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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Comparative proteomic and metabolomic analyses reveal mechanisms of improved cold stress tolerance in bermudagrass (Cynodon dactylon(L.) Pers.) by exogenous calcium显示文摘As an important second messenger, calcium is involved in plant cold stress response, including chilling(<20 °C) and freezing(<0 °C). In this study, exogenous application of calcium chloride(CaCl2) improved both chilling and freezing stress tolerances, while ethylene glycol‐bis‐(b‐aminoethyl) ether‐N,N,N,N‐tetraacetic acid(EGTA) reversed CaCl2 effects in bermudagrass(Cynodon dactylon(L.) Pers.).Pysiological analyses showed that CaCl2 treatment alleviated the reactive oxygen species(ROS) burst and cell damage triggered by chilling stress, via activating antioxidant enzymes,non‐enzymatic glutathione antioxidant pool, while EGTA treatment had the opposite effects. Additionally, comparative proteomic analysis identified 51 differentially expressed proteins that were enriched in redox, tricarboxylicacid cycle,glycolysis, photosynthesis, oxidative pentose phosphate pathway, and amino acid metabolisms. Consistently, 42 metabolites including amino acids, organic acids, sugars, and sugar alcohols were regulated by CaCl2 treatment under control and cold stress conditions, further confirming the Researchcommon modulation of CaCl2 treatment in carbon metabolites and amino acid metabolism. Taken together, this study reported first evidence of the essential and protective roles of endogenous and exogenous calcium in bermudagrass response to cold stress, partially via activation of the antioxidants and modulation of several differentially expressed proteins and metabolic homeostasis in the process of cold acclimation. | Haitao Shi Tiantian Ye Bao Zhong Xun Liu Zhulong Chan | 2014 | Journal of Integrative Plant Biology2014，56，11： | 19 |
| 3 | Identification of rice cultivars with low brown rice mixed cadmium and lead contents and their interactions with the micronutrients iron,zinc,nickel and manganese显示文摘Paddy fields in mining areas are usually co-contaminated by a cocktail of mixed toxic heavy metals(e.g.,Cd and Pb in Pb/Zn mines).However,previous studies on rice cultivars screened for effective metal exclusion have mostly focused on individual metals,and have been conducted under pot-trial or hydroponic solution conditions.This study identified rice cultivars with both low Cd and Pb accumulation under Cd-and Pb-contaminated field conditions,and the interactions of the toxic elements Cd and Pb with the micronutrient elements Fe,Zn,Mn and Ni were also studied.Among 32 rice cultivars tested,there were significant differences in Cd(0.06-0.59 mg/kg) and Pb(0.25-3.15 mg/kg) levels in their brown rice,and similar results were also found for the micronutrient elements.Significant decreases in concentrations of Fe and Mn were detected with increasing Cd concentrations and a significant elevation in Fe,Mn and Ni with increasing Pb concentrations.A similar result was also shown by Cd and Ni.Three cultivars were identified with a combination of low brown rice Cd and Pb,high micronutrient and grain yield(Wufengyou 2168,Tianyou 196 and Guinongzhan).Present results suggest that it is possible to breed rice cultivars with low mixed toxic element(Cd,Pb) and high micronutrient contents along with high grain yields,thus ensuring food safety and quality. | Bing Li Xun Wang Xiaoli Qi Lu Huang Zhihong Ye | 2012 | Journal of Environmental Sciences2012，24，10： | 18 |
| 4 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 5 | Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors显示文摘Programmed cell death protein-1(PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T(CAR-T)cells in solid tumors.We generated PD-1 and T cell receptor(TCR)deficient mesothelin-specific CAR-T(MPTK-CAR-T)cells using CRISPR-Cas9 technology and evaluated them in a dose-escalation study.A total of 15 patients received one or more infusions of MPTK-CAR-T cells without prior lymphodepletion.No dose-limiting toxicity or unexpected adverse events were observed in any of the 15 patients.The best overall response was stable disease(2/15 patients).Circulating MPTK-CAR-T cells peaked at days 7–14 and became undetectable beyond 1 month.TCR-positive CAR-T cells rather than TCR-negative CAR-T cells were predominantly detected in effusion or peripheral blood from three patients after infusion.We further confirmed the reduced persistence of TCR-deficient CAR-T cells in animal models.Our results establish the preliminary feasibility and safety of CRISPR-engineered CAR-T cells with PD-1 disruption and suggest that the natural TCR plays an important role in the persistence of CAR-T cells when treating solid tumors. | Zhenguang Wang Na Li Kaichao Feng Meixia Chen Yan Zhang Yang Liu Qingming Yang Jing Nie Na Tang Xingying Zhang Chen Cheng Lianjun Shen Jiaping He Xun Ye Wei Cao Haoyi Wang Weidong Han | 2021 | Cellular & Molecular Immunology2021，18，9： | 7 |
| 6 | MicroRNA-98 induces an Alzheimer's disease-like disturbance by targeting insulin-like growth factor 1显示文摘Alzheimer 's disease( A D) is a progressive neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles.Many microRNAs(miRs) participate in regulating amyloid β(Aβ) formation and the metabolism of tau protein in the process of AD,and some are up-regulated in AD patients or transgenic models of AD.However,the role of miR-98 in AD remains unclear.Here,we showed that the expression of miR-98 was negatively correlated with the insulin-like growth factor 1(IGF-1) protein level in APP/PS1 mice.MiR-98 target sites in IGF-1 were confirmed by luciferase assay in HEK293 cells.Overexpression of miR-98 in N2a/APP cells down-regulated the IGF-1 protein level and promoted Aβ production,whereas inhibition of miR-98 in N2a/APP cells up-regulated the IGF-1 protein level and suppressed Aβ production.Furthermore,overexpression of miR-98 in N2a/WT cells increased the phosphorylation of tau,whereas inhibition of miR-98 reduced it.These results suggest that miR-98 increases Aβ formation and tau phosphorylation by inhibiting the translation of IGF-1,which might provide a therapeutic strategy for AD. | Yi-Kui Hu Xun Wang Lian Li Yan-Hua Du Heng-Tai Ye Cheng-Yan Li | 2013 | Neuroscience Bulletin2013，29，6： | 7 |
| 7 | Prognostic significance of computed tomography-detected extramural vascular invasion in colon cancer显示文摘AIM: To compare disease-free survival(DFS) between extramural vascular invasion(EMVI)-positive and-negative colon cancer patients evaluated by computed tomography(CT).METHODS: Colon cancer patients(n = 194) undergoing curative surgery between January 2009 and December 2013 were included. Each patient's demographics, cancer characteristics, EMVI status, pathological status and survival outcomes were recorded. All included patients had been routinely monitored until December 2015. EMVI was defined as tumor tissue within adjacent vessels beyond the colon wall as seen on enhanced CT. Disease recurrence was defined as metachronous metastases, local recurrence, or death due to colon cancer. Kaplan-Meier analyses were used to compare DFS between the EMVI-positive and-negative groups. Cox's proportional hazards models were used to measure the impact of confounding variables on survival rates.RESULTS: EMVI was observed on CT(ct EMVI) in 60 patients(30.9%, 60/194). One year after surgery, there was no statistically significant difference regarding the rates of progressive events between EMVI-positive and-negative patients [11.7%(7/60) and 6.7%(9/134), respectively; P = 0.266]. At the study endpoint, the EMVI-positive patients had significantly more progressive events than the EMVI-negative patients [43.3%(26/60) and 14.9%(20/134), respectively; oddsratio = 4.4, P < 0.001]. Based on the Kaplan-Meier method, the cumulative 1-year DFS rates were 86.7%(95%CI: 82.3-91.1) and 92.4%(95%CI: 90.1-94.7) for EMVI-positive and EMVI-negative patients, respectively. The cumulative 3-year DFS rates were 49.5%(95%CI: 42.1-56.9) and 85.8%(95%CI: 82.6-89.0), respectively. Cox proportional hazards regression analysis revealed that ctE MVI was an independent predictor of DFS with a hazard ratio of 2.15(95%CI: 1.12-4.14, P = 0.023). CONCLUSION: ctE MVI may be helpful when evaluating disease progression in colon cancer patients. | Xun Yao Su-Xing Yang Xing-He Song Yan-Cheng Cui Ying-Jiang Ye Yi Wang | 2016 | World Journal of Gastroenterology2016，22，31： | 6 |
| 8 | Coherent optical adaptive technique improves the spatial resolution of STED microscopy in thick samples显示文摘Stimulated emission depletion(STED) microscopy is one of far-field optical microscopy techniques that can provide sub-diffraction spatial resolution. The spatial resolution of the STED microscopy is determined by the specially engineered beam profile of the depletion beam and its power. However, the beam profile of the depletion beam may be distorted due to aberrations of optical systems and inhomogeneity of a specimen's optical properties, resulting in a compromised spatial resolution. The situation gets deteriorated when thick samples are imaged. In the worst case, the severe distortion of the depletion beam profile may cause complete loss of the superresolution effect no matter how much depletion power is applied to specimens. Previously several adaptive optics approaches have been explored to compensate aberrations of systems and specimens. However, it is difficult to correct the complicated high-order optical aberrations of specimens. In this report, we demonstrate that the complicated distorted wavefront from a thick phantom sample can be measured by using the coherent optical adaptive technique. The full correction can effectively maintain and improve spatial resolution in imaging thick samples. | WEI YAN YANLONG YANG YU TAN XUN CHEN YANG LI JUNLE QU TONG YE | 2017 | Photonics Research2017，5，3： | 5 |
| 9 | A Streptococcus suis serotype 2 caused streptococcal toxic shock syndrome(STSS) in a patient显示文摘Streptococcus suis(S.suis)is a Gram-positive,facultatively anaerobic coccus that has been implicated as the cause of a wide range of clinical disease syndromes in swine and other domestic animals.S.suis has also been implicated in disease in humans,especially among abattoir workers,swine and pork handlers.Here we report a case of streptococcal toxic shock syndrome(STSS)caused by S.suis in a 59-year-old man.Despite of intensive treatment,the patient died of shock with multiple organ failure 14 h after admission.One bacterial isolate obtained from blood culture was identified to the species level by biochemical tests and serological tests as S.suis serotype 2.Identification was confirmed by PCR amplification of genes encoding 16sRNA of S.suis and the capsule of S.suis serotype 2(cps 2J).Genes encoding virulence factors were also detected.An investigation to identify the source of S.suis revealed that several days before admission the affected man had been handling sick pigs or their meat.Transmission may occur through breaks in the skin of feet with tinea due to that no measures for personal protection was taken.This case should highten awareness of the potential for occupational exposure and human infection with S.suis. | Yefei Zhu Zhongmin Tan Lingyang Zhu Hongxing Pan Xuejun Zhang Lei Xu Huimin Qian Ling Gu Xun Ye Chen Dong Changjun Bao Rongqiang Zhu Fengcai Zhu Hua Wang | 2008 | Journal of Nanjing Medical University2008，22，5： | 3 |
| 10 | STUDIES ON THE CHEMICAL CONSTITUENTS OF PULSATILLA CHINENSIS (Ⅱ)显示文摘Two new compounds have been isolated from methanol extract of roots of Pulsatilla chinensis(Bunge) Hegel. Their structures were established as 3-oxo-23-hydroxy-lup-20(29)-en-28-oic acid (Ⅱ) and 3-0-(?)-L-arabinopyranosyl-3β, 23-dihydroxylup-20(29)-en-28-oic acid (Ⅲ). | Wen Cai YE~*, Shou Xun ZHAO, Hao CAI, and Jing Han LIU Department of Phytochemistry, China Pharmaceutical University, Nanjing, 210009 | 1991 | Chinese Chemical Letters1991，2，5： | 3 |
| 11 | Thermodynamic and economic analyses of a coal and biomass indirect coupling power generation system显示文摘The coal and biomass coupling power genera-tion technology is considered as a promising technology for energy conservation and emission reduction.In this paper,a novel coal and biomass indirect coupling system is proposed based on the technology of biomass gasification and co-combustion of coal and gasification gas.For the sake of comparison,a coal and biomass direct coupling system is also introduced based on the technology of co-combustion of coal and biomass.The process of the direct and the indirect coupling system is simulated.The thermodynamic and economic performances of two systems are analyzed and compared.The simulation indicates that the thermodynamic performance of the indirect coupling system is slightly worse,but the economic performance is better than that of the direct coupling system.When the blending ratio of biomass is 20%,the energy and exergy fficiencies of the indirect coupling system are 42.70%and 41.14%,the intemal rate of returm(IRR)and discounted payback period(DPP)of the system are 25.68%and 8.56 years.The price fluctuation of fuels and products has a great influence on the economic performance of the indirect coupling system.The environmental impact analysis indicates that the indirect coupling system can inhibit the propagation of NOx and reduce the environmental cost. | Buqing YE Rui ZHANG Jin CAO Bingquan SHI Xun ZHOU Dong LIU | 2020 | Frontiers in Energy2020，14，3： | 3 |
| 12 | Plant Male Sterility Induced by Anti-Gene CYP86MF in Brassica oleracea var. italica显示文摘An anti-gene CYP86MF was introduced into hypocotyls of broccoli (Brassica oleracea L.var. italica Plenck) with Agrobacterium tumefaciens, and the transgenic plants were obtained by kanamycin selection. The results of PCR, Southern blot and Northern blot indicated that the anti-CYP86MF has been integrated into chromosome of the transgenic plant. And also, plants with hypogenetic stamina or ungerminated pollen were observed. The transgenic male sterility plant could fructify via artificial pollination with normal pollen. Thus it was proved that the pistil of male sterility plant was normally developed, and the sterility originated from anti-CYP86MF. | HUANG Ke CAO Jia-shu YU Xiao-lin YE Wan-zhi LU Gang XIANG Xun | 2005 | Agricultural Sciences in China2005，4，11： | 2 |
| 13 | Biofilm formation and electricity generation of a microbial fuel cell started up under different external resistances显示文摘 | Liang Zhang Xun Zhu Jun Li Qiang Liao Dingding Ye | 2011 | Journal of Power Sources2011，，15： | 2 |
| 14 | Exogenous nerve growth factor supplementation elevates myocardial immunoreactivity and attenuates cardiac remodeling in pressure-overload rats显示文摘外长的神经生长因素(NGF ) 的补充可能调停,这被要求在心失败(HF ) 的心脏的同情的神经功能的改进。心脏的同情的 ganglia 附近的 NGF 的本地肌内的注射能影响神经分布模式,新肾上素 transporter (网) 基因表示,并且改进在试验性的 HF 动物的心脏的改变。在这研究,我们与腹的大动脉的收缩(交流) 把 NGF 注入了 SpragueDawley 老鼠的 scalenus medius 肌肉。神经与交流在老鼠刺激了模式,左室的形态学,和功能追随者注射被 immunohistochemistry 和 echocardiography 分别地调查。网络的 mRNA 表示的层次,生长联系了蛋白质 43 (差距 43 ) , NGF 和它的受体 TrkA 和 p75NTR,和大脑 natriuretic 肽(BNP ) 被即时聚合酶链反应测量。结果证明心肌的 NGF mRNA 层次在有交流的老鼠是可比较的。外长的 NGF 的短期的补充提起了心肌的 NGF immunoreactivity,但是没在交流老鼠引起 hyperinnervation 和网 mRNA upregulation。而且,心肌的 TrkA mRNA 被发现显著地被减少, p75NTR mRNA 被增加。心肌的 TrkA downregulation 可以为避免 hyperinnervation 玩有益的效果,并且要求是合理的那 p75NTR 能当 TrkA 不在时作为 NGF 受体工作。有趣地,进 ganglia 附近的颈肌肉的本地 NGF 管理能稀释心脏的改变和 downregulate BNP mRNA。这些结果建议外长的 NGF 能 anterogradely 沿着轴突到达目标织物,并且改进心脏的改变。 | Bing He Fan Ye Xin Zhou He Li Xiaoqing Xun Xiaoqing Ma Xudong Liu Zhihong Wang Pengxiao Xu Yuming Li | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 2 |
| 15 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 16 | An MFC capable of regenerating the cathodic electron acceptor under sunlight显示文摘A renewable MFC (microbial fuel cell) cathode was used in this study because the iodide ion could react with oxygen to generate triiodide under natural sunlight.The feasibility of the regeneration of triiodide ion under natural sunlight and the effect of the regenerated triiodide ion concentration on the MFC performance were studied.The results showed that the power density of the MFC using triiodide ion as cathodic electron acceptor was significantly higher than that of using ferricyanate,and that the iodide ion can be oxidized to triiodide ion by oxygen in air at the expense of natural sunlight.In addition,it was obvious from the experimental results that the MFC performance was improved with the increase of the triiodide concentration,indicating that the concentration of triiodide ion had a critical effect on the MFC performance.The linear sweep voltammetry (LSV) curves for the electro-reduction of triiodide ion on the carbon paper were obtained and the results suggested that the diffusion process of triiodide ions to cathode was the control factor for the MFC performance. | FU Qian,LI Jun,ZHU Xun,LIAO Qiang,YE DingDing & ZHANG Liang Institute of Engineering Thermophysics,Chongqing University,Chongqing 400030,China | 2010 | Science China(Technological Sciences)2010，53，9： | 2 |
| 17 | Cardiac metallothi-onein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation 显示文摘 | Wang Jian xun Song Ye Laila E | 2006 | Circulation2006，113，： | 1 |
| 18 | Electrodeposition of Pd catalyst layer on graphite rod electrodes for direct formic acid oxidation显示文摘 | Biao Zhang Dingding Ye Jun Li Xun Zhu Qiang Liao | 2012 | Journal of Power Sources2012，，： | 1 |
| 19 | Digital subtraction angiographic characteristics of progression of moyamoya disease 6 months prior to surgical revascularisation显示文摘background Evidence on the natural angiographic course of moyamoya disease(MMD)is lacking.It takes about 6 months for waiting for revascularisation surgery.The issue of when to perform subtraction angiography(DSA)for follow-up remains unclear.We investigated the natural course of MMD by DSA and attempted to determine the best interval to perform the follow-up DSA.Methods This is a single-centre cohort study of Chinese MMD inpatients treated from 1 January 2015 to 31 August 2019.Their angiographic findings were evaluated on Suzuki stage and collateral circulation between two follow-ups of the same hemisphere.results A total of 110 patients who met the criteria were enrolled in this study.After a median 6 months follow-up,five patients(4.5%)had progression,four females and one male.Time interval of progression ranged from 4 to 137 months with a mean of 61.4 months.Of five patients with progression,four had unilateral lesion(two ipsilateral and two contralateral)and one had bilateral lesions.Collateral circulation was changed in three of five patients.Conclusions The angiographic evidence of progression in MMD was rare in the short-term follow-up,and most patients with progression had initial unilateral involvement.DSA re-examination may be not needed in patients with bilateral MMD,but needed in unilateral MMD. | Peicong Ge Qian Zhang Xun Ye Xingju Liu Xiaofeng Deng Jia Wang Rong Wang Yan Zhang Dong Zhang Ji Zong Zhao | 2020 | Stroke & Vascular Neurology2020，5，1： | 1 |
| 20 | MiR‐200c suppresses TGF‐β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer显示文摘 | Wen‐Dong Bai Xing‐Ming Ye Meng‐Yao Zhang Hua‐Yu Zhu Wen‐Jin Xi Xun Huang Jiao Zhao Bin Gu Guo‐Xu Zheng An‐Gang Yang Lin‐Tao Jia | 2014 | Int J Cancer2014，，6： | 1 |
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