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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Structural reliability analysis and reliability-based design optimization: Recent advances显示文摘We review recent research activities on structural reliability analysis,reliability-based design optimization(RBDO) and applications in complex engineering structural design.Several novel uncertainty propagation methods and reliability models,which are the basis of the reliability assessment,are given.In addition,recent developments on reliability evaluation and sensitivity analysis are highlighted as well as implementation strategies for RBDO. | QIU ZhiPing HUANG Ren WANG XiaoJun QI WuChao | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 14 |
| 3 | Analysis on the hourly spatiotemporal complementarities between China's solar and wind energy resources spreading in a wide area显示文摘China is rich in solar and wind energy resources,of which the proportion of China's power sources has been rapidly increasing.Such fluctuating and intermittent energy sources will bring significant challenges to the safe and stable operation power system.However,making use of the spatiotemporal complementarities between different renewable energy resources is a feasible way to level fluctuating power especially when they have a widely geographical dispersion.Based on the data provided by China Meteorological Administration(CMA),this research explores the spatiotemporal complementarities between wind and solar energy resources.This paper nondimensionalizes hourly wind speed and global solar radiation data and employs several indexes to compare the smoothing effect with various combining scenarios.The results show that combining wind and solar powers within a certain area can cause a fall of zero-power or very-full power hours.Besides,combining different resources improves 'smoothness' in power output when compared with that from each individual resource.However,under hourly time scale,when the dispersion of sites is large enough,the smoothing effect of combining the dispersed wind power is very close to the combination of those two different resources.Nevertheless,this complementary effect is much better than that of just combining solar energy resources. | LIU Yi XIAO LiYe WANG HaiFeng DAI ShaoTao QI ZhiPing | 2013 | Chinese Science Bulletin2013，58，7： | 14 |
| 4 | A collocation interval analysis method for interval structural parameters and stochastic excitation显示文摘Uncertainty propagation, one of the structural engineering problems, is receiving increasing attention owing to the fact that most significant loads are random in nature and structural parameters are typically subject to variation. In the study, the collocation interval analysis method based on the first class Chebyshev polynomial approximation is presented to investigate the least favorable responses and the most favorable responses of interval-parameter structures under random excitations. Compared with the interval analysis method based on the first order Taylor expansion, in which only information including the function value and derivative at midpoint is used, the collocation interval analysis method is a non-gradient algorithm using several collocation points which improve the precision of results owing to better approximation of a response function. The pseudo excitation method is introduced to the solving procedure to transform the random problem into a deterministic problem. To validate the procedure, we present numerical results concerning a building under seismic ground motion and aerofoil under continuous atmosphere turbulence to show the effectiveness of the collocation interval analysis method. | QI WuChao QIU ZhiPing | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，1： | 11 |
| 5 | New approach to determine the priorities from interval fuzzy preference relations显示文摘An approach is proposed to solve the problem how to obtain the priorities from interval fuzzy preference relations. Firstly, another expression of interval numbers is given. Then, some basic definitions on consistency and weak transitivity of real and interval fuzzy preference relations are described. Based on these definitions, a two-phase process for determining the priorities from interval fuzzy preference relations is presented. Finally, two exam- ples are used to illustrate the use of the proposed approach. | Qi Yue Zhiping Fan Lihua Shi | 2011 | Journal of Systems Engineering and Electronics2011，22，2： | 6 |
| 6 | Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis显示文摘 | Guohong Han Xingshun Qi Chuangye He Zhanxin Yin Jianhong Wang Jielai Xia Zhiping Yang Ming Bai Xiangjie Meng Jing Niu Kaichun Wu Daiming Fan | 2010 | Journal of Hepatology2010，，： | 5 |
| 7 | Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design显示文摘Acute respiratory distress syndrome(ARDS)is characterized by the severe inflammation and destruction of the lung aireblood barrier,leading to irreversible and substantial respiratory function damage.Patients with coronavirus disease 2019(COVID-19)have been encountered with a high risk of ARDS,underscoring the urgency for exploiting effective therapy.However,proper medications for ARDS are still lacking due to poor pharmacokinetics,non-specific side effects,inability to surmount pulmonary barrier,and inadequate management of heterogeneity.The increased lung permeability in the pathological environment of ARDS may contribute to nanoparticle-mediated passive targeting delivery.Nanomedicine has demonstrated unique advantages in solving the dilemma of ARDS drug therapy,which can address the shortcomings and limitations of traditional anti-inflammatory or antioxidant drug treatment.Through passive,active,or physicochemical targeting,nanocarriers can interact with lung epithelium/endothelium and inflammatory cells to reverse abnormal changes and restore homeostasis of the pulmonary environment,thereby showing good therapeutic activity and reduced toxicity.This article reviews the latest applications of nanomedicine in pre-clinical ARDS therapy,highlights the strategies for targeted treatment of lung inflammation,presents the innovative drug delivery systems,and provides inspiration for strengthening the therapeutic effect of nanomedicine-based treatment. | Qi Qiao Xiong Liu Ting Yang Kexin Cui Li Kong Conglian Yang Zhiping Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 5 |
| 8 | Effects of Rice-Fish Co-culture on Oxygen Consumption in Intensive Aquaculture Pond显示文摘Rice-fish co-culture has gained increasing attention to remediate the negative environmental impacts induced by intensive aquaculture. However, the effect of rice-fish co-culture on oxygen depletion has rarely been investigated. We constructed a rice-fish co-culture system in yellow catfish(Pelteobagrus fulvidraco) and freshwater shrimp(Macrobrachium nipponense) ponds using a new high-stalk rice variety, and conducted a field experiment to investigate the effect of rice-fish co-culture on water parameters and oxygen consumption. The results showed that rice-fish co-culture reduced the nutrients(total nitrogen, ammonia-N, total phosphorous and potassium) and the dissolved oxygen content in fish and shrimp ponds. However, they showed similar seasonal change of dissolved oxygen in the water of fish and shrimp ponds. Rice-fish co-culture reduced the total amount of oxygen consumption and optimized the oxygen consumption structure in pond. The respiration rates in water and sediment were significantly reduced by 66.1% and 31.7% in the catfish pond, and 64.4% and 38.7% in the shrimp pond, respectively, by additional rice cultivation. Rice-fish co-culture decreased the proportions of respiration in sediment and water, and increased the proportion of fish respiration. These results suggest that rice-fish co-culture is an efficient way to reduce hypoxia in intensive culture pond. | LI Fengbo SUN Zhiping QI Hangying ZHOU Xiyue XU Chunchun WU Dianxin FANG Fuping FENG Jinfei ZHANG Ning | 2019 | Rice science2019，26，1： | 4 |
| 9 | Factors affecting directional migration of bone marrow mesenchymal stem cells to the injured spinal cord显示文摘Microtubule-associated protein 1B plays an important role in axon guidance and neuronal migration. In the present study, we sought to discover the mechanisms underlying microtubule-associated protein 1B mediation of axon guidance and neuronal migration. We exposed bone marrow mesenchymal stem cells to okadaic acid or N-acetyl-D-erythro-sphingosine(an inhibitor and stimulator, respectively, of protein phosphatase 2A) for 24 hours. The expression of the phosphorylated form of type I microtubule-associated protein 1B in the cells was greater after exposure to okadaic acid and lower after N-acetyl-D-erythro-sphingosine. We then injected the bone marrow mesenchymal stem cells through the ear vein into rabbit models of spinal cord contusion. The migration of bone marrow mesenchymal stem cells towards the injured spinal cord was poorer in cells exposed to okadaic acid- and N-acetyl-D-erythro-sphingosine than in non-treated bone marrow mesenchymal stem cells. Finally, we blocked phosphatidylinositol 3-kinase(PI3K) and extracellular signal-regulated kinase 1/2(ERK1/2) pathways in rabbit bone marrow mesenchymal stem cells using the inhibitors LY294002 and U0126, respectively. LY294002 resulted in an elevated expression of phosphorylated type I microtubule-associated protein 1B, whereas U0126 caused a reduction in expression. The present data indicate that PI3 K and ERK1/2 in bone marrow mesenchymal stem cells modulate the phosphorylation of microtubule-associated protein 1B via a cross-signaling network, and affect the migratory efficiency of bone marrow mesenchymal stem cells towards injured spinal cord. | Peng Xia Su Pan Jieping Cheng Maoguang Yang Zhiping Qi Tingting Hou Xiaoyu Yang | 2014 | Neural Regeneration Research2014，9，18： | 3 |
| 10 | Static response analysis of structures with interval parameters using the second-order Taylor series expansion and the DCA for QB显示文摘In this paper, based on the second-order Taylor series expansion and the difference of convex functions algorithm for quadratic problems with box constraints(the DCA for QB), a new method is proposed to solve the static response problem of structures with fairly large uncertainties in interval parameters. Although current methods are effective for solving the static response problem of structures with interval parameters with small uncertainties, these methods may fail to estimate the region of the static response of uncertain structures if the uncertainties in the parameters are fairly large. To resolve this problem, first, the general expression of the static response of structures in terms of structural parameters is derived based on the second-order Taylor series expansion. Then the problem of determining the bounds of the static response of uncertain structures is transformed into a series of quadratic problems with box constraints. These quadratic problems with box constraints can be solved using the DCA approach effectively. The numerical examples are given to illustrate the accuracy and the efficiency of the proposed method when comparing with other existing methods. | Qi Li Zhiping Qiu Xudong Zhang | 2015 | Acta Mechanica Sinica2015，31，6： | 2 |
| 11 | Transjugular intrahepatic portosystemic shunt in combination with or without variceal embolization for the prevention of variceal rebleeding: A meta‐analysis显示文摘 | Xingshun Qi Lei Liu Ming Bai Hui Chen Juan Wang Zhiping Yang Guohong Han Daiming Fan | 2014 | J Gastroenterol Hepatol2014，，4： | 2 |
| 12 | Occlusive portal vein thrombosis as a new marker of decompensated cirrhosis显示文摘 | Xingshun Qi Ming Bai Zhiping Yang Shanshan Yuan Cheng Zhang Guohong Han Daiming Fan | 2010 | Medical Hypotheses2010，，4： | 2 |
| 13 | Mineralogy of Chang’e-4 landing site:preliminary results of visible and near-infrared imaging spectrometer显示文摘The exploration of mafic anomaly in South Pole-Aitken(SPA,the largest confirmed)basin on the Moon provides important insights into lunar interior.The landing of Chang’e-4(CE-4)and deployment of Yutu-2 rover on the discontinuous ejecta from Finsen crater enabled in-situ measurements of the unusual mineralogy in the central portion of SPA basin with visible and near-infrared imaging spectrometer(VNIS).Here we present detailed processing procedures based on the level 2B data of CE-4 VNIS and preliminary mineralogical results at the exploration area of Yutu-2 rover.A systematic processing pipeline is developed to derive credible reflectance spectra,based on which several spectral and mineral indices are calculated to constrain the mafic mineralogy.The mafic components in the soils and boulder around CE-4 landing site are concluded as clinopyroxene-bearing with intermediate composition and probably dominated by pigeonite although the possibility of mixing orthopyroxen(OPX)and calcic clinopyroxene(CPX)also exists.These mineralogical results are more consistent with a petrogenesis that the CE-4 regolith and rock fragment are derived from rapid-cooling magmatic systems and we interpret that the materials at the CE-4 landing site ejected from Finsen crater are probably recrystallized from impact melt settings. | Jian CHEN Zongcheng LING Le QIAO Zhiping HE Rui XU Lingzhi SUN Jiang ZHANG Bo LI Xiaohui FU Changqing LIU Xiaobin QI | 2020 | Science China(Information Sciences)2020，63，4： | 2 |
| 14 | Trace Nb-doped Na_(0.7)Ni_(0.3)Co_(0.1)Mn_(0.6)O_(2) with suppressed voltage decay and enhanced low temperature performance显示文摘The P2-type manganese-based Na_(0.7)MnO_(2) cathode materials attract great interest due to their high theoretical capacity.However,these materials suffer from rapid capacity fading,poor rate performance and severe voltage decay resulting from phase transition and sluggish reaction kinetics.In this work we report a novel Nb-doped Na_(0.7)[Ni_(0.3)Co_(0.1)Mn_(0.6)]_(1-x)Nb_(x)O_(2) with significantly suppre ssed voltage decay and enhanced cycling stability.The strong Nb-O bond can efficiently stabilize the TMO fra mework,and the as prepared material demonstrates much lower discharge midpoint voltage decay(0.132 V) than that of pristine one(0.319 V) after 200 cycles.Consequently,a remarkably improved cycling perfo rmance with a capacity retention of 87.9% after 200 cycle at 0.5 C is achieved,showing a 2.4 fold improvement as compared to the control sample Na_(0.7)Ni_(0.3)Co_(0.1)Mn_(0.6)O_(2)(~37% rotation).Even at 2 C,a capacity retention of 68.4% is retained after 500 cycles.Remarkably,the as prepared material can be applied at low temperature of-20℃,showing a capacity retention of 81% as compared to that at room temperature. | Ruyun Yue Fang Xia Ruijuan Qi Da Tie Shanshan Shi Zhiping Li Yufeng Zhao Jiujun Zhang | 2021 | Chinese Chemical Letters2021，32，2： | 2 |
| 15 | Prevalence of Covert Duplicate Publications in Budd-Chiari Syndrome Articles in China: A Systematic Analysis显示文摘 | Xingshun Qi Weirong Ren Lei Liu Zhiping Yang Man Yang Daiming Fan Guohong Han | 2013 | The American Journal of Medicine2013，，7： | 2 |
| 16 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 17 | l ‐ornithine‐ l ‐aspartate for hepatic encephalopathy in patients with cirrhosis: A meta‐analysis of randomized controlled trials显示文摘 | Ming Bai Zhiping Yang Xingshun Qi Daiming Fan Guohong Han | 2013 | J Gastroenterol Hepatol2013，，5： | 1 |
| 18 | An approach to group decision-making with uncertain preference ordi nals显示文摘 | Fan Zhiping Yue Qi Feng Bo | 2010 | Computers Industrial Engineering2010，58，1： | 1 |
| 19 | Enhanced tolerance to drought stress in transgenic tobacco plants overexpressing VTE1 for increased tocopherol production from Arabidopsis thaliana显示文摘 | Xiaoli Liu Xuejun Hua Juan Guo Dongmei Qi Lijuan Wang Zhipeng Liu Zhiping Jin Shuangyan Chen Gongshe Liu | 2008 | Biotechnology Letters2008，，7： | 1 |
| 20 | An approach to group decision-nmking with uncertain preference ordinals显示文摘 | Fan ZhiPing Yue Qi Feng Bo Liu Yang | 2010 | Computers & Industrial Engineering2010，58，1： | 1 |
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