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| 1 | The response of annual runoff to the height change of the summertime 0℃ level over Xinjiang显示文摘According to climate features and river runoff conditions,Xinjiang could be divided into three research areas:The Altay-Tacheng region,the Tianshan Mountain region and the northern slope of the Kunlun Mountains.Utilizing daily observations from 12 sounding stations and the annual runoff dataset from 34 hydrographical stations in Xinjiang for the period 1960-2002,the variance of the summertime 0℃ level height and the changing trends of river runoff are analyzed both qualitatively and quantitatively,through trend contrast of curves processed by a 5-point smoothing procedure and linear correlation.The variance of the summertime 0℃ level height in Xinjiang correlates well with that of the annual river runoff,especially since the early 1990s,but it differs from region to region,with both the average height of the 0℃ level and runoff quantity significantly increasing over time in the Altay-Tacheng and Tianshan Mountain regions but decreasing on the northern slope of the Kunlun Mountains.The correlation holds for the whole of Xinjiang as well as the three individual regions,with a 0.01 significance level.This indicates that in recent years,climate change in Xinjiang has affected not only the surface layer but also the upper levels of the atmosphere,and this raising and lowering of the summertime 0℃ level has a direct impact on the warming and wetting process in Xinjiang and the amount of river runoff.Warming due to climate change increases the height of the 0℃ level,but also speeds up,ice-snow melting in mountain regions,which in turn increases river runoff,leading to a season of plentiful water instead of the more normal low flow period. | ZHANG Guangxing SUN Shufang MA Yufen ZHAO Ling | 2010 | Journal of Geographical Sciences2010，20，6： | 10 |
| 2 | The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent显示文摘P2X7 受体的激活导致阳离子的快速的、双向流动,引起包括 cytotoxicity 的生物回答的宽广范围。然而,调停 P2X7 的 cytotoxicity 的机制仍然保持大部分未经勘探。在我们的以前的学习,在正常条件下面的调停 P2X7 的钙反应的缺乏在 P2X7+ 造血的房间线被发现。在这研究,在房间的不同类型的调停 P2X7 的 cytotoxicity (P2X7 ? ,有钙反应的 P2X7+ ,和没有钙反应的 P2X7+) 被调查。我们的结果证明 P2X7 收缩筋,腺苷 5-triphosphate ( ATP )或2,3-O-( 4 benzoylbenzoyl )-ATP, dose-dependently 在测试的所有P2X7+房间减少了房间生存能力,包括为 调停P2X7 的钙反应否定的 J6-1 , LCL ,和 Namalva 房间,尽管这些效果比在有正常 P2X7 功能的 KG1a 房间观察的那些低。细胞毒素的效果能被 P2X7 对手,氧化 ATP 和 1- 堵住[N, O 二度(5-isoquinolinesulfonyl )-N-methyl-l-tyrosyl]-4-phenylpiperazine。另外, phosphatidylserine 的外表表现能以一种时间依赖者方式和 apoptotic 被检测词法变化能在 J6-1 房间在 P2X7 受体的激活以后被观察。而且,调停 P2X7 的毛孔形成能在低离子的条件下面,然而并非在低二价的条件下面在 KG1a 和 J6-1 房间被检测。这些效果不能在 P2X7 被观察吗?Ramos 房间。这些结果建议 P2X7 调停受体的细胞毒素的效果可以发生独立于钙反应。 | Xiujun Zhang Lijun Meng Baoling He Jing Chen Peng Liu Jie Zhao Yufen Zhang Ming Li Dong An | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 7 |
| 3 | N-phosphoryl amino acid models for P–N bonds in prebiotic chemical evolution显示文摘Post-translational modification of proteins by N-phosphorylation of the basic amino acid residues plays important roles in biological processes. The high-energy P–N bond might have contributed to the evolution of prebiotic chemistry. N-phosphoryl amino acids(PAAs) can serve as interesting small molecular models for the study of P–N bonds in prebiotic chemical evolution. PAAs are capable of simultaneously producing several important biomolecules such as polypeptides and oligonucleotides under mild reaction conditions. In this review, we describe the chemistry of PAAs, discusse their likely prebiotic origins and their reactivity and how they relate to biological P–N bond species. We also depict a possible prebiotic scenario mediated by PAAs in which PAAs may have acted as one of the essential forces driving prebiotic biomolecules to the first protocell. | Feng Ni Chuan Fu Xiang Gao Yan Liu Pengxiang Xu Liu Liu Ye Lv Songsen Fu Ying Sun Daxiong Han Yan-Mei Li Yufen Zhao | 2015 | Science China Chemistry2015，58，3： | 3 |
| 4 | Exploring the binding mechanism of thioflavin-T to the β-amyloid peptide by blind docking method显示文摘Using blind dock method,we find that thioflavin-T(ThT) can bind to both monomers and fibrils of the full-length β-amyloid peptide(Aβ1-42) and has a higher binding affinity to the fibrils.It is shown that the hydrophobic interaction between the ligand(ThT) and substrate(Aβ1-42) are stronger than hydrogen bonds.Furthermore,ThT tends to be located near the C-terminus of Aβ monomer through hydrophobic and electrostatic interactions,while it tends to contact the residues Met35 and Gly27 of the fibril surface mainly through hydrophobic interaction.Finally,according to the docking results and ThT fluorescence assay,a kinetic equation is proposed to deduce the aggregation rate coefficient of Aβ1-42. | ZHAO DeSheng CHEN YongXiang LIU Qian ZHAO YuFen LI YanMei | 2012 | Science China Chemistry2012，55，1： | 3 |
| 5 | Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine显示文摘Dear Editor,Urine passes through the entire kidney and urinary tract system starting from the glomerulus and ending to the urethra.Cells in the kidney and urinary tract could be exfoliated from the epithelium into the urine,while leukocyte could infiltrate from the local tissue into the urine,which makes the urine a useful subject for clinical evaluation of relevant diseases. | Yujia Wang Yu Zhao Zixian Zhao Dandan Li Hao Nie Yufen Sun Xiaobei Feng Ting Zhang Yu Ma Jing Nie Guangyan Cai Xiangmei Chen Wei Zuo | 2021 | Protein & Cell2021，12，4： | 2 |
| 6 | Orientation of the peptide formation of N-phosphoryl amino acids in solution显示文摘The peptide formation of N-phosphoryl aminoacids with amino acids proceeds in aqueous solution withoutany coupling reagents. After being separated in sephadex gelcolumn, the phosphoryl dipeptides were analyzed by theelectrospray ionization tandem mass spectrometry (ESIMS/MS). The result demonstrates that phosphoryl dipeptideswere datected in all the reaction systems. It is found tkat theformation of N-phosphoryl dipeptides is oriented: theN-terminal amino acid residues of the N-phosphoryl dipep-tides are from N-phosphoryl amino acids, and the peptideelongation happened at the C-terminal. Only adipeptide, noβ-dipeptide, is formed in the N-phosphoryl dipeptides,showing that α-carboxylic group is activated selectively byN-pbosphorylation. Theoretical calculation shows that thepeptide formation of N-phosphoryl amino acids might hap-pen through a pentu-coordinate carboxylic-phosphoric in-termediate in solution. These results might give some clues tothe stlidy on the origin of proteins and protein | CHEN Zhongzhou TONG Yufeng CHEN Shuibing LI Yanmei CHEN YI ZHAO Yufen WANG Jinfeng | 2002 | Chinese Science Bulletin2002，47，22： | 2 |
| 7 | Synthesis of urea derivatives from amines and CO2 in the absence of catalyst and solvent 显示文摘 | Wu Chaoyong Cheng Haiyang Liu Ruixia Wang Qiang Hao Yufen Yu Yancun Zhao Fengyu | 2010 | Green Chemistry2010，12，： | 1 |
| 8 | Suppression of ETI by PTI priming to balance plant growth and defense through an MPK3/MPK6-WRKYs-PP2Cs module显示文摘Pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)are required for host defense against pathogens.Although PTI and ETI are intimately connected,the underlying molecular mechanisms remain elusive.In this study,we demonstrate that flg22 priming attenuates Pseudomonas syringae pv.tomato DC3000(Pst)AvrRpt2-induced hypersensitive cell death,resistance,and biomass reduction in Arabidopsis.Mitogen-activated protein kinases(MAPKs)are key signaling regulators of PTI and ETI.The absence of MPK3 and MPK6 significantly reduces pre-PTI-mediated ETI suppression(PES).We found that MPK3/MPK6 interact with and phosphorylate the downstream transcription factor WRKY18,which regulates the expression of AP2C1 and PP2C5,two genes encoding protein phosphatases.Furthermore,we observed that the PTI-suppressed ETI-triggered cell death,MAPK activation,and growth retardation are significantly attenuated in wrky18/40/60 and ap2c1 pp2c5 mutants.Taken together,our results suggest that the MPK3/MPK6-WRKYs-PP2Cs module underlies PES and is essential for the maintenance of plant fitness during ETI. | Dacheng Wang Lirong Wei Ting Liu Jinbiao Ma Keyi Huang Huimin Guo Yufen Huang Lei Zhang Jing Zhao Kenichi Tsuda Yiming Wang | 2023 | Molecular Plant2023，16，5： | 1 |
| 9 | Simultaneous formation of peptides and nucleotides from n-phosphothreonine显示文摘 | Weihua Zhou Young Ju Yufen Zhao Qinggang Wang Guoan Luo | 1996 | Origins of Life and Evolution of the Biosphere1996，，6： | 1 |
| 10 | Exploring the binding mechanism of thioflavin-T to the β-amyloid peptide by blind docking method显示文摘Using blind dock method,we find that thioflavin-T(ThT) can bind to both monomers and fibrils of the full-length β-amyloid peptide(Aβ1-42) and has a higher binding affinity to the fibrils.It is shown that the hydrophobic interaction between the ligand(ThT) and substrate(Aβ1-42) are stronger than hydrogen bonds.Furthermore,ThT tends to be located near the C-terminus of Aβ monomer through hydrophobic and electrostatic interactions,while it tends to contact the residues Met35 and Gly27 of the fibril surface mainly through hydrophobic interaction.Finally,according to the docking results and ThT fluorescence assay,a kinetic equation is proposed to deduce the aggregation rate coefficient of Aβ1-42. | ZHAO DeSheng CHEN YongXiang LIU Qian ZHAO YuFen LI YanMei | 2012 | 中国科学:化学2012，42，2： | 1 |
| 11 | Seismic behavior of ring beam joints between concrete - filled twin steel tubes columns and reinforced concrete beams 显示文摘 | ZHANG Yufen ZHAO Junhai CAI C S | 2012 | Engineering Structures2012，39，： | 1 |
| 12 | Role of oxygen-containing groups on MWCNTs in enhanced separation and permeability performance for PVDF hybrid ultrafiltration membranes显示文摘 | Jilan Ma Yufen Zhao Zhiwei Xu Chunying Min Baoming Zhou Yinglin Li Baodong Li Jiarong Niu | 2013 | Desalination2013，，： | 1 |
| 13 | Mechanism of intramolecular mixed anhydride formation as intermediates in the reactions of N-phosphorylamino-acids──An MNDO research显示文摘N-phosphoryl-α-amino acids can react to form esters, peptides, phosphoryl ester-exchanged products and phosphoryl group migration products under mild conditions, which are very important in researches on arohebiont. It has been proposed that intramolecular mixed carboxylic-phosphoric anhydrides (IMCPAs) might be the common intermediates of the reactions, which are difficult to be experimentally observed because of their high activity. In this note, it has been revealed, by means of MNDO, that the IMCPAs are situated at the relatively minimal points of the potential surface and can form in a non-synchronous concerted reaction pathway that passes through a transition state with a hydrogen-bond-bridge structure. The results give a successful explanation to the structure and formation of IMCPAs and their ability to promote the various reactions mentioned above. | ZHONG Rugang 1, 2, ZHAO Yufen 1,* and DAI Qianhuan 2 1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100022, China 2. Center for Chemistry and Bioengineering of Cancer Research, Beijing Polytec | 1998 | Chinese Science Bulletin1998，43，11： | 1 |
| 14 | Effect of graphite oxide and multi-walled carbon nanotubes on the microstructure and performance of PVDF membranes显示文摘 | Zhao Yufen Xu Zhiwei | 2013 | Separation and Purification Technology2013，103，： | 1 |
| 15 | Simultaneous formation of peptides and nucleotides from n-phosphothreonine显示文摘 | Weihua Zhou Young Ju Yufen Zhao Qinggang Wang Guoan Luo | 1996 | Origins of Life and Evolution of the Biosphere1996，，6： | 1 |
| 16 | Research progresses of artificial nucleic acid cleavage agents显示文摘Artificial nucleic acid cleavage agents have attracted close attention because they play important roles in biochemistry and molecular biology. According to the cleavage mechanism of nucleic acid, they are divided into three types, namely free radical, phosphodiester bond hydrolysis and elimination cleavage agents. In this review, a series of cleavage agents, including the site- and sequence-specific ones, are illustrated, and some suggestions for the future researches in this field are also put forward. | Rong Wan Gang Zhao Jing Chen Yufen Zhao | 2000 | Chinese Science Bulletin2000，45，22： | 1 |
| 17 | Seismic behavior of ring beam joints between concrete- filled twin steel tubes columns and reinforced concrete beams 显示文摘 | Zhang Yufen Zhao Junhai Cai C S | 2012 | Engineering Structures2012，39，： | 1 |
| 18 | Simultaneous formation of peptides and nucleotides from n-phosphothreonine显示文摘 | Weihua Zhou Young Ju Yufen Zhao Qinggang Wang Guoan Luo | 1996 | Origins of Life and Evolution of the Biosphere1996，，6： | 1 |
| 19 | Simultaneous formation of peptides and nucleotides from n-phosphothreonine显示文摘 | Weihua Zhou Young Ju Yufen Zhao Qinggang Wang Guoan Luo | 1996 | Origins of Life and Evolution of the Biosphere1996，，6： | 1 |
| 20 | Effect of graphite oxide and multi-walled carbon nanotubes on the microstructure and per- formance of PVDF membranes 显示文摘 | Zhao Yufen Xu Zhiwei Shan Mingjing | 2013 | Separation and Purification Te- chnology2013，103，： | 1 |
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