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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Combined Pollution and Pollution Index of Heavy Metals in Red Soil显示文摘A field experiment was conducted to study the effects of Pb, Cd, Cu, Zn and As coexisting in red soilon growth of rice (Oryza sativa L.), mung bean (Vigna rabiata (Linn.) Wilczek), alfalfa (Medicago sativaL.), slash pine (Pinus elliottii Engelm.) and aspen (Populus L.). Results showed that rice, mung bean andalfalfa were significantly innuenced by combined pollution of the heavy metals. The contents of Pb, cd andAs in rice grains greatly exceeded the National Standards for Food Hygiene of China. Heavy metals at ahigh concentration seriously retarded growth of mung bean and alfalfa, but not so obviously with slash pineand aspen. The composite index is suggested for evaluating the relativity of combined pollution witll heavymetals in soil. | CHEN HUAIMAN ZHENG CHUNRONG WANG SHENQIANG and TU CONG(Institute of Soil Science, the Chinese Academy of Sciences, P.O. Box 821, Naroing 210008 China) | 2000 | Pedosphere2000，10，2： | 56 |
| 3 | Photocatalytic properties of BiOX (X = Cl, Br, and Ⅰ)显示文摘A novel series of photocatalysts,bismuth oxyhalide(BiOX,X =Cl,Br,and I),were synthesized by a hydrolysis method.The powder sam- pies were characterized by the use of X-ray diffraction(XRD),scanning electron microscope,and UV-Vis spectrophotometer.The XRD pattern showed that all the BiOX were well crystallized in the tetragonal structure.The band gaps of the sheet-shaped compounds BiOX(X= Cl,Br,and I)were 3.44,2.76,and 1.85 eV,respectively.BiOBr showed the highest photocatalytic activity in degrading rhodamine B(RhB) and evolving O_2 for its proper valence band(VB).BiOI has no photocatalytic activity.BiOCl showed the highest activity in decomposing isopropanol because of electron-hole pair separation through trapping electrons by oxygen vacancies. | AN Huizhong DU Yi WANG Tianmin WANG Cong HAO Weichang ZHANG Junying | 2008 | Rare Metals2008，27，3： | 43 |
| 4 | Optimization of phenol degradation by Candida tropicalis Z-04 using Plackett-Burman design and response surface methodology显示文摘Statistical experimental designs were used to optimize the process of phenol degradation by Candida tropicalis Z-04,isolated from phenol-degrading aerobic granules.The most important factors influencing phenol degradation (p<0.05),as identified by a two-level Plackett-Burman design with 11 variables,were yeast extract,phenol,inoculum size,and temperature.Steepest ascent method was undertaken to determine the optimal regions of these four significant factors.Central composite design (CCD) and response surface analysis were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum phenol degradation.The analysis results indicated that interactions between yeast extract and temperature,phenol and temperature,inoculum size and temperature affected the response variable (phenol degradation) significantly.The predicted results showed that the maximum removal efficiency of phenol (99.10%) could be obtained under the optimum conditions of yeast extract 0.41 g/L,phenol 1.03 g/L,inoculum size 1.43% (V/V) and temperature 30.04°C.These predicted values were further verified by validation experiments.The excellent correlation between predicted and experimental values confirmed the validity and practicability of this statistical optimum strategy.This study indicated the excellent ability of C.tropicalis Z-04 in degrading high-strength phenol.Optimal conditions obtained in this experiment laid a solid foundation for further use of this microorganism in the treatment of highstrength phenol effluents. | Jiangya Zhou Xiaojuan Yu Cong Ding Zhiping Wang Qianqian Zhou Hao Pao Weimin Ca | 2011 | Journal of Environmental Sciences2011，23，1： | 48 |
| 5 | CFD SIMULATION OF 3D FLOW IN LARGE-BORE AXIAL-FLOW PUMP WITH HALF-ELBOW SUCTION SUMP显示文摘Numerical simulations of 3D turbulent flow in a large-bore axial-flow pump coupled with half-elbow suction sump were performed by using CFD approach. The numerical model and velocity and pressure distributions in entire flow passage were presented. The obvious backflow in half-elbow suction sump and strong flow nonuniformity at suction sump outlet were observed, whereas these phenomena were not observed in existing studies performed for a separate suction sump by either experimental or numerical approach. This result indicates that the interaction between half-elbow suction sump and impeller has significant effect on the flow distribution in the pump passage. The change of pump efficiency caused by the interaction was discussed. | WANG Fu-jun LI Yao-jun CONG Guo-hui WANG Wen-e WANG Hai-song | 2006 | Journal of Hydrodynamics2006，18，2： | 36 |
| 6 | Mechanical behavior of coal under different mining rates:A case study from laboratory experiments to field testing显示文摘During the development of hot dry rock,the research on thermal fatigue damage caused by thermal shock of cold and heat cycles is the basis that ensures the long-term utilization of geothermal resources,but there are not enough relevant studies at present.Based on this,the thermal damage tests of granite at different temperatures(250,350,450°C)and quenching cycles(1,5,10,15 cycles)were carried out.Preliminary reveals the damage mechanism and heat transfer law of the quenching cycle effect on hot dry rock.The results show that with the increase of temperature and cycles,the uneven thermal expansion of minerals and the thermal shock caused by quenching promote the crack development of granite,resulting in the decrease of P-wave velocity,thermal conductivity and uniaxial compressive strength of granite.Meanwhile,the COMSOL was used to simulate the heat transfer of hot dry rock under different heat treatment conditions.It concluded that the increase in the number of quenching cycles reduced the heat transfer capacity of the granite,especially more than 10 quenching cycles,which also reflects that the thermal fatigue damage leads to a longer time for the temperature recovery of the hot dry rock mass.In addition,the three-dimensional nonlinear fitting relationship among thermal conductivity,temperature and cycle number was established for the first time,which can better reveal the change rule of thermal conductivity after quenching thermal fatigue effect of hot dry rock.The research results provide theoretical support for hot dry rock reservoir reconstruction and production efficiency evaluation. | Mingzhong Gao Jing Xie Yanan Gao Wenyong Wang Cong Li Bengao Yang Junjun Liu Heping Xie | 2021 | International Journal of Mining Science and Technology2021，31，5： | 39 |
| 7 | Hydrophobicity mechanism of non-smooth pattern on surface of butterfly wing显示文摘Twenty-nine species (24 genera, 6 families) of butterflies typical and common in northeast China were selected to make qualitative and quantitative studies on the pattern, hydrophobicity and hydrophobicity mechanism by means of scanning electron microscopy and contact angle measuring system. The scale surface is composed of submicro-class vertical gibbosities and horizontal links. The distance of scale is 48—91 μm, length 65—150 μm, and width 35—70 μm. The distance of submicro-class vertical gib-bosities on scale is 1.06—2.74 μm, height 200—900 nm, and width 200—840 nm. The better hydropho-bicity on the surface of butterfly wing (static contact angle 136.3°—156.6°) is contributed to the co-effects of micro-class scale and submicro-class vertical gibbosities on the wing surface. The Cassie equation was revised, and new mathematical models and equations were established. | FANG Yan SUN Gang WANG TongQing CONG Qian REN LuQuan | 2007 | Chinese Science Bulletin2007，52，5： | 31 |
| 8 | Electro-acupuncture regulates the cholinergic anti-inflammatory pathway in a rat model of chronic obstructive pulmonary disease显示文摘Objective: Acupuncture has a definite therapeutic effect on chronic obstructive pulmonary disease(COPD), and the cholinergic anti-inflammatory pathway(CAP) has been shown to be involved in regulation of inflammation. In this study, we investigated whether electro-acupuncture(EA) affects the CAP in COPD.Methods: Sprague-Dawley rats were induced into COPD through exposure to cigarette smoke combined with lipopolysaccharide. EA treatment was applied at Zusanli(ST36) and Feishu(BL13) points for 30 min/d for 7 d. Seventy-two rats were randomly divided into six study groups, including normal, normal + EA,normal + α-bungarotoxin(a-BGT)(the antagonist of the nicotinic acetylcholine receptor a7 subunit(a7 nAChR)) + EA, COPD, COPD + EA, and COPD + α-BGT + EA. Lung function, pathology and vagus nerve discharge were tested. The levels of acetylcholine(ACh), acetylcholinesterase(AChE), interleukin-6(IL-6) and tumor necrosis factor-a(TNF-a) in bronchoalveolar lavage fluid(BALF) and lung tissue were measured by enzyme-linked immunosorbent assay. The mRNA and protein expression and immunoreactivity of a7 nAChR and its postreceptor inflammation signal pathway, including janus kinase 2(JAK2), signal transducers and activators of transcription 3(STAT3), nuclear factor-KB(NF-κB), were observed by quantitative reverse transcription-polymerase chain reaction, Western blot and immunohistochemistry.Results: Compared with normal rats, there were a significant decline in lung function and discharge of the vagus nerve(P < 0.01), a marked sign of lung inflammation and an increase of ACh, AChE, IL-6 and TNF-a level in BALF or lung tissue(P < 0.05, P < 0.01) and higher expression of a7 nAChR, JAK2, STAT3 and NF-κB(P<0.05, P<0.01) in the COPD rats. In rats receiving EA, the lung function and vagal discharge were enhanced(P < 0.01), lung inflammation was improved and the levels of ACh, AChE, IL-6 and TNF-a were decreased(P<0.01). Further, the expression of a7 nAChR, JAK2, STAT3 and NF-κB was downregulated(P < 0.05, P < 0.01). However, the above effects of EA were blocked in rats injected with α-BGT(P < 0.01).Conclusion: EA treatment can reduce the lung inflammatory response and improve lung function in COPD, which may be related to its involvement in the regulation of CAP. | Xin-fang Zhang Shui-ying Xiang Wen-ye Geng Wen-juan Cong Jing Lu Chuan-wei Jiang Kun Wang Zi-bing Liu | 2018 | Journal of Integrative Medicine2018，16，6： | 32 |
| 9 | Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion显示文摘 | Sheng-Long Ye Xun-Ke Gu Li-Yuan Tao Ji-Mei Cong Yong-Qing Wang | 2017 | Chinese Medical Journal2017，，12： | 30 |
| 10 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 11 | Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats显示文摘AIM To explore the exact interaction between Notch and transforming growth factor(TGF)-β signaling in liver fibrosis. METHODS We established a rat model of liver fibrosis induced by concanavalin A. Peripheral blood mononuclear cells(PBMCs) were isolated from the modeled rats, and cultured with γ-secretase inhibitor DAPT and TGF-β inhibitor for 24 h. The m RNA levels of Notch and TGF-β signaling were detected by quantitative real-time polymerase chain reaction. Expression of Notch and TGF-β proteins was analyzed by western blotting.RESULTS Compared to control rats, Notch and TGF-β signaling was activated in PBMCs of model rats. Administration of DAPT and TGF-β inhibitor suppressed Notch and TGF-β signal transducer in PBMCs of model rats. DAPT reduced m RNA and protein expression of TGF-β signaling, such as TGF-β1 and Smad3. TGF-β inhibitor also downregulated Notch1, Hes1 and Hes5, and m RNA and protein expression of the Notch signaling pathway.CONCLUSION Notch and TGF-β signaling play a role in liver fibrosis. TGF-β signaling upregulates Notch signaling, which promotes TGF-β signaling. | Yi Wang Ruo-Wu Shen Bing Han Zhen Li Le Xiong Feng-Yu Zhang Bei-Bei Cong Bei Zhang | 2017 | World Journal of Gastroenterology2017，23，13： | 25 |
| 12 | Hepatitis B virus infects hepatic stellate cells and affects their proliferation and expression of collagen type I显示文摘 | LIU Xuan ZHU Sheng-tao YOU Hong CONG Min LIU Tian-hui WANG Bao-en JIA Ji-dong | 2009 | Chinese Medical Journal2009，，12： | 22 |
| 13 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 14 | Microstructural characteristics and aging response of Zn-containing Al-Mg-Si-Cu alloy显示文摘Al-Mg-Si-Cu alloys with and without Zn addition were fabricated by conventional ingot metallurgy method. The microstructures and properties were investigated using optical microscopy (OM), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), tensile test, hardness test, and electrical conductivity measurement. It is found that the as-cast Al-Mg-Si-Cu-Zn alloy is composed of coarse dendritic grains, long needle-like β/δ-AlFeSi white intermetallics, and Chinese script-like α-AlFeSi compounds. During high temperature homogenization treatment, only harmful needle-like β-AlFeSi phase undergoes fragmentation and spheroidizing at its tips, and the destructive needle-like δ-phase does not show any morphological and size changes. Phase transitions from β-AlFeSi to α-AlFeSi and from δ-AlFeSi to β-AlFeSi are also not found. Zn addition improves the aging hardening response during the former aging stage and postpones the peak-aged hardness to a long aging time. In T4 condition, Zn addition does not obviously increase the yield strength and decrease the elongation, but it markedly improves paint-bake hardening response during paint-bake cycle. The addition of 0.5wt% Zn can lead to an increment of 99 MPa in yield strength compared with the value of 69 MPa for the alloy without Zn after paint-bake cycle. | Yuan-hua Cai Cong Wang Ji-shan Zhang | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，7： | 23 |
| 15 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 16 | The Dabie-Sulu UHP rocks belt:review and prospect显示文摘The new results in the studies of the Dabie-Sulu UHP rocks belt during the past 5 years were summarized and discussed. The discussion included the following key points: ( i ) UHP eclogite has two kinds of country rocks, with one being UHP eclogite facies rocks and the other non-UHP granitic gneiss. ( ii ) The FeTiO3 in olivine indicated exsolution at depth of 300-400 km. However, the key point is to prove the peridotite in which the FeTiO3 in olivine was found once had been subducted down that depth. (iii ) UHP hydrous phase evidenced that fluids had taken part in the UHP metamorphism, while the meter-scale inhomogeneous distribution of O-, C-isotope indicated no fluid activity in the deep subduction environment. (iv ) No agreement has been arrived on many problems related to the tectonic background of the UHP rocks, such as 'whether or not ophiolitic rocks there exist now?', 'when did UHP metamorphism proceed?', 'what is the subdution polarity?', etc. ( V ) How did the UHP rocks exhume from mantle | Bolin Cong Qingchen Wang | 1999 | Chinese Science Bulletin1999，44，12： | 21 |
| 17 | Coordinated flight control of miniature fixed-wing UAV swarms: methods and experiments显示文摘In this paper,we present our recent advances in both theoretical methods and field experiments for the coordinated control of miniature fixed-wing unmanned aerial vehicle(UAV)swarms.We propose a multi-layered group-based architecture,which is modularized,mission-oriented,and can implement large-scale swarms.To accomplish the desired coordinated formation flight,we present a novel distributed coordinated-control scheme comprising a consensus-based circling rendezvous,a coordinated path-following control for the leader UAVs,and a leader-follower coordinated control for the follower UAVs.The current framework embeds a formation pattern reconfiguration technique.Moreover,we discuss two security solutions(inter-UAV collision avoidance and obstacle avoidance)in the swarm flight problem.The effectiveness of the proposed coordinated control methods was demonstrated in field experiments by deploying up to 21 fixed-wing UAVs. | Xiangke WANG Lincheng SHEN Zhihong LIU Shulong ZHAO Yirui CONG Zhongkui LI Shengde JIA Hao CHEN Yangguan YU Yuan CHANG Yajing WANG | 2019 | Science China(Information Sciences)2019，62，11： | 21 |
| 18 | Genetic analysis and gene mapping of a dominant presenescing leaf gene PSL3 in rice (Oryza sativa L.)显示文摘Leaf senescence as an active process is essential for plant survival and reproduction.However,premature senility is harmful to agricultural production.In this study,a rice mutant,named as psl3 (presescing leaf 3) isolated from EMS-treated Jinhui 10,displays obvious premature senility features both in morphological and physiological level.Genetic analysis showed that mutant trait was controlled by a single dominant gene (PSL3),which was located on rice chromosome 7 between SSR marker c7sr1 and InDel marker ID10 with an interval of 53.5 kb.The result may be useful for the isolation of the PSL3 gene. | FANG LiKui LI YunFeng GONG XiaoPing SANG XianChun LING YingHua WANG XiaoWen CONG YunFei HE GuangHua | 2010 | Chinese Science Bulletin2010，55，23： | 20 |
| 19 | Strain-induced direct-indirect bandgap transition and phonon modulation in monolayer WS2显示文摘 | Yanlong Wang Chunxiao Cong Weihuang Yang Jingzhi Shang Namphung Peimyoo Yu Chen Junyong Kang Jianpu Wang Wei Huang Ting Yu | 2015 | Nano Research2015，8，8： | 20 |
| 20 | Cold adaptation in pigs depends on UCP3 in beige adipocytes显示文摘 | Jun Lin Chunwei Cao Cong Tao Rongcai Ye Meng Dong Qiantao Zheng Chao Wang Xiaoxiao Jiang Guosong Qin Changguo Yan Kui Li John R. Speakman Yanfang Wang Wanzhu Jin Jianguo Zhao | 2017 | Journal of Molecular Cell Biology2017，9，5： | 20 |
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