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| 1 | MAPK signaling in inflammation-associated cancer development显示文摘Mitogen-activated protein(MAP)kinases comprise a family of protein-serine/threonine kinases,which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms,including mammals.These kinases,including ERKs,JNKs and p38s,are regulated by a phosphorelay cascade,with a prototype of three protein kinases that sequentially phosphorylate one another.MAPKs transduce extracellular signals into a variety of cellular processes,such as cell proliferation,survival,death,and differentiation.Consistent with their essential cellular functions,MAPKs have been shown to play critical roles in embryonic development,adult tissue homeostasis and various pathologies.In this review,we discuss recent findings that reveal the profound impact of these pathways on chronic inflammation and,particularly,inflammation-associated cancer development. | Pengyu Huang Jiahuai Han Lijian Hui | 2010 | Protein & Cell2010，1，3： | 25 |
| 2 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 3 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 4 | Progress in human liver organoids显示文摘Understanding the development,regeneration,and disorders of the liver is the major goal in liver biology.Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines,which fall short in recapitulating the features of human liver cells or the structures and functions of human livers.Organoids as an in vitro system hold the promise to generate organ-like tissues in a dish.Recent advances in human liver organoids also facilitate the understanding of the biology and diseases in this complex organ.Here we review the progress in human liver organoids,mainly focusing on the methods to generate liver organoids,their applications,and possible future directions. | Lulu Sun Lijian Hui | 2020 | Journal of Molecular Cell Biology2020，12，8： | 4 |
| 5 | miR-27b synergizes with anticancer drugs via p53 activation and CYPIB1 suppression显示文摘 | Wenjing Mu Chaobo Hu Haibin Zhang Zengqiang Qu Jin Cen Zhixin Qiu Chao Li Haozhen Ren Yixue Li Xianghuo He Xiaolei Shi Lijian Hui | 2015 | Cell Research2015，25，4： | 3 |
| 6 | Microstructure and Mechanical Properties of a CuCrZr Welding Joint After Continuous Extrusion显示文摘The effect of continuous extrusion forming(CEF) process on the microstructure and mechanical properties of a CuCrZr welding joint was investigated. The experimental results showed that after the CEF process the grains were refined to submicron-scale through dynamic recrystallization,which improved the mechanical properties of the welding joint as well as the base material. Meanwhile,the micron-scale precipitates aggregated at the grain boundaries in the welding process were broken down to smaller ones and recrystallized grains of several micrometers formed around the precipitates after CEF process,which could alleviate the negative effect induced by the micron-scale precipitates during plastic deforming process. Finer grains and smaller micronscale precipitates made contributions to improve the properties of a CuCrZr alloy with a welding joint. | Hui Feng Haichang Jiang Desheng Yan Lijian Rong | 2015 | Journal of Materials Science & Technology2015，31，2： | 3 |
| 7 | mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines显示文摘Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte(CTL) responses, Toll-like receptor(TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover the mechanisms underlying TLR-induced IL-12 expression and the Th1 response. By systemic screening, we identified a number of protein kinases involved in the regulation of TLRinduced IL-12 expression. In particular, PI3 K, ERK, and m TOR play critical roles in the TLR-induced Th1 response by regulating IL-12 and IL-10 production in innate immune cells. Moreover, we identified c-fos as a key molecule that mediates m TOR-regulated IL-12 and IL-10 expression in TLR signaling. Mechanistically, m TOR plays a crucial role in c-fos expression, thereby modulating NFκB binding to promoters of IL-12 and IL-10. By controlling the expression of a special innate gene program, m TOR can specifically regulate the TLR-induced T cell response in vivo. Furthermore, blockade of m TOR by rapamycin efficiently boosted TLR-induced antigen-specific T and B cell responses to HBV and HCV vaccines. Taken together, these results reveal a novel mechanism through which m TOR regulates TLR-induced IL-12 and IL-10 production, contributing new insights for strategies to improve vaccine efficacy. | Li He Aiping Zang Min Du Dapeng Ma Chuanping Yuan Chun Zhou Jing Mu Huanjing Shi Dapeng Li Xulin Huang Qiang Deng Jianhua Xiao Huimin Yan Lijian Hui Ke Lan Sidong Xiong Xiaoxia Li Zhong Huang Hui Xiao | 2015 | Virologica Sinica2015，30，3： | 2 |
| 8 | p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis显示文摘成红血球细胞的 Enucleation 对哺乳动物在终端区别期间唯一。尽管 erythroid enucleation 广泛地被学习了,包括 retinoblastoma 蛋白质(Rb ) ,仅仅一些基因被识别了调整原子挤出。它由哪个仍然保持大部分未定义发信号的分子,外来的刺激例如 erythropoietin (Epo ) ,是 transduced 导致 enucleation。这里,我们显示出那 p38α,激活 mitogen 的蛋白质 kinase (MAPK ) ,为 erythroid enucleation 被要求。在包含高 Epo 层次并且模仿的一个前 vivo 区别系统强调红血球生成, p38α在 erythroid 区别期间被激活。p38α 的损失;完全堵住主要成红血球细胞的 enucleation。而且, p38α在胎儿、贫血的压力红血球生成期间在 vivo 以一种房间自治的方式调整成红血球细胞 enucleation。显著地, p38α 的损失;导致 p21 目标 Rb 的 p21,和减少的激活的 downregulation,哪个是成红血球细胞 enucleation 的重要管理者。这研究表明那 p38α在压力红血球生成期间是为成红血球细胞 enucleation 的一个关键发信号分子。 | Simon M Schultze Andreas Mairhofer Dan Li Jin Cen Hartmut Beug Erwin F Wagner Lijian Hui | 2012 | Cell Research2012，22，3： | 2 |
| 9 | Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening显示文摘由系特定的抄写因素的表示的系变换是改变那的 epigenetic 的进程有低效率。一个房间由抵抗系变换的机制大部分是未知的。使用肝特定的抄写因素 Foxa3, Hnf1 和 Gata4 (3TF ) 在老鼠成纤维细胞导致肝的变换,我们证明 3TF 导致了 ATM-p53 小径的强壮的激活,它导致了增长拘捕和房间死亡,和它进一步阻止了肝的变换。尤其是, ATM 激活,独立于 DNA 损坏,对染色质在肝的变换期间开作出回应。由在肝的变换期间描绘早分子的事件,我们发现了那 Baf60b,改变建筑群的 SWI/SNF 染色质的一个成员,连接染色质洞到由便于 ATM 招募到肝的基因 loci 的一块面板的开的染色质区域的 ATM 激活。这些调查结果由在察觉到揭示 ATM-p53 小径的功能使细胞的回答清楚些到系变换染色质洞。 | Shuyi Ji Linying Zhu Yimeng Gao Xiaoran Zhang Yupeng Yan Jin Cen Rongxia Li Rong Zeng Lujian Liao Chunhui Hou Yawei Gao Shaorong Gao Gang Wei Lijian Hui | 2017 | Cell Research2017，27，5： | 2 |
| 10 | Quantitative evaluation of heavy metals’ pollution hazards in liquefaction residues of sewage sludge显示文摘 | Huajun Huang Xingzhong Yuan Guangming Zeng Huina Zhu Hui Li Zhifeng Liu Hongwei Jiang Lijian Leng Wenkai Bi | 2011 | Bioresource Technology2011，，22： | 2 |
| 11 | Reduced dietary nitrogen with a high Lys:CP ratio restricted dietary N excretion without negatively affecting weaned piglets显示文摘We hypothesized that balancing the content of exogenous amino acids, especially lysine, to reduce protein content in swine diets could reduce nitrogen(N) pollution associated with animal husbandry. Two experiments(45 d each experiment) were performed on weaned piglets(Duroc x Landrace x Yorkshire,28 d of age) to test this and to determine the optimal lysine to crude protein(Lys:CP) ratio in diet. In Exp. 1,12 piglets(6 replicates [n = 6]) were fed diets containing different levels of CP(17% and 20%) but the same level of Lys, Increased CP content resulted in significant increases(P < 0.05) of average daily gain(ADG), average daily feed intake(ADFI), and body weight(BW);but did not affect the feed to gain ratio. In Exp. 2,24 piglets(8 replicates [n = 8]) were fed 1 of 3 diets as follows: 1) 20% CP with a regular Lys:CP ratio(6.23%, control);2) 17% CP with a reduced Lys:CP ratio(6.14%, LL);or 3) 17% CP with a standard Lys:CP ratio(7.32%, SL). The ADG, final BW, serum concentrations of growth hormone and insulin-like growth factor-1, villus height in the jejunum, and villus height to crypt depth ratio were the lowest in piglets fed LL diet, whereas blood urea N concentration was the lowest and the value of lipase activity was the highest in the piglets fed SL diet. The SL diet did not affect growth performance,intestinal morphology, or serum hormone concentrations, indicating that reduced dietary N with a high Lys:CP ratio can efficiently reduce dietary N excretion without negatively affecting weaned piglets. | Hongnan Liu Li Wu Hui Han Yuying Li Lijian Wang Jie Yin Wenjun Fan Miaomiao Bai Jiming Yao Xingguo Huang Tiejun Li | 2019 | Animal Nutrition2019，，2： | 2 |
| 12 | The dominant hepatitis B virus genotype identified in Tibet is a C/D hybrid显示文摘 | Chaoyin Cui Jinxiu Shi Lijian Hui Huifeng Xi Zhuoma Quni Tsedan and Gengxi Hu | 2002 | J Gen Virol2002，83，： | 1 |
| 13 | Effect of continuous extrusion on the microstructure and mechanical properties of a CuCrZr alloy显示文摘 | Hui Feng Haichang Jiang Desheng Yan Lijian Rong | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 14 | Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation显示文摘 | Xiao Yun Qiao Guilin Tang Juan Tang Rong Guo Hui Warwar Samantha Langdon Wallace Y. Tao Lijian Zhang Jian | 2015 | The Journal of Immunology2015，，9： | 1 |
| 15 | Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin显示文摘 | Shi Jinxiu Hui Lijian Xu Yonghai | 2002 | Human Mutation2002，19，4： | 1 |
| 16 | Rhamnolipid based glycerol-in-diesel microemulsion fuel: Formation and characterization显示文摘 | Lijian Leng Xingzhong Yuan Guangming Zeng Xiaohong Chen Hou Wang Hui Li Lihuan Fu Zhihua Xiao Longbo Jiang Cui Lai | 2015 | Fuel2015，，： | 1 |
| 17 | Establishing a cancer cell in the inflammatory tissue: an epigenetic circuit显示文摘 | Wenjing Mu Lijian Hui | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 0 |
| 18 | Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation显示文摘Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation(AST).However,it remains largely unknown how Lkb1 deficiency dynamically regulates AST.Using the classical AST mouse model(Kras LSL-G12D/+;Lkb1flox/flox,KL),we here comprehensively analyze the temporal transcriptomic dynamics of lung tumors at different stages by dynamic network biomarker(DNB)and identify the tipping point at which the Wnt signaling is abruptly suppressed by the excessive accumulation of reactive oxygen species(ROS)through its downstream effector FOXO3A.Bidirectional genetic perturbation of the Wnt pathway using two different Ctnnb1 conditional knockout mouse strains confirms its essential role in the negative regulation of AST.Importantly,pharmacological activation of the Wnt pathway before but not after the tipping point inhibits squamous transdifferentiation,highlighting the irreversibility of AST after crossing the tipping point.Through comparative transcriptomic analyses of mouse and human tumors,we find that the lineage-specific transcription factors(TFs)of adenocarcinoma and squamous cell carcinoma form a“Yin-Yang”counteracting network.Interestingly,inactivation of the Wnt pathway preferentially suppresses the adenomatous lineage TF network and thus disrupts the“Yin-Yang”homeostasis to lean towards the squamous lineage,whereas ectopic expression of NKX2-1,an adenomatous lineage TF,significantly dampens such phenotypic transition accelerated by the Wnt pathway inactivation.The negative correlation between the Wnt pathway and AST is further observed in a large cohort of human lung adenosquamous carcinoma.Collectively,our study identifies the tipping point of AST and highlights an essential role of the ROS-Wnt axis in dynamically orchestrating the homeostasis between adeno-and squamous-specific TF networks at the AST tipping point. | Zhaoyuan Fang Xiangkun Han Yueqing Chen Xinyuan Tong Yun Xue Shun Yao Shijie Tang Yunjian Pan Yihua Sun Xue Wang Yujuan Jin Haiquan Chen Liang Hu Lijian Hui Lin Li Luonan Chen Hongbin Ji | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 19 | A multi-module with a two-way feedback method for Ulva drift-diffusion显示文摘The outbreak of Ulva in the Yellow Sea has seriously affected marine ecology and economic activities.Therefore,effective prediction of the distribution of Ulva is of great significance for disaster prevention and reduction.However,the prediction method of Ulva is mainly based on numerical simulation.There are two problems with these methods.First is that the initial distribution of Ulva is simulated using independent pixel-level particles.Besides,the influence of Ulva growth and diffusion on the drift is not considered.Therefore,this paper proposes a multi-module with a two-way feedback method(MTF)to solve the above problems.The main contributions of our approach are summarized as follows.First,the initialization module,the generation and elimination module,and the drive module are composed in our way.Second,we proposed an initialization method using rectangle objects to simulate the Ulva distribution extracted from remote sensing images.Thirdly,the drift and diffusion mechanism of the Ulva is considered to realize the two-way feedback between the generation and elimination module and the drive module.The results of our experiments show that the MTF performs better than the traditional method in predicting the drift and diffusion of Ulva.The code is already publicly available at http://gffzz188fe103f8f1460as6ncv5fq5x9pk6kkn.ffgz.tsg.suse.edu.cn/UPCGIT/A-multi-module-with-a-two-way-feedback-method-for-Ulva-drift-diffusion. | Hui Sheng Jianmeng Li Qimao Wang Bin Zou Lijian Shi Mingming Xu Shanwei Liu Jianhua Wan Zhe Zeng Yanlong Chen | 2023 | Acta Oceanologica Sinica2023，42，12： | 0 |
| 20 | Selective preparation for biofuels and high value chemicals based on biochar catalysts显示文摘The reuse of biomass wastes is crucial toward today’s energy and environmental crisis,among which,biomass-based biochar as catalysts for biofuel and high value chemical production is one of the most clean and economical solutions.In this paper,the recent advances in biofuels and high chemicals for selective production based on biochar catalysts from different biomass wastes are critically summarized.The topics mainly include the modification of biochar catalysts,the preparation of energy products,and the mechanisms of other high-value products.Suitable biochar catalysts can enhance the yield of biofuels and higher-value chemicals.Especially,the feedstock and reaction conditions of biochar catalyst,which affect the efficiency of energy products,have been the focus of recent attentions.Mechanism studies based on biochar catalysts will be helpful to the controlled products.Therefore,the design and advancement of the biochar catalyst based on mechanism research will be beneficial to increase biofuels and the conversion efficiency of chemicals into biomass.The advanced design of biochar catalysts and optimization of operational conditions based on the biomass properties are vital for the selective production of high-value chemicals and biofuels.This paper identifies the latest preparation for energy products and other high-value chemicals based on biochar catalysts progresses and offers insights into improving the yield of high selectivity for products as well as the high recyclability and low toxicity to the environment in future applications. | Hui LI Changlan HOU Yunbo ZHAI Mengjiao TAN Zhongliang HUANG Zhiwei WANG Lijian LENG Peng LIU Tingzhou LEI Changzhu LI | 2023 | Frontiers in Energy2023，17，5： | 0 |
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