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| 1 | Towards an Esox lucius inspired multimodal robotic fish显示文摘In this paper, we further explore multimodal locomotion via an updated robotic fish model based on Esox lucius. Besides the improved actuation properties like higher torque servomotors and powerful electronics,the robotic fish has some innovative mechanical design to pursue diverse swimming modes and superior performance. Specifically, we introduced a ±50° yawing head joint that functions as the neck for enhancing turning ability. A pair of pectoral mechanisms with two DOFs per fin is constructed to achieve 3-D swimming and to enrich multiple pectoral motions. At the control level, an improved central pattern generator(CPG) model allowing for free adjustment of the phase relationship among outputs is employed to produce rhythmic signals of multimodal swimming. Extensive experiments were carried out to examine how characteristic parameters in CPGs including amplitude, frequency, and phase lag affect the swimming performance. As a result, the robotic fish successfully performed various locomotion actions such as forward swimming, backward swimming, turning, diving, surfacing, as well as three pectoral motions in the form of pitching, heaving, and heaving-pitching.We found that small phase lag between oscillating joints which means large propulsive body wave length and undulation width could lead to a faster swimming in body and/or caudal fin(BCF) locomotion. | WU ZhengXing YU JunZhi SU ZongShuai TAN Min LI ZhenLong | 2015 | Science China(Information Sciences)2015，58，5： | 11 |
| 2 | Geospatial Service Web:towards integrated cyberinfrastructure for GIScience显示文摘A geospatial cyberinfrastructure is needed to support advanced GIScience research and education activities.However,the heterogeneous and distributed nature of geospatial resources creates enormous obstacles for building a unified and interoperable geospatial cyberinfrastructure.In this paper,we propose the Geospatial Service Web(GSW)to underpin the development of a future geospatial cyberinfrastructure.The GSW excels over the traditional spatial data infrastructure by providing a highly intelligent geospatial middleware to integrate various geospatial resources through the Internet based on interoperable Web service technologies.The development of the GSW focuses on the establishment of a platform where data,information,and knowledge can be shared and exchanged in an interoperable manner.Theoretically,we describe the conceptual framework and research challenges for GSW,and then introduce our recent research toward building a GSW.A research agenda for building a GSW is also presented in the paper. | GONG Jianya WU Huayi ZHANG Tong GUI Zhipeng LI Zhenlong YOU Lan SHEN Shengyu ZHENG Jie GENG Jing QI Kunlun YANG Wenjing LI Zhenqiang YU Jingmin | 2012 | Geo-Spatial Information Science2012，15，2： | 5 |
| 3 | Spatiotemporal event detection: a review显示文摘The advancements of sensing technologies,including remote sensing,in situ sensing,social sensing,and health sensing,have tremendously improved our capability to observe and record natural and social phenomena,such as natural disasters,presidential elections,and infectious diseases.The observations have provided an unprecedented opportunity to better understand and respond to the spatiotemporal dynamics of the environment,urban settings,health and disease propagation,business decisions,and crisis and crime.Spatiotemporal event detection serves as a gateway to enable a better understanding by detecting events that represent the abnormal status of relevant phenomena.This paper reviews the literature for different sensing capabilities,spatiotemporal event extraction methods,and categories of applications for the detected events.The novelty of this review is to revisit the definition and requirements of event detection and to layout the overall workflow(from sensing and event extraction methods to the operations and decision-supporting processes based on the extracted events)as an agenda for future event detection research.Guidance is presented on the current challenges to this research agenda,and future directions are discussed for conducting spatiotemporal event detection in the era of big data,advanced sensing,and artificial intelligence. | Manzhu Yu Myra Bambacus Guido Cervone Keith Clarke Daniel Duffy Qunying Huang Jing Li Wenwen Li Zhenlong Li Qian Liu Bernd Resch Jingchao Yang Chaowei Yang | 2020 | International Journal of Digital Earth2020，13，12： | 2 |
| 4 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 5 | E2F-1-Mediated apoptosis as a target of cancer therapy 显示文摘 | Wu Zhenlong Yu Qiang | 2009 | Current Molecular Pharmacology2009，2，2： | 1 |
| 6 | Real-time identification of gut microbiota with aminopeptidase N using an activable NIR fluorescent probe显示文摘A NIR fluorescent probe(DDAA) derived from fluorophore DDAO with alanine as the recognition group was developed for sensing aminopeptidase N(APN) in gut microbiota.Using DDAA as the real-time guidance tool for the fluorescence imaging of intestinal microorganism,target bacteria and saccharomycete possessing active APN were identified successfully from human feces. | Lei Feng Zhenhao Tian Ming Zhang Xin He Xiangge Tian Zhenlong Yu Xiaochi Ma Chao Wang | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 7 | Antibacterial conductive self-healable supramolecular hydrogel dressing for infected motional wound healing显示文摘Wounds on stretchable parts of the human body cause prolonged suffering and involve more severe healing processes than wounds on stationary parts. However, they have received insufficient attention compared with other types of chronic wounds. In this study, a novel supramolecular gelatin(GT) hydrogel composed of GT-graft-aniline tetramer and quaternized chitosan was presented. The hydrogel was crosslinked by monoaldehyde β-cyclodextrin via host-guest interaction and dynamic Schiff base and was free from permanent covalent bonds, heavy metals, and oxidants. Given its dynamic feature, the hydrogel exhibited flexibility, self-healing, and tissue adhesiveness and well adapted to motion wounds. Moreover, the hydrogel was bioactive with conductivity, antioxidant property, hemostatic effect, antibacterial, and photothermal effect(the killing ratio for methicillinresistant Staphylococcus aureus(MRSA) was higher than 99.8% after 5 min of near-infrared irradiation) and exhibited ondemand removability. In the full-thickness MRSA-infected motional wound healing experiment, this novel hydrogel exhibited a significantly enhanced wound healing efficacy with a fast wound closure ratio(about 99.0% for 14 days), mild inflammatory response, high level of collagen deposition, and enhanced re-epithelialization by downregulating interleukin-6 and CD68 and upregulating vascular endothelial growth factor. The results indicated that this hydrogel has great potential in wound healing and skin tissue engineering and serves as an inspiration for the design of supramolecular biomaterials. | Rui Yu Zhenlong Li Guoying Pan Baolin Guo | 2022 | Science China Chemistry2022，65，11： | 0 |
| 8 | Discussion on construction methods and precautions of building water supply and drainage显示文摘As an important construction link in the construction project,the quality of the water supply and drainage directly affects the overall quality of the construction project.Because of the strong function of the water supply and drainage project,the construction quality is easily affected by the construction method.For this reason,construction enterprises should attach importance to the mastery of water supply and drainage construction methods.And further understand the relevant precautions of construction water supply and drainage construction,in order to achieve the purpose of improving the quality of water supply and drainage construction. | Guoliang Yu Fan Yang Li Li Zhenfeng Li Zhenlong Shi | 2018 | Smart Construction Research2018，2，1： | 0 |
| 9 | A practical strategy to develop isoform-selective near-infrared fluorescent probes for human cytochrome P450 enzymes显示文摘Currently,the development of selective fluorescent probes toward targeted enzymes is still a great challenge,due to the existence of numerous isoenzymes that share similar catalytic capacity.Herein,a double-filtering strategy was established to effectively develop isoenzyme-specific fluorescent probe(s)for cytochrome P450(CYP)which are key enzymes involving in metabolism of endogenous substances and drugs.In the first-stage of our filtering approach,near-infrared(NIR)fluorophores with alkoxyl group were prepared for the screening of CYP-activated fluorescent substrates using a CYPs-dependent incubation system.In the second stage of our filtering approach,these candidates were further screened using reverse protein-ligand docking to effectively determine CYP isoenzyme-specific probe(s).Using our double-filtering approach,probes S9 and S10 were successfully developed for the real-time and selective detection of CYP2C9 and CYP2J2,respectively,to facilitate high-throughput screening and assessment of CYP2C9-mediated clinical drug interaction risks and CYP2J2-associated disease diagnosis.These observations suggest that our strategy could be used to develop the isoform-specific probes for CYPs. | Lei Feng Xiangge Tian Dahong Yao Zhenlong Yu Xiaokui Huo Zhenhao Tian Jing Ning Jingnan Cui Tony D.James Xiaochi Ma | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 10 | Correction: Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal lcancergrowth显示文摘In the process of collating the raw data,the authors noticed an inadvertent mistake occurred in Fig.3b that needs to be corrected after online publication of the article.In Fig.3b,as a result of an error in the graphics panel arrangement process,the band of NEMO was repeatedly inserted asβ-actin by mistake.The correct band is shown as below and in the updated Fig.3b.The correction did not affect any of our results or discussion as present in the original publication.We regret any inconvenience this has caused. | Zhenlong Yu Jian Gao Xiaolei Zhang Yulin Peng Wenlong Wei Jianrong Xu Zhenwei Li Chao Wang Meirong Zhou Xiangge Tian Lei Feng Xiaokui Huo Min Liu Mingliang Ye De-an Guo Xiaochi Ma | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 11 | Characterization of a small-molecule inhibitor targeting NEMO/IKKβto suppress colorectal cancer growth显示文摘NEMO/IKKβcomplex is a central regulator of NF-κB signaling pathway,its dissociation has been considered to be an attractive therapeutic target.Herein,using a combined strategy of molecular pharmacological phenotyping,proteomics and bioinformatics analysis,Shikonin(SHK)is identified as a potential inhibitor of the IKKβ/NEMO complex.It destabilizes IKKβ/NEMO complex with IC_(50) of 174 nM,thereby significantly impairing the proliferation of colorectal cancer cells by suppressing the NF-κB pathway in vitro and in vivo.In addition,we also elucidated the potential target sites of SHK in the NEMO/IKKβcomplex.Our study provides some new insights for the development of potent small-molecule PPI inhibitors. | Zhenlong Yu Jian Gao Xiaolei Zhang Yulin Peng Wenlong Wei Jianrong Xu Zhenwei Li Chao Wang Meirong Zhou Xiangge Tian Lei Feng Xiaokui Huo Min Liu Mingliang Ye De-an Guo Xiaochi Ma | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 12 | Discussion on construction methods and precautions of building water supply and drainage显示文摘As an important construction link in the construction project, the quality of the water supply and drainage directly affects the overall quality of the construction project. Because of the strong function of the water supply and drainage project, the construction quality is easily affected by the construction method. For this reason, construction enterprises should attach importance to the mastery of water supply and drainage construction methods. And further understand the relevant precautions of construction water supply and drainage construction, in order to achieve the purpose of improving the quality of water supply and drainage construction. | Guoliang Yu Fan Yang Li Li Zhenfeng Li Zhenlong Shi | 2018 | Smart Construction Research2018，2，2： | 0 |
| 13 | Angioarchitecture and prognosis of pediatric intracranial pial arteriovenous fistula显示文摘Objective Pial arteriovenous fistulas(PAVFs)are rare and mostly observed in children.However,the overall angioarchitecture,clinical features,treatments and long-term prognosis for pediatric patients remain unclear.Methods Clinical data of consecutive 42 pediatric PAVFs were documented and analysed.According to the differences of age distribution and clinical features,they were split into a younger group(≤3 years old;20 cases)and an older group(3-14 years old;22 cases).Results Their mean age was 4.9±3.9 years,and the mean preoperative modified Rankin Scale(mRS)score was 1.64±1.57.Fourteen patients(33.3%)were asymptomatic,followed by epilepsy(21.4%),intracranial haemorrhage(16.7%),hydrocephalus(9.5%),developmental delay(7.1%),intermittent headache(7.1%)and congestive heart failure(4.8%).Annual bleeding rate and rebleeding rate before treatment reached 3.86%and 3.17%.Poor venous drainage including sinus dynamic obstruction(21 cases,50.0%)and sinus occlusion(17 cases,40.48%)were found with high frequency among these patients.Finally,33 cases were cured(78.57%),and 4 cases faced surgery-related complications(9.52%).During 24-140 months’follow-up,the mean mRS score reduced to 0.57±0.40.However,only 22 cases(52.38%)recovered to absolutely normal,and poor venous drainage was the risk factor for patients’incomplete recovery(p=0.028,Exp(B)=14.692,95%CI 1.346 to 160.392).Compared with the older group,younger group showed more chronic symptoms,more secondary pathological changes,more times treatment and worse prognosis(p=0.013,0.002,0.000 and 0.032,respectively).Conclusions Pediatric PAVF has different angioarchitectures,clinical features and prognoses in different age groups.Poor venous drainage is an important factor leading to poor prognosis,and it accounts for incomplete recovery in nearly half of patients. | Jingwei Li Zhenlong Ji Jiaxing Yu Jian Ren Fan Yang Lisong Bian Xinglong Zhi Guilin Li Hongqi Zhang | 2023 | Stroke & Vascular Neurology2023，8，4： | 0 |
| 14 | Hydroxyproline alleviates 4-hydroxy-2-nonenal-induced DNA damage and apoptosis in porcine intestinal epithelial cells显示文摘Oxidative stress has been confirmed in relation to intestinal mucosa damage and multiple bowel diseases.Hydroxyproline (Hyp) is an imino acid abundant in sow's milk. Compelling evidence has beengathered showing the potential antioxidative properties of Hyp. However, the role and mechanism ofHyp in porcine intestinal epithelial cells in response to oxidative stress remains unknown. In this study,small intestinal epithelial cell lines of piglets (IPEC-1) were used to evaluate the protective effects of Hypon 4-hydroxy-2-nonenal (4-HNE)-induced oxidative DNA damage and apoptosis. IPEC-1 pretreated with0.5 to 5 mmol/L Hyp were exposed to 4-HNE (40 mmol/L) in the presence or absence of Hyp. Thereafter,the cells were subjected to apoptosis detection by Hoechst staining, flow cytometry, and Western blot orDNA damage analysis by comet assay, immunofluorescence, and reverse-transcription quantitative PCR(RT-qPCR). Cell apoptosis and the upregulation of cleaved-caspase-3 induced by 4-HNE (40 mmol/L) wereinhibited by 5 mmol/L of Hyp. In addition, 5 mmol/L Hyp attenuated 4-HNE-induced reactive oxygenspecies (ROS) accumulation, glutathione (GSH) deprivation and DNA damage. The elevation in transcriptionof GADD45a (growth arrest and DNA-damage-inducible protein 45 alpha) and GADD45b(growth arrest and DNA-damage-inducible protein 45 beta), as well as the phosphorylation of H2AX(H2A histone family, member X), p38 MAPK (mitogen-activated protein kinase), and JNK (c-Jun N-terminalkinase) in cells treated with 4-HNE were alleviated by 5 mmol/L Hyp. Furthermore, Hyp supplementationincreased the protein abundance of Krüppel like factor 4 (KLF4) in cells exposed to 4-HNE.Suppression of KLF4 expression by kenpaulone impeded the resistance of Hyp-treated cells to DNAdamage and apoptosis induced by 4-HNE. Collectively, our results indicated that Hyp serves to protectagainst 4-HNE-induced apoptosis and DNA damage in IPEC-1 cells, which is partially pertinent with theenhanced expression of KLF4. Our data provides an updated explanation for the nutritional values ofHyp-containing animal products. | Yun Ji Yu He Ying Yang Zhaolai Dai Zhenlong Wu | 2022 | Animal Nutrition2022，，2： | 0 |
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