|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 2 | High-entropy ceramics:Present status,challenges,and a look forward显示文摘High-entropy ceramics (HECs) are solid solutions of inorganic compounds with one or more Wyckoff sites shared by equal or near-equal atomic ratios of multi-principal elements.Although in the infant stage,the emerging of this new family of materials has brought new opportunities for material design and property tailoring.Distinct from metals,the diversity in crystal structure and electronic structure of ceramics provides huge space for properties tuning through band structure engineering and phonon engineering.Aside from strengthening,hardening,and low thermal conductivity that have already been found in high-entropy alloys,new properties like colossal dielectric constant,super ionic conductivity,severe anisotropic thermal expansion coefficient,strong electromagnetic wave absorption,etc.,have been discovered in HECs.As a response to the rapid development in this nascent field,this article gives a comprehensive review on the structure features,theoretical methods for stability and property prediction,processing routes,novel properties,and prospective applications of HECs.The challenges on processing,characterization,and property predictions are also emphasized.Finally,future directions for new material exploration,novel processing,fundamental understanding,in-depth characterization,and database assessments are given. | Huimin XIANG Yan XING Fu-zhi DAI Hongjie WANG Lei SU Lei MIAO Guojun ZHANG Yiguang WANG Xiwei QI Lei YAO Hailong WANG Biao ZHAO Jianqiang LI Yanchun ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 28 |
| 3 | Physical Location of the Rice Pi-5(t), Glh and RTSV Genes by ISH of BAC Clones显示文摘Mapplng of low of slngle-copy sequences on plant chromosomes has proven dirricult because ofvery low frequency or slgnal detectlon. Rlce BAC Ilbrary ls belng used wldely ln rlce genome research due tolts distlnctlve advantages over other llbrary systems. In tkls study, two blotln-Iabeled rice BAC clones closelylinked to a rlce blast reslstance, green Ieaf hopper reslstance and tungro spherlcal virus resistance gene,Pi-5(t),Glh, RTSV, were in situ hybrldlred to rlce ckromosomes. They were located on the long arm andshort arm of ckromosome 4 with FL value of 40% and 100% respectively-The rrequency of signal detectionreacked 46. 8% and 59- 2%- The slgnal location were conslstent wltk the selectlve marker on rice saturatedm0Iecular map. The results demonstrated the advautages to Iocate BAC cIones to ckromosomes by in sho hybrldization and will racilitate tke rlce low of slngle-copy gene Iocation by using the BAC library. | Yan Huimin, Song Yunchun, Li Lijia, Bi Xuezhi, Fu Binying(College of Life Sciences, Wuhan University, Wuhan 430072, China) | 1998 | Wuhan University Journal of Natural Sciences1998，3，2： | 24 |
| 4 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 5 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 6 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 7 | Effects of Chinese herbs in children with Henoch-Schonlein purpura nephritis:a randomized controlled trial显示文摘OBJECTIVE:To research the curative effect of Chinese herbs for clearing away heat,promoting diuresis,nourishing the kidney,and consolidating essence in children with Henoch-Schonlein purpura nephritis(HSPN)with internal accumulation of damp-toxin using randomized controlled observations on large samples.To seek the mechanism of the therapy and its scope of indications.METHODS:Overall,186 children with HSPN were randomly divided into two groups:treatment group(n=126)treated with Chinese herbs for clearing heat and promoting diuresis and a control group(n=60)treated with Western Medicine.The treatment was carried out for three courses of 4weeks each.We recorded changes in patient urine routines,24 h urinary protein,blood-coagulating series,immunoglobulin and T-cell subgroups,and improvements in main symptoms.We evaluated the alleviation of clinical symptoms and the improvement of proteinuria,hematuria,and other lab-oratory test results.Finally,we analyzed the patient population suitable for this therapy according to the relationship between the grouping of patient body weight and curative effect.RESULTS:Damp-heat syndrome improved in the treatment group,with a significant difference in total effective rate after a 4-week treatment(χ2=13.5220,P=0.0002)and in curative rate after a12-week treatment(χ2=6.3410,P=0.0118),compared to those in the control group.The curative effect in the treatment group was greater than that in the control group but there was no statistical difference between the two groups.The curative effect after a 4-week treatment of patients in the treatment group weighing 30 kg or less based on Traditional Chinese Medicine(TCM)signs and urinary protein was significantly greater than that in the control group.However,there was no statistical difference in the curative effect on urinary red cells and various indexes after a 12-week treatment between the two groups.CONCLUSION:Therapy for clearing away heat,promoting diuresis,nourishing the kidney,and consolidating essence using TCM is effective in children with HSPN from internal accumulation of damp-toxin.The therapy is especially suitable for patients weighing 30 kg or less.The curative effect may be related to the improvement of immune function and blood-coagulation. | Dandan Ding Huimin Yan Xiaofang Zhen | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 12 |
| 8 | Multiple Cropping Intensity in China Derived from Agro-meteorological Observations and MODIS Data显示文摘Double-and triple-cropping in a year have played a very important role in meeting the rising need for food in China.However,the intensified agricultural practices have significantly altered biogeochemical cycles and soil quality.Understanding and mapping cropping intensity in China′s agricultural systems are therefore necessary to better estimate carbon,nitrogen and water fluxes within agro-ecosystems on the national scale.In this study,we investigated the spatial pattern of crop calendar and multiple cropping rotations in China using phenological records from 394 agro-meteorological stations(AMSs)across China.The results from the analysis of in situ field observations were used to develop a new algorithm that identifies the spatial distribution of multiple cropping in China from moderate resolution imaging spectroradiometer(MODIS)time series data with a 500 m spatial resolution and an 8-day temporal resolution.According to the MODIS-derived multiple cropping distribution in 2002,the proportion of cropland cultivated with multiple crops reached 34%in China.Double-cropping accounted for approximately 94.6%and triple-cropping for 5.4%.The results demonstrat that MODIS EVI(Enhanced Vegetation Index)time series data have the capability and potential to delineate the dynamics of double-and triple-cropping practices.The resultant multiple cropping map could be used to evaluate the impacts of agricultural intensification on biogeochemical cycles. | YAN Huimin XIAO Xiangming HUANG Heqing LIU Jiyuan CHEN Jingqing BAI Xuehong | 2014 | Chinese Geographical Science2014，24，2： | 11 |
| 9 | Preparation and properties of CMAS resistant bixbyite structured high-entropy oxides RE_(2)O_(3)(RE=Sm,Eu,Er,Lu,Y,and Yb):Promising environmental barrier coating materials for Al_(2)O_(3)f/Al_(2)O_(3) composites显示文摘Y_(2)O_(3) is regarded as one of the potential environmental barrier coating(EBC)materials for Al_(2)O_(3)f/Al_(2)O_(3)ceramic matrix composites owing to its high melting point and close thermal expansion coefficient to Al_(2)O_(3).However,the relatively high thermal conductivity and unsatisfactory calcium-magnesium-aluminosilicate(CMAS)resistance are the main obstacles for the practical application of Y_(2)O_(3).In order to reduce the thermal conductivity and increase the CMAS resistance,four cubic bixbyite structured high-entropy oxides RE_(2)O_(3),including(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3),(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3),(Sm_(0.2)Eu_(0.2)Er_(0.2)Y_(0.2)Yb_(0.2))2O_(3),and(Sm_(0.2)Eu_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)were designed and synthesized,among which(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)bulks were prepared by spark plasma sintering(SPS)to investigate their mechanical and thermal properties as well as CMAS resistance.The mechanical properties of(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3) are close to those of Y_(2)O_(3) but become more brittle than Y_(2)O_(3).The thermal conductivities of(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3) and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb02)2O_(3)(5.1 and 4.6 W·m^(-1)·K^(-1))are only 23.8%and 21.5%respectively of that of Y_(2)O_(3)(21.4 W·m^(-1)·K^(-1)),while their thermal expansion coefficients are close to those of Y_(2)O_(3) and A12O_(3).Most importantly,HE RE_(2)O_(3) ceramics exhibit good CMAS resistance.After being attacked by CMAS at 1350℃for 4 h,the HE RE_(2)O_(3) ceramics maintain their original morphologies without forming pores or cracks,making them promising as EBC materials for Al_(2)O_(3)f/Al_(2)O_(3) composites. | Yanan SUN Huimin XIANG Fu-Zhi DAI Xiaohui WANG Yan XING Xiaojun ZHAO Yanchun ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 10 |
| 10 | Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice显示文摘Flagellin 是涉及天生、适应的免疫的大量房间类型的有势力使活跃之物。因此,它是疫苗的一个好辅助候选人,并且它可能在癌症放射疗法和放射紧急情况的一个缓和者期间对主要尖锐放射症候群作为生物杀虫撒布剂工作。然而,积累证据含有在一些煽动性的疾病的出现的 flagellin 例如尖锐的肺发炎,心血管的倒塌和煽动性的肠疾病。这研究的目的是阐明 flagellin-TLR5 发信号激活是否仅仅或是否在肝的 pathophysiology 起一个作用某另外的 flagellin 活动也经由细菌的感染或在临床的应用期间贡献肝损害。Recombinant flagellin 蛋白质与或没有刺激 TLR5 活动被用来评估 flagellin-TLR5 在肝损害发信号在的角色野类型并且 TLR5 击倒老鼠。粗野损害和 hepatocellular 坏死的大区域在 100 或 200 µ 的 intraperitoneal 管理以后在肝织物 12 h 被观察;在一个剂量依赖者的 g flagellin (警察) 和在野类型的老鼠,然而并非在 TLR5 击倒老鼠的时间依赖者举止。flagellin 的 N 终端或 TLR5 绑定域的删除禁止了导致 flagellin 的煽动性的回答和随后的尖锐的肝函数反常和损坏。这些数据证实 flagellin 是肝损害的一个必要决定因素并且证明由高剂量的 flagellin 发信号的 TLR5 的在激活上在肝引起了尖锐煽动性的回答,嗜中性的累积和氧化应力,它贡献导致 flagellin 的肝损害的前进和严厉。 | Yang Xiao Fang Liu Jingyi Yang Maohua Zhong Ejuan Zhang Yaoming Li Dihan Zhou Yuan Cao Wei Li Jie Yu Yi Yang Huimin Yan | 2015 | Cellular & Molecular Immunology2015，12，6： | 9 |
| 11 | Efficacy of capecitabine-based combination therapy and singleagent capecitabine maintenance therapy in patients with metastatic breast cancer显示文摘Objective: The purpose of this study was to observe the efficacy and toxicities of capecitabine-based chemotherapy and capecitabine monotherapy as maintenance therapy in the treatment of metastatic breast cancer(MBC).Patients and methods: A total of 98 MBC patients were treated with capecitabine combined with vinorelbine(NX). Results: The median number of treatment was 6 cycles(1-7 cycles). There were two cases of complete remission(CR), 58 partial remission, 27 stable disease(SD), 11 progression disease. The overall response rate(ORR)(CR + PR) was 61.2%. The clinical benefit rate(CBR) was 75.5%. Fifty of effective patients received with capecitabine monotherapy as maintenance therapy. The ORR(CR + PR) was 4%. The CBR was 48%. The median progression-free survival(PFS) was 12 months. In maintenance therapy or not, the median post metastasis survival rate(MSR) was 63 and 28 months, respectively. In the combination therapy group, the major grade 3/4 toxicities included hand-foot syndrome(3.1%), skin pigmentation(2.0%), diarrhoea and abdominal distension(5.1%), stomatitis(1.0%), and leukopenia(20.4%).Conclusions: Capecitabine-based combination therapy and single-agent capecitabine maintenance therapy were well tolerated and effective to MBC. | Huimin Lv Min Yan Mengwei Zhang Limin Niu Huiai Zeng Shude Cui | 2014 | Chinese Journal of Cancer Research2014，26，6： | 8 |
| 12 | Impacts of ecological restoration projects on agricultural productivity in China显示文摘在农田数量和质量的变化由于陆地使用是国家食物安全的批评担心,特别地为中国。尽管有重要生态的效果,生态的恢复节目(ERP ) ,从 1999 开始了,显然改变了瓷器农田和农业生产率的空间模式。从 2000 ~ 2008 把动态数据基于农田首先与主要生产率建模的 30-m 分辨率和基于卫星的网源于卫星图象,我们在 ERP 引起的农业生产率上识别了影响,包括为格林的谷物,节目(GFGP ) 和到湖(RCTL ) 的回收农田编程序。我们的结果显示农业生产率与 132.67lis 的率输了。在 R 的射击的 Pb 的累积。pseudoacacia 比另外的种类显著地高。在学习区域的土壤的 Pb 的数量是 s 吗?? | QIN Yuanwei YAN Huimin LIU Jiyuan DONG Jinwei CHEN Jingqing XIAO Xiangming | 2013 | Journal of Geographical Sciences2013，23，3： | 8 |
| 13 | Clinical practices s of Traditional Chinese Medicine for acute upper respiratory tract infection in children显示文摘OBJECTIVE:To develop Clinical practice s of Traditional Chinese Medicine(TCM) for acute upper respiratory tract infection(AURI) in children;TCM is usedalone or administered together with antibiotics.METHODS:Under the guidance of evidence-based medicine concept,in strict accordance with the rules of international s development,as well as on the basis of evidence of clinical research of TCM,the s solicited opinions from clinical experts and methodologists in TCM and Western Medicine.GRADE standard was applied to form experts' consensus.RESULTS:The s standardized classification of TCM patterns and TCM treatments in children with AURI,including prescription,Chinese patent medicine,non-drug treatment and prevention.CONCLUSION:Follows the principle of 'evidence based,consensus supplemented,and experience referred',these s were formulated,but the quality of evidence of included studies were relatively low.Further refinement of the s should be needed as deeper clinical studies as available in future. | Rong Ping Li Li Zhang Xilian Liu Quanhui Yan Huimin Xin Deli Xue Zheng Ren Xianqing Wu Zhenqi Ma Rong Zhang Junhua | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 7 |
| 14 | Distribution and accumulation of biogenic silica in the intertidal sediments of the Yangtze Estuary显示文摘沉积源於生物的硅石被知道是一个重要参数在河口和沿海的生态系统理解 biogeochemical 进程和 paleoenviromental 记录。因而,在沉积调查源於生物的硅石的累积和分发意义大。二拍子的圆舞温和酸温和的碱的抽取过程被用来沥滤源於生物的硅石和它的早 diagenetic 产品在内部 Yangtze 河口的潮汐的沉积。结果显示出那全部的源於生物的硅石( t-BSi )在内部潮汐的沉积从 237.7-419.4 亩摩尔 Si/g 变化了,当时可滤取的硅石( Si-HCl )和温和碱的可滤取的硅石( Si-Alk )在 25.1-72.9 亩摩尔 Si/g 和 208.1-350.4 亩 rnol Si/g 的范围的温和的酸, respectively.Significant 关联为沉积和不同源於生物的硅石水池的粒度分布被观察在内部潮汐的沉积。这证实粒度分发能显著地在沉积影响源於生物的硅石内容。有器官的碳和氮的源於生物的硅石的关系也是的结束发现在源於生物的硅石和有机物 biogeochemical 之间有强壮的联合在,反映那内部 Yangtze 河口的潮汐的系统。另外,在沉积的源於生物的硅石的早 diagenetic 变化在现在的学习被讨论。 | HOU Lijun LIU Min XU Shiyuana YAN Huimin OU Dongni CHENG Shubo LIN Xiao | 2008 | Journal of Environmental Sciences2008，20，5： | 7 |
| 15 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 16 | Effect of cold rolling process on microstructure and mechanical properties of high strength β titanium alloy thin sheets显示文摘The microstructure and mechanical properties of Ti-3.5Al-5Mo-6V-3Cr-2Sn-0.5Fe high strength titanium alloy sheets prepared by unidirectional cold rolling and two-step cross cold rolling were investigated. Results showed that the β phase grains were refined significantly by cold rolling followed by solution treatment for a short time.Compared to unidirectional cold rolling, the short time solution treatment after two-step cross rolling could significantly reduce the non-uniformity of the microstructure of the alloy sheets. After aging treatment at 550 ℃,the anisotropy of the mechanical properties still existed in the unidirectional rolled sheets, and the tensile strength was highest along the rolling direction. After solution and aging treatment, the anisotropy of the mechanical properties of the two-step cross rolling process sheet was not obvious than unidirectional cold rolling,and alloy had good strength and plasticity matching. | Yan Ma Zhaoxin Du Xiaoming Cui Jun Cheng Guolong Liu Tianhao Gong Huimin Liu Xiaopeng Wang Yuyong Chen | 2018 | Progress in Natural Science:Materials International2018，28，6： | 6 |
| 17 | In vitro differentiation of human adipose-derived mesenchymal stem cells into endothelial-like cells显示文摘The neovascularization of ischemic tis- sue is a crucial initial step for the functional rehabili- tation and wound healing. However, the short of seed cell candidate for the foundation of vascular network is still a big issue. Human adipose tissue derived mesenchymal stem cells (hADSCs), which possess multilineage potential, are capable of adipogenic, osteogenic, and chondrogenic differentiation. We examined whether this kind of stem cells could dif- ferentiate into endothelial-like cells and participate in blood vessel formation, and whether they could be used as an ideal cell source for therapeutic angio- genesis in ischemic diseases or vascularization of tissue constructs. The results showed that hADSCs, grown under appropriately induced conditions, dis- played characteristics similar to those of vessel en- dothelium. The differentiated cells expressed endo- thelial cell markers CD34 and vWF, and had high metabolism of acetylated low-density lipoprotein and prostacyclin. In addition, the induced cells were able to form tube-like structures when cultured on matrigel. Our data indicated that induced hADSCs could ex- hibit characteristics of endothelial cells. Therefore, these cells, as a source of human endothelial cells, may find many applications in such realms as engi- neering blood vessels, endothelial cell transplantation for myocardial regeneration, and induction of angio- genesis for treatment of regional ischemia. | GUAN Lidong LI Shaoqing WANG Yunfang YUE Huimin LIU Daqing HE Lijuan BAI Cixian YAN Fang NAN Xue SHI Shuangshuang PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，15： | 6 |
| 18 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 19 | Effect of heat treatment of titanium substrates on the properties of IrO_2-Ta_2O_5 coated anodes显示文摘The Ti substrates of IrO 2 -Ta 2 O 5 coated anodes were treated by solid-solution and aging, stress relieving annealing, and recrystallization annealing, and the coatings were prepared by thermal decomposition of a mixture of H 2 IrCl 6·6H 2 O dissolved in hydrochloric acid and TaCl 5 dissolved in alcohol. Scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and accelerated life test (ALT) were employed to study the microstructure and electrochemical properties of the anodes. Compared with the anode without heat treatment, the anodes with heat treatment are of higher electrochemical activity and longer accelerated life; especially, the anode with recrystallization annealing treatment has the best electrochemical properties and the longest accelerated life. | YAN Zhenwei MENG Huimin | 2011 | Rare Metals2011，30，5： | 5 |
| 20 | NLRC4 downregulates 的激活对 flagellin 的调停 TLR5 的抗体免疫者回答显示文摘细菌的 flagellin 是一个唯一的联系病原体的分子的模式(PAMP ) ,它能被表面认出局部性的像使用费的受体 5 (TLR5 ) 并且 cytosolic 像点头的受体(NLR ) 蛋白质 4 (NLRC4 ) 受体。由 flagellin 和产生有免疫力的回答戏表明小径的 TLR5 或 NLRC4 的激活在抗菌剂免疫的重要角色。然而,它仍然保持不清楚怎么 flagellin 的双活动激活 TLR5 或 NLRC4 发信号小径安排有免疫力的回答。在这研究,我们估计了缺乏能力对 flagellin 在适应有免疫力的回答上独自或在联合激活 TLR5 和 NLRC4 的 flagellin 和它的异种的效果。是不能的激活 NLRC4 的 Flagellin 比的导致了显著地更高的抗体回答野类型的 flagellin。当巨噬细胞在 vivo 被弄空时,增加的抗体反应能被消除。由 flagellin downregulated 的 NLRC4 的激活对 flagellin 的导致 flagellin 、调停 TLR5 的有免疫力的回答。 | Wei Li Jingyi Yang Ejuan Zhang Maohua Zhong Yang Xiao Jie Yu Dihan Zhou Yuan Cao Yi Yang Yaoming Li Huimin Yan | 2016 | Cellular & Molecular Immunology2016，13，4： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员