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| 1 | Amino acids and mammary gland development:nutritional implications for milk production and neonatal growth显示文摘Milk is synthesized by mammary epithelial cel s of lactating mammals. The synthetic capacity of the mammary gland depends largely on the number and efficiency of functional mammary epithelial cel s. Structural development of the mammary gland occurs during fetal growth, prepubertal and post-pubertal periods, pregnancy, and lactation under the control of various hormones(particularly estrogen, growth hormone, insulin-like growth factor-I, progesterone, placental lactogen, and prolactin) in a species- and stage-dependent manner. Milk is essential for the growth, development, and health of neonates. Amino acids(AA), present in both free and peptide-bound forms, are the most abundant organic nutrients in the milk of farm animals. Uptake of AA from the arterial blood of the lactating dam is the ultimate source of proteins(primarily β-casein and α-lactalbumin) and bioactive nitrogenous metabolites in milk. Results of recent studies indicate extensive catabolism of branched-chain AA(leucine, isoleucine and valine) and arginine to synthesize glutamate,glutamine, alanine, aspartate, asparagine, proline, and polyamines. The formation of polypeptides from AA is regulated not only by hormones(e.g., prolactin, insulin and glucocorticoids) and the rate of blood flow across the lactating mammary gland, but also by concentrations of AA, lipids, glucose, vitamins and minerals in the maternal plasma, as well as the activation of the mechanistic(mammalian) target rapamycin signaling by certain AA(e.g.,arginine, branched-chain AA, and glutamine). Knowledge of AA utilization(including metabolism) by mammary epithelial cells will enhance our fundamental understanding of lactation biology and has important implications for improving the efficiency of livestock production worldwide. | Reza Rezaei Zhenlong Wu Yongqing Hou Fuller W.Bazer Guoyao Wu | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 36 |
| 2 | Biochemical and physiological bases for utilization of dietary amino acids by young Pigs显示文摘Protein is quantitatively the most expensive nutrient in swine diets. Hence it is imperative to understand the physiological roles played by amino acids in growth, development, lactation, reproduction, and health of pigs to improve their protein nutrition and reduce the costs of pork production. Due to incomplete knowledge of amino acid biochemistry and nutrition, it was traditionally assumed that neonatal, post-weaning, growing-finishing, and gestating pigs could synthesize sufficient amounts of all 'nutritionally nonessential amino acids' (NEAA) to support maximum production performance. Therefore, over the past 50 years, much emphasis has been placed on dietary requirements of nutritionally essential amino acids as building blocks for tissue proteins. However, a large body of literature shows that NEAA, particularly glutamine, glutamate, arginine and proline regulate physiological functions via cell signaling pathways, such as mammalian target of rapamycin, AMP-activated protein kinase, extracellular signal-related kinase, Jun kinase, mitogen-activated protein kinase, and NEAA-derived gaseous molecules (e.g., nitric oxide, carbon monoxide, and hydrogen sulfide). Available evidence shows that under current feeding programs, only 70% and 55% of dietary amino acids are deposited as tissue proteins in 14-day-old sow-reared piglets and in 30-day-old pigs weaned at 21 days of age, respectively. Therefore, there is an urgent need to understand the roles and dietary requirements of NEAA in swine nutrition. This review highlights the basic biochemistry and physiology of absorption and utilization of amino acids in young pigs to enhance the efficacy of utilization of dietary protein and to minimize excretion of nitrogenous wastes from the body. | Reza Rezaei Weiwei Wang Zhenlong Wu Zhaolai Dai Junjun Wang Guoyao Wu | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 22 |
| 3 | Protein hydrolysates in animal nutrition:Industrial production, bioactive peptides,and functional significance显示文摘Recent years have witnessed growing interest in the role of peptides in animal nutrition. Chemical, enzymatic, or microbial hydrolysis of proteins in animal by-products or plant-source feedstuffs before feeding is an attractive means of generating high-quality small or large peptides that have both nutritional and physiological or regulatory functions in livestock, poultry and fish. These peptides may also be formed from ingested proteins in the gastrointestinal tract, but the types of resultant peptides can vary greatly with the physiological conditions of the animals and the composition of the diets. In the small intestine, large peptides are hydrolyzed to small peptides,which are absorbed into enterocytes faster than free amino acids(AAs) to provide a more balanced pattern of AAs in the blood circulation. Some peptides of plant or animal sources also have antimicrobial, antioxidant,antihypertensive, and immunomodulatory activities. Those peptides which confer biological functions beyond their nutritional value are called bioactive peptides. They are usually 2–20 AA residues in length but may consist of >20AA residues. Inclusion of some(e.g. 2–8%) animal-protein hydrolysates(e.g., porcine intestine, porcine mucosa,salmon viscera, or poultry tissue hydrolysates) or soybean protein hydrolysates in practical corn-and soybean mealbased diets can ensure desirable rates of growth performance and feed efficiency in weanling pigs, young calves,post-hatching poultry, and fish. Thus, protein hydrolysates hold promise in optimizing the nutrition of domestic and companion animals, as well as their health(particularly gut health) and well-being. | Yongqing Hou Zhenlong Wu Zhaolai Dai Genhu Wang Guoyao Wu | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 22 |
| 4 | Towards an Esox lucius inspired multimodal robotic fish显示文摘In this paper, we further explore multimodal locomotion via an updated robotic fish model based on Esox lucius. Besides the improved actuation properties like higher torque servomotors and powerful electronics,the robotic fish has some innovative mechanical design to pursue diverse swimming modes and superior performance. Specifically, we introduced a ±50° yawing head joint that functions as the neck for enhancing turning ability. A pair of pectoral mechanisms with two DOFs per fin is constructed to achieve 3-D swimming and to enrich multiple pectoral motions. At the control level, an improved central pattern generator(CPG) model allowing for free adjustment of the phase relationship among outputs is employed to produce rhythmic signals of multimodal swimming. Extensive experiments were carried out to examine how characteristic parameters in CPGs including amplitude, frequency, and phase lag affect the swimming performance. As a result, the robotic fish successfully performed various locomotion actions such as forward swimming, backward swimming, turning, diving, surfacing, as well as three pectoral motions in the form of pitching, heaving, and heaving-pitching.We found that small phase lag between oscillating joints which means large propulsive body wave length and undulation width could lead to a faster swimming in body and/or caudal fin(BCF) locomotion. | WU ZhengXing YU JunZhi SU ZongShuai TAN Min LI ZhenLong | 2015 | Science China(Information Sciences)2015，58，5： | 11 |
| 5 | Geospatial Service Web:towards integrated cyberinfrastructure for GIScience显示文摘A geospatial cyberinfrastructure is needed to support advanced GIScience research and education activities.However,the heterogeneous and distributed nature of geospatial resources creates enormous obstacles for building a unified and interoperable geospatial cyberinfrastructure.In this paper,we propose the Geospatial Service Web(GSW)to underpin the development of a future geospatial cyberinfrastructure.The GSW excels over the traditional spatial data infrastructure by providing a highly intelligent geospatial middleware to integrate various geospatial resources through the Internet based on interoperable Web service technologies.The development of the GSW focuses on the establishment of a platform where data,information,and knowledge can be shared and exchanged in an interoperable manner.Theoretically,we describe the conceptual framework and research challenges for GSW,and then introduce our recent research toward building a GSW.A research agenda for building a GSW is also presented in the paper. | GONG Jianya WU Huayi ZHANG Tong GUI Zhipeng LI Zhenlong YOU Lan SHEN Shengyu ZHENG Jie GENG Jing QI Kunlun YANG Wenjing LI Zhenqiang YU Jingmin | 2012 | Geo-Spatial Information Science2012，15，2： | 5 |
| 6 | Fetal and neonatal programming of postnatal growth and feed efficiency in swine显示文摘Maternal undernutrition or overnutrition during pregnancy alters organ structure, impairs prenatal and neonatal growth and development, and reduces feed efficiency for lean tissue gains in pigs. These adverse effects may be carried over to the next generation or beyond. This phenomenon of the transgenerational impacts is known as fetal programming, which is mediated by stable and heritable alterations of gene expression through covalent modifications of DNA and histones without changes in DNA sequences(namely, epigenetics). The mechanisms responsible for the epigenetic regulation of protein expression and functions include chromatin remodeling; DNA methylation(occurring at the 5′-position of cytosine residues within CpG dinucleotides); and histone modifications(acetylation, methylation, phosphorylation, and ubiquitination). Like maternal malnutrition, undernutrition during the neonatal period also reduces growth performance and feed efficiency(weight gain:feed intake; also known as weightgain efficiency) in postweaning pigs by 5–10%, thereby increasing the days necessary to reach the market bodyweight. Supplementing functional amino acids(e.g., arginine and glutamine) and vitamins(e.g., folate) play a key role in activating the mammalian target of rapamycin signaling and regulating the provision of methyl donors for DNA and protein methylation. Therefore, these nutrients are beneficial for the dietary treatment of metabolic disorders in offspring with intrauterine growth restriction or neonatal malnutrition. The mechanism-based strategies hold great promise for the improvement of the efficiency of pork production and the sustainability of the global swine industry. | Yun Ji Zhenlong Wu Zhaolai Dai Xiaolong Wang Ju Li Binggen Wang Guoyao Wu | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 4 |
| 7 | On transitioning from PID to ADRC in thermal power plants显示文摘This paper focuscs on the recent progress in the adoption of active disturbance rejection control(ADRC)in thermal pro-cesses as a viable alternative to proportional-_integral-derivative(PID),especially in coa-fired power plants.The profound interpretation of this paradigm shift,with backward compatibility,is discussed in detail.A few fundamental issues associated with ADRC's applications in thermal processes are discussed,such as implementation,tuning,and the structural changes.Examples and case studies are presented,encompassing coal-fired power plants,gas turbines and nuclear power plants,as well as highlighting results of field applications.Also discussed are future research opportunities brought by ADRC's entry as the baseline control technology in thermal processes. | Zhenlong Wu Zhiqiang Gao Donghai Li YangQuan Chen Yanhong Liu | 2021 | Control Theory and Technology2021，19，1： | 4 |
| 8 | Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells:a feed-back regulation by mechanistic target of rapamycin complex 1(mTORC1)显示文摘Background: Endoplasmic reticulum(ER) stress is associated with multiple pathological processes of intestinal diseases. Despite a critical role of mechanistic target of rapamycin complex 1(m TORC1) in regulating cellular stress response, the crosstalk between m TORC1 and ER stress signaling and its contribution to the intestinal barrier function is unknown.Results: In the present study, we showed that intestinal epithelial cells(IEC-6) incubated with tunicamycin led to caspase-3-dependent apoptotic cell death. The induction of cell death was accompanied by activation of unfolded protein response as evidenced by increased protein levels for Bi P, p-IRE1α, p-e IF2α, p-JNK, and CHOP. Further study demonstrated that tunicamycin-induced cell death was enhanced by rapamycin, a specific inhibitor of m TORC1.Consistently, tunicamycin decreased transepithelial electrical resistance(TEER) and increased permeability of the cells. These effects of tunicamycin were exacerbated by m TORC1 inhibitor.Conclusions: Taken together, the data presented here identified a previously unknown crosstalk between an unfold protein response and m TORC1 signaling in the intestinal epithelium. This feed-back loop regulation on ER stress signaling by m TORC1 is critical for cell survival and intestinal permeability in epithelial cells. | Yun Ji Xuan Luo Ying Yang Zhaolai Dai Guoyao Wu Zhenlong Wu | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 3 |
| 9 | Dietary L-arginine supplementation reduces lipid accretion by regulating fatty acid metabolism in Nile tilapia(Oreochromis niloticus)显示文摘Background: Excessive white fat accumulation in humans and other animals is associated with the development of multiple metabolic diseases. It is unknown whether dietary L-arginine supplementation reduces lipid deposition in high fat diet-fed Nile tilapia(Oreochromis niloticus).Results: In the present study, we found that dietary supplementation with 1% or 2% arginine decreased the deposition and concentration of fats in the liver;the concentrations of triglycerides, low-density lipoprotein, total cholesterol, and high-density lipoprotein in the serum;and the diameter of adipocytes in intraperitoneal adipose tissue. Compared with the un-supplementation control group, the hepatic activities of alanine aminotransferase,aspartate aminotransferase, and lactate dehydrogenase, and hepatic concentration of malondialdehyde were reduced but these for catalase and superoxide dismutase were enhanced by dietary supplementation with 2% arginine. Arginine supplementation reduced the total amounts of monounsaturated fatty acids, while increasing the total amounts of n-3 and n-6 polyunsaturated fatty acids in the liver. These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis(sterol regulatory element-binding protein-1, acetyl-CoA carboxylase α, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid β-oxidation(carnitine palmitoyltransferase 1α and peroxisome proliferator-activated receptor α). In addition, hepatic mRNA levels for Δ4 fatty acyl desaturase 2 and elongase 5 of very long-chain fatty acids were enhanced by arginine supplementation.Conclusion: These results revealed that dietary L-arginine supplementation to tilapia reduced high fat diet-induced fat deposition and fatty acid composition in the liver by regulating the expression of genes for lipid metabolism. | Senlin Li Yunchang Zhang Ning Liu Jingqing Chen Lina Guo Zhaolai Dai Chao Wang Zhenlong Wu Guoyao Wu | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
| 10 | Cinnamicaldehyde regulates the expression of tight junction proteins and amino acid transporters in intestinal porcine epithelial cells显示文摘Background: Cinnamicaldehyde(CA) is a key flavor compound in cinnamon essential oil possessing various bioactivities. Tight junction(TJ) proteins are vital for the maintenance of intestinal epithelial barrier function,transport, absorption and utilization of dietary amino acids and other nutrients. In this study, we tested the hypothesis that CA may regulate the expression of TJ proteins and amino acid transporters in intestinal porcine epithelial cells(IPEC-1) isolated from neonatal pigs.Results: Compared with the control, cells incubated with 25 μmol/L CA had increased transepithelial electrical resistance(TEER) and decreased paracellular intestinal permeability. The beneficial effect of CA on mucosal barrier function was associated with enhanced protein abundance for claudin-4, zonula occludens(ZO)-1, ZO-2, and ZO-3. Immunofluorescence staining showed that 25 μmol/L CA promoted the localization of claudin-1 and claudin-3 to the plasma membrane without affecting the localization of other TJ proteins, including claudin-4, occludin,ZO-1, ZO-2, and ZO-3, compared with the control cells. Moreover, protein abundances for rBAT, xCT and LAT2 in IPEC-1 cells were enhanced by 25 μmol/L CA, while that for EAAT3 was not affected.Conclusions: CA improves intestinal mucosal barrier function by regulating the distribution of claudin-1 and claudin-3 in enterocytes, as well as enhancing protein abundance for amino acid transporters rBAT, xCT and LAT2 in enterocytes. Supplementation with CA may provide an effective nutritional strategy to improve intestinal integrity and amino acid transport and absorption in piglets. | Kaiji Sun Yan Lei Renjie Wang Zhenlong Wu Guoyao Wu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 3 |
| 11 | Numerical simulation of aerodynamic interactions among helicopter rotor,fuselage,engine and body of revolution显示文摘Numerical simulations of helicopter aerodynamic interactions among the main rotor,fuselage,engine inlets/outlets and slung loads of specific geometries have been conducted by very few researchers.In this work,the steady-state compressible Reynolds-averaged navier-stokes equations are solved to study the aerodynamic interactions among helicopter rotor,fuselage,engine and body of revolution in three cases,namely MI-171V5,ROBIN and UH-60A.In the first case,the downwash flow provided by the rotor of the uniform actuator disc model induces a significant deflection of the airflow velocity.The vortex-shaped distribution and evolution are discussed in detail.The engine can effectively change the overall flow field.The asymmetry of the flow field is observed by using the non-uniform actuator disc model.Qualitative analysis of ROBIN and quantitative computation of UH-60A show a consistent accuracy of the rotating reference frame model for rotor.The blade tip vortex motion of UH-60A is simulated and its radial position prediction is compared to empirical formulas.While performing flow of UH-60A in hover,both the fuselage normal force and rotor lift decrease because of the impact of the body of revolution. | CAO YiHua WU ZhenLong HUANG JunSen | 2014 | Science China(Technological Sciences)2014，57，6： | 2 |
| 12 | Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats显示文摘 | Jing Tang Yijuan Sun William Ka Kei Wu Tianyu Zhong Yawei Liu Jinfang Xiao Tao Tao Zhenlong Zhao Miaoning Gu | 2010 | BBA - Proteins and Proteomics2010，，9： | 1 |
| 13 | E2F-1-Mediated apoptosis as a target of cancer therapy 显示文摘 | Wu Zhenlong Yu Qiang | 2009 | Current Molecular Pharmacology2009，2，2： | 1 |
| 14 | A new tetrodotoxin-producing actinomycete,Nocardiopsis dassonvillei,isolated from the ovaries of puffer fish Fugu rubripes显示文摘 | WU Zhenlong XIE Liping XIA Guoliang | 2005 | Toxicon2005，45，7： | 1 |
| 15 | Toxicity and distribution of tetrodotoxin-producing bacteria in puffer fish Fugu rubripes collected from the Bohai Sea of China显示文摘 | WU Zhenlong YANG Ying XIE Liping | 2005 | Toxicon2005，46，4： | 1 |
| 16 | Toxicity and distribution of tetrodotoxin-producing bacteria in puffer fish Fugu rubripes collected from the Bohai sea of China显示文摘 | WU Zhenlong YANG Ying XIE Liping | 2005 | Toxicon2005，46，： | 1 |
| 17 | Analysis of amino acid composition in proteins of animal tissues and foods as pre-column o -phthaldialdehyde derivatives by HPLC with fluorescence detection显示文摘 | Zhaolai Dai Zhenlong Wu Sichao Jia Guoyao Wu | 2014 | Journal of Chromatography B2014，，： | 1 |
| 18 | Toxicity and distribution of tetrodotoxin-producing bacteria in puffer fish Fugu rubripes collected from the Bohai Sea of China显示文摘 | Wu Zhenlong Yang Ying Xie Liping | 2005 | Toxicon2005，43，： | 1 |
| 19 | An Optimized Framework for Seamlessly Integrating OGC Web Services to Support Geospatial Sciences显示文摘 | LI Zhenlong YANG Chaowei WU Huayi | 2011 | International Journal of Geographical Information Science2011，25，4： | 1 |
| 20 | Glutamic acid supplementation recovers the reduced performance of weanling pigs fed reduced crude protein diets显示文摘This study was conducted to evaluate the supplementation of glutamic acid(Glu)to reduced protein diets on the performance of weanling pigs.One hundred and eighty crossbred weanling pigs([YorkshireLandrace]Duroc,21 d old)having similar body weight(BW)of 6.45 kg were randomly allotted to 1 of 6 dietary treatments(5 pigs per pen[2 barrows and 3 gilts];6 pens per treatment)based on BW and sex during a 6-week trial.Dietary treatments consisted of positive control(PC)diet formulated to have 226.9,205.6,and 188.8 g crude protein(CP)during phases 1,2,and 3,respectively,and negative control(NC)diets with 20 g CP reduction from PC diets and addition of Glu with increasing levels,resulting in the calculated Lys-to-Glu ratios of 1:2.25,1:2.30.1:2.35,1:2.40,and 1:2.45,designated as NC,NC1,NC2,NC3,and NC4,respectively.The BW of pigs receiving PC diet was higher(P<0.05)than those receiving NC diet at d 7,21 and 42.A higher(P<0.05)average daily gain(ADG)from d 1 to 7,8 to 21,22 to 42 and during the overall experiment period was observed in pigs fed PC than NC diet.Pigs fed NC diets including the graded level of Glu linearly increased(P<0.05)BW at d 42,ADG and gain-to-feed ratio(G:F)during the overall experimental period.In addition,trends in linear increase in BW(P=0.056)at d 7 and ADG from d 1 to 7 and d 22 to 42(linear effect,P=0.081,P=0.058 respectively)were observed.A tendency in the linear increment of NH3(P=0.082)at d 21 and linear reduction in methyl mercaptans(P=0.054)emission at d 42 was observed in pigs fed NC diets supplemented with graded level of Glu.In conclusion,supplementing the reduced protein diet with Glu enhanced the growth performance in weanling pigs suggesting that supplementation of Glu can compensate the reduction of 2%CP in the basal diets. | Santi D.Upadhaya Sang Seon Lee Young Hwa Kim Zhenlong Wu In Ho Kim | 2022 | Animal Nutrition2022，，1： | 1 |
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