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| 1 | Incidence,mortality and survival of female breast cancer during 2003-2011 in Jiangsu province,China显示文摘Objective: To assess the incidence, mortality and survival status of female breast cancer in Jiangsu province of China.Methods: Population-based cancer registry data in Jiangsu province were collected during 2003-2011. Crude rates, age-specific rates, age-standardized rates and annual percent changes of incidence and mortality were calculated to describe the epidemiologic characteristics and time trends. Patients diagnosed from 2003 to 2005 were chosen for analyzing the survival status of breast cancer.Results: From 2003 to 2011, 17,605 females were diagnosed with breast cancer and 4,883 died in selected registry areas in Jiangsu province. The crude incidence rate was 25.18/100,000, and the age-standardized rates by Chinese population(ASRC) and by world population(ASRW) were 19.03/100,000 and 17.92/100,000, respectively. During the same period, the crude mortality rate was 6.98/100,000 and the ASRC and ASRW were 4.93/100,000 and 4.80/100,000, respectively. From 2003 to 2011, the incidence and mortality increased with annual percent change of 11.37% and 5.78%, respectively. For survival analysis, 1,392 patients in 7 areas were identified in 2003-2005 and finished 5 years of follow-up. Survival rates were found to decrease with survival years, the 5-year observed survival rate was 45.9% and the relative survival rate was 52.0%. We also found that the survival rate varied across the province, which was lower in the north and higher in the south of Jiangsu province.Conclusions: Breast cancer has become a significant public health problem in Jiangsu province and China. More resources should be invested in primary prevention, earlier diagnosis and better health services in order to increase survival rates among Chinese females. | Xinran Yan Renqiang Han Jinyi Zhou Hao Yu Jie Yang Ming Wu | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 2 | Recent Advances in Design Strategies and Multifunctionality of Flexible Electromagnetic Interference Shielding Materials显示文摘With rapid development of 5G communication technologies,electromagnetic interference(EMI)shielding for electronic devices has become an urgent demand in recent years,where the development of corresponding EMI shielding materials against detrimental electromagnetic radiation plays an essential role.Meanwhile,the EMI shielding materials with high flexibility and functional integrity are highly demanded for emerging shielding applications.Hitherto,a variety of flexible EMI shielding materials with lightweight and multifunctionalities have been developed.In this review,we not only introduce the recent development of flexible EMI shielding materials,but also elaborate the EMI shielding mechanisms and the index for'green EMI shielding'performance.In addition,the construction strategies for sophisticated multifunctionalities of flexible shielding materials are summarized.Finally,we propose several possible research directions for flexible EMI shielding materials in near future,which could be inspirational to the fast-growing next-generation flexible electronic devices with reliable and multipurpose protections as offered by EMI shielding materials. | Junye Cheng Chuanbing Li Yingfei Xiong Huibin Zhang Hassan Raza Sana Ullah Jinyi Wu Guangping Zheng Qi Cao Deqing Zhang Qingbin Zheng Renchao Che | 2022 | Nano-Micro Letters2022，14，5： | 5 |
| 3 | Graphene oxide as a photocatalytic nuclease mimicking nanozyme for DNA cleavage显示文摘Developing nanomaterial-based enzyme mimics for DNA cleavage is an interesting challenge and it has many potential applications.Single-layered graphene oxide(GO)is an excellent platform for DNA adsorption.In addition,GO has been employed for photosensitized generation of reactive oxygen species(ROS).Herein,we demonstrate that GO sheets could cleave DNA as anuclease mimicking nanozyme in the presence of UV or blue light.For various DNA sequences and lengths,well-defined product bands were observed along with photobleaching of the fluorophore label on the DNA.Different from previously reported GO cleavage of DNA,our method did not require metal ions such as Cu^2+.Fluorescence spectroscopy suggested a high adsorption affinity between GO and DNA.For comparison,although zero-dimensional fluorescent carbon dots(C-dots)had higher photosensitivity ir terms of producing ROS,their cleavage activity was much lower and only smeared cleavage products were observed,indicatingthat the ROS acted on the DNA in solution.Based on the results,GO behaved like a classic heterogeneous catalyst following substrate adsorption,reaction,and product desorption steps.This simple strategy may help in the design of new nanozymes by introducing light. | Jinyi Zhang Shihong Wu Lingzi Ma Peng Wu Juewen Liu | 2020 | Nano Research2020，13，2： | 4 |
| 4 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 5 | High-density fermentation of microalga Chlorella protothecoides in bioreactor for microbio-diesel production显示文摘 | Wei Xiong Xiufeng Li Jinyi Xiang Qingyu Wu | 2008 | Applied Microbiology and Biotechnology2008，，1： | 1 |
| 6 | High-density fermentation of microalga Chlorella protothecoides in bioreactor for microbio-diesel production显示文摘 | Wei Xiong Xiufeng Li Jinyi Xiang Qingyu Wu | 2008 | Applied Microbiology and Biotechnology2008，，1： | 1 |
| 7 | Chronobiologic Approach to Beat-To-Beat Variations of Cultrued Murine Myocardial Cells显示文摘 | Huiwan Han Dali Shao Jinyi Wu | 1991 | Cell Biophysics1991，18，： | 1 |
| 8 | Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation显示文摘 | Dahong Li Shengtao Xu Hao Cai Lingling Pei Hengyuan Zhang Lei Wang Hequan Yao Xiaoming Wu Jieyun Jiang Yijun Sun Jinyi Xu | 2013 | European Journal of Medicinal Chemistry2013，，： | 1 |
| 9 | Weakly-coupled mode division multiplexing over conventional multi-mode fiber with intensity modulation and direct detection显示文摘Multi-mode fiber(MMF)links are expected to greatly enhance capacity to cope with rapidly increasing data traffic in optical short-reach systems and networks.Recently,mode division multiplexing(MDM)over MMF has been proposed,in which different modes in MMF are utilized as spatial channels for data transmission.Stronglycoupled MDM techniques utilizing coherent detection and multiplex-input-multiplex-output(MIMO)digital signal processing(DSP)are complex and expensive for shortreach transmission.So the weakly-coupled approach by significantly suppressing mode coupling in the fiber and optical components has been proposed.In this way,the signals in each mode can be independently transmitted and received using conventional intensity modulation and direct detection(IM-DD).In this paper,we elaborate the key technologies to realize weakly-coupled MDM transmission over conventional MMF,including mode characteristic in MMF and weakly-coupled mode multiplexer/ demultiplexer(MUX/DEMUX).We also present the upto-date experimental results for weakly-coupled MDM transmission over conventional OM3 MMF.We show that weakly-coupled MDM scheme is promising for high-speed optical interconnections and bandwidth upgrade of already-deployed MMF links. | Juhao LI Zhongying WU Dawei GE Jinglong ZHU Yu TIAN Yichi ZHANG Jinyi YU Zhengbin LI Zhangyuan CHEN Yongqi HE | 2019 | Frontiers of Optoelectronics2019，12，1： | 1 |
| 10 | Erratum to:Forecasts on CMB lensing observations with AliCPT-1显示文摘One of the authors regrets that there was an omission of affiliation in this published article[1].The affiliation information of author Yi-WenWu only included the institution name for the author,and it is advised to add the university as the author’s second affiliation,which is the 16th affiliation of this article. | Jinyi Liu Zeyang Sun Jiakang Han Julien Carron Jacques Delabrouille Siyu Li Yang Liu Jing Jin Shamik Ghosh Bin Yue Pengjie Zhang Chang Feng Zhi-Qi Huang Hao Liu Yi-Wen Wu Le Zhang Zi-Rui Zhang Wen Zhao Bin Hu Hong Li Xinmin Zhang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 0 |
| 11 | Molecular glues modulate protein functions by inducing protein aggregation:A promising therapeutic strategy of small molecules for disease treatment显示文摘Molecular glues can specifically induce aggregation between two or more proteins to modulate biological functions.In recent years,molecular glues have been widely used as protein degraders.In addition,however,molecular glues play a variety of vital roles,such as complex stabilization,interactome modulation and transporter inhibition,enabling challenging therapeutic targets to be druggable and offering an exciting novel approach for drug discovery.Since most molecular glues are identified serendipitously,exploration of their systematic discovery and rational design are important.In this review,representative examples of molecular glues with various physiological functions are divided into those mediating homo-dimerization,homo-polymerization and hetero-dimerization according to their aggregation modes,and we attempt to elucidate their mechanisms of action.In particular,we aim to highlight some biochemical techniques typically exploited within these representative studies and classify them in terms of three stages of molecular glue development:starting point,optimization and identification. | Hongyu Wu Hong Yao Chen He Yilin Jia Zheying Zhu Shengtao Xu Dahong Li Jinyi Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 0 |
| 12 | Observation of changes in the number of myocardial capillaries in rabbits after treatment of acute myocardial infarction by Tongxinluo superfine powder显示文摘OBJECTIVE: To investigate the effects of Tongxinluo superfine powder on cardiac function, infarct size and the number of myocardial capillaries in a rabbit model of acute myocardial infarction.METHODS: A total of 32 New Zealand white rabbits were randomly divided into four groups: sham operation group, model group, treatment group,and pre-treatment, the experiment of pre-treatment group was performed 6 weeks early than the treat) group,The four groups use a unified modeling technique. An acute myocardial infarction model was established through external application of70% ferric chloride on the coronary artery. After 7 d,electrocardiogram, ultrasonography of cardiac function, micro-computed tomography, pathology and other data were collected.RESULTS: In the treatment and pre-treatment groups, ejection fraction, left ventricular short axis shortening rate, left ventricular end-systolic diameter and cardiac output significantly improved, the number of capillaries significantly increased, and infarct size significantly decreased. In addition, the results suggest that the value of intra-ventricular pressure and the situation of electrocardiogram also changed to different degrees with the increasing of treatment of cycle.CONCLUSION: Tongxinluo superfine powder can protect the myocardium, improve the blood supply of the myocardium and reduce the degree of myocardial injury, during acute stage of myocardial infarction. | Wu Haotian Zhang Fengshun Liu Jinyi Li Xuezhao Guo Fei Wu Yiling | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 0 |
| 13 | Clinical Diagnosis and Treatment Recommendations for Immune Checkpoint Inhibitor-Associated Myocarditis显示文摘Immune checkpoint inhibitors(ICIs)are often beneficial in the treatment of multiple types of malignant tumors.However,ICI-associated myocarditis has introduced new clinical challenges.This report highlights the key clinical issues of ICI-associated myocarditis,such as risk factors,diagnosis and differential diagnosis,clinical classification and treatment,monitoring of outcomes,and restart of treatment.Additionally,practical guidance and suggestions for the diagnosis and treatment of ICI-associated myocarditis are proposed with reference to the relevant consensuses or guidelines and newly published evidence-based studies in China and other countries in combination with clinical experience of physicians from Shanghai,China. | Yan WANG Huiyong CHEN Jinyi LIN Jiahui CHEN Yuhong ZHOU Yingmei ZHANG Hongwei ZHANG Wei ZHU Jie HU Gang ZHAO Xiangdong YANG Shisuo DU Xiaoyu LI Guoming SHI Jie CUI Wei WU Jing LI Chi ZHANG Cong WANG Rongle LIU Zheng LI Chunhui WANG Leilei CHENG Junbo GE | 2022 | Clinical Cancer Bulletin2022，1，3： | 0 |
| 14 | Forecasts on CMB lensing observations with AliCPT-1显示文摘Ali CPT-1 is the first Chinese cosmic microwave background(CMB) experiment aiming for the high-precision measurement of CMB B-mode polarization. The telescope, currently under deployment in Tibet, will observe in two frequency bands centered at 90 and 150 GHz. We forecast the CMB lensing reconstruction, lensing-galaxy, and lensing-cosmic infrared background(CIB) cross-correlation signal-to-noise ratio(SNR) for Ali CPT-1. We consider two stages with different integrated observation times, namely “4 module*yr”(first stage) and “48 module*yr”(final stage). For lensing reconstruction, we use three different quadratic estimators, namely temperature-only, polarization-only and minimum-variance(MV) estimators, using curved sky geometry. We take into account the impacts of inhomogeneous hit counts and mean-field bias due to incomplete sky coverage.In the first stage, our results show that the 150 GHz channel can measure the lensing signals at 15σ significance with the MV estimator. In the final stage, the measurement significance will increase to 31σ. We also combine the two frequency data in the harmonic domain to optimize the SNR. Our results show that the coadding procedure can significantly reduce the reconstruction bias in the high multiple range. Owning to the high quality of the polarization data in the final stage of Ali CPT-1, the EB estimator will dominate the lensing reconstruction in this stage. We also estimate the SNR of cross-correlations between Ali CPT-1 CMB lensing and other tracers of the large scale structure of the universe. For its cross-correlation with Dark Energy Spectroscopic Instrument(DESI) galaxies/quasars, we report the cross-correlation SNR = 10-20 for the four redshift bins at 0.05 < z < 2.1. In the first stage, the total SNR is approximately 32. In the final stage, the lensing-galaxy cross-correlation can reach SNR = 52. For lensing-CIB cross-correlation, in the first stage, the cross-correlations between Ali CPT-1 lensing and Planck CIB 353, 545 and857 GHz channels are approximately SNR = 18, 19, and 23, respectively. In the final stage, the cross-correlations can reach SNR = 25, 33 and 42. Due to the strong correlations between frequency bands, the total lensing-CIB cross-correlations by combining the three frequencies in Planck CIBs are SNR = 23 and 43 for the Ali CPT-1 first and final stages, respectively. | Jinyi Liu Zeyang Sun Jiakang Han Julien Carron Jacques Delabrouille Siyu Li Yang Liu Jing Jin Shamik Ghosh Bin Yue Pengjie Zhang Chang Feng Zhi-Qi Huang Hao Liu Yi-Wen Wu Le Zhang Zi-Rui Zhang Wen Zhao Bin Hu Hong Li Xinmin Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，10： | 0 |
| 15 | Discovery of two broad absorption line quasars at redshift about 4.75 using the Lijiang 2.4 m telescope显示文摘The ultraviolet broad absorption lines have been seen in the spectra of quasars at high redshift, and are generally considered to be caused by outflows with velocities from thousands kilometers per second to one tenth of the speed of light. They provide crucial implications for the cosmological structures and physical evolutions related to the feedback of active galactic nuclei(AGNs).Recently, through a dedicated program of optically spectroscopic identifications of selected quasar candidates at redshift 5 by using the Lijiang 2.4 m telescope, we discovered two luminous broad absorption line quasars(BALQSOs) at redshift about 4.75. One of them may even have the potentially highest absorption Balnicity Index(BI) ever found to date, which is remarkably characterized by its deep, broad absorption lines and sub-relativistic outflows. Further physical properties, including the metal abundances,variabilities, evolutions of the supermassive black holes(SMBH) and accretion disks associated with the feedback process, can be investigated with multi-wavelength follow-up observations in the future. | YI WeiMin WU XueBing WANG FeiGe YANG JinYi YANG Qian BAI JinMing | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，9： | 0 |
| 16 | Structural insights into the activation initiation of full-length mGlu1显示文摘Dear Editor,Glutamate is the main excitatory neurotransmitter in the human brain,and it exerts diverse responses through ionotropic glutamate receptors(iGluRs)and metabotropic glutamate receptors(mGluRs)(Nakanishi and Masu,1994).mGluRs are members of the C family of GPCRs,and are divided into three groups based on G protein coupling,sequence homology,and ligand selectivity(Stansley and Conn,2019).mGlu1 and mGlu5 belong to group I and predominantly couple to Gq/11. | Jinyi Zhang Lu Qu Lijie Wu Xiaomeng Tang Feng Luo Weixiu Xu Yueming Xu Zhi-Jie Liu Tian Hua | 2021 | Protein & Cell2021，12，8： | 0 |
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