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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Hypoxia-inducible factor-lαand semaphorin4D genes involved with tumor-associated macrophage-induced metastatic behavior and clinical significance in colon cancer显示文摘 | Mu Linjun Wang Jinshen Chen Yuezhi Li Leping Guo Xiaobo Zheng Sheng Jing Changqing | 2014 | Chinese Medical Journal2014，，20： | 15 |
| 3 | Effect of acupotomy on nitric oxide synthase and beta-endorphin in third lumbar vertebrae transverse process syndrome model rats显示文摘OBJECTIVE: To explore the long-term effects and pain relief mechanism of acupotomy by observing changes in nitric oxide synthase(NOS) and beta-endorphin(β-EP) in the hypothalamus, spinal cord,and peripheral blood of rats with third lumbar vertebrae(L3) transverse process syndrome.METHODS:Twenty-eight SD rats were randomly assigned to normal, model, electroacupuncture(EA),and acupotomy group. The last three groups were put through an operation to emulate L3transverse process syndrome. Fourteen days after the simulation operation, EA and acupotomy treatments were applied to the respective groups. Fifty-six days afterthe simulation operation, biochemistry tests and enzyme-linked immunosorbent assay were used to measure NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood.RESULTS: Rats with the simulation operation showed significantly higher levels of NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood than those in the normal group. The EA and acupotomy groups had significantly lower levels of NOS and β-EP than those in the model group.There was no statistical difference between the EA and acupotomy groups.CONCLUSION: EA and acupotomy treatments significantly lowered NOS and β-EP levels in the hypothalamus, spinal cord, and peripheral blood and alleviated L3transverse process syndrome. | Changqing Guo Naigang Liu Xiaohong Li Hongmei Sun Bo Hu Jing Lu Yan Guo Chuxi Liang Hong Xu Haixia Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 15 |
| 4 | Discoloration mechanism,structures and recent applications of thermochromic materials via different methods:A review显示文摘Thermochromic material is a kind of smart material whose color will vary as the result of the phase transition caused by the temperature change. The characteristics of thermochromic materials are the memory functions to the temperature, having great potential applications in aerospace, military, anticounterfeiting technology, construction and other fields. In recent years, many kinds of thermochromic materials have been prepared by different methods and their discoloration mechanisms are various according to published literatures. In this paper, the classification, discoloration mechanism, preparation methods, application fields and development trend of thermochromic materials are reviewed. | Youliang Cheng Xiaoqiang Zhang Changqing Fang Jing Chen Zhen Wang | 2018 | Journal of Materials Science & Technology2018，34，12： | 12 |
| 5 | Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus(HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established. In this study, we evaluated the expression of HCMV pp65 antigen in brain sections from 26 patients with RE and 20 non-RE patients by immunohistochemistry and in situ hybridization, and assessed the associations between HCMV infection and clinical parameters.Elevated expression of HCMV pp65 protein and DNA was observed in 88.5%(23/26) and 69.2%(18/26) of RE cases, respectively. In the non-RE group, HCMV pp65 antigen was detected only in two cases(10%), both of which were negative for DNA staining. Additionally, the intensity of HCMV pp65 staining was correlated with a shorter duration of the prodromal stage, younger age of seizure onset, and more severe unilateral cortical atrophy. Elevated expression of HCMV pp65 was observed in RE brain tissue and was correlated with the clinical features of RE disease. In summary, our results suggested that HCMV infection may be involved in the occurrence and progression of RE disease. Thus, further studies are needed to determine whether early treatment with anti-HCMV antibodies could modulate the course of RE. | Yao Zhang Yisong Wang Sichang Chen Shuai Chen Yuguang Guan Changqing Liu Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，2： | 9 |
| 6 | Synthesis of fluorescent carbon quantum dots from aqua mesophase pitch and their photocatalytic degradation activity of organic dyes显示文摘A synthesis strategy of fluorescent carbon quantum dots(CQDs) with high quantum yield(QY) using aqua mesophase pitch(AMP) as the carbon source has been developed via the hydrothermal method in this study. The hydrothermal temperature and soaking time have important effects on the morphology and QY of CQDs. As-prepared CQDs at 120℃ holding for 24 h(CQDs-120-24) have the uniform size of about 2.8 nm, and the QY can reach 27.6%. The obtained CQDs are successfully modified with ammonia and thionyl chloride, respectively, and they exhibit an excellent photocatalytic performance on degrading rhodamine B(Rh B), methyl blue(MB) and indigo carmine(IC). Importantly, the degradation percentage of N-CQDs on Rh B under natural light for 4 h reaches 97% with the degradation rate constant of 0.02463 min^(-1) and it can maintain 93% after repetitively used 5 times. The results indicate that these as-prepared CQDs have the potential application in degrading organic dyes. | Youliang Cheng Mengsha Bai Jian Su Changqing Fang Hang Li Jing Chen Jieming Jiao | 2019 | Journal of Materials Science & Technology2019，35，8： | 6 |
| 7 | Correlation of Raw Materials and Waterborne Polyurethane Properties by Sequence Similarity Analysis显示文摘Anionomer-type waterborne polyurethane dispersions(PUDs) were obtained from poly(propylene glycol)(PPG), isophorone diisocyanate(IPDI) and dimethylolpropionic acid(DMPA) through a modi?ed prepolymer isocyanate process. Two series of polyurethanes were prepared(Groups A and B) and a new prediction model based on grey relational analysis is introduced to predict the impact order of raw materials on several properties, such as solids content, viscosity, acid number and electrolytic stability of polyurethanes. It is found that the model can successfully predict the impact of raw materials on the properties through the designed demonstration experiments. Furthermore, the results of the prediction model show that DMPA plays a key role in viscosity, partial acid values and electrolytic stability. | Xing Zhou Changqing Fang Jing Chen Shujuan Li Yan Li Wanqing Lei | 2016 | Journal of Materials Science & Technology2016，32，7： | 5 |
| 8 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 9 | Spatial-temporal Distribution Characteristics of Global Seismic Clusters and Associated Spatial Factors显示文摘Earthquakes exhibit clear clustering on the earth. It is important to explore the spatial-temporal characteristics of seismicity clusters and their spatial heterogeneity. We analyze effects of plate space, tectonic style, and their interaction on characteristic of cluster.Based on data of earthquakes not less than moment magnitude(M_w) 5.6 from 1960 to 2014, this study used the spatial-temporal scan method to identify earthquake clusters. The results indicate that seismic spatial-temporal clusters can be classified into two types based on duration: persistent clusters and burst clusters. Finally, we analysed the spatial heterogeneity of the two types. The main conclusions are as follows: 1) Ninety percent of the persistent clusters last for 22-38 yr and show a high clustering likelihood;ninety percent of the burst clusters last for 1-1.78 yr and show a high relative risk. 2) The persistent clusters are mainly distributed in interplate zones, especially along the western margin of the Pacific Ocean. The burst clusters are distributed in both intraplate and interplate zones, slightly concentrated in the India-Eurasia interaction zone. 3) For the persistent type, plate interaction plays an important role in the distribution of the clusters’ likelihood and relative risk. In addition, the tectonic style further enhances the spatial heterogeneity. 4) For the burst type,neither plate activity nor tectonic style has an obvious effect on the distribution of the clusters’ likelihood and relative risk. Nevertheless,interaction between these two spatial factors enhances the spatial heterogeneity, especially in terms of relative risk. | YANG Jing CHENG Changxiu SONG Changqing SHEN Shi ZHANG Ting NING Lixin | 2019 | Chinese Geographical Science2019，29，4： | 2 |
| 10 | High pressure effects on the crystal structure andelectric conductivity of perovskite like (Ca/Sr)_2CuO_2Cl_2 compounds显示文摘The crystal structure stability as well as electric conductance of (Sr/Ca)_2CuO_2Cl_2 compound with K_2NiF_4 structure was investigated up to 31 GPa using diamond anvil technique. It seems that (Sr/Ca)_2CuO_2Cl_2 is quite stable under pressure but with obvious anisotropic compressibility. The equation of state (EOS) obtained shows relative large bulk modulus. | LIU QingQing WANG FuRen LI FengYing CHEN LiangChen YU RiCheng JIN ChangQing LI YanChun LIU Jing | 2008 | Chinese Science Bulletin2008，53，18： | 2 |
| 11 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 12 | Structural stability and Raman scattering of CoPt and NiPt hollow nanospheres under high pressure显示文摘This paper reports that the high pressure in situ angle dispersive x-ray diffraction and Raman scattering studies on CoPt and NiPt hollow nanospheres are performed by means of a diamond anvil cell for generating external pressure at room temperature.The crystal structures of both the CoPt and NiP hollow nanospheres keep stable up to about 41 GPa.Moreover,it shows that the hollow nanospheres possess higher bulk moduli than their bulk counterparts by using the frst-principles density functional theory. | Xi Shen Qian Sun Jie Zhu Yuan Yao Jing Liu Changqing Jin Richeng Yu Rongming Wang | 2013 | Progress in Natural Science:Materials International2013，23，4： | 1 |
| 13 | Particle acceleration on the background of the Kerr–Taub–NUT spacetime显示文摘 | Changqing Liu Songbai Chen Chikun Ding Jiliang Jing | 2011 | Physics Letters B2011，，3： | 1 |
| 14 | RELOCATION ALGORITHM FOR NON-UNIFORM DISTRIBUTION IN MOBILE SENSOR NETWORK显示文摘Energy is the determinant factor for the survival of Mobile Sensor Networks(MSN).Based on the analysis of the energy distribution in this paper,a two-phase relocation algorithm is proposed based on the balance between the energy provision and energy consumption distribution.Our main objectives are to maximize the coverage percentage and to minimize the total distance of node movements.This algorithm is designed to meet the requirement of non-uniform distribution network applications,to extend the lifetime of MSN and to simplify the design of the routing protocol.In ad-dition,test results show the feasibility of our proposed relocation algorithm. | Pei Zhiqiang Xu Changqing Teng Jing | 2009 | Journal of Electronics(China)2009，26，2： | 1 |
| 15 | Multilayer sodium alginate beads with porous core containing chitosan based nanoparticles for oral delivery of anticancer drug显示文摘 | Jing Li Changqing Jiang Xuqian Lang Ming Kong Xiaojie Cheng Ya Liu Chao Feng Xiguang Chen | 2016 | International Journal of Biological Macromolecule2016，，： | 1 |
| 16 | Ginkgo Biloba Extract EGB761 Protects against Aging-Associated Diastolic Dysfunction in Cardiomyocytes of D-Galactose-Induced Aging Rat显示文摘 | Jing Liu Junhong Wang Xiangjian Chen Changqing Guo Yan Guo Hui Wang Ana Fortuno | 2012 | Oxidative Medicine and Cellular Longevity2012，，： | 1 |
| 17 | A technique of treating negative weights in WENO schemes 显示文摘 | SHI Jing HU Changqing SHU Chiwang | 2002 | J Comput Phys2002，175，1： | 1 |
| 18 | Intensive atorvastatin therapy attenuates the inflammatory responses in monocytes of patients with unstable angina undergoing pereutaneous coronary intervention via peroxisome prolifemtor- activated receptor γactivation显示文摘 | Jing Yang Changqing Liu Linxia Zhang | 2015 | Inflammation2015，38，4： | 1 |
| 19 | AF-hTERT-TK/GCV靶向端粒酶抗肝癌实验研究(英文)显示文摘Objective:The aim of this study was to observe the affection of targeted therapy to plasmid AF-pGL3-hTERT-TK in HCC cell line HepG2.Methods:We constructed therapeutic plasmid pGL3-hTERT-TK(containing suicide gene TK that promoted by promoter of hTERT) and was conjugated with AF-liposome(a protein that can combine with the receptor ASPGR on HCC cell surface).Then we transfected HCC cell line HepG2 and hepatic cell L02 with AF-pGL3-hTERT-TK,observed the effects of therapeutic plasmid AF-pGL3-hTERT-TK for HCC cell line growth and apoptosis in vitro by Flow cytometry and Tunnel method.Results:Our results showed that TK gene was 1100 bp in plasmid pGL3-hTERT-TK.Plasmid pGL3-hTERT-TK can effectively transfect HCC cell HepG2 and the transfection rate was 8.91%.By recognizing and combining effects of receptor protein ASPGR on HCC cell surface the therapeutic plasmid AF-pGL3-hTERT-TK could easily enter into HCC cell HepG2 and induce its apoptosis.The apoptosis rate was 85.87% while only 8.65% in L02 cell.Four days after AF-pGL3-hTERT-TK transfected HepG2 was intervention by ganciclovir(GCV),a lot of apoptotic bodies were found by Tunnel analysis,while little apoptotic body was found in hepatic cell L02.Conclusion:AF-pGL3-hTERT-TK can target to HCC cell line and induce it to apoptosis,almost has no influence on hepatic cell L02.AF-pGL3-hTERT-TK has the potential therapeutic effects for HCC. | Zhihua Deng Changqing Yang Guiqin Wang Suya Guo Yan Liu Jing Jia Jie zhao | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，7： | 1 |
| 20 | The RhHB1/RhLOX4 module affects the dehydration tolerance of rose flowers(Rosa hybrida)by fine-tuning jasmonic acid levels显示文摘Phytohormones are key factors in plant responsiveness to abiotic and biotic stresses,and maintaining hormone homeostasis is critically important during stress responses.Cut rose(Rosa hybrida)flowers experience dehydration stress during postharvest handling,and jasmonic acid(JA)levels change as a result of this stress.However,how JA is involved in dehydration tolerance remains unclear.We investigated the functions of the JA-and dehydration-induced RhHB1 gene,which encodes a homeodomain-leucine zipper Iγ-clade transcription factor,in rose flowers.Silencing RhHB1 decreased petal dehydration tolerance and resulted in a persistent increase in JA-Ile content and reduced dehydration tolerance.An elevated JA-Ile level had a detrimental effect on rose petal dehydration tolerance.RhHB1 was shown to lower the transient induction of JA-Ile accumulation in response to dehydration.In addition to transcriptomic data,we obtained evidence that RhHB1 suppresses the expression of the lipoxygenase 4(RhLOX4)gene by directly binding to its promoter both in vivo and in vitro.We propose that increased JA-Ile levels weaken the capacity for osmotic adjustment in petal cells,resulting in reduced dehydration tolerance.In conclusion,a JA feedback loop mediated by an RhHB1/RhLOX4 regulatory module provides dehydration tolerance by fine-tuning bioactive JA levels in dehydrated flowers. | Youwei Fan Jitao Liu Jing Zou Xiangyu Zhang Liwei Jiang Kun Liu Peitao Lü Junping Gao Changqing Zhang | 2020 | Horticulture Research2020，7，1： | 1 |
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