|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hypoxia-induced factor-1 alpha upregulates vascular endothelial growth factor C to promote lymphangiogenesis and angiogenesis in breast cancer patients显示文摘Hypoxia-induced factor-1 alpha(HIF-1α)affects many effector molecules and regulates tumor lymphangiogenesis and angiogenesis during hypoxia.The aim of this study was to investigate the role of HIF-1αin the regulation of vascular endothelial growth factor C(VEGF-C)expression and its effect on lymphangiogenesis and angiogenesis in breast cancer.Lymphatic vessel density(LVD),microvessel density(MVD)and the expressions of HIF-1αand VEGF-C proteins were evaluated by immunohistochemistry in 75 breast cancer samples.There was a significant correlation between HIF-1αand VEGF-C(P=0.014,r=0.273,Spearman's coefficient of correlation).HIF-1αand VEGF-C overexpression was significantly correlated with higher LVD(P=0.003 and P=0.017,respectively),regional lymph nodal involvement(P=0.002 and P=0.004,respectively)and advanced tumor,node,metastasis(TNM)classification(P=0.001 and P=0.01,respectively).Higher MVD was observed in the group expressing higher levels of HIF-1αand VEGF-C(P=0.033 and P=0.037,respectively).Univariate analysis showed shorter survival time in patients expressing higher levels of HIF-1αand VEGF-C.HIF-1αwas also found to be an independent prognostic factor of overall survival in multivariate analysis.The results suggest that HIF-1αmay affect VEGF-C expression,thus acting as a crucial regulator of lymphangiogenesis and angiogenesis in breast cancer.This study highlights promising potential of HIF-1αas a therapeutic target against tumor lymph node metastasis. | Xiaojian Ni Yingchun Zhao Jingjing Ma Tiansong Xia Xiaoan Liu Qiang Ding Xiaoming Zha Shui Wang | 2013 | The Journal of Biomedical Research2013，27，6： | 10 |
| 2 | A survey on chemical and microbiological composition of kurut, naturally fermented yak milk from Qinghai in China显示文摘 | Heping Zhang Jie Xu Junguo Wang Menghebilige Tiansong Sun Haiping Li Mingruo Guo | 2007 | Food Control2007，，6： | 3 |
| 3 | Fermentation characteristics of six probiotic strains in soymilk显示文摘 | Haiping Li Liya Yan Jicheng Wang Qing Zhang Qi Zhou Tiansong Sun Wei Chen Heping Zhang | 2012 | Annals of Microbiology2012，，4： | 1 |
| 4 | In vitro screen of Lactobacillus plantarum as probiotic bacteria and their fermented characteristics in soymilk显示文摘 | Yan Bao Yong Zhang Haiping Li Yong Liu Shuiquan Wang Ximei Dong Fang Su Guoqiang Yao Tiansong Sun Heping Zhang | 2012 | Annals of Microbiology2012，，3： | 1 |
| 5 | Analysis of Microbial Composition in Acid Whey for Dairy Fan Making in Yunnan by Conventional Method and 16S rRNA Sequencing显示文摘 | Wenjun Liu Zhihong Sun Jiachao Zhang Wa Gao Weihong Wang Lan Wu Tiansong Sun Wei Chen Xiaoming Liu Heping Zhang | 2009 | Current Microbiology2009，，2： | 1 |
| 6 | A survey on chemical and microbiological composition of kurut, naturally fermented yak milk from Qinghai in China显示文摘 | Heping Zhang Jie Xu Junguo Wang Menghebilige Tiansong Sun Haiping Li Mingruo Guo | 2007 | Food Control2007，，6： | 1 |
| 7 | TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation显示文摘Dear Editor,The diversity and composition of gut microbiota play critical roles for maintaining the homeostasis of host commensal bacteria which are correlated with mammalian health(Ding and Schloss,2014).Disorder of microbial community is implicated in the pathogenesis of several human diseases,such as autoimmune disease,allergy,diabetes,obesity,and inflammatory bowel disease(IBD),which is clearly demonstrated to relate to gut dysbiosis in patients and mouse models(Saleh and Elson,2011). | Guotao Yu Fang Wang Menghao You Tiansong Xu Chunlei Shao Yuning Liu Ruiqi Liu Min Deng Zhihong Qi Zhao Wang Jingjing Liu Yingpeng Yao Jingjing Chen Zhen Sun Shanshan Hao Wenhui Guo Tianyan Zhao Zhengquan Yu Qian Zhang Yaofeng Zhao Feng Chen Shuyang Yu | 2020 | Protein & Cell2020，11，5： | 1 |
| 8 | 显示文摘 | WANG Tiansong AIKEN J H HUIE C W | 1991 | Anal Chem1991，63，： | 1 |
| 9 | In vitro screen of Lactobacillus plantarum as probiotic bacteria and their fermented characteristics in soymilk显示文摘 | Yan Bao Yong Zhang Haiping Li Yong Liu Shuiquan Wang Ximei Dong Fang Su Guoqiang Yao Tiansong Sun Heping Zhang | 2012 | Annals of Microbiology2012，，3： | 1 |
| 10 | Integrated'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome显示文摘OBJECTIVE:To observe the efficacy of moxibustion in the treatment of chronic fatigue syndrome(CFS)and explore the effects on gut microbiota and metabolic profiles.METHODS:Forty-eight male Sprague-Dawley rats were randomly assigned to control group(Con),CFS model group(Mod,established by multiple chronic stress for 35 d),MoxA group(CFS model with moxibustion Shenque(CV8)and Guanyuan(CV4),10 min/d,28 d)and MoxB group(CFS model with moxibustion Zusanli(ST36),10 min/d,28 d).Open-field test(OFT)and Morris-water-maze test(MWMT)were determined for assessment the CFS model and the therapeutic effects of moxibustion.16S rRNA gene sequencing analysis based gut microbiota integrated untargeted liquid chromatograph-mass spectrometer(LC-MS)based fecal metabolomics were executed,as well as Spearman correlation analysis,was utilized to uncover the functional relevance between the potential metabolites and gut microbiota.RESULTS:The results of our behavioral tests showed that moxibustion improved the performance of CFS rats in the OFT and the MWMT.Microbiome profiling analysis revealed that the gut microbiomes of CFS rats were less diverse with altered composition,including increases in pro-inflammatory species(such as Proteobacteria)and decreases in anti-inflammatory species(such as Bacteroides,Lactobacillus,Ruminococcus,and Prevotella).Moxibustion partially normalized these changes in the gut microbiota.Furthermore,CFS was associated with metabolic disorders,which were effectively ameliorated by moxibustion.This was demonstrated by the normalization of 33 microbiota-related metabolites,including mannose(P=0.001),aspartic acid(P=0.009),alanine(P=0.007),serine(P=0.000),threonine(P=0.027),methionine(P=0.023),5-hydroxytryptamine(P=0.008),alpha-linolenic acid(P=0.003),eicosapentaenoic acid(P=0.006),hypoxanthine(P=0.000),vitamin B6(P=0.000),cholic acid(P=0.013),and taurocholate(P=0.002).Correlation analysis showed a significant association between the perturbed fecal microbiota and metabolite levels,with a notable negative relationship between LCA and Bacteroides.CONCLUSIONS:In this study,we demonstrated that moxibustion has an antifatigue-like effect.The results from the 16S rRNA gene sequencing and metabolomics analysis suggest that the therapeutic effects of moxibustion on CFS are related to the regulation of gut microorganisms and their metabolites.The increase in Bacteroides and decrease in LCA may be key targets for the moxibustion treatment of CFS. | LI Chaoran YANG Yan FENG Chuwen LI Heng QU Yuanyuan WANG Yulin WANG Delong WANG Qingyong GUO Jing SHI Tianyu SUN Xiaowei WANG Xue HOU Yunlong SUN Zhongren YANG Tiansong | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
| 11 | Effectiveness of Xiaoyao capsule(逍遥丸)on sleep disorders and mood disturbance in patients in recovery from coronavirus disease 2019:a randomized controlled trial显示文摘OBJECTIVE:To study the efficacy of Xiaoyao capsule(逍遥丸)in improving the clinical symptoms of sleep and mood disorders during recovery from coronavirus disease 2019(COVID-19).METHODS:The study cohort comprised 200 patients with sleep and mood disorders during recovery from COVID-19.Patients were randomized into the control group and the experimental group in a 1:1 ratio by blocked randomization.The patients received either Xiaoyao capsule(experimental group)or a placebo Xiaoyao capsule(control group)for 2 weeks.The improvements in the Traditional Chinese Medicine(TCM)syndrome scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep were compared between the two groups.RESULTS:The TCM syndrome pattern scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep did not significantly differ between the experimental group versus the control group in the full analysis set and the per protocol set after 1 and 2 weeks of treatment(P>0.05).CONCLUSIONS:Xiaoyao capsule do not significantly improve the clinical symptoms of sleep and mood disorders in patients in recovery from COVID-19. | YANG Cunqing LIAN Fengmei YANG Guiping HUANG Yufeng ZHANG Shuangbin WANG Jianghua ZHOU Jing GUO Dongqing SHEN Chuanyun YE Tiansong FU Aojie LI Xiaoli CHEN Le ZHANG Huifeng TU Qiyin WANG Ying YANG Wenzhe TONG Xiaolin BA Yuanming | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 0 |
| 12 | Value of negatively correlated miR-205-5p/HMGB3 and miR-96-5p/FOXO1 on the diagnosis of breast cancer and benign breast diseases显示文摘Background:MicroRNA(miRNA)and mRNA levels in matching specimens were used to identify miRNA–mRNA interactions.We aimed to integrate transcriptome,immunophenotype,methylation,mutation,and survival data analyses to examine the profiles of miRNAs and target mRNAs and their associations with breast cancer(BC)diagnosis.Methods:Based on the Gene Expression Omnibus(GEO)database and The Cancer Genome Atlas(TCGA),differentially expressed miRNAs and targeted mRNAs were screened from experimentally verified miRNA-target interaction databases using Pearson's correlation analysis.We used real-time quantitative reverse transcription polymerase chain reaction to verify BC and benign disease samples,and logistic regression analysis was used to establish a diagnostic model based on miRNAs and target mRNAs.Receiver operating characteristic curve analysis was performed to test the ability to recognize the miRNA-mRNA pairs.Next,we investigated the complex interactions between miRNA-mRNA regulatory pairs and phenotypic hallmarks.Results:We identified 27 and 359 dysregulated miRNAs and mRNAs,respectively,based on the GEO and TCGA databases.Using Pearson's correlation analysis,10 negative miRNA-mRNA regulatory pairs were identified after screening both databases,and the related miRNA and target mRNA levels were assessed in 40 BC tissues and 40 benign breast disease tissues.Two key regulatory pairs(miR-205-5p/High mobility group box 3(HMGB3)and miR-96-5p/Forkhead Box O1(FOXO1))were selected to establish the diagnostic model.They also had utility in survival and clinical analyses.Conclusions:A diagnostic model including two miRNAs and their respective target mRNAs was established to distinguish between BC and benign breast diseases.These markers play essential roles in BC pathogenesis. | Jiaying Li Shuang Peng Xuan Zou Xiangnan Geng Tongshan Wang Wei Zhu Tiansong Xia | 2023 | Cancer Pathogenesis and Therapy2023，1，3： | 0 |
| 13 | Surveillance of ClassⅠNewcastle Disease Virus at Live Bird Markets and Commercial Poultry Farms in Eastern China Reveals the Epidemic Characteristics显示文摘Dear Editor,Newcastle disease(ND),caused by virulent Newcastle disease virus(NDV),is a highly contagious and economically devastating viral disease of birds(Habib et al.2018).NDV,also termed as avian paramyxovirus type 1(APMV-1),belongs to the genus Orthoavulavirus in the family Paramyxoviridae according to the International Committee on Taxonomy of Viruses(ICTV)(Amarasinghe et al.2019).According to the latest phylogenetic classification system. | Xiaolong Lu Xiaoquan Wang Tiansong Zhan Yifan Sun Xin Wang Naiqing Xu Tianxing Liao Yu Chen Min Gu Shunlin Hu Xiaowen Liu Xiufan Liu | 2021 | Virologica Sinica2021，36，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员