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| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China显示文摘The dengue virus(DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope(E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype Ⅰ strains, including 8genotype Ⅰ and 9 genotype V strains. Additionally, 6 genotype Ⅰ strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype Ⅰ strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype Ⅴ strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou. | Geng Li Pan Pan Qiuyan He Xiujuan Kong Kailang Wu Wei Zhang Yuntao Liu Huiting Huang Jianbo Liu Zhongde Zhang De Wu Xiaoping Lai Xiaohong Liu Jianguo Wu | 2017 | Virologica Sinica2017，32，1： | 7 |
| 3 | Recent advances in multi-layer composite polymeric membranes for CO_2 separation: A review显示文摘The development of multilayer composite membranes for CO_2 separation has gained increasing attention due to the desire for energy efficient technologies. Multilayer composite membranes have many advantages, including the possibility to optimize membrane materials independently by layers according to their different functions and to reduce the overall transport resistance by using ultrathin selective layers, and less limitations on the material mechanical properties and processability. A comprehensive review is required to capture details of the progresses that have already been achieved in developing multilayer composite membranes with improved CO_2 separation performance in the past 15-20 years.In this review, various composite membrane preparation methods were compared, advances in composite membranes for CO_2/CH_4 separation,CO_2/N_2 and CO_2/H_2 separation were summarized with detailed data, and challenges facing for the CO_2 separation using composite membranes,such as aging, plasticization and long-term stability, were discussed. Finally the perspectives and future research directions for composite membranes were presented. | Zhongde Dai Luca Ansaloni Liyuan Deng | 2016 | Green Energy & Environment2016，1，2： | 6 |
| 4 | The privacy protection mechanism of Hyperledger Fabric and its application in supply chain finance显示文摘Blockchain technology ensures that data is tamper-proof,traceable,and trustworthy.This article introduces a wellknown blockchain technology implementation—Hyperledger Fabric.The basic framework and privacy protection mechanisms of Hyperledger Fabric such as certificate authority,channel,Private Data Collection,etc.are described.As an example,a specific business scenario of supply chain finance is figured out.And accordingly,some design details about how to apply these privacy protection mechanisms are described. | Chaoqun Ma Xiaolin Kong Qiujun Lan Zhongding Zhou | 2019 | Cybersecurity2019，2，1： | 6 |
| 5 | Digital high-efficiency print forming method and device for multi-material casting molds显示文摘Sand mold 3D printing technology based on the principle of droplet ejection has undergone rapid development in recent years and has elicited increasing attention from engineers and technicians.However,current sand mold 3D printing technology exhibits several problems,such as single-material printing molds,low manufacturing efficiency,and necessary post-process drying and heating for the manufacture of sand molds.This study proposes a novel high-efficiency print forming method and device for multi-material casting molds.The proposed method is specifically related to the integrated forming of two-way coating and printing and the shortflow manufacture of roller compaction and layered heating.These processes can realize the high-efficiency print forming of high-performance sand molds.Experimental results demonstrate that the efficiency of sand mold fabrication can be increased by 200%using the proposed two-way coating and printing method.The integrated forming method for layered heating and roller compaction presented in this study effectively shortens the manufacturing process for 3D-printed sand molds,increases sand mold strength by 63.8%,and reduces resin usage by approximately 30%.The manufacture of multi-material casting molds is demonstrated on typical wheeled cast-iron parts.This research provides theoretical guidance for the engineering application of sand mold 3D printing. | Zhongde SHAN Zhi GUO Dong DU Feng LIU Wenjiang LI | 2020 | Frontiers of Mechanical Engineering2020，15，2： | 5 |
| 6 | CO_2 absorption with ionic liquids at elevated temperatures显示文摘CO_2 capture with ionic liquids(ILs) has attracted many attentions, and most works focused on absorption ability at ambient temperatures, while seldom research was concerned at elevated temperatures.This not only limits the CO_2 absorption application at elevated temperature, but also the determination of the operation condition of the CO_2 desorption generally occurring at higher temperature. This work mainly reported CO_2 solubilities in ILs at elevated temperatures and related properties were also provided. 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide([CnMIm][Tf_2N]) ILs were selected as physical absorbents for CO_2 capture in this work due to their relative higher CO_2 absorption capacities and good thermal stabilities. The long-term stability tests showed that [CnMIm][Tf_2N] is thermally stable at 393.15 K for long time. CO_2 solubilities in [CnMIm][Tf_2N] were systematically determined at temperatures from 353.15 K to 393.15 K. It demonstrated that CO_2 solubility obviously increases with the increase of pressure while slightly decreases with increase of temperature. As the length of alkyl chain on the cation increases, CO_2 solubility in ILs increases. Additionally, the thermodynamic properties including the Gibbs free energy, enthalpy, and entropy of CO_2 were also calculated. | Lu Bai Dawei Shang Mengdie Li Zhongde Dai Liyuan Deng Xiangping Zhang | 2017 | Journal of Energy Chemistry2017，26，5： | 5 |
| 7 | PVA/PVP blend polymer matrix for hosting carriers in facilitated transport membranes: Synergistic enhancement of CO2 separation performance显示文摘CO2 separation performance in facilitated transport membranes has been reported depended not only on the CO2 carrier properties but also to a great extent on the polymeric matrix regarding the capacity of retaining water and carriers as well as the processability for coating defect-free ultra-thin films. In this study, the blends of hydrophilic polymers polyvinyl pyrrolidone(PVP) and polyvinyl alcohol(PVA) were studied to find an optimal polymer matrix to host carriers in facilitated transport membranes for enhanced CO2 separation. It is found out that the optimized blend is 50/50 PVA/PVP by weight, which shows a significant increase in the water uptake(from 63 to 84%) at equilibrium state compared to the neat PVA. Polyethyleneimine(PEI) was employed to provide sample carriers to evaluate the synergistic effect of PVA and PVP on the CO2 separation performance. A thin film composite(TFC) membrane of the optimized blend(50/50 PVA/PVP with 50 wt% PEI) was fabricated on polysulfone(PSf) porous support. The fabrication of the TFC membranes is simple and low cost, and CO2 permeance of the optimized blend membrane is nearly doubled with the CO2/N2 selectivity remained unchanged, showing great potential for industrial applications of the resulted membranes. | Ragne Marie Lilleby Helberg Zhongde Dai Luca Ansaloni Liyuan Deng | 2020 | Green Energy & Environment2020，5，1： | 5 |
| 8 | Interfacial Bonding Mechanism and Mechanical Performance of Continuous Fiber Reinforced Composites in Additive Manufacturing显示文摘The additive manufacturing of continuous fiber composites has the advantage of a high-precision and efficient forming process,which can realize the lightweight and integrated manufacturing of complex structures.However,many void defects exist between layers in the printing process of additive manufacturing;consequently,the bonding performance between layers is poor.The bonding neck is considered a key parameter for representing the quality of interfacial bonding.In this study,the formation mechanism of the bonding neck was comprehensively analyzed.First,the influence of the nozzle and basement temperatures on the printing performance and bonding neck size was measured.Second,CT scanning was used to realize the quantitative characterization of bonding neck parameters,and the reason behind the deviation of actual measurements from theoretical calculations was analyzed.When the nozzle temperature increased from 180 to 220℃,CT measurement showed that the bonding neck diameter increased from 0.29 to 0.34 mm,and the cross-sectional porosity reduced from 5.48%to 3.22%.Finally,the fracture mechanism was studied,and the influence of the interfacial bonding quality on the destruction process of the materials was determined.In conclusion,this study can assist in optimizing the process parameters,which improves the precision of the printing parts and performance between the layers. | Congze Fan Zhongde Shan Guisheng Zou Li Zhan Dongdong Yan | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 4 |
| 9 | Design of an MRI quadrature-data acquisition card显示文摘照数据获得的一个图案基于外部部件相连(一种总线标准) 去微型的公共汽车磁性的回声成像(MRI ) 系统被报导。取样 MRI 信号和二静态的随机使用二个高速度 analog-to-digital 变换器(模数转换器) 存取记忆(静态存储器) 存储将被一种总线标准公共汽车在采样以后读到计算机的数据。卡片上的所有逻辑控制信号由这块地被产生可编程的门数组(FPGA ) 。软件基础 3.1 被用来设计 FPGA 并且在模仿并且实现以后完成有用结果。卡有正常的商业卡没有的一些记忆。例如,采样参数能根据不同脉搏序列被改变。 | JIANG Zhongde ZU Donglin GU Xiaofang | 2006 | Progress in Natural Science:Materials International2006，16，3： | 3 |
| 10 | Modelling of a tubular membrane contactor for pre-combustion CO_2 capture using ionic liquids:Influence of the membrane configuration, absorbent properties and operation parameters显示文摘A membrane contactor using ionic liquids(ILs) as solvent for pre-combustion capture CO_2 at elevated temperature(303-393 K) and pressure(20 bar) has been studied using mathematic model in the present work. A comprehensive two-dimensional(2 D) mass-transfer model was developed based on finite element method. The effects of liquid properties, membrane configurations, as well as operation parameters on the CO_2 removal efficiency were systematically studied. The simulation results show that CO_2 can be effectively removed in this process. In addition, it is found that the liquid phase mass transfer dominated the overall mass transfer. Membranes with high porosity and small thickness could apparently reduce the membrane resistance and thus increase the separation efficiency. On the other hand, the membrane diameter and membrane length have a relatively small influence on separation performance within the operation range. | Zhongde Dai Muhammad Usman Magne Hillestad Liyuan Deng | 2016 | Green Energy & Environment2016，1，3： | 3 |
| 11 | Centrifuge experiment on the penetration test for evaluating undrained strength of deep-sea surface soils显示文摘Rapid advances in deep-sea mining engineering have created an urgent need for the accurate evaluation of the undrained strength of marine soils,especially surface soils.Significant achievements have been made using full-flow penetration penetrometers to evaluate marine soil strength in the deep penetration;however,a method considering the effect of ambient water on the surface penetration needs to be established urgently.In this study,penetrometers with multiple probes were developed and used to conduct centrifuge experiments on South China Sea soil and kaolin clay.First,the forces on the probes throughout the penetration process were systematically analyzed and quantified.Second,the spatial influence zone was determined by capturing the resistance changes and sample crack development,and the penetration depth for a sample to reach a stable failure mode was given.Third,the vane shear strength was used to invert the penetration resistance factor of the ball and determine the range of the penetration resistance factor values.Furthermore,a methodology to determine the penetration resistance factors for surface marine soils was established.Finally,the effect of the water cavity above various probes in the surface penetration was used to formulate an internal mechanism for variations in the penetration resistance factor. | Xingsen Guo Tingkai Nian Wei Zhao Zhongde Gu Chunpeng Liu Xiaolei Liu Yonggang Jia | 2022 | International Journal of Mining Science and Technology2022，32，2： | 2 |
| 12 | Effects of intercropping with persimmon on the rhizosphere environment of tea显示文摘The rhizosphere environment of tea(Camelllia sinensis Kuntze)intercropped with persimmon(Diospyros kaki)differs from monocultures of tea.A trial was conducted to determine the effects of intercropping with persimmon on root exudates and soil nutrient condition of tea.Amino acid exuded in intercropping was three times higher than that in monoculture.Phenol,phenol/amino acid ration,dissolved sugar,and total organic acid were also lower in intercropping.The value of pH in soil was higher,and soil nutrient condition of rhizosphere,especially available nutrient,was not as well in intercropping as that in tea grown alone.While soil nutrient of non-rhizosphere was better than that in monoculture,tea quality and soil nutrient condition were better in intercropping ecosystem. | ZHU Haiyan LIU Zhongde WANG Changrong ZHONG Zhangcheng | 2006 | Frontiers in Biology2006，1，4： | 2 |
| 13 | Hot stamp- ing die design for vehicle door beams using ultra-high strength steel 显示文摘 | Jiang Chao Shan Zhongde Zhuang Bailiang | 2012 | International Journal of Precision Engineering and Manufacturing2012，13，7： | 1 |
| 14 | Capacitance behaviors of nanorod polyaniline films controllably synthesized by using a novel unipolar pulse electro-polymerization method显示文摘 | Yue Li Kai Zhao Xiao Du Zhongde Wang Xiaogang Hao Shibin Liu Guoqing Guan | 2011 | Synthetic Metals2011，，1： | 1 |
| 15 | Steam reforming of tar derived from the steam pyrolysis of biomass over metal catalyst supported on zeolite显示文摘 | Malinee Kaewpanha Guoqing Guan Xiaogang Hao Zhongde Wang Yutaka Kasai Seiji Kakuta Kastuki Kusakabe Abuliti Abudula | 2013 | Journal of the Taiwan Institute of Chemical Engin2013，，6： | 1 |
| 16 | Research on Patternless Casting CNC Manufacturing Technology and Development of the Equipment显示文摘 | Zhongde Shan Feng Liu Li Zhan Zhilin Lin | | Advanced0，，： | 1 |
| 17 | Shangguan Rapid and sensitive suspension array for multiplex detection oforganophospho- rus pesticides and carbamate pesticides based onsilica hydrogel hybrid microbeads 显示文摘 | Xuan Wang Zhongde Mu Fengqi et al | 2014 | Journal of Hazardous Materials2014，273，： | 1 |
| 18 | Valid machine tool setup for helical groove machining 显示文摘 | Shi Zhongde Malkin Stephen | 2004 | Journal of Manufacturing Processes2004，6，2： | 1 |
| 19 | A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options显示文摘Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not clear.We analyzed 317 urine proteomes,including 86 COVID-19,55 pneumonia and 176 healthy controls,and identified specific RNA virus detector protein DDX58/RIG-I only in COVID-19 samples.Comparison of the COVID-19 urinary proteomes with controls revealed major pathway alterations in immunity,metabolism and protein localization.Biomarkers that may stratify severe symptoms from moderate ones suggested that macrophage induced inflammation and thrombolysis may play a critical role in worsening the disease.Hyper activation of the TCA cycle is evident and a macrophage enriched enzyme CLYBL is up regulated in COVID-19 patients.As CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA,an increase in CLYBL may lead to the depletion of itaconate,limiting its anti-inflammatory function.These observations suggest that supplementation of itaconate and inhibition of CLYBL are possible therapeutic options for treating COVID-19,opening an avenue of modulating host defense as a means of combating SARS-CoV-2 viruses. | Yuntao Liu Lan Song Nairen Zheng Jinwen Shi Hongxing Wu Xing Yang Nianci Xue Xing Chen Yimin Li Changqing Sun Cha Chen Lijuan Tang Xiaotian Ni Yi Wang Yaling Shi Jianwen Guo Guangshun Wang Zhongde Zhang Jun Qin | 2022 | Science China(Life Sciences)2022，65，9： | 1 |
| 20 | Numerical simulation of force distributions in the grinding contact zone 显示文摘 | M Srinivasaraghavan Zhongde Shi H Attia | 2010 | Abrasive Technology2010，3，1： | 1 |
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