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60篇 您的检索式:作者名="Haibo Shen"
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1Preliminary assessment of the navigation and positioning performance of BeiDou regional navigation satellite system显示文摘BeiDou regional navigation satellite system(BDS)also called BeiDou-2 has been in full operation since December 27,2012.It consists of 14 satellites,including 5 satellites in Geostationary Orbit(GEO),5 satellites in Inclined Geosynchronous Orbit(IGSO),and 4 satellites in Medium Earth Orbit(MEO).In this paper,its basic navigation and positioning performance are evaluated preliminarily by the real data collected in Beijing,including satellite visibility,Position Dilution of Precision(PDOP)value,the precision of code and carrier phase measurements,the accuracy of single point positioning and differential positioning and ambiguity resolution(AR)performance,which are also compared with those of GPS.It is shown that the precision of BDS code and carrier phase measurements are about 33 cm and 2 mm,respectively,which are comparable to those of GPS,and the accuracy of BDS single point positioning has satisfied the design requirement.The real-time kinematic positioning is also feasible by BDS alone in the opening condition,since its fixed rate and reliability of single-epoch dual-frequency AR is comparable to those of GPS.The accuracy of BDS carrier phase differential positioning is better than 1 cm for a very short baseline of 4.2 m and 3 cm for a short baseline of 8.2 km,which is on the same level with that of GPS.For the combined BDS and GPS,the fixed rate and reliability of single-epoch AR and the positioning accuracy are improved significantly.The accuracy of BDS/GPS carrier phase differential positioning is about 35 and 20%better than that of GPS for two short baseline tests in this study.The accuracy of BDS code differential positioning is better than 2.5 m.However it is worse than that of GPS,which may result from large code multipath errors of BDS GEO satellite measurements.YANG YuanXi LI JinLong WANG AiBing XU JunYi HE HaiBo GUO HaiRong SHEN JunFei DAI Xian 2014Science China Earth Sciences2014,57,1:125
2Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui 2017Cell Research2017,27,6:28
3Internet of Vehicles in Big Data Era显示文摘As the rapid development of automotive telematics,modern vehicles are expected to be connected through heterogeneous radio access technologies and are able to exchange massive information with their surrounding environment. By significantly expanding the network scale and conducting both real-time and long-term information processing, the traditional Vehicular AdHoc Networks(VANETs) are evolving to the Internet of Vehicles(Io V), which promises efficient and intelligent prospect for the future transportation system. On the other hand, vehicles are not only consuming but also generating a huge amount and enormous types of data, which is referred to as Big Data. In this article, we first investigate the relationship between Io V and big data in vehicular environment, mainly on how Io V supports the transmission, storage, computing of the big data, and how Io V benefits from big data in terms of Io V characterization,performance evaluation and big data assisted communication protocol design. We then investigate the application of Io V big data in autonomous vehicles. Finally, the emerging issues of the big data enabled Io V are discussed.Wenchao Xu Haibo Zhou Nan Cheng Feng Lyu Weisen Shi Jiayin Chen Xuemin (Sherman) Shen 2018IEEE/CAA Journal of Automatica Sinica2018,5,1:19
4Cooperative Vehicular Content Distribution in Edge Computing Assisted 5G-VANET显示文摘By leveraging the 5G enabled vehicular ad hoc network(5G-VANET), it is widely recognized that connected vehicles have the potentials to improve road safety, transportation intelligence and provide in-vehicle entertainment experience. However, many enabling applications in 5G-VANET rely on the efficient content sharing among mobile vehicles, which is a very challenging issue due to the extremely large data volume, rapid topology change, and unbalanced traffic. In this paper, we investigate content prefetching and distribution in 5G-VANET. We first introduce an edge computing based hierarchical architecture for efficient distribution of large-volume vehicular data. We then propose a multi-place multi-factor prefetching scheme to meet the rapid topology change and unbalanced traffic. The content requests of vehicles can be served by neighbors, which can improve the sharing efficiency and alleviate the burden of networks. Furthermore, we use a graph theory based approach to solve the content distribution by transforming it into a maximum weighted independent set problem. Finally, the proposed scheme is evaluated with a greedy transmission strategy to demonstrate its efficiency.Guiyang Luo Quan Yuan Haibo Zhou Nan Cheng Zhihan Liu Fangchun Yang Xuemin (Sherman) Shen 2018China Communications2018,15,7:13
5Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers.Rui Chen Shancheng Ren Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun 2014Asian Journal of Urology2014,1,1:13
6Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world.Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao 2022Acta Pharmaceutica Sinica B2022,12,12:12
7A Modified Ant Colony Optimization Algorithm for Tumor Marker Gene Selection显示文摘Microarray data are often extremely asymmetric in dimensionality,such as thousands or even tens of thousands of genes but only a few hundreds of samples or less.Such extreme asymmetry between the dimensionality of genes and samples can lead to inaccurate diagnosis of disease in clinic.Therefore,it has been shown that selecting a small set of marker genes can lead to improved classification accuracy.In this paper,a simple modified ant colony optimization (ACO) algorithm is proposed to select tumor-related marker genes,and support vector machine (SVM) is used as classifier to evaluate the performance of the extracted gene subset.Experimental results on several benchmark tumor microarray datasets showed that the proposed approach produces better recognition with fewer marker genes than many other methods.It has been demonstrated that the modified ACO is a useful tool for selecting marker genes and mining high dimension data.Hualong Yu Guochang Gu Haibo Liu Jing Shen Jing Zhao 2009Genomics, Proteomics & Bioinformatics2009,7,4:6
86G service-oriented space-air-ground integrated network: A survey显示文摘As an indispensable component of the emerging 6G networks,Space-Air-Ground Inte-grated Networks(SAGINs)are envisioned to provide ubiquitous network connectivity and services by integrating satellite networks,aerial networks,and terrestrial networks.In 6G SAGINs,a wide variety of network services with the features of diverse requirements,complex mobility,and multi-dimensional resources will pose great challenges to service provisioning,which urges the develop-ment of service-oriented SAGINs.In this paper,we conduct a comprehensive review of 6G SAGINs from a new perspective of service-oriented network.First,we present the requirements of service-oriented networks,and then propose a service-oriented SAGINs management architec-ture.Two categories of critical technologies are presented and discussed,i.e.,heterogeneous resource orchestration technologies and the cloud-edge synergy technologies,which facilitate the interoperability of different network segments and cooperatively orchestrate heterogeneous resources across different domains,according to the service features and requirements.In addition,the potential future research directions are also presented and discussed.Nan CHENG Jingchao HE Zhisheng YIN Conghao ZHOU Huaqing WU Feng LYU Haibo ZHOU Xuemin SHEN 2022Chinese Journal of Aeronautics2022,35,9:6
9Virtual reality-based rehabilitation in patients following total knee arthroplasty:a systematic review and meta-analysis of randomized controlled trials显示文摘Background:Physical therapy is regarded as an essential aspect in achieving optimal outcomes following total knee arthroplasty(TKA).The coronavirus disease 2019(COVID-19)pandemic has made face-to-face rehabilitation inaccessible.Virtual reality(VR)is increasingly regarded as a potentially effective option for offering health care interventions.This systematic review and meta-analysis investigate VR-based rehabilitation's effectiveness on outcomes following TKA.Methods:From inception to May 22,2021,PubMed/Medline,Embase,Web of Science,the Cochrane Central Register of Controlled Trials,Scopus,PsycINFO,Physiotherapy Evidence Database,China National Knowledge Infrastructure,and Wanfang were comprehensively searched to identify randomized controlled trials(RCTs)evaluating the effect of VR-based rehabilitation on patients following TKA according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the Cochrane Handbook for Systematic Reviews of Interventions.Results:Eight studies were included in the systematic review,and seven studies were included in the meta-analysis.VR-based rehabilitation significantly improved visual analog scale(VAS)scores within 1 month(standardized mean difference[SMD]:−0.44;95%confidence interval[CI]:−0.79 to−0.08,P=0.02),the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)within 1 month(SMD:−0.71;95%CI:−1.03 to−0.40,P<0.01),and the Hospital for Special Surgery Knee Score(HSS)within 1 month and between 2 months and 3 months(MD:7.62;95%CI:5.77 to 9.47,P<0.01;MD:10.15;95%CI:8.03 to 12.27,P<0.01;respectively)following TKA compared to conventional rehabilitation.No significant difference was found in terms of the Timed Up and Go(TUG)test.Conclusions:VR-based rehabilitation improved pain and function but not postural control following TKA compared to conventional rehabilitation.More high-quality RCTs are needed to prove the advantage of VR-based rehabilitation.As the COVID-19 pandemic continues,it is necessary to promote this rehabilitation model.Linbo Peng Yi Zeng Yuangang Wu Haibo Si Bin Shen 2022Chinese Medical Journal2022,,2:5
10Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics显示文摘Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy.Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo Cheng Xianjia Qi Yuxian Shen Qiang Xu Hongqi Chen Dijun Chen Yang Sun 2022Acta Pharmaceutica Sinica B2022,12,1:5
11Effects of different biochars on antibiotic resistance genes during swine manure thermophilic composting显示文摘Elimination of antibiotic resistance genes(ARGs)in animal manure from concentrated animal feeding operations by thermophilic composting has drawn increasing attention.This study investigated the effects of sawdust biochar,corn stover biochar and peanut hull biochar with three spiked levels on ARGs in swine manure during thermophilic composting.Thirteen ARGs corresponding to four classes of antibiotics(tetracyclines,sulfonamides,macrolides and quinolones)were determined in the composting piles.Results indicated that the ten tested composting groups became fully mature after 30-day thermophilic composting process.tetM,tetO and ermB were reduced in all tested groups;tetC and tetG,tetX,sul1,sul2,ermF,qnrD and aac(6’)-Ib were mostly reduced under low level biochar addition but increased under higher level biochar addition;gyrA increased under medium biochar addition and reduced in other groups;oqxB remained comparatively stable throughout the composting process.The addition levels of spiked biochar are more important than types of spiked biochar on the removal of ARGs in the composting pile.The average removal rates of ARGs in the control group,low,medium and high level biochar addition groups were 0.24 logs,0.52-0.72 logs,-0.52-0.18 logs and-0.19-0.21 logs,respectively.In summary,low level biochar addition could enhance the elimination of studied ARGs in swine manure during the composting process,while medium level biochar addition to the composting piles would increase the risk of ARGs’propagation.Jian Wang Bin Sui Yujun Shen Haibo Meng Lixin Zhao Haibin Zhou Ran Li Jingtao Ding Hongsheng Cheng Xi Zhang 2018International Journal of Agricultural and Biological Engineering2018,11,6:5
12High electrocaloric effect in barium titanate-sodium niobate ceramics with core-shell grain assembly显示文摘Electrocaloric effect(ECE)is promising in realizing solid-state cooling as an alternative to the conventional refrigeration with environmentally harmful coolant and low efficiency.High ECE in lead-free ferroelectric ceramics is highly desirable for the EC cooling.In this work,different from the researches that tune the ECE by conventional compositional design or external stress engineering,we fabricated the(1-x)BaTiO_(3)-xNaNbO_(3)(BTO-xNN)lead-free ceramics with a core-shell grain structure arising from the inhomogeneous stoichiometry of element distribution,leading to the internal compressing stress in the grains.It is interesting that the phase transition behavior,including the phase transition temperature and the diffusion property,is regulated by the core-shell grain structure induced internal stress,which can be capitalized on for the favorable ECE.Cooperated with 0.02 NN,a high ECE,e.g.adiabatic temperature change(ΔT)of 3.6 K and isothermal entropy change(ΔS)of 4.5 J kg^(-1) K^(-1),is attained in the BTO ceramic.As the internal stress further increases with more NN,the BTO-0.06NN exhibits an extremely stable ECE with a variety rate below ±4% in a wide temperature range from 300 K to 360 K.This work provides a novel approach to explore pronounced ECE in lead-free ferroelectrics for eco-friendly refrigeration.Chao Zhang Quanpei Du Wenru Li Dong Su Meng Shen Xiaoshi Qian Bing Li Haibo Zhang Shenglin Jiang Guangzu Zhang 2020Journal of Materiomics2020,6,3:4
13Metagenome analysis reveals potential microbial functions in topsoil of wheat-maize rotation system with five-year application of fertilizers显示文摘Fertilization mode affects soil quality and ecological health.The effects of four fertilization regimens on lignocellulose content,readily degradable carbohydrate decomposition,and potential microbial functions in the topsoil of a wheat-maize rotation system between 2012 and 2017 were investigated.The fertilization regimens of control(control NFNB),high chemical fertilizer(HCF),high biochar plus low chemical fertilizer(HBLCF),and biochar-based fertilizer(BBF)were compared on soil fundamental properties,microbial structure,and potential function in soil carbohydrate degradation based on metagenome analysis.The diversity of carbohydrate-active enzyme genes in the topsoil microbial consortia in the four trials was primarily distributed within the ten ecologically most dominant phyla.Application of BBF was associated with the lowest decline in total nitrogen and P2O5(2012-2017:6.5%and 28.1%,respectively)and the most effective carbohydrate decomposition(2015-2017:67.0%for cellulose and 59.9%for readily degradable carbohydrate).Carbohydrate transport and metabolism accounted for 6.0%of reads assigned functional classification under the BBF regimen.These findings reveal the ecologically functional diversity of topsoil microorganisms and suggest BBF application as a promising strategy for sustainable agriculture and beneficial to soil health.Yujun Shen Lixin Zhao Haibo Meng Hongsheng Cheng Jingtao Ding Jiarui Wang Shanshan Dong Xi Zhang Liqiu Song Shengwei Zheng 2019International Journal of Agricultural and Biological Engineering2019,12,6:3
14Tuning parallel symbolic execution engine for better performance显示文摘Anil Kumar KARNA Jinbo DU Haihao SHEN Hao ZHONG Jiong GONG Haibo YU Xiangning MA: Jianjun ZHAO 2018Frontiers of Computer Science2018,12,1:3
15Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling显示文摘Dear Editor,Colorectal cancer(CRC)is one of the most frequent diseases with high mortality around the world.Conventional treatments of CRC remain unsatisfactory due to the increasing recurrence rate and adverse reactions including neutropenia,drug resistance,etc.Recently,autophagy has been shown to be involved in regulating cancer development and progression by regulating apoptosis through pro-apoptosis proteins including caspases,in addition to being a potential target for cancer therapeutic intervention.1 Trifolirhizin(Supplementary Fig.S1a)is a natural flavonoid glycosides isolated from Sophora flavescens as well as a bioactive constituent of Xian-Lian-Ke-Li,a commercial traditional Chinese medicine for the cancer prevention.Numerous evidence manifested that trifolirhizin inhibited proliferative activity in melanoma B16 cell,lung cancer H23 cell,human ovarian A2780 cell,and human gastric cancer cell MKN45.2 However,its pharmacological effect and mechanism on CRC remain elusive.Herein,we evaluated the effect of trifolirhizin on autophagy and apoptosis on CRC as well as its related mechanisms,in order to provide evidence to develop a potential agent with less adverse effect in treating CRC.Dongdong Sun Weiwei Tao Feng Zhang Weixing Shen Jiani Tan Liu Li Qinghai Meng Yugen Chen Ye Yang Haibo Cheng 2020Signal Transduction and Targeted Therapy2020,5,1:3
16Investigation and analysis of the linkage mechanism and whole process cost of livestock manure organic fertilizer显示文摘In recent years,the utilization of manure resources for livestock and poultry farming has attracted a widespread attention,and manure resources utilization models suitable for different regional characteristics have formed gradually.Among them,the production of organic fertilizer from animal manure is a vital utilization method.However,there are still some problems such as high production costs,difficult sales,and the unwillingness of farmers to use organic fertilizers which have affected the breeding cycle and the sustainability of manure treatment in livestock and poultry breeding.This article selected 371 organic fertilizer plants,related farms and farmers in China,focusing on the main links of the entire process of livestock manure-organic fertilizer-farm application,and studied the mode of animal manure collection by organic fertilizer plants.The costs of organic fertilizer production and farmland application were discussed.Moreover,suggestions were made for the promotion and implementation of large-scale organic fertilizers to make good utilization of manure resources in livestock and poultry farming.Shanshan Dong Bin Sui Yujun Shen Haibo Meng Lixin Zhao Jingtao Ding Haibin Zhou Xi Zhang Hongsheng Cheng Jian Wang Ran Li Liqiu Song Pengxiang Xu Ji Li 2020International Journal of Agricultural and Biological Engineering2020,13,2:2
17Applications and prospects of functional oligosaccharides in pig nutrition:A review显示文摘Oligosaccharides are low molecular weight carbohydrates between monosaccharides and poly-saccharides,which consist of 2 to 20 monosaccharides linked by glycosidic bonds.They have the effects of promoting growth,regulating immunity,improving the structure of intestinal flora,and are anti-inflammatory and antioxidant.With the comprehensive implementation of the antibiotic prohibition policy in China,oligosaccharides as new green feed additive have been paid more attention.Oligosac-charides can be divided into the following 2 categories according to their digestive characteristics:one is easy to be absorbed by the intestine,called common oligosaccharides,such as sucrose and maltose oligosaccharide;the other is difficult to be absorbed by the intestine and has special physiological functions,called functional oligosaccharides.The common functional oligosaccharides include mannan oligosaccharides(MOS),fructo-oligosaccharides(FOS),chitosan oligosaccharides(COS),xylo-oligosaccharides(XOS)and so on.In this paper,we review the types and sources of functional oligo-saccharides,their application in pig nutrition,and the factors limiting their efficacy in recent years.This review provides the theoretical basis for further research of functional oligosaccharides,and the future application of alternative antibiotics in pig industry.Nian Liu Haibo Shen Fan Zhang Xiang Liu Qinrui Xiao Qian Jiang Bie Tan Xiaokang Ma 2023Animal Nutrition2023,,2:2
18Cybertwin-Assisted Mode Selection in Ultra-Dense LEO Integrated Satellite-Terrestrial Network显示文摘Ultra-dense low earth orbit(LEO)integrated satellite-terrestrial network(ULISTN)has become an emerging paradigm to support massive access of Internet of things(IoT)in beyond fifth generation mobile networks(B5G).In ULISTN,there are two communication modes:cellular mode and satellite mode,where IoT users assessing terrestrial small base stations(TSBSs)and terrestrial-satellite terminals(TSTs)respectively.However,how to optimize the network performance and guarantee self-interests of the operator and IoT users in ULISTN is a challenging issue.In this paper,we propose a cybertwin-assisted joint mode selection and dynamic pricing(JMSDP)scheme for effective network management in ULISTN,where cybertwin serves as the intelligent agent.In JMSDP,the operator determines optimal access prices of TSBSs and TSTs,while each user selects the access mode according to access prices.Specifically,the operator conducts the Stackelberg game aiming at maximizing average throughput depending on the mode selection results of IoT users.Meanwhile,IoT users as followers adopt the evolutionary game to choose an access mode based on the access prices provided by the operator.Simulation results show that the proposed JMSDP can improve the average throughput and reduce the delay effectively,comparing with random access(RA)and maximum rate access.Xin Zhang Bo Qian Xiaohan Qin Ting Ma Jiachen Chen Haibo Zhou Xuemin(Sherman)Shen 2022Journal of Communications and Information Networks2022,7,4:1
19Energy-Efficient Beaconless Geographic Routing in Wireless Sensor Networks 显示文摘ZHANG Haibo HONG Shen 2010IEEE Transactions on Parallel and Distributed Systems2010,21,6:1
20Percutaneous nephroscopic with holmium laser and ultrasound lithotripsy for complicated renal calculi显示文摘Zhengqin Gu Jun Qi Haibo Shen Jianhe Liu Jianhua Chen 2010Lasers in Medical Science2010,,4:1
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