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| 1 | Preliminary molecular epidemiology of the Staphylococcus aureus in lower respiratory tract infections: a multicenter study in China显示文摘 | LI De-zhi CHEN Yu-sheng YANG Jing-ping ZHANG Wei HU Cheng-ping LI Jia-shu MU Lan HU Ying-hui GENG Rong HU Ke CAI Shao-xi WAN Huan-ying WANG Qiu-yue WEI Li-ping DU Juan YU Qin ZHONG Xiao-ning WANG Rui-qin MA Jian-jun TIAN Gui-zhen WANG Si-qin GAO Zhan-cheng | 2011 | Chinese Medical Journal2011，，5： | 21 |
| 2 | Optimization of stratification scheme for a fishery-independent survey with multiple objectives显示文摘Fishery-independent surveys are often used for collecting high quality biological and ecological data to support fisheries management. A careful optimization of fishery-independent survey design is necessary to improve the precision of survey estimates with cost-effective sampling efforts. We developed a simulation approach to evaluate and optimize the stratification scheme for a fishery-independent survey with multiple goals including estimation of abundance indices of individual species and species diversity indices. We compared the performances of the sampling designs with different stratification schemes for different goals over different months. Gains in precision of survey estimates from the stratification schemes were acquired compared to simple random sampling design for most indices. The stratification scheme with five strata performed the best. This study showed that the loss of precision of survey estimates due to the reduction of sampling efforts could be compensated by improved stratification schemes, which would reduce the cost and negative impacts of survey trawling on those species with low abundance in the fishery-independent survey. This study also suggests that optimization of a survey design differed with different survey objectives. A post-survey analysis can improve the stratification scheme of fishery-independent survey designs. | XU Binduo REN Yiping CHEN Yong XUE Ying ZHANG Chongliang WAN Rong | 2015 | Acta Oceanologica Sinica2015，34，12： | 21 |
| 3 | Synthesis of spherical LiNi_(0.8)Co_(0.15)Al_(0.05)O_2 cathode materials for lithium-ion batteries by a co-oxidation-controlled crystallization method显示文摘球形的 Ni0.8Co0.15Al0.05OOH 先锋,由一个 co-oxidation-controlled 结晶化方法准备了,被用来综合 LiNi0.8Co0.15Al0.05O2。获得的 LiNi0.8Co0.15Al0.05O2 材料看了优秀电气化学的性能,与 193.5 mAh/g 的一个起始的分泌物能力和在 50 个周期以后的 95.1% 的能力保留什么时候以在 2.8 和 4.3 V 之间的 0.2 C 率骑车了。 | Wan Min Liu Guo Rong Hu Zhong Dong Peng Ke Du Yan Bing Cao Qiang Liu | 2011 | Chinese Chemical Letters2011，22，9： | 17 |
| 4 | Classification,clinicopathologic features and treatment of gastric neuroendocrine tumors显示文摘Gastric neuroendocrine tumors(GNETs)are rare lesions characterized by hypergastrinemia that arise from enterochromaffin-like cells of the stomach.GNETs consist of a heterogeneous group of neoplasms comprising tumor types of varying pathogenesis,histomorphologic characteristics,and biological behavior.A classification system has been proposed that distinguishes four types of GNETs;the clinicopathological features of the tumor,its prognosis,and the patient’s survival strictly depend on this classification.Thus,correct management of patients with GNETs can only be proposed when the tumor has been classified by an accurate pathological and clinical evaluation of the patient.Recently developed cancer therapies such as inhibition of angiogenesis or molecular targeting of growth factor receptors have been used to treat GNETs,but the only definitive therapy is the complete resection of the tumor.Here we review the literature on GNETs,and summarize the classification,clinicopathological features(especially prognosis),clinical presentations and current practice of management of GNETs.We also present the latest findings on new gene markers for GNETs,and discuss the effective drugs developed for the diagnosis,prognosis and treatment of GNETs. | Ting-Ting Li Feng Qiu Zhi Rong Qian Jun Wan Xiao-Kun Qi Ben-Yan Wu | 2014 | World Journal of Gastroenterology2014，20，1： | 16 |
| 5 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 6 | Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection显示文摘 | DAI Ning LI De-zhi CHEN Ji-chao CHEN Yu-sheng GENG Rong HU Ying-hui YANG Jing-ping DU Juan HU Cheng-ping ZHANG Wei LI Jia-shu YU Qin WAN Huan-ying MU Lan ZHONG Xiao-ning WEI Li-ping MA Jian-jun WANG Qiu-yue HU Ke TIAN Gui-zhen CAI Shao-xi WANG Rui-qin HE Bei WANG Si-qin WANG Zhan-wei ZHAO Su-rui GAO Zhan-cheng | 2010 | Chinese Medical Journal2010，，18： | 13 |
| 7 | Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus显示文摘 | Zhang Wei Wan Jianguo Qian Kejian Liu Xiaoqing Xiao Zuke Sun Jian Zeng Zhenguo Wang Qi Zhang Jinxiang Jiang Guanghui Nie Cheng Jiang Rong Ding Chengzhi Li Ran Horby Peter Gao Zhancheng | 2014 | Chinese Medical Journal2014，，18： | 12 |
| 8 | First report of the South American tomato leafminer, Tuta absoluta (Meyrick), in China显示文摘Tuta absoluta(Meyrick) originated in South America and is one of the most serious pests of tomatoes. It is also known to attack other solanaceous crops, including potato, eggplant, pepper, tobacco, and weedy species such as black nightshade. After accidental introduction into Spain in 2006, this pest spread rapidly throughout Afro-Eurasia and has become a major threat to tomato production worldwide. Here, we report the first record of T. absoluta as an invasive pest in China. It was found in tomato fields in Ili Kazakg Autonomous Prefecture, Xinjiang Uygur Autonomous Region(Ili, Xinjiang), China, and its occurrence was confirmed by both morphological and molecular approaches. In Ili, T. absoluta has been found to attack eggplant, potato, and black nightshade. We found the larvae generally mining and feeding on leaves and boring into tomato fruits, with multiple larvae sometimes observed in a single fruit. Its infestation levels differ among the tomato fields and host species. In all of the surveyed tomato fields, T. absoluta infested 100% of plants. In some of the fields, up to 90% of the eggplant and 100% of the potato plants were infested. Since no natural enemies were found under field conditions, suitable management practices are urgently needed to stop the further spread of this destructive pest in China. | ZHANG Gui-fen MA De-ying WANG Yu-sheng GAO You-hua LIU Wan-xue ZHANG Rong FU Wen-jun XIAN Xiao-qing WANG Jun KUANG Meng WAN Fang-hao | 2020 | Journal of Integrative Agriculture2020，19，7： | 12 |
| 9 | Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma显示文摘包含蛋白质 1 的 Oxidored-nitro 领域(NOR1 ) 基因是首先从鼻咽的癌(NPC ) 孤立的新奇 nitroreductase 基因。它为它的 nitrosation 功能在化学致癌物的形成和 NPC 的 carcinogenesis 起一个重要作用。在鼻咽的癌细胞的野类型的 NOR1 基因的 Overexpression 是有效的禁止细胞生长和增长。在这研究,第一次,我们产生了高度特定的 NOR1 抗体并且在人的纸巾和 NPC 活体检视分析了 NOR1 分发。结果证明那 NOR1 蛋白质主要在人的鼻咽和气管的纸巾被表示。人的心,肝,怒气,胃,冒号,肾,骨胳的肌肉,胸腺,和胰都 NOR1 蛋白质是缺乏的。更重要地,我们在 NPC 纸巾执行了 NOR1 蛋白质表示的 immunohistochemistry 试金,并且结果证明那 NOR1 蛋白质在 NPC 经常是下面表示的。这些数据使 NOR1 的潜在的生理的函数的选择清楚些并且提供不可缺少的引用给 NPC 的 carcinogenesis 进程并且到识别或验证织物特定的药目标。 | Bo Xiang Mei Yi Li Wang Wei Liu Wenling Zhang Jue Ouyang Ya Peng Wenjuan Li Ming Zhou Huaying Liu Minghua Wu Rong Wan Xiaoling Li Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 10 |
| 10 | Spatial and Seasonal Patterns of Ichthyoplankton Assemblages in the Haizhou Bay and Its Adjacent Waters of China显示文摘Surveys were conducted in five voyages in Haizhou Bay and its adjacent coastal area from March to December 2011 during full moon spring tides. The ichthyoplankton assemblages and the environmental factors that affect their spatial and seasonal patterns were determined. Totally 35 and 12 fish egg and larvae taxa were identified, respectively. Over the past several decades, the egg and larval species composition has significantly changed in Haizhou Bay and its adjacent waters, most likely corresponding with the alteration of fishery resources, which are strongly affected by anthropogenic activities and climate change. The Bray-Curtis dissimilarity index identified four assemblages: near-shore bay assemblage, middle bay assemblage and two closely related assemblages(near-shore/middle bay assemblage and middle/edge of bay assemblage). The primary species of each assemblage principally reflected the spawning strategies of adult fish. The near-shore bay assemblage generally occurred in near-shore bay, with depths measuring <20 m, and the middle bay assemblage generally occurred in the middle of bay, with depths measuring 20 to 40 m. Spatial and seasonal variations in ichthyoplankton in each assemblage were determined by interactions between biological behavioral traits and oceanographic features, particularly the variation of local conditions within the constraint of a general reproductive strategy. The results of Spearman's rank correlation analysis indicated that both fish egg and larval abundance were positively correlated with depth, which is critical to the oceanographic features in Haizhou Bay. | LI Zengguang YE Zhenjiang WAN Rong | 2015 | Journal of Ocean University of China2015，14，6： | 10 |
| 11 | Independent and combined effects of environmental factors and miR-126, miR-143, and miR-145 on the risk of coronary heart disease显示文摘ObjectiveTo 在冠的心疾病(CHD ) 的风险上评估环境因素和 microRNAs (miRNAs )(miR-126, miR-143,和 miR-145 ) 的效果 .MethodsA 匹配频率的盒子控制学习(450 个病人, 450 控制) 在 Fuzhou 城市里从 2014 年 4 月被进行到 2016 年 12 月,中国。环境因素用一张自我管理的问询表,和表示被调查 miR-126, miR-143,和 miR-145 的层次被量的即时聚合酶链反应(PCR ) 在外部血 mononuclear 房间决定。无条件的逻辑回归模型被用于物理活动的统计 evaluation.ResultsAlcohol 消费,高盐的食谱,高紧张的工作,和缺乏显著地与增加的 CHD 风险被联系,而轻饮食显著地与减少的风险被联系。MiR-126, miR-143,和 miR-145 高度与控制组相比在 CHD 组被表示。在为另外的环境因素的调整以后,无条件的逻辑回归结果表明 miR-126 , miR-143 ,和消沉是 CHD 的独立风险因素,并且轻饮食是 CHD.ConclusionsOur 数据的独立保护的因素建议那 CHD 的家庭历史,焦虑,并且白酒消费显著地与增加的 CHD 风险被联系,而轻饮食显著地与减少的风险被联系。而且,在有几的联合的 miR-126 和 miR-143 冒险因素,能在 CHD 的发展起一个联合作用。因此,在所有方向和多重水平与 CHD 管理病人是必要的。 | Da-Cen LIN Jia-Bing LIN Zhou CHEN Rong CHEN Chun-Yu WAN Shao-Wei LIN Qi-Shuang RUAN Huang-Yuan LI Si-Ying WU | 2017 | Journal of Geriatric Cardiology2017，14，11： | 10 |
| 12 | Effects of recombinant retroviral vector mediated human insulin like growth factor-1 gene transfection on skeletal muscle growth in rat显示文摘Background This study transferred a recombinant gene encoding human insulin like growth factor-1 (hIGF-1) into modified primary skeletal myoblasts with a retroviral vector (pLgXSN ) and determined whether the hIGF-1 promoted growth of skeletal muscle in rat. Methods hIGF-1cDNA was amplified in vitro from normal human liver cells by using RT-PCR and cloned into plasmid vector pLgXSN. The recombinant vector pLghIGF-1SN and control vector pLgGFPSN were transfected into packaging cell PT67 and G418 was used to select positive colony. Myoblasts were infected with a high titre viral supernatant and transduction efficiency was evaluated as GFP expression. The expression of hIGF-1 mRNA in myoblasts was investigated by immunocytochemistry and RT-PCR. MTT assays detected the growth of myoblasts in vitro. Myoblasts transduced with pLghIGF-1SN were injected into hind limb muscles of 10-12 week male SD rats. Formed tissues were harvested 4 weeks later. Myocyte diameter, mean weight of hind limb and body were measured to evaluate the skeletal muscle growth. Results Recombinant retroviral plasmid vector pLghIGF-1SN was constructed successfully. The titre of the packaged recombinant retrovirus was 1×106 cfu/ml. The transfection rate of PT67 cells reached 100% after G418 screening. hIGF-1 expression was positive in myoblast-IGF-1. The proliferation rate of myoblast-IGF-1 in vitro was higher than GFP-myoblast or myoblast (P< 0.05). The mean weights of hind limb and body of rats injected myoblast-IGF-1 were higher than those of the rats injected with myoblast-GFP or myoblast (P< 0.05). Myocyte diameter had a significant increase in IGF-1 group compared to GFP group and myoblast group (P< 0.05). Conclusions The transfection of the human IGF-1 gene mediated by a retroviral vector can promote the growth of skeletal muscle in rats. Genetically modified primary skeletal myoblasts provide a possibly effective approach to treat some skeletal muscle diseases. | RONG Shu-Ling LU Yong-Xin LIAO Yu-Hua WANG Xiao-Lin GUO He-Ping CHANG Chao GAO Yan-Zhang MI Shao-Hua Wan Jian-Ping | 2006 | Chinese Medical Journal2006，，23： | 10 |
| 13 | Clinical characteristics and corticosteroid therapy in patients with autoimmune-hepatitis-induced liver failure显示文摘AIM:To investigate the clinical features,response to corticosteroids,and prognosis of autoimmune hepatitis(AIH)-induced liver failure in China.METHODS:A total of 22 patients(19 female and 3male;average age 51±15 years)with AIH-induced liver failure treated in our hospital from 2004 to 2012were retrospectively analyzed.Clinical,biochemical and pathological characteristics of the 22 patients and responses to corticosteroid treatment in seven patients were examined retrospectively.The patients were divided into survivor and non-survivor groups,and the clinical characteristics and prognosis were compared between the two groups.The t test was used for data analysis of all categorical variables,and overall survival was calculated by the Kaplan-Meier method.RESULTS:At the time of diagnosis,mean IgG was2473±983 mg/dL,with three(18.8%)patients showing normal levels.All of the patients had elevated serum levels of antinuclear antibody(≥1:640).Liver histology from one patient showed diagnostic pathological changes,including massive necrosis and plasma cell infiltration.Four patients survived(18.2%)and 18died(81.8%)without liver transplantation.The results showed that patients with low admission Model for End-Stage Liver Disease(MELD)scores(21.50±2.08vs 30.61±6.70,P<0.05)and corticosteroid therapy(100%vs 16.7%,P<0.05)had better prognosis.A total of seven patients received corticosteroid therapy,of whom,four responded and survived,and the other three died.Survivors showed young age,shorter duration from diagnosis to corticosteroid therapy,low MELD score,and absence of hepatic encephalopathy at the time of corticosteroid administration.Six patients who were administered corticosteroids acquired fungal infections but recovered after antifungal therapy.CONCLUSION:Early diagnosis and corticosteroid therapy are essential for improving the prognosis of patients with AIH-induced liver failure without liver transplantation. | Bing Zhu Shao-Li You Zhi-Hong Wan Hong-Ling Liu Yi-Hui Rong Hong Zang Shao-Jie Xin | 2014 | World Journal of Gastroenterology2014，20，23： | 10 |
| 14 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013，，5： | 9 |
| 15 | MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression显示文摘AIM To explore the mechanism by which micro RNA-155(miR-155) regulates the pathogenesis of experimental colitis.METHODS A luciferase assay was performed to confirm the binding of miR-155 to the SHIP-1 3'-UTR. MiR-155 mimics, negative controls and SHIP-1 expression/knockdown vectors were established and then utilized in gain-and loss-of-function studies performed in raw264.7 cells and primary bone marrow-derived macrophages (BMDMs). Thereafter, dextran sulfate sodium(DSS)-induced colitis mouse model with or without antagomiR-155 treatment was established, and the levels of miR-155 and SHIP-1, as well as the pro-inflammatory capabilities, were measured by western blot, quantitative polymerase chain reaction, and immunohistochemistry.RESULTS MiR-155 directly bound to the 3'-UTR of SHIP-1 mRNA and induced a significant decrease in SHIP-1 expression in both raw264.7 cells and primary BMDMs. MiR-155 markedly promoted cell proliferation and proinflammatory secretions including IL-6, TNF-α, IL-1β, and IFN-γ, whereas these effects could be reversed by the restoration of SHIP-1 expression. In vivo studies showed that antagomiR-155 administration could alleviate DSS-induced intestinal inflammation in Balb/c mice. Moreover, significantly increased SHIP-1 expression, as well as decreased Akt activation and inflammatory response, were observed in the antagomiR-155-treated mice.CONCLUSION MiR-155 promotes experimental colitis by repressing SHIP-1 expression. Thus, the inhibition of miR-155 might be a promising strategy for therapy. | Zhan-Jun Lu Jian-Jiong Wu Wei-Liang Jiang Jun-Hua Xiao Kai-Zhong Tao Lei Ma Ping Zheng Rong Wan Xing-Peng Wang | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 16 | Effect of Lianshu preparation on lipopolysaccharide-induced diarrhea in rats显示文摘AIM:To investigate the effect of Lianshu preparation on lipopolysaccharide (LPS)-induced diarrhea in rats.METHODS: A diarrhea model was established in Sprague Dawley rats via injection of 1 mL of 30 mg/kg LPS. A total of 40 rats were randomly divided into normal group, LPS group, LPS + Lianshu group, LPS + berberine group (n=10 in each group). Their intestinal mucosal barrier and frequency of diarrhea were observed. Levels of glucose, serum Na+, K+, Cl- and hematocrit, plasma nitrogen monoxide (NO), diamine oxidase (DAO), and D (-)-lactate were measured. The number of IgA+ plasma cells in small intestine was detected and SIgA levels in the intestinal fluid were measured. The antipyretic activity of Lianshu preparation in rats was evaluated using Brewer's yeast-induced pyrexia (10 mL/kg of 20% aqueous suspension). Acetaminophen (250 mg/kg, intragastric administration, bid) was used as a standard drug for comparison. Temperature was recorded 1 h before and 6 h after Brewer's yeast injection. Finally, small intestinal transmission in mice treated with Lianshu was detected after intraperitoneal injection of methyl prostigmin (2 mg/kg). Atropine (10 g/kg) was used as a control. The ink content in intestine was determined and the total length of intestine was measured.RESULTS: The frequency of diarrhea was higher in LPS group than in LPS + Lianshu group and LPS + berberine group (36.70±5.23 vs 28.50 ±4.06 and 32.70±9.30 respectively, P<0.01), and lower in LPS + Lianshu group than in LPS + berberine group (P=0.03). The levels of Na+, glucose, Cl-, K+ were significantly lower in LPS + Lianshu group than in LPS + berberine group (140.35±3.19 mmol/L vs 131.99±4.86 mmol/L, 8.49 ±1.84 mmol/L vs 6.54±2.30 mmol/L, 106.29±4.41 mmol/L vs 102.5±1.39 mmol/L, 5.08±0.66 mmol/L vs 4.32±0.62 mmol/L respectively, p<0.05). The level of hematocrit was lower in LPS + Lianshu group than in LPS + berberine group (0.50% ± 0.07% vs 0.59% ± 0.10% respectively, P<0.05). The plasma levels of NO, DAO and D (-)-lactate were higher in LPS group than in normal group (79.74±7.39 μmol/L vs 24.94±3.38 μmol/L, 2.48±0.42 μ/mL vs 0.82±0.33 μ/mL, 5.63±0.85 μg/mL vs 2.01±0.32 μg/mL respectively, P<0.01), and lower in LPS + Lianshu group than in LPS+berberine group (48.59±4.70 μmol/L vs 51.56±8.38 μmol/L, 1.43±0.53 μmol/mL vs 1.81±0.42 μmol/mL, 4.00±0.54 μg/mL vs 4.88±0.77 μg/mL respectively, P<0.05). The morphology of the intestinal mucosa showed destroyed villi in LPS group and atrophied intestinal mucosa in other groups. The pathological intestinal mucosal changes were less in LPS + Lianshu group than in LPS group. The number of IgA+ plasma cells and amount of SIgA were higher in LPS + Lianshu group than in LPS group (1.16±0.19/μm2 vs 1.09±0.28/μm2, P=0.026; 0.59±0.12 mg/L vs 0.15±0.19 mg/L respectively, P=0.000). Lianshu had counteractive effects on yeast-induced pyrexia and enterokinesia in rats.CONCLUSION: Lianshu preparation has therapeutic effects on LPS-induced diarrhea and enterokinesia in rats. | Jun Liu Rong Wan Xuan-Fu Xu Xing-Peng Wang Wen-Juan Yang Yu-Jing Xia Hua Liu Qian-Lin Yan De-Xin Yan Chuan-Yong Guo | 2009 | World Journal of Gastroenterology2009，15，16： | 7 |
| 17 | Rationale,new anus positioning methods,and updated protocols:Expert recommendations on cap-assisted endoscopic sclerotherapy for hemorrhoids from China Gut Conference显示文摘Injection sclerotherapy is most effective for internal hemorrhoids,especially for patients with bleeding.Howev-er,traditional sclerotherapy via anoscope may cause iatrogenic risk and complications due to misplaced injections.[1]The flexible endoscopic sclerotherapy for internal hemorrhoids using a short needle without cap assistant was first reported in 1991 in the United States.[2]The flexible endoscopic injection using a short needle with cap assistant was reported in 2014 in Japan.[3]Cap-assisted endoscopic sclerotherapy(CAES)primarily using a long needle was reported in 2015[4]as an emerging flexible endoscopic therapy,and has been widely used for internal hemorrhoids and some prolapse in China.A panel of experts aimed to develop expert recommendations for CAES and derived guidelines on the key issues in hemorrhoidal disease,including rationale,new positioning methods for anus,indications,contraindications,techniques,post-procedure management,and core outcome set for evaluation[Figure 1]. | Fa-Ming Zhang Kai-Chun Wu Jing-Nan Li Xin Wang Xing-Xiang He Rong Wan Shi-Yao Chen CAES-LPRA Study Group | 2021 | Chinese Medical Journal2021，，22： | 6 |
| 18 | Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids显示文摘Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and isolation of ten compounds. Further investigation of the crude extract of C. arbuscula Δhda A strain resulted in the isolation of twelve new diterpenoids including three cassanes(1-3), one cleistanthane(4), six pimaranes(5-10), and two isopimaranes(11 and 12) along with two know cleistanthane analogues. Their structures were elucidated by extensive NMR spectroscopic data analysis. Compounds 2 and 4 showed potent inhibitory effects on the expression of MMP1 and MMP2(matrix metalloproteinases family) in human breast cancer(MCF-7) cells. | Jian Bai Rong Mu Man Dou Daojiang Yan Bingyu Liu Qian Wei Jun Wan Yi Tang Youcai Hu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 5 |
| 19 | A large-scale functional approach to uncover human genes and pathways in Drosophila显示文摘我们表明为他们导致 overexpression 显型的能力由 assaying 在果蝇为人的基因功能执行一幅系统的屏幕的可行性。相应于 236 人的基因的超过 1 500 根转基因的苍蝇线被建立了。总共, 51 根线能够得到建议人的基因是功能的显型。当我们发现类似的变异的显型也被主导的否定异种引起了,这些 heterologous 基因是机能上地相关的人的 ribosomal 蛋白质 L8 基因或由果蝇 RPL8 的 RNAi downregulation 的形式。显著地,果蝇 RPL8 异种能被野类型的人的 RPL8 救。我们也提供果蝇 RPL8 是表明小径的胰岛素的一个新成员的基因证据。在摘要,许多人的基因的功能出现到高度被保存,并且在果蝇识别他们的能力在 vivo 为人的抄本的大规模分析代表一个强大的基因工具。 | Rong Xu Kejing Deng Yi Zhu Yue Wu Jing Ren Min Wan Shouyuan Zhao Xiaohui Wu Min Han Yuan Zhuang Tian Xu | 2008 | Cell Research2008，18，11： | 5 |
| 20 | Polycyclic Aromatic Hydrocarbons in Agricultural Soils of the Southern Subtropics,China显示文摘从到全球环境的污染的中国的副热带的区域的坚持的有机污染物(流行音乐) 的贡献被付了大注意;然而,很少在中国的这些区域以内在农业生态系统对流行音乐的国家被知道。这研究首先揭示了污染的国家和多不的芳族烃的分发(哼) 在在副热带的区域的农业土壤。115 表土(0 20 厘米) 在这些区域的胃被取样。集中和类型哼坚定的使用气体色层法被连接到质谱法(GCMS ) 。总数哼集中从 22.1 ~ 1 256.9 ng g ? 1,与 318.2 ±的一个平均数 148.2 ng g ? 1。措辞笼统地,水流哼集中比大多数哼低层次从不同国家和区域在很多调查报导了。哼异构体比率显示了那焦性没食子酸 lysin 的起源例如与车辆尾巴气体和工业排出物有关的石块燃料燃烧,是主导的来源在中国的南部的副热带的区域哼。尽管哼集中与减少的污染,人口,和交通密度减少了,在很大程度上哼作文在整个副热带的土壤是类似的与萘,菲, fluoranthene,和是主导的 benzo (b) fluoranthene。 | HAO Rong WAN Hong-Fu SONG Yan-Tun JIANG Hong PENG Shao-Lin | 2007 | Pedosphere2007，17，5： | 5 |
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