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| 1 | The development of China's Yangtze River Economic Belt:how to make it in a green way?显示文摘The Yangtze River is one of the largest and longest rivers in Asia.The river originates in the Tibet-Qinghai Plateau(headwater reach),passes through the mountainous provinces of Sichuan,Yunnan and Chongqing(upper reach),flows into the Central Plain(middle reach)and Lower Plain(lower reach),and finally empties into the East China Sea in Shanghai(estuary).The Yangtze River Economic Belt(YREB;Fig.1)has a surface area of 2.1 | Yushun Chen Shuanghu Zhang Desheng Huang Bai-Lian Li Junguo Liu Wenjin Liu Jing Ma Fang Wang Yong Wang Shengjun Wu Yegang Wu Jinyue Yan Chuanbo Guo Wei Xin Hao Wang | 2017 | Science Bulletin2017，62，9： | 20 |
| 2 | Effect of minor Sc addition on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy显示文摘Influence of Sc content on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy have been investigated by optical microscopy, scanning electron microscopy, electron backscatter diffraction, transmission electron microscopy and slow strain rate test. The results indicate that the addition of Sc results in the formation of the quaternary coherent Al_3(Sc, Zr, Ti) dispersoids during homogenization treatment, which will inhibit the dynamic recrystallization behavior. The number density of Al_3(Sc, Zr, Ti) particles increases with the increase of Sc content, and thus the recrystallization fraction of hot-extruded alloy is reduced and the peak strength in two-stage artificial aging sample is enhanced. At the same time, the wide of precipitation free zone is reduced, and the content of Zn and Mg in grain boundary particles and precipitation free zone is increased with the increase of Sc content. In peak-aged state, the 0.06 wt% Sc added alloy shows the better stress corrosion cracking resistance than the Sc-free alloy because of the reduction of recrystallization fraction and the interrupted distribution of grain boundary precipitates along grain boundary. However, the further addition of Sc to 0.11 wt% will result in the deterioration of stress corrosion cracking resistance due to the increase of electrochemical activity of grain boundary particles and precipitation free zone as well as hydrogen embrittlement. | Zhaoming Li Haichang Jiang Yunli Wang Duo Zhang Desheng Yan Lijian Rong | 2018 | Journal of Materials Science & Technology2018，34，7： | 14 |
| 3 | Effect of Sc addition on microstructure and mechanical properties of 1460 alloy显示文摘The effect of minor addition of Sc on microstructure,age hardening behavior,tensile properties and fracture morphology of 1460 alloy have been studied. It is found that Sc content increase from 0.11 wt% to 0.22 wt% is favorable for grain refinement in as-cast alloy but results in a coarsening of Cu-rich particles. The alloy with 0.11 wt% Sc exhibits enhanced mechanical properties and age hardening effect. Transmission electron microscopy(TEM) investigations on the alloy with 0.11 wt% Sc have suggested that a large amount of Al3(Sc,Zr) particles precipitated at the earlier aging may inhibit recrystallization effectively. | Juan Ma Desheng Yan Lijian Rong Yiyi Li | 2014 | Progress in Natural Science:Materials International2014，24，1： | 10 |
| 4 | Study on Compressive Properties of Z-pinned Laminates in RTD and Hygrothermal Environment显示文摘Compressive tests of [0] 12 and [90] 12 unidirectional laminates and [45/0/-45/90] 2S quasi-isotropic laminates are accomplished in both room-temperature and dry (RTD) and hygrothermal environment. And simulation studies on the compressive strength of Z-pinned laminates of [0] 12 and [45/0/-45/90] 2S are conducted by using finite element analysis (FEA). A microstructural unit cell for FEA is created to simulate a representative laminates unit with one pin. Within the unit cell, the first directions of the elements’ material coordinate systems are changed to simulate the fibres’ deflecting around the pin. The hygrothermal effect is simulated by the material properties’ adjustments which are determined by the compressive tests of non-pined laminates. The experimental results indicate that the percentage of reduction in the compressive modulus of Z-pinned laminates caused by Z-pin becomes smaller with the percentage of 0° fibres decreasing in the laminates; the compressive strength of quasi-isotropic laminates reduces and the percentage of the reduction in the compressive strength declines with Z-pin volume content increasing, and the moisture absorption ratio of the Z-pinned specimens is greater than that of the non-pinned specimens, because the cracks around Z-pin increase the moisture absorption. In addition, the simulations show that the deflection of fibres around Z-pin is the main factor for the reduction in the compressive strength of Z-pinned unidirectional laminates, the dilution of fibre volume content caused by resin-rich pocket is the principal factor for the decline in the compressive strength of Z-pinned quasi-istropic laminates, and the compressive strength of Z-pinned specimens in hygrothermal environment reduces as the result of superimposition of some factors, including the changes in material properties caused by hygrothermal environment, the deflection of fibres and the resin-rich pocket caused by Z-pin. | LI Chenghu YAN Ying WANG Ping QI Desheng WEN Yonghai | 2012 | Chinese Journal of Aeronautics2012，25，1： | 4 |
| 5 | Microstructure and Mechanical Properties of a CuCrZr Welding Joint After Continuous Extrusion显示文摘The effect of continuous extrusion forming(CEF) process on the microstructure and mechanical properties of a CuCrZr welding joint was investigated. The experimental results showed that after the CEF process the grains were refined to submicron-scale through dynamic recrystallization,which improved the mechanical properties of the welding joint as well as the base material. Meanwhile,the micron-scale precipitates aggregated at the grain boundaries in the welding process were broken down to smaller ones and recrystallized grains of several micrometers formed around the precipitates after CEF process,which could alleviate the negative effect induced by the micron-scale precipitates during plastic deforming process. Finer grains and smaller micronscale precipitates made contributions to improve the properties of a CuCrZr alloy with a welding joint. | Hui Feng Haichang Jiang Desheng Yan Lijian Rong | 2015 | Journal of Materials Science & Technology2015，31，2： | 3 |
| 6 | A Novel TiNi/AlSi Composite with High Strength and High Damping Capacity显示文摘A novel TiNi/AlSi composite with high compressive strength and high damping capacity was obtained by infiltrating Al-12%Si alloy into porous TiNi alloy.It had been found that the high compressive strength (440 MPa) of TiNi/AlSi composite is due to the increase of effective carrying area after infiltrating Al-12%Si alloy,while the high damping capacity is contributed to TiNi carcass,Al-12%Si filling material and micro- slipping at the interface. | Shuwei LIU Xiuyan LI Desheng YAN Haichang JIANG Lijian RONG | 2008 | Journal of Materials Science & Technology2008，24，6： | 3 |
| 7 | Spectroscopic Analysis on the Effect of Temperature on Kunitz Domain 1 of Human Tissue Factor Pathway Inhibitor-2显示文摘Kunitz 领域 1 人的织物因素 pathwayinhibitor-2 (hTFPI-2/KD1 ) 的符合构造被 Fourier 变换学习了红外线的光谱学,圆形的二色性,和拉曼光谱学。hTFPI-2/KD1 在详细 conformational 揭示的 Fouriertransform 红外线的光谱学,圆形的二色性和拉曼光谱学观察的激烈的蛋白质改变的 25 ° C .The 包含了近似 17%alpha-helices,24% 贝它海滨, 46% 随机的卷, 13% 贝它拐弯,和二种二硫键(gggand tgt ) ,这被发现那 hTFPI-2/KDlwas 热地稳定。然而, KD1 能在高温度形成一种中间的形式,当温度被降低时,然后回到它的正常符合构造。活动试金也证明 thathTFPI-2/KDl 能在为 5min 被加热到 80 ° C 以后在胞质素上保留它的禁止的活动。 | Chenqi ZHANG Desheng KONG Xingang LIU Xiaomin YAN Linsen DAI Duan MA | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 3 |
| 8 | Effect of Cu content on microstructure and properties of Fe-16Cr-2.5Mo damping alloy显示文摘Five Fe-16 Cr-2.5 Mo damping alloys with different Cu contents(0%,0.25%,0.5%,1.0% and 2.0%) were prepared.The microstructure was observed by scanning transmission electron microscopy(STEM) and the damping behavior was measured by using a dynamic mechanical analyzer(DMA).The results show that the grain size of experimental alloy with(0.25–1.0%) Cu was refined compared with the 0 Cu alloy.The Cu element is fully dissolved in the matrix and there are no Cu precipitates and carbides observed.Although the internal stress increases because of Cu addition,the damping capacity of the 0.5 Cu and1.0 Cu alloys has been significantly improved.The reason of damping improvement is that the magnetic domain structure is strongly modified.Meanwhile,the strength was improved gradually due to the Cu solid solution strengthening and grain refining.In the 2.0 Cu alloy,lots of Cu-riched particles appeared in the matrix.These Cu precipitates with 10–15 nm in size are spherical and homogeneously distributed,which strongly induce strength improvement through precipitation strengthening.On the contrary,the elongation and impact energy of the 2.0 Cu alloy decrease sharply.In addition,lots of Cu precipitates will significantly decrease the damping capacity by hindering the mobility of domain walls. | Xiaofeng Hu Yubin Du Desheng Yan Lijian Rong | 2018 | Journal of Materials Science & Technology2018，34，5： | 2 |
| 9 | Fabrication and Microwave Absorption Properties of Fe_(0.64)Ni_(0.36)-NiFe_2O_4 Nanocomposite显示文摘Fe_(0.64)Ni_(0.36)-NiFe_2O_4 nanocomposite was performed with partially reducing NiFe_2O_4 nanoparticles in Ar/H_2 ambient.The microwave and static magnetic properties were investigated.The results showed that the nanocomposite was characterized with enhanced microwave absorption properties.The optimal reflection loss(RL)of the nanocomposite reached-24.8 dB at 14 GHz for an absorber thickness of 1.5 mm.Meanwhile,a broad bandwidth for RL<-10 dB was obtained in the range of 3.1—15.1 GHz for an absorber thickness from1.0 to 4.0 mm.The enhancement is attributed to the increase of dielectric and magnetic loss after reducing procedure. | Xu Yan Desheng Xue | 2012 | Nano-Micro Letters2012，4，3： | 2 |
| 10 | Coarsening Behavior of Al_3(Sc, Zr) Precipitates and Its Influence on Recrystallization Temperature of Al-Mg-Sc-Zr Alloy显示文摘Effects of intermediate annealing temperature and time after hot working on recrystallization temperature (Tr) of Al-Mg-Sc-Zr alloy subjected to further cold working were investigated. It was found that Tr of cold worked alloy dropped with the rise of intermediate annealing temperature or extension of annealing time, due to coarsening of Al3(Sc, Zr) particles during intermediate annealing. After annealed at 550°C for 1 h or 475°C for 50 h, Tr is nearly same as that in a Sc, Zr free 5A06 alloy. Coarsening mechanism was also discussed. After hot rolling, residual dislocations promoted diffusion of Sc and Zr atoms at the elevated temperature of the intermediate annealing. Easier diffusion sped the growth of the Al3(Sc, Zr) particles, resulting in a coherency loss and quantity reduction of the particles. | Gang Du Jingwei Deng Desheng Yan Mingjiu Zhao Lijian Rong | 2009 | Journal of Materials Science & Technology2009，25，6： | 2 |
| 11 | Effect of deformation on martensitic transformation behavior in Ni50.1Ti46.9Nb3 shape memory alloy显示文摘 | Xiangming He Lijian Rong Desheng Yan Zhimin Jiang Yiyi Li | 2005 | Journal of Materials Science2005，，19： | 1 |
| 12 | A non-viral vector for potential DMD gene therapy study by targeting a minidystrophin-GFP fusion gene into the hrDNA locus显示文摘基因治疗为 Duchenne 肌肉发达的营养障碍(DMD ) 的致命的混乱作为一条有希望的途径出现了。用一个新奇非病毒的交货系统,指向向量的人的 ribosomal DNA (hrDNA ) ,我们与 10 的高地点特定的综合效率指向了 minidystrophin-GFP 熔化基因进 HT1080 房间的 hrDNA 地点 ? 5,在里面 transgene 能高效地并且连续地表示它。minidystrophin-GFP 熔化蛋白质容易被发现在 HT1080 房间的血浆膜上本地化,显示它的可能的生理的表演。我们的调查结果证明指向 hrDNA 向量可能为 DMD 基因治疗学习是高度有用的。 | Junlin Yang Xionghao Liu Jiaoling Yu Liang Sheng Yan Shi Zhuo Li Youjin Hu Jinfeng Xu Lingqian Wu Yu Liang Jiahui Xia Desheng Liang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，12： | 1 |
| 13 | Effect of continuous extrusion on the microstructure and mechanical properties of a CuCrZr alloy显示文摘 | Hui Feng Haichang Jiang Desheng Yan Lijian Rong | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 14 | New type of system for high-temperature measurement using fiber optic sensor显示文摘 | Dai Heng Jiang Desheng | 2000 | Proc SPIE Int Soc Opt Eng2000，4077，： | 1 |
| 15 | A new type of system for high-temperature measurement using fiber optic sensor显示文摘 | DAI Heng JIANG Desheng | 2000 | Proceedings of SPIE2000，4077，2000： | 1 |
| 16 | Preparation and magnetic properties of Nd 5 Fe 95? x B x nanowire arrays显示文摘 | Daqiang Gao Junli Fu Yan Xu Desheng Xue | 2008 | Materials Letters2008，，17： | 1 |
| 17 | The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor显示文摘Cancer stem cells(CSCs)exhibit highly aggressive and metastatic features and resistance to chemotherapy and radiotherapy.Aryl hydrocarbon receptor(AhR)expression varies among non-small cell lung cancers(NSCLCs),and the mechanisms that support abnormal AhR expression in CSCs remain elusive.Here,we identified ubiquitin carboxyl terminal hydrolase L3(UCHL3),a DUB enzyme in the UCH protease family,as a bona fide deubiquitylase of the AhR in NSCLC.UCHL3 was shown to interact with,deubiquitylate,and stabilize AhR in a manner dependent on its deubiquitylation activity.Moreover,we showed that UCHL3 promotes the stem-like characteristics and potent tumorigenic capacity of NSCLC cells.UCHL3 increased AhR stability and the binding of AhR to the promoter regions of the“stemness”genes ATP-binding cassette subfamily G member 2(ABCG2),KLF4,and c-Myc.Depletion of UCHL3 markedly downregulated the“stemness”genes ABCG2,KLF4,and c-Myc,leading to the loss of selfrenewal and tumorigenesis in NSCLCs.Furthermore,the UCHL3 inhibitor TCID induced AhR degradation and exhibited significantly attenuated efficacy in NSCLC cells with stem cell-like properties.Additionally,UCHL3 was shown to indicate poor prognosis in patients with lung adenocarcinoma.In general,our results reveal that the UCHL3 deubiquitylase is pivotal for AhR protein stability and a potential target for NSCLC-targeted therapy. | Lianlian Ouyang Bin Yan Yating Liu Chao Mao Min Wang Na Liu Zuli Wang Shouping Liu Ying Shi Ling Chen Xiang Wang Yan Cheng Ya Cao Desheng Xiao Lingqiang Zhang Shuang Liu Yongguang Tao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 18 | The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties显示文摘Posttranslational modifications(PTMs)of proteins,including chromatin modifiers,play crucial roles in the dynamic alteration of various protein properties and functions including stem-cell properties.However,the roles of Lymphoid-specific helicase(LSH),a DNA methylation modifier,in modulating stem-like properties in cancer are still not clearly clarified.Therefore,exploring PTMs modulation of LSH activity will be of great significance to further understand the function and activity of LSH.Here,we demonstrate that LSH is capable to undergo PTMs,including methylation and phosphorylation.The arginine methyltransferase PRMT5 can methylate LSH at R309 residue,meanwhile,LSH could as well be phosphorylated by MAPK1 kinase at S503 residue.We further show that the accumulation of phosphorylation of LSH at S503 site exhibits downregulation of LSH methylation at R309 residue,which eventually promoting stem-like properties in lung cancer.Whereas,phosphorylation-deficient LSH S503A mutant promotes the accumulation of LSH methylation at R309 residue and attenuates stem-like properties,indicating the critical roles of LSH PTMs in modulating stem-like properties.Thus,our study highlights the importance of the crosstalk between LSH PTMs in determining its activity and function in lung cancer stem-cell maintenance. | Na Liu Rui Yang Ying Shi Ling Chen Yating Liu Zuli Wang Shouping Liu Lianlian Ouyang Haiyan Wang Weiwei Lai Chao Mao Min Wang Yan Cheng Shuang Liu Xiang Wang Hu Zhou Ya Cao Desheng Xiao Yongguang Tao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 19 | Study on Dynamic Characteristics of Crustal Deformation in the Yunnan Area Using GPS显示文摘Based on the GPS velocity field data of 1999-2007 and 2011-2013,we used the least squares configuration method and GPS velocity profile results to synthetically analyze the dynamic evolution characteristics of crustal deformation in the Yunnan area before and after the Wenchuan earthquake. The dynamic evolution of GPS velocity field shows that the direction is gradually changed from the south in the southern part of the SichuanYunnan block to the south-west in the southern Yunnan block and there is a clear relative motion characteristic near the block boundary fault zone. Compared with the GPS velocity of 1999-2007,the results of 2011-2013 also reflect segmental deformation characteristics of the block boundary fault zone. Southeast movement shows a significant increase,which may be related to crustal deformation adjustment after the Wenchuan earthquake. The dynamic evolution of strain parameters shows a pattern of'extension in the middle and compression at both ends'in the whole area and the distribution of deformation(shear,extension or compression)is closely related to the background motion and deformation characteristics of the main fault zone. Compared with the results of the period of 1999-2007,the extensional deformation zone of 2011-2013 is expanded eastward and southward. The compressional deformation of the eastern boundary(the Xiaojiang fault zone)of the Sichuan-Yunnan block is no longer significant,which is mainly concentrated in the northern section of the Xiaojiang fault zone and may be related to the post-seismic deformation adjustment of the Wenchuan earthquake. The GPS velocity profile results show that the left-lateral slip velocity of the Xiaojiang fault zone reduced gradually from north to south(10 mm/a-5 mm/a),and the width of the northern section is wider. The right-lateral slip rate of the Honghe fault zone is about 4 mm/a,and the deformation width is wider. The dynamic results show that the Wenchuan earthquake has little effect on the deformation modes of these two fault zones. | WANG Yan SHAO Desheng HONG Min | 2019 | Earthquake Research in China2019，33，3： | 0 |
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