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| 1 | Vision,Requirements and Network Architecture of 6G Mobile Network beyond 2030显示文摘With the 5th Generation(5G)Mobile network being rolled out gradually in 2019,the research for the next generation mobile network has been started and targeted for 2030.To pave the way for the development of the 6th Generation(6G)mobile network,the vision and requirements should be identified first for the potential key technology identification and comprehensive system design.This article first identifies the vision of the society development towards 2030 and the new application scenarios for mobile communication,and then the key performance requirements are derived from the service and application perspective.Taken into account the convergence of information technology,communication technology and big data technology,a logical mobile network architecture is proposed to resolve the lessons from 5G network design.To compromise among the cost,capability and flexibility of the network,the features of the 6G mobile network are proposed based on the latest progress and applications of the relevant fields,namely,on-demand fulfillment,lite network,soft network,native AI and native security.Ultimately,the intent of this article is to serve as a basis for stimulating more promising research on 6G. | Guangyi Liu Yuhong Huang Na Li Jing Dong Jing Jin Qixing Wang Nan Li | 2020 | China Communications2020，17，9： | 37 |
| 2 | Study of BESIII trigger efficiencies with the 2018 J/ψ data显示文摘Using a dedicated data sample taken in 2018 on the J/ψpeak,we perform a detailed study of the trigger efficiencies of the BESIII detector.The efficiencies are determined from three representative physics processes,namely Bhabha scattering,dimuon production and generic hadronic events with charged particles.The combined efficiency of all active triggers approaches 100%in most cases,with uncertainties small enough not to affect most physics analyses. | M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An X.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.Chelkov D.Y.Chen G.Chen H.S.Chen M.L.Chen S.J.Chen X.R.Chen Y.B.Chen Z.J Chen W.S.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai X.C.Dai A.Dbeyssi R.E.de Boer D.Dedovich Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding C.Dong J.Dong L.Y.Dong M.Y.Dong X.Dong S.X.Du Y.L.Fan J.Fang S.S.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng M.Fritsch C.D.Fu Y.Gao Y.Gao Y.Gao Y.G.Gao I.Garzia P.T.Ge C.Geng E.M.Gersabeck A Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu S.Gu Y.T.Gu C.Y Guan A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov T.T.Han W.Y.Han X.Q.Hao F.A.Harris H Hüsken K.L.He F.H.Heinsius C.H.Heinz T.Held Y.K.Heng C.Herold M.Himmelreich T.Holtmann Y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang L.Q.Huang X.T.Huang Y.P.Huang Z.Huang T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad S.Jaeger S.Janchiv Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.B.Jiang X.S.Jiang J.B.Jiao Z.Jiao S.Jin Y.Jin T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.G.Kurth W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.Li H.B.Li H.J.Li J.L.Li J.Q.Li J.S.Li Ke Li L.K.Li Lei Li P.R.Li S.Y.Li W.D.Li W.G.Li X.H.Li X.L.Li Z.Y.Li H.Liang H.Liang H.Liang Y.F.Liang Y.T.Liang L.Z.Liao J.Libby C.X.Lin B.J.Liu C.X.Liu D.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.L.Liu J.Y.Liu K.Liu K.Y.Liu Ke Liu L.Liu M.H.Liu P.L.Liu Q.Liu Q.Liu S.B.Liu Shuai Liu T.Liu W.M.Liu X.Liu Y.Liu Y.B.Liu Z.A.Liu Z.Q.Liu X.C.Lou F.X.Lu H.J.Lu J.D.Lu J.G.Lu X.L.Lu Y.Lu Y.P.Lu C.L.Luo M.X.Luo b P.W.Luo T.Luo X.L.Luo S.Lusso X.R.Lyu F.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma R.Q.Ma R.T.Ma X.X.Ma X.Y.Ma F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni Y.J.Mao Z.P.Mao S.Marcello Z.X.Meng J.G.Messchendorp G.Mezzadri T.J.Min R.E.Mitchell X.H.Mo Y.J.Mo N.Yu.Muchnoi H.Muramatsu S.Nakhoul Y.Nefedov F.Nerling I.B.Nikolaev Z.Ning S.Nisar S.L.Olsen Q.Ouyang S.Pacetti X.Pan Y.Pan A.Pathak P.Patteri M.Pelizaeus H.P.Peng K.Peters J.Pettersson J.L.Ping R.G.Ping R.Poling V.Prasad H.Qi H.R.Qi K.H.Qi M.Qi T.Y.Qi T.Y.Qi S.Qian W.-B.Qian Z.Qian C.F.Qiao L.Q.Qin X.S.Qin Z.H.Qin J.F.Qiu S.Q.Qu K.H.Rashid K.Ravindran C.F.Redmer A.Rivetti V.Rodin M.Rolo G.Rong Ch.Rosner M.Rump H.S.Sang A.Sarantsev Y.Schelhaas C.Schnier K.Schoenning M.Scodeggio D.C.Shan W.Shan X.Y.Shan J.F.Shangguan M.Shao C.P.Shen P.X.Shen X.Y.Shen H.C.Shi R.S.Shi X.Shi X.D Shi W.M.Song Y.X.Song S.Sosio S.Spataro K.X.Su P.P.Su F.F.Sui G.X.Sun H.K.Sun J.F.Sun L.Sun S.S.Sun T.Sun W.Y.Sun X Sun Y.J.Sun Y.K.Sun Y.Z.Sun Z.T.Sun Y.H.Tan Y.X.Tan C.J.Tang G.Y.Tang J.Tang J.X.Teng V.Thoren I.Uman B.Wang C.W.Wang D.Y.Wang H.J.Wang H.P.Wang K.Wang L.L.Wang M.Wang M.Z.Wang Meng Wang W.Wang W.H.Wang W.P.Wang X.Wang X.F.Wang X.L.Wang Y.Wang Y.D.Wang Y.F.Wang Y.Q.Wang Y.Y.Wang Z.Wang Z.Y.Wang Ziyi Wang Zongyuan Wang D.H.Wei P.Weidenkaff F.Weidner S.P.Wen D.J.White U.Wiedner G.Wilkinson M.Wolke L.Wollenberg J.F.Wu L.H.Wu L.J.Wu X.Wu Z.Wu L.Xia H.Xiao S.Y.Xiao Z.J.Xiao X.H.Xie Y.G.Xie Y.H.Xie T.Y.Xing G.F.Xu Q.J.Xu W.Xu X.P.Xu F.Yan L.Yan W.B.Yan W.C.Yan Xu Yan H.J.Yang H.X.Yang L.Yang S.L.Yang Y.X.Yang Yifan Yang Zhi Yang M.Ye M.H.Ye J.H.Yin Z.Y.You B.X.Yu C.X.Yu G.Yu J.S.Yu T.Yu C.Z.Yuan L.Yuan X.Q.Yuan Y.Yuan Z.Y.Yuan C.X.Yue A.Yuncu A.A.Zafar Y.Zeng B.X.Zhang Guangyi Zhang H.Zhang H.H.Zhang H.Y.Zhang J.J.Zhang J.L.Zhang J.Q.Zhang J.W.Zhang J.Y.Zhang J.Z.Zhang Jianyu Zhang Jiawei Zhang L.Q.Zhang Lei Zhang S.Zhang S.F.Zhang Shulei Zhang X.D.Zhang X.Y.Zhang Y.Zhang Y.H.Zhang Y.T.Zhang Yan Zhang Yao Zhang Yi Zhang Z.H.Zhang Z.Y.Zhang G.Zhao J.Zhao J.Y.Zhao J.Z.Zhao Lei Zhao Ling Zhao M.G.Zhao Q.Zhao S.J.Zhao Y.B.Zhao Y.X.Zhao Z.G.Zhao A.Zhemchugov B.Zheng J.P.Zheng Y.Zheng Y.H.Zheng B.Zhong C.Zhong L.P.Zhou Q.Zhou X.Zhou X.K.Zhou X.R.Zhou A.N.Zhu J.Zhu K.Zhu K.J.Zhu S.H.Zhu T.J.Zhu W.J.Zhu W.J.Zhu Y.C.Zhu Z.A.Zhu B.S.Zou J.H.Zou | 2021 | Chinese Physics C2021，45，2： | 33 |
| 3 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 4 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 5 | The SOLIDS 6G Mobile Network Architecture:Driving Forces,Features,and Functional Topology显示文摘With the large-scale commercial launch of fifth generation(5G)mobile network,the development of new services and applications catering to the year 2030,along with the deep convergence of information,communication,and data technologies(ICDT),and the lessons and experiences from 5G practice will drive the evolution of the next generation of mobile networks.This article surveys the history and driving forces of the evolution of the mobile network architecture and proposes a logical function architecture for sixth generation(6G)mobile network.The proposed 6G network architecture is termed SOLIDS(related to the following basic features:soft,on-demand fulfillment,lite,native intelligence,digital twin,and native security),which can support self-generation,self-healing,self-evolution,and self-immunity without human involvement and address the primary issues in the legacy 5G network(e.g.,high cost,high power consumption,and highly complicated operation and maintenance),significantly well. | Guangyi Liu Na Li Juan Deng Yingying Wang Junshuai Sun Yuhong Huang | 2022 | Engineering2022，8，1： | 8 |
| 6 | Super-resolution fluorescence-assisted diffraction computational tomography reveals the threedimensional landscape of the cellular organelle interactome显示文摘The emergence of super-resolution(SR)fluorescence microscopy has rejuvenated the search for new cellular substructures.However,SR fluorescence microscopy achieves high contrast at the expense of a holistic view of the interacting partners and surrounding environment.Thus,we developed SR fluorescence-assisted diffraction computational tomography(SR-FACT),which combines label-free three-dimensional optical diffraction tomography(ODT)with two-dimensional fluorescence Hessian structured illumination microscopy.The ODT module is capable of resolving the mitochondria,lipid droplets,the nuclear membrane,chromosomes,the tubular endoplasmic reticulum,and lysosomes.Using dual-mode correlated live-cell imaging for a prolonged period of time,we observed novel subcellular structures named dark-vacuole bodies,the majority of which originate from densely populated perinuclear regions,and intensively interact with organelles such as the mitochondria and the nuclear membrane before ultimately collapsing into the plasma membrane.This work demonstrates the unique capabilities of SR-FACT,which suggests its wide applicability in cell biology in general. | Dashan Dong Xiaoshuai Huang Liuju Li Heng Mao Yanquan Mo Guangyi Zhang Zhe Zhang Jiayu Shen Wei Liu Zeming Wu Guanghui Liu Yanmei Liu Hong Yang Qihuang Gong Kebin Shi Liangyi Chen | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 7 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 8 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 9 | The POM-DOM piezophilic microorganism continuum(PDPMC)—The role of piezophilic microorganisms in the global ocean carbon cycle显示文摘The deep ocean piezosphere accounts for a significant part of the global ocean,hosts active and diverse microbial communities which probably play a more important role than hitherto recognized in the global ocean carbon cycle.The conventional biological pump concept and the recently proposed microbial carbon pump mechanism provide a foundation for our understanding of the role of microorganisms in cycling of carbon in the ocean.However,there are significant gaps in our knowledge and a lack of mechanistic understanding of the processes of microbially-mediated production,transformation,degradation,and export of marine dissolved and particulate organic matter(DOM and POM)in the deep ocean and the ecological consequence.Here we propose the POM-DOM piezophilic microorganism continuum(PDPMC)conceptual model,to address these important biogeochemical processes in the deep ocean.We propose that piezophilic microorganisms(bacteria and archaea)play a pivotal role in deep ocean carbon cycle where microbial production of exoenzymes,enzymatic breakdown of DOM and transformation of POM fuels the rapid cycling of marine organic matter,and serve as the primary driver for carbon cycle in the deep ocean. | FANG JiaSong ZHANG Li LI Jiang Tao Chiaki KATO Christian TAMBURINI ZHANG YuZhong DANG HongYue WANG GuangYi WANG FengPing | 2015 | Science China Earth Sciences2015，58，1： | 4 |
| 10 | Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis显示文摘Dear Editor,The axolotl,Ambystoma mexicanum,has extraordinary capability to fully recover multiple tissues after lost,whereas such capability has disappeared in mammals.Thus,deci-phering detailed mechanisms underlying axolotl regenera-tion could provide valuable lessons for regenerative medicine.However,many questions,such as the origin of essential progenitor cells and key responses of individual types of cells for regeneration remain elusive(Haas and Whited,2017).Newly developed single-cell RNA sequenc-ing(scRNA-seq)method enables researchers to observe cellular and molecular dynamics in axolotl regeneration at the single-cell resolution(Gerber et al.,2018;Leigh et al.,2018),but the reported transcriptome landscapes are only for certain cell types or in certain regenerative stages.A complete overview of the regeneration process for all cell types is still lacking. | Hanbo Li Xiaoyu Wei Li Zhou Weiqi Zhang Chen Wang Yang Guo Denghui Li Jjianyang Chen Tianbin Liu Yingying Zhang Shuai Ma Congyan Wang Fujian Tan Jiangshan Xu Yang Liu Yue Yuan Liang Chen Qiaoran Wang Jing Qu Yue Shen Shanshan Liu Guangyi Fan Longqi Liu Xin Liu Yong Hou Guang-Hui Liu Ying Gu Xun Xu | 2021 | Protein & Cell2021，12，1： | 3 |
| 11 | The Marine Redox Change and Nitrogen Cycle in the Early Cryogenian Interglacial Time: Evidence from Nitrogen Isotopes and Mo Contents of the Basal Datangpo Formation, Northeastern Guizhou, South China显示文摘Cryogenian Datangpo Formation was deposited during the interglacial time between the Sturtian and Marinoan ice ages. We studied nitrogen isotope compositions and contents of Mo of the black shales from the basal Datangpo Formation in northeastern Guizhou, South China, for an attempt to reconstruct the marine redox change and nitrogen cycle during the interglacial time. Based on lithostratigraphy as well as geochemical profiles, the basal black shales can be divided into four intervals: Interval 1 has the lowest δ^(15)N value(+5.0‰); in interval 2, δ^(15)N values vary between +6.4‰ and +7.4‰(the first peak); interval 3 records stable values of δ^(15)N around +6‰; and interval 4 is characterized by its higher δ^(15)N values, between +6.7‰ and +7.8‰(the second peak). The values of enrichment factor of Mo decrease from 56.8 to 2.6 with the ascending stratigraphic trend. It indicated that immediately after the Sturtian glaciations, the marine seawater above the transitional zone between the shelf to slope of the southern margin of the Yangtze Platform was stratified, with shallow seawater being oxic but deep water being sulfidic. Subsequently, high denitrification rates prevailed in expanded suboxic areas in spite of a short emergence of an oxic condition in the surface seawater, and the deep seawaters were still anoxic or even euxinic. | Wei Wei Dan Wang Da Li Hongfei Ling Xi Chen Guangyi Wei Feifei Zhang Xiangkun Zhu Bin Yan | 2016 | Journal of Earth Science2016，27，2： | 3 |
| 12 | A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration显示文摘Osteoporosis is one of the most disabling consequences of aging,osteoporotic fractures and higher risk of the subsequent fractures leading to substantial disability and deaths,indicating both local fractures healing and the early anti-osteoporosis therapy are of great significance.Teriparatide is strong bone formation promoter effective in treating osteoporosis,while side effects limit clinical applications.Traditional drug delivery is lack of sensitive and short-term release,finding a new non-invasive and easily controllable drug delivery to not only repair the local fractures but also improve total bone mass has remained a great challenge.Thus,bioinspired by the natural bone components,we develop appropriate interactions between inorganic biological scaffolds and organic drug molecules,achieving both loaded with the teriparatide in the scaffold and capable of releasing on demand.Herein,biomimetic bone microstructure of mesoporous bioglass,a near-infrared ray triggered switch,thermosensitive liposomes based on a valve,and polydopamine coated as a heater is developed rationally for osteoporotic bone regeneration.Teriparatide is pulsatile released from intelligent delivery,not only rejuvenating osteoporotic bone defect,but also presenting strong systemic anti-osteoporosis therapy.This biomimetic bone carrying novel drug delivery platform is well worth expecting to be a new promising strategy and clinically commercialized to help patients survive from the osteoporotic fracture. | Lingbin Che Ying Wang Dongyong Sha Guangyi Li Ziheng Wei Changsheng Liu Yuan Yuan Dianwen Song | 2023 | Bioactive Materials2023，，1： | 3 |
| 13 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 14 | Hydrothermal conversion of lignin and black liquor for phenolics with the aids of alkali and hydrogen donor显示文摘The potentials of phenolic productions from lignin and black liquor(BL)via hydrothermal technology with the aids of alkalis and hydrogen donors were investigated,by conducting batch experiments in micro-tube reactors with 300℃ sub-critical water as the solvent.The results showed that all the employed alkalis improved lignin degradation and thus phenolics production,and the strong alkalis additionally manifested deoxygenation to produce more phenolics free of methoxyl group(s).Relatively,hydrogen donors more visibly facilitated phenolics formation.Combination of strong alkali and hydrogen donors exhibited synergistically positive effects on producing phenolics(their total yield reaching 22 wt%)with high selectivities to phenolics,among which the yields of catechol and cresols respectively peaked 16 and 3.5 wt%.BL could be hydrothermally converted into phenolics at high yields(approaching 10 wt%with the yields of catechol and cresols of about 4 and 2 wt%,respectively)with the aids of its inherent alkali and hydrogen donors,justifying its cascade utilization. | Cuina Peng Guangyi Zhang Jiangze Han Xiaolei Li | 2019 | Carbon Resources Conversion2019，2，2： | 2 |
| 15 | Syntheses and Anti-cancer Activities of Derivatives of Tetrandrine and Fangchinoline显示文摘 | LIU Yazhou HUANG Lan SUN Qianyun ZHANG Maosheng LI Tianlei LIANG Guangyi PAN Weidong | 2014 | Chemical Research in Chinese Universities2014，30，6： | 2 |
| 16 | Graph Computing Based Distributed Parallel Power Flow for AC/DC Systems with Improved Initial Estimate显示文摘The sequential method is easy to integrate with existing large-scale alternating current(AC)power flow solvers and is therefore a common approach for solving the power flow of AC/direct current(DC)hybrid systems.In this paper,a highperformance graph computing based distributed parallel implementation of the sequential method with an improved initial estimate approach for hybrid AC/DC systems is developed.The proposed approach is capable of speeding up the entire computation process without compromising the accuracy of result.First,the AC/DC network is intuitively represented by a graph and stored in a graph database(GDB)to expedite data processing.Considering the interconnection of AC grids via high-voltage direct current(HVDC)links,the network is subsequently partitioned into independent areas which are naturally fit for distributed power flow analysis.For each area,the fast-decoupled power flow(FDPF)is employed with node-based parallel computing(NPC)and hierarchical parallel computing(HPC)to quickly identify system states.Furthermore,to reduce the alternate iterations in the sequential method,a new decoupled approach is utilized to achieve a good initial estimate for the Newton-Raphson method.With the improved initial estimate,the sequential method can converge in fewer iterations.Consequently,the proposed approach allows for significant reduction in computing time and is able to meet the requirement of the real-time analysis platform for power system.The performance is verified on standard IEEE 300-bus system,extended large-scale systems,and a practical 11119-bus system in China. | Wei Feng Chen Yuan Qingxin Shi Renchang Dai Guangyi Liu Zhiwei Wang Fangxing Li | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，2： | 2 |
| 17 | Understanding the mechanism of social tie in the propagation process of social network with communication channel显示文摘The propagation of information in online social networks plays a critical role in modern life,and thus has been studied broadly.Researchers have proposed a series of propagation models,generally,which use a single transition probability or consider factors such as content and time to describe the way how a user activates her/his neighbors.However,the research on the mechanism how social ties between users play roles in propagation process is still limited.Specifically,comprehensive summary of factors which affect user’s decision whether to share neighbor’s content was lacked in existing works,so that the existing models failed to clearly describe the process a user be activated by a neighbor.To this end,in this paper,we analyze the close correspondence between social tie in propagation process and communication channel,thus we propose to exploit the communication channel to describe the information propagation process between users,and design a social tie channel(STC)model.The model can naturally incorporate many factors affecting the information propagation through edges such as content topic and user preference,and thus can effectively capture the user behavior and relationship characteristics which indicate the property of a social tie.Extensive experiments conducted on two real-world datasets demonstrate the effectiveness of our model on content sharing prediction between users. | Kai LI Guangyi LV Zhefeng WANG Qi LIU Enhong CHEN Lisheng QIAO | 2019 | Frontiers of Computer Science2019，13，6： | 2 |
| 18 | The Characteristics and Distribution Pattern of Seafloor Sinuous Pockmark Train in the Niger Delta Basin,West Africa显示文摘Objective The term'pockmark'was introduced by King and Mac Lean(1970)to describe small'circular'on echosounder records in Nova Scotia.Pockmarks are usually described as circular,near circular or elongated depressions,generally 10–400 m in diameter and 30–50 | JIANG Li WU Shenghe HU Guangyi ZHANG Jiajia | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 2 |
| 19 | Optimal therapeutic dose and time window of picroside II in cerebral ischemic injury显示文摘A preliminary study from our research group showed that picroside II inhibited neuronal apoptosis in ischemic penumbra,reduced ischemic volume,and improved neurobehavioral function in rats with cerebral ischemia.The aim of the present study was to validate the neuroprotective effects of picroside II and optimize its therapeutic time window and dose in a rat model of cerebral ischemia.We found that picroside II inhibited cell apoptosis and reduced the expression of neuron-specific enolase,a marker of neuronal damage,in rats after cerebral ischemic injury.The optimal treatment time after ischemic injury and dose were determined,respectively,as follows:(1)2.0 hours and 10 mg/kg according to the results of toluidine blue staining;(2)1.5 hours and 10 mg/kg according to early apoptotic ratio by flow cytometry;(3)2.0 hours and 10 mg/kg according to immunohistochemical and western blot analysis;and(4)1.5 hours and 10 mg/kg according to reverse transcription polymerase chain reaction.The present findings suggest that an intraperitoneal injection of 10 mg/kg picroside II 1.5–2.0 hours after cerebral ischemic injury in rats is the optimal dose and time for therapeutic benefit. | Guangyi Liu Li Zhao Tingting Wang Meizeng Zhang Haitao Pei | 2014 | Neural Regeneration Research2014，9，15： | 1 |
| 20 | Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging. | Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai | 2020 | Engineering2020，6，11： | 1 |
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