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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 3 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 4 | Economic analysis in admitted patients with acute exacerbation of chronic obstructive pulmonary disease显示文摘背景:在北京的长期的妨碍的肺的疾病(AECOPD ) 的尖锐恶化的社会经济的负担充分没被理解。学习与 AECOPD 和联系因素在病人调查了住院费用。方法:一个多中心,回顾的学习包括二所水平 III 医院和二所水平 II 医院在北京在四所医院里被进行。有 AECOPD 的病人承认了到在 1 月之间的医院,在 2006 的 12 月被注册。住院花费了,它与疾病严厉和治疗的关系被分析。结果:完全, 439 个病人与 294 个人(67.0%) 和吝啬的年龄一起被注册 73.4 年。吝啬的医院停留是 20.7 天。204 个病人(46.5%) 的一个总数有呼吸衰竭, 153 (34.9%) 与肺性心病, 123 (28.0%) 与冠的动脉疾病, 231 (52.6%) 与高血压, 70 (15.9%) 与脑血管的疾病并且 32 (7.3%) 与肾衰竭。到全部的费用的药费用的百分比是最高(71.2%) ,由实验室费用(16.7%) 列在后面,治疗费用(9.7%) ,氧费用(7.3%) ,辐射学费用(4.5%) ,考试费用(4.5%) ,床费用(4.1%) 。关联分析证明费用断然与年龄被相关,住院天,合作病态象呼吸衰竭和肺性心病那样,高血压。321 个病人进一步被分析。住院费用与非侵略的通风在病人增加了(P <
0.01 ) ,侵略机械通风(P <
0.01 ) , ICU 停留(P <
0.01 ) ,抗菌素(P <
0.05 ) ,全身的类固醇(P <
0.01 ) ,并且差的预后(P <
0.05 ) 。关联分析证明住院费用否定地与百分比被相关在 1 秒( FEV ( 1 )%)的强迫的吐气的体积( r =-0.149, P <
0.05 ), pH ( r =-0.258, P <
0.01 ),并且 PaO ( 2 )( r =-0.131, P <
0.05 ),断然与 PaCO ( 2 )相关( r = 0.319 , P <
0.01 ),非侵略的正压通风( r = 0.375 , P <
0.01 )并且持续时间( r = 0.463 , P <
0.01 ),侵略机械通风( r = 0.416 , P <
0.01 )并且持续时间( r = 0.511 , P <
0.01 ), ICU 留下来( r 0.390 , P <
0.01 )并且持续时间( r <
0.05 )并且全身的类固醇( r = 0.202 , P <
0.01 )。结论:AECOPD 在保健资源利用上有大影响。疾病严厉,非侵略或侵略的通风的使用, ICU 停留和抗菌素和全身的类固醇的用法是住院费用的主要决定因素。针对减少尖锐恶化愿望的频率的长期的常规处理降低长期的妨碍的肺的疾病(COPD ) 的社会、经济的负担。 | CHEN Ya-hong YAO Wan-zhen CAI Bai-qiang WANG Hong DENG Xiao-mei GAO Hui-li HUANG Jia-sheng WANG Xin-mao | 2008 | Chinese Medical Journal2008，，7： | 49 |
| 5 | Colorectal cancer lymph node staining by activated carbon nanoparticles suspension in vivo or methylene blue in vitro显示文摘AIM:To investigate whether activated carbon nanoparticles suspension(ACNS) or methylene blue(MB) can increase the detected number of lymph nodes in colorectal cancer.METHODS:Sixty-seven of 72 colorectal cancer patients treated at our hospital fulfilled the inclusion criteria of the study which was conducted from December 2010 to February 2012.Seven patients refused to participate.Eventually,60 patients were included,and randomly assigned to three groups(20 in each group):ACNS group(group A),MB group(group B) and non-stained conventional surgical group(group C).In group A,patients received subserosal injection of 1 mL ACNS in a 4-quadrant region around the mass.In group B,the main artery of specimen was identified and isolated after the specimen was removed,and 2 mL MB was slowly injected into the isolated,stretched and fixed vessel.In group C,no ACNS and MB were injected.All the mesentery lymph nodes were isolated and removed systematically by visually inspecting and palpating the adipose tissue.RESULTS:No difference was observed among the three groups in age,gender,tumor location,tumor diameter,T-stage,degree of differentiation,postoperative complications and peritoneal drainage retention time.The total number of detected lymph nodes was 535,476 and 223 in the three groups,respectively.The mean number of detected lymph nodes per patient was significantly higher in group A than in group C(26.8 ± 8.4 vs 12.2 ± 3.2,P < 0.001).Similarly,there were significantly more lymph nodes detected in group B than in group C(23.8 ± 6.9 vs 12.2 ± 3.2,P < 0.001).However,there was no significant difference between group A and group B.There were 50,46 and 32 metastatic lymph nodes dissected in 13 patients of group A,10 patients of group B and 11 patients of group C,without significant differences among the three groups.Eleven of the 60 patients had insufficient number of detected lymph nodes(< 12).Only one patient with T 4a rectal cancer had 10 lymph nodes detected in group B,the other 10 patients were all from group C.Based on the different diameter categories,the number of detected lymph nodes in groups A and B was significantly higher than in group C.However,there was no statistically significant difference between group A and group B.The metastatic lymph nodes were not significant different among the three groups.Similarly,tumor location,T stage and tumor differentiation did not affect the staining results.Body mass index was a minor influencing factor in the two different staining methods.The stained lymph nodes can easily be identified from the mesenteric adipose tissues,and the staining time for lymph nodes was not significantly different compared with unstained group.None of the patients in groups A and B had drug-related complications.CONCLUSION:Both activated carbon nanoparticles suspension in vivo and methylene blue in vitro can be used as tracers to increase the detected number of lymph nodes in colorectal cancer. | Hong-Ke Cai Hai-Fei He Wei Tian Mei-Qi Zhou Yue Hu Yong-Chuan Deng | 2012 | World Journal of Gastroenterology2012，18，42： | 39 |
| 6 | Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients: A Multicenter Study in China显示文摘 | Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu Ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang Yue-Yi Deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，8： | 39 |
| 7 | Inhibiting Effects of Achyranthes Bidentata Polysaccharide and Lycium Barbarum Polysaccharide on Nonenzyme Glycation in D-galactose Induced Mouse Aging Model显示文摘To investigate the inhibiting effects and mechanism of achyranthes bidentata polysaccharide (ABP) and lycium barbarum polysaccharide (LBP) on nonenzyme glycation in D-galactose induced mouse aging model. Methods Serum AGE levels were determined by AGE-ELISA, MTT method was used to determine lymphocyte proliferation, IL-2 activity was determined by a bioassay method. Spontaneous motor activity was used to detect mouse's neuromuscular movement, latency of step-through method was used to examine learning and memory abilities of mouse, colormetric assay was used to determine hydroxyproline concentration in mouse skin, pyrogallol autoxidation method was used to determine superoxide dismutase (SOD) activity of erythrocytes. Results Decreased levels of serum AGE, hydroxyproline concentration in mouse skin and spontaneous motor activity in D-galactose mouse aging model were detected after treated with ABP or LBP, while lymphocyte proliferation and IL-2 activity, learning and memory abilities,SOD activity of erythrocytes, were enhanced. Conclusions ABP and LBP could inhibit nonenzyme glycation in D-galactose induced mouse aging model in vivo and ABP has a better inhibiting effect than LBP. | HONG-BIN DENG, DA-PENG CUI, JIAN-MING JIANG, YAN-CHUN FENG,NIAN-SHENG CAI, AND DIAN-DONG LIInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China | 2003 | Biomedical and Environmental Sciences2003，16，3： | 33 |
| 8 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 9 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 10 | Identification of fruit and branch in natural scenes for citrus harvesting robot using machine vision and support vector machine显示文摘With the decrease of agricultural labor and the increase of production cost,the researches on citrus harvesting robot(CHR)have received more and more attention in recent years.For the success of robotic harvesting and the safety of robot,the identification of mature citrus fruit and obstacle is the priority of robotic harvesting.In this work,a machine vision system,which consisted of a color CCD camera and a computer,was developed to achieve these tasks.Images of citrus trees were captured under sunny and cloudy conditions.Due to varying degrees of lightness and position randomness of fruits and branches,red,green,and blue values of objects in these images are changed dramatically.The traditional threshold segmentation is not efficient to solve these problems.Multi-class support vector machine(SVM),which succeeds by morphological operation,was used to simultaneously segment the fruits and branches in this study.The recognition rate of citrus fruit was 92.4%,and the branch of which diameter was more than 5 pixels,could be recognized.The results showed that the algorithm could be used to detect the fruits and branches for CHR. | Lü Qiang Cai Jianrong Liu Bin Deng Lie Zhang Yajing | 2014 | International Journal of Agricultural and Biological Engineering2014，7，2： | 17 |
| 11 | Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury显示文摘Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects and has been used to treat cardiovascular and cerebrovascular diseases in China. However, the mechanisms by which scutellarin mediates neuroprotection in cerebral ischemia remain unclear. The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity. Cultures of primary astrocytes isolated from the cerebral cortex of neonatal Sprague-Dawley rats were pretreated with 2, 10 or 50 μM scutellarin for 30 minutes. The astrocytes were then subjected to oxygen/glucose deprivation by incubation for 2 hours in glucose-free Dulbecco's modified Eagle's medium in a 95% N2/5% CO_2 incubator, followed by simulated reperfusion for 22 hours. Cell viability was assessed by cell counting kit-8 assay. Expression levels of NOX2, connexin 43 and caspase-3 were assessed by western blot assay. Reactive oxygen species were measured spectrophotometrically. Pretreatment with 10 or 50 μM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion. We also assessed the effects of scutellarin in vivo in the rat transient middle cerebral artery occlusion model of cerebral ischemia-reperfusion injury. Rats were given intraperitoneal injection of 100 mg/kg scutellarin 2 hours before surgery. The Bederson scale was used to assess neurological deficit, and 2,3,5-triphenyltetrazolium chloride staining was used to measure infarct size. Western blot assay was used to assess expression of NOX2 and connexin 43 in brain tissue. Enzyme-linked immunosorbent assay was used to detect 8-hydroxydeoxyguanosine(8-OHd G), 4-hydroxy-2-nonenal(4-HNE) and 3-nitrotyrosin(3-NT) in brain tissue. Immunofluorescence double staining was used to determine the co-expression of caspase-3 and Neu N. Pretreatment with scutellarin improved the neurological function of rats with focal cerebral ischemia, reduced infarct size, diminished the expression of NOX2, reduced levels of 8-OHd G, 4-HNE and 3-NT, and reduced the number of cells co-expressing caspase-3 and Neu N in the injured brain tissue. Furthermore, we examined the effect of the NOX2 inhibitor apocynin. Apocynin substantially increased connexin 43 expression in vivo and in vitro. Collectively, our findings suggest that scutellarin protects against ischemic injury in vitro and in vivo by downregulating NOX2, upregulating connexin 43, decreasing oxidative damage, and reducing apoptotic cell death. | Jing-Bo Sun Yan Li Ye-Feng Cai Yan Huang Shu Liu Patrick KK Yeung Min-Zhen Deng Guang-Shun Sun Prince LM Zilundu Qian-Sheng Hu Rui-Xin An Li-Hua Zhou Li-Xin Wang Xiao Cheng | 2018 | Neural Regeneration Research2018，13，8： | 16 |
| 12 | Effects of land uses on soil physic-chemical properties and erodibility in collapsing-gully alluvial fan of Anxi County,China显示文摘As a special kind of soil erosion that severely deteriorates the qualities of soil in granite regions,collapsing gully is widely distributed in the tropical and subtropical areas of South China.In particular,collapsing-gully erosion produces a large amount of sediment deposited on the plough layer of alluvial fan farmland and causes increase of desertification,great reduction of nutrients and rapid enhancement of erodibility in the soil.This study was designed to evaluate the effects of different land uses on the soil physic-chemical properties and erodibility of collapsing-gully alluvial fan.Our results show that the physical properties of soil in alluvial fan were greatly improved with smaller bulk density,increased soil porosity,strengthened water holding capacity and a higher particulate matter content.The chemical properties of soil were also significantly improved,including pH,cation exchange capacity,and the contents of organic matter,total and available nitrogen,potassium and phosphorus.All the land uses were proved to improve the soil properties,especially in the tea garden,vegetable land and paddy field.The results of correlation analyses among the properties demonstrate that the physical and chemical properties were significantly correlated,indicating that improving the soil physical properties is an effective method to increase the soil nutrient in the farmland of collapsing-gully alluvial fan.In addition,the application of land uses included grass land,eucalyptus forest land,vegetable land,tea garden,sweet potato land,and paddy field reduced the erodibility of the soil compare to bare land.The erodibility K values of soils in grass land,eucalyptus forest land,vegetable land,tea garden,sweet potato land,and paddy field were 14.43,16.97,45.45,33.12,18.94,and 34.01%lowerthan those of bare land,respectively.The results of multiple linear regression analysis show that the soil erodibility had a significant correlation with the physic-chemical properties,especially the soil texture and the content of organic matter.In conclusion,our results demonstrate that different land use patterns are effective to improve the quality of the soil in collapsing-gully alluvial fan,including the improvements of the soil structure,nutrients and anti-erosion ability.Ourfindings provide important implications for the soil improvement in the farmland of collapsing-gully alluvial fan. | DENG Yu-song XIA Dong CAI Chong-fa DING Shu-wen | 2016 | Journal of Integrative Agriculture2016，15，8： | 15 |
| 13 | Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction显示文摘 | Mei Hua Jiang Bing Cai Ying Tuo Jiancheng Wang Zhi Jun Zang Xiang'an Tu Yong Gao Zhijian Su Weiqiang Li Guilan Li Min Zhang Jianwei Jiao Zi Wan Chunhua Deng Bruce T Lahn Andy Peng Xiang | 2014 | Cell Research2014，24，12： | 14 |
| 14 | Differences in thermal effects of moxibustion at Zusanli(ST 36) and Hegu(LI 4) on various facial areas in healthy people显示文摘OBJECTIVE:To study the effects of temperature on different facial areas by suspended moxibustion at two points,Zusanli(ST 36) and Hegu(LI 4),and probe the phenomena underlying self-regulation in the human body after thermal stimulation.METHODS:Thirty healthy volunteers accepted moxibustion over Zusanli(ST 36) and Hegu(LI 4),and the order of moxibustion points was randomly determined.Moxibustion method:suspension of moxibustion over Zusanli(ST 36) and Hegu(LI 4) on both sides was performed using an ignited moxa stick stuck in a support for 20 min.Observation method:An infrared thermal image of the face was taken before and after suspended moxibustion using a CK350 medical infrared thermal imaging instrument.Data analysis:A thermal microscopic section view system(TMTSys) was used to analyze the change in temperature in special facial areas.Statistical analysis was carried out using SPSS 14.0 software.RESULTS:Before moxibustion was suspended,the facial thermal image showed a T-shaped thermal area related to the vascular distribution with even temperature and good symmetry on both sides.Suspended moxibustion over Zusanli(ST 36) have a very significant increase in temperature at the forehead,around the nose,at the corners of the mouth,and at the cheeks and lips(P<0.01).Suspended moxibustion over Hegu(LI 4) also have a significant(P<0.05) increase in temperature around the nose,the corners of the mouth,the cheeks,and lips,where has a new high temperature area was formed(P<0.01).Suspended moxibustion over Hegu(LI 4) raised the temperature at the middle point of the lips more obviously than did Zusanli(ST 36) in the same person,(P<0.05).After 10 min of moxibustion over Zusanli(ST 36) and Hegu(LI 4),the change in temperature in the facial area reached its peak value.CONCLUSIONS:Facial infrared thermography of healthy people revealed a T-shaped thermal area reflecting a physiological thermal area.Moxibustion over Zusanli(ST 36) or Hegu(LI 4) raised the temperature in this facial T-shaped thermal area.Hegu(LI 4) led to the formation of a new thermal area in the lips.The time required for moxibustion to regulate human body temperature was 10 min. | Yiling Yang Laixi Ji Gaobo Li Xiufang Deng Peisi Cai Ling Guan | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 13 |
| 15 | Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography显示文摘AIM: To investigate microvascular changes in eyes with central retinal vein occlusion(CRVO) complicated by macular edema before and after intravitreal conbercept injection and evaluate correlations between these changes and best-corrected visual acuity(BCVA) and retinal thickness. METHODS: Twenty-eight eyes of 28 patients with macular edema caused by CRVO were included in this retrospective study. All patients received a single intravitreal conbercept injection to treat macular edema. BCVA and the results of optical coherence tomography angiography(OCTA) automatic measurements of the vessel density in the superficial(SCP) and deep retinal capillary plexus(DCP), the foveal avascular zone(FAZ) area, the FAZ perimeter(PERIM), the vessel density within a 300-μm wide ring surrounding the FAZ(FD-300), the acircularity index(AI), the choriocapillaris flow area, and retinal thickness were recorded before and at one month after treatment and compared with the results observed in age-and sexmatched healthy subjects. RESULTS: The vessel density in the SCP and DCP, the FD-300, and the flow area of the choriocapillaris were allsignificantly lower in CRVO eyes than in healthy eyes, while the AI and retinal thickness were significantly higher(all P<0.05). After treatment, retinal thickness was significantly decreased, and the mean BCVA had markedly improved from 20/167 to 20/65(P=0.0092). The flow area of the choriocapillaris was also significantly improved, which may result from the reduction of shadowing effect caused by the attenuation of macular edema. However, there were no significant changes in SCP and DCP vessel density after treatment. The flow area of the choriocapillaris at baseline was negatively correlated with retinal thickness.CONCLUSION: OCTA enables the non-invasive, layerspecific and quantitative assessment of microvascular changes both before and after treatment, and can therefore be used as a valuable imaging tool for the evaluation of the follow-up in CRVO patients. | Yang Deng Qi-Wen Zhong Ai-Qi Zhang Xiao-Juan Cai Ming-Zhi Lu Shao-Chong Zhang Li-Shi Su Hui Chen Ying Lin Li-Mei Sun Guan-Di Chen Li-Ting Zhong Chen-Jin Jin Wei Chi | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 13 |
| 16 | An advanced carbon dioxide retrieval algorithm for satellite measurements and its application to GOSAT observations显示文摘An advanced carbon dioxide retrieval algorithm for satellite observations has been developed at the Institute of Atmospheric Physics, Chinese Academy of Sciences. The algorithm is tested using Greenhouse gases Observing SATellite(GOSAT) L1 B data and validated using the Total Column Carbon Observing Network(TCCON) measurements. The retrieved XCO2 agrees well with TCCON measurements in a low bias of 0.15 ppmv and RMSE of 1.48 ppmv, and captured the seasonal variation and increasing of XCO2 in Northern and Southern Hemisphere, respectively, as other measurements. | Dongxu Yang Yi Liu Zhaonan Cai Jianbo Deng Jing Wang Xi Chen | 2015 | Science Bulletin2015，60，23： | 12 |
| 17 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 18 | 饲粮中添加月桂酸单甘油酯对蛋鸡产蛋性能、蛋品质、血清生化指标以及小肠形态的影响(英文)显示文摘目的:基于传统食品添加剂月桂酸单甘油酯(GML)的抗菌、抗病毒和免疫调节特性,研究其对蛋鸡产蛋性能、蛋品质和生理健康的影响。创新点:将传统食品添加剂GML应用于蛋鸡养殖行业,探究其作为饲粮添加剂改善动物营养健康状况的潜能。方法:将360只海兰褐蛋鸡随机分为4组,每组6个重复,每个重复15只蛋鸡,分别饲喂以玉米-豆粕为主的日粮,并在日粮中分别添加0、0.15、0.30和0.45 g/kg GML.饲喂8周后,测定蛋鸡的产蛋性能、蛋品质、蛋清以及蛋黄相关营养成分组成、血清生理生化以及激素相关指标,并对空肠和附睾脂肪切片进行形态学观察,系统研究GML对蛋鸡的影响。结论:0.15、0.30和0.45 g/kg GML处理能显著降低饲料转化率,并显著提高产蛋率和平均蛋重。在鸡蛋品质方面,GML显著提高了蛋白的高度和哈夫单位,并增强了蛋黄的颜色。此外,GML还增加了蛋黄中多不饱和脂肪酸和单不饱和脂肪酸的浓度,降低了蛋黄中总饱和脂肪酸的浓度。蛋白组成在GML作用下也有显著改变,其中0.30 g/kg GML显著增加了总蛋白含量以及组氨酸和谷氨酸的含量.GML对蛋鸡脂代谢也表现除了积极作用,能显著降低血清甘油三酯和总胆固醇水平,减少腹部脂肪组织的沉积。在改善肠道形态方面,GML增加了绒毛长度以及绒毛高度与隐窝深度的比值。总体来说,GML对蛋鸡的生产性能和生理特性均有显著的改善作用,表明GML有作为功能性饲料添加剂的潜能,拓宽了传统食品添加剂GML的应用领域。 | Min-jie ZHAO Hai-ying CAI Meng-yun LIU Ling-li DENG Yang LI Hui ZHANG Feng-qin FENG | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，11： | 11 |
| 19 | Characteristics analysis on high density spatial sampling seismic data显示文摘中国的大陆人免职盆被复杂地质的结构和各种各样的水库岩性学描绘。因此,高精确探索方法被需要。高密度空间采样是一种新技术增加地震探索的精确性。我们简短讨论点来源和接收装置技术,分析高密度在 situ 方法的空间采样,介绍吉季斯· J · O 介绍的对称的采样原则。Vermeer,并且讨论高密度从波浪地连续性的观点的空间采样技术。我们强调高密度的分析空间采样特征,包括高密度,首先,裂缝为近的表面结构的调查有利,改善静态的修正精确,在到增加的短偏移量的稠密的接收装置间距的使用在浅深度的有效范围,和思考成像的精确性。协调噪音不是 aliased 和噪音分析精确,抑制作为结果增加。空间采样提高的高密度各种各样的数学变换的波浪地连续性和精确性,它受益飘动地分离。最后,我们指出空间采样技术是的高密度的困难的部分处理的数据。更多的研究需要在分析并且处理地震数据的巨大的数量的方法上被做。 | Cai Xiling Liu Xuewei Deng Chunyan Lv Yingme | 2006 | Applied Geophysics2006，3，1： | 11 |
| 20 | A double-blind,randomized,placebo-and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis显示文摘Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque psoriasis.We conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque psoriasis.Methods:We randomly assigned 686 patients(2:1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12 weeks.The primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week 12.Results:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,P<0.05)and placebo(13.9%,P<0.05)groups.The proportion of patients achieving an sPGA score 0 or 1 was 66.3%in the benvitimod group and 63.9%in the calcipotriol group,which were both significantly higher than that in the placebo group(34%,P<0.05).In the long-term follow-up study,50.8%of patients experienced recurrence.After retreatment with 1%benvitimod,73.3%of patients achieved an sPGA score of 0 or 1 again at week 52.Adverse events included application site irritation,follicular papules,and contact dermatitis.No systemic adverse reactions were reported.Conclusion:During this 12-week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis. | Lin Cai Gen-Hui Chen Qian-Jin Lu Min Zheng Yu-Zhen Li Jin Chen Jie Zheng Fu-Ren Zhang Jian-Bin Yu Sen Yang Fu-Qiu Li Sheng-Xiang Xiao Qiu-Ning Sun Jin-Hua Xu Xing-Hua Gao Hong Fang Tian-Wen Gao Fei Hao Quan-Zhong Liu Ya-Ting Tu Ruo-Yu Li Bao-Xi Wang Dan-Qi Deng Qing-Shan Zheng Hong-Xia Liu Jian-Zhong Zhang | 2020 | Chinese Medical Journal2020，，24： | 11 |
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