale power systems.For model construction,the general modeling of traditional power systems and special modeling for renewable generations and high-voltage direct-current transmissions are introduced.For transient stability analysis,Lyapunov based methods and non-Lyapunov based methods are thoroughly reviewed.In Lya-punov based methods,we focus on the energy function method,the sum-of-squares based method and decentralized stability analysis methods.Meanwhile,in non-Lyapunov based methods,the time-domain simulation,extended equal-area criterion and data-driven based methods are considered.The basic working principles,features and recent research progresses of all the above-mentioned methods are described in detail.In particular,their performances on several aspects,such as computational speed,conservativeness of stability region estimation or stability margin calculation,and adaptability to various types of system models,are mentioned.Finally,a brief discussion of potential directions for future research on transient stability analysis of large-scale power systems is included.Index Terms-connective stability,large-scale system analysis,Lyapunov functions,power systems,transient stability analysis. | Qing-Hua Wu Yuqing Lin Chao Hong Yinsheng Su Tianhao Wen Yang Liu | 2023 | CSEE Journal of Power and Energy Systems2023，9，4： | 0 |
| 20 | Efficacy of electroacupuncture stimulating Zusanli(ST36)and Xuanzhong(GB39)on synovial angiogenesis in rats with adjuvant arthritis显示文摘OBJECTIVE:To investigate the efficacy of electroacupuncture(EA)stimulating Zusanli(ST36)and Xuanzhong(GB39)on synovial angiogenesis in rats with adjuvant arthritis(AA).METHODS:AA models were established by bilateral injection of Freund's complete adjuvant(FCA)in male Sprague-Dawley rats.Three days after injection,rats were given EA at Zusanli(ST36)and Xuanzhong(GB39)acupoints,once every other day,for 16 d.The arthritis index score,paw volume,and hematoxylin-eosin(HE)staining was performed for each animal.Angiogenesis marker cluster of differentiation 34(CD34)expression and synovial cell apoptosis in synovial tissue were observed.The levels of Notch1,hairy and enhancer of split homolog-1(Hes1),transforming growth factor-beta(TGF-β)and basic fibroblast growth factor(bFGF)were subsequently detected.RESULTS:We found that EA significantly decreased arthritis index scores,paw volume,and HE staining scores.EA could significantly inhibit the expression of CD34,promoting apoptosis of synovial cells in the joint synovial tissue of AA rats.The expression of Notch1 signaling pathway proteins and mR NAs(Notch1,Hes1,TGF-β,and bFGF)were markedly downregulated by EA treatment.CONCLUSIONS:These results prove that EA attenuates synovial angiogenesis by inhibiting the Notch1 signaling pathway in AA rat models.Based on our findings,we propose that EA is a promising complementary and alternative therapy in rheumatoid arthritis. | JIANG Jianzhen ZHANG Xin LUO Zhenguo SU Chengguo ZHOU Haiyan JIANG Yuqing XIAO Xianjun CHEN Yunfei ZHU Jun | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 0 |
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