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| 1 | High efficiency production of ginsenoside compound K by catalyzing ginsenoside Rb1 using snailase显示文摘The rare ginsenoside Compound K(C-K) is attracting more attention because of its good physiological activity and urgent need. There are many pathways to obtain ginsenoside C-K, including chemical and biological methods. Among these, the conversion of PPD-type ginsenosides by enzymatic hydrolysis is a trend due to its high efficiency and mild conditions. For effectively extracting from the other panaxadiol saponins, the conversion process for ginsenoside C-K was investigated using snailases in this study. The univariate experimental design and response surface methodology were used to determine the optimal hydrolysis conditions for the conversion of ginsenoside Rb1 into ginsenoside C-K by snailases. The optimum conditions were as follows: p H 5.12, temperature 51 °C, ratio of snailase/substrate 0.21, and reaction time 48 h. On the basis of these parameters, the addition of 1.0 mmol·L^(-1) ferric ion was found to significantly improve the enzymolysis of snailases for the first time. With the above conditions, the maximum conversion rate reached 89.7%, suggesting that the process can obviously increase the yield of ginsenoside C-K. The bioassay tests indicated that the ginsenoside C-K showed anti-tumor activity in a series of tumor cell lines. Based on these results, we can conclude that the process of rare ginsenoside CK production by enzymolysis with snailase is feasible, efficient, and suitable for the industrial production and application. | Zhiguang Duan Chenhui Zhu Jingjing Shi Daidi Fan Jianjun Deng Rongzhan Fu Rong Huang Cuiying Fan | 2018 | Chinese Journal of Chemical Engineering2018，26，7： | 5 |
| 2 | Fine genetic mapping of the chromosome 11q23.3 region in a Han Chinese population:insights into the apolipoprotein genes underlying the blood lipid-lipoprotein variances显示文摘The unusual chromosome 11q23.3 harboring the apolipoprotein(APO)gene cluster has been well documented for its essential roles in plasma lipid-related traits and atherosclerotic cardiovascular diseases.However,its genetic architecture and the potential biological mechanisms underlying complex phenotypes have not been well assessed.We conducted a study for this target region in a Han Chinese population through a stepwise forward framework based on massive parallel sequencing,association analyses,genetic fine mapping,and functional interpretation.The present study identified new meaningful genetic associations that were not simply determined by statistical significance.In addition to the APOA5 gene,we found robust evidence of the genetic commitments of APOC3 and APOA1 to blood lipids.Several variants with high confidence were prioritized along with the potential biological mechanism interpretations in the wake of adaptive fine-mapping analyses.rs2849174 in the APOC3 enhancer was discovered with an unrivaled posterior probability of causality for triglyceride levels and could mediate APOC3 expression through enhancer activity modulated by a combination of histone modifications and transcription factor accessibility.Similarly,multiple lines of evidence converged in favor of rs3741297 as a causal variant influencing high-density lipoprotein cholesterol.Our findings provided novel insights into this genomic locus in the Chinese population. | Weihua Shou Chenhui Zhang Jinxiu Shi Hong Wu Wei Huan | 2020 | Journal of Genetics and Genomics2020，47，12： | 1 |
| 3 | Collision Attacks against AEZ-PRF for Authenticated Encryption AEZ显示文摘AEZ is an AES-based authenticated encryption submitted to the ongoing CAESAR competition and was presented at Eurocrypt2015 with AEZ v3. There are three models for AEZ, AEZ-core, AEZ-tiny and AEZ-prf. In this paper, we consider the security of AEZprf for AEZ v4.2, the latest version of AEZ.Our major finding is a collision of any 256-bit associated data for AES-prf. Then we launch collision attacks in a quantum setting and a classical setting respectively under different assumptions. In the quantum setting, by Simon's quantum algorithm, we amount a forgery with O(n) quantum superposition queries and an overwhelming probability close to 1.In the classical setting, one with the key of AEZ-prf can also construct the forgeries. Our results show that the AEZ-prf models of AEZ v4.2 is not secure in both the quantum setting and classical world. Furthermore, our results can also be applied to AEZ v3, which has been published on Eurocrypt 2015. As far as we know, no cryptanalysis of AEZ v4.2 has been published so far. | Tairong Shi Chenhui Jin Jie Guan | 2018 | China Communications2018，15，2： | 1 |
| 4 | Determination of oxadiargyl residues in environmental samples and rice samples显示文摘 | Shi Chenhui Gui Wenjun Chen Jie | 2010 | Bull Environ Contam Toxicol2010，84，2： | 1 |
| 5 | Indirect selective laser sintering of epoxy resin-Al2O3 ceramic powders combined with cold isostatic pressing显示文摘 | LIU Kai SHI Yusheng LI Chenhui | 2014 | Ceramics International2014，40，5： | 1 |
| 6 | A monocular visual SLAM system augmented by lightweight deep local feature extractor using in-house and low-cost LIDAR-camera integrated device显示文摘Simultaneous Localization and Mapping(SLAM)has been widely used in emergency response,self-driving and city-scale 3D mapping and navigation.Recent deep-learning based feature point extractors have demonstrated superior performance in dealing with the complex environmental challenges(e.g.extreme lighting)while the traditional extractors are struggling.In this paper,we have successfully improved the robustness and accuracy of a monocular visual SLAM system under various complex scenes by adding a deep learning based visual localization thread as an augmentation to the visual SLAM framework.In this thread,our feature extractor with an efficient lightweight deep neural network is used for absolute pose and scale estimation in real time using the highly accurate georeferenced prior map database at 20cm geometric accuracy created by our in-house and low-cost LiDAR and camera integrated device.The closed-loop error provided by our SLAM system with and without this enhancement is 1.03m and 18.28m respectively.The scale estimation of the monocular visual SLAM is also significantly improved(0.01 versus 0.98).In addition,a novel camera-LiDAR calibration workflow is also provided for large-scale 3D mapping.This paper demonstrates the application and research potential of deep-learning based vision SLAM with image and LiDAR sensors. | Jing Li Chenhui Shi Jun Chen Ruisheng Wang Zhiyuan Yang Fan Zhang Jianhua Gong | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 7 | A common variant in AAK1 reduces risk of noise-induced hearing loss显示文摘Noise-induced hearing loss(NIHL)is one of the most common types of hearing loss and contributes to significant morbidity worldwide,as well as being the major cause of age-related hearing loss and tinnitus.The World Health Organization(WHO)estimates that 10%of the world's population is exposed to sound levels that could potentially cause NIHL[1].It has been widely accepted that NIHL is a multifactorial genetic disorder with estimated heritability of 36%to 40%[2].Ideally,identification of the modifying genetic variants would help protect individuals at high risk of NIHL.For decades,many geneticists have searched for genes that either predispose or protect from NIHL.Howeve r,the majority of genetic studies for NIHL were conducted in independent known candidate genes[3]. | Qixuan Wang Xueling Wang Tao Yang Lu Yang Huihui Liu Yihang Zheng Guixian Jiang Hongchao Liu Chenhui Huang Juan Chen Zhentao Wang Zhaoyan Wang Wei Zhao Jiannan Lin Xuejie Zhang Junbo Shi Kun Han Xingyu Le Yan Ren Yun Li Yingying Hong Wentao Shi Dongqi Cui Minfei Qian Jun Xu Xiaofei Zheng Yunge Gao Chen Li James Lin Zhiwu Huang Hao Wu | 2023 | National Science Review2023，10，7： | 0 |
| 8 | 人源RNase P全酶的冷冻电镜结构显示文摘文章简介tRNA作为生命体中遗传信息的传递者,其首先是以前体RNA的形式被转录出来,转录生成的tRNA前体具有未成熟的5’和3’末端,需要经历一系列的加工反应才能完成最终的成熟。其中5’前导序列的切割是由一类必需的核酶RNase P完成。 | 武健 牛双双 谭明 Chenhui Huang Mingyue Li Yang Song Qianmin Wang Juan Chen Shaohua Shi 兰鹏飞 雷鸣 | 2019 | 科学新闻2019，0，2： | 0 |
| 9 | The Tianlai Cylinder Pathfinder array: System functions and basic performance analysis显示文摘The Tianlai Cylinder Pathfinder is a radio interferometer array designed to test techniques for 21 cm intensity mapping in the post-reionization Universe,with the ultimate aim of mapping the large scale structure and measuring cosmological parameters such as the dark energy equation of state.Each of its three parallel cylinder reflectors is oriented in the north-south direction,and the array has a large field of view.As the Earth rotates,the northern sky is observed by drift scanning.The array is located in Hongliuxia,a radio-quiet site in Xinjiang,and saw its first light in September 2016.In this first data analysis paper for the Tianlai cylinder array,we discuss the sub-system qualification tests,and present basic system performance obtained from preliminary analysis of the commissioning observations during 2016-2018.We show typical interferometric visibility data,from which we derive the actual beam profile in the east-west direction and the frequency band-pass response.We describe also the calibration process to determine the complex gains for the array elements,either using bright astronomical point sources,or an artificial on site calibrator source,and discuss the instrument response stability,crucial for transit interferometry.Based on this analysis,we find a system temperature of about 90 K,and we also estimate the sensitivity of the array. | JiXia Li ShiFan Zuo FengQuan Wu YouGang Wang JuYong Zhang ShiJie Sun YiDong Xu ZiJie Yu Reza Ansari YiChao Li Albert Stebbins Peter Timbie YanPing Cong JingChao Geng Jie Hao QiZhi Huang JianBin Li Rui Li DongHao Liu YingFeng Liu Tao Liu John PMarriner ChenHui Niu Ue-Li Pen Jeffery BPeterson HuLi Shi Lin Shu YaFang Song HaiJun Tian GuiSong Wang QunXiong Wang RongLi Wang WeiXia Wang Xin Wang KaiFeng Yu Jiao Zhang BoQin Zhu JiaLu Zhu XueLei Chen | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，12： | 0 |
| 10 | 三阴性乳腺癌基因组与转录组全景图:亚型及治疗策略显示文摘文章简介三阴性乳腺癌(triple-negative breast cancer,TNBC)是雌激素受体、孕激素受体和HER-2均为阴性的一群乳腺癌,缺乏有效靶向治疗,预后差,是乳腺癌学界的世界性难题。近年的研究表明TNBC是一个异质性很强的群体,为更全面而深入地认识这类疾病,寻找精准治疗的突破口,研究团队全面分析了465例原发性三阴性乳腺癌(TNBC)队列的临床、基因组学和转录组学数据。 | Yi-Zhou Jiang Ding Ma Chen Suo Jinxiu Shi Mengzhu Xue Xin Hu Yi Xiao Ke-Da Yu Yi-Rong Liu Ying Yu Yuanting Zheng Xiangnan Li Chenhui Zhang Pengchen Hu Jing Zhang Qi Hua Jiyang Zhang Wanwan Hou Luyao Ren Ding Bao Bingying Li Jingcheng Yang Ling Yao Wen-Jia Zuo Shen Zhao Yue Gong Yi-Xing Ren Ya-Xin Zhao Yun-Song Yang Zhenmin Niu Zhi-Gang Cao Daniel G.Stover Claire Verschraegen Virginia Kaklamani Anneleen Daemen John R.Benson Kazuaki Takabe Fan Bai Da-Qiang Li 王鹏 石乐明 黄薇 邵志敏 | 2020 | 科学新闻2020，，2： | 0 |
| 11 | Bone morphogenetic protein-7 induced bone marrow stromal cells differentiate into neuron-like cells显示文摘Bone morphogenetic protein-7 is widely accepted as an inducer for bone marrow stem cells differ-entiating into osteoblasts and chondrocytes. Whether bone marrow stromal cells differentiate into neuron-like cells remains unclear. The current study examined the presence of positive cells for in-termediate filament protein and microtubule associated protein-2 in the cytoplasm of bone marrow stromal cells induced by bone morphogenetic protein-7 under an inverted microscope, while no expression of glial fibrillary acidic protein was found. Reverse transcription PCR electrophoresis also revealed a positive target band for intermediate filament protein and microtubule-associated protein 2 mRNA. These results confirmed that bone morphogenetic protein-7 induces rat bone marrow stromal cells differentiating into neuron-like cells. | Kuanxin Li Yuling Zhang Weishan Wang Bin He Jianhua Sun Jinbo Dong Chenhui Shi | 2011 | Neural Regeneration Research2011，6，22： | 0 |
| 12 | A ɑ-KA fluorescent probe for discrimination of blood cancer serum显示文摘a-Ketoglutaric acid(a-KA) is an important metabolic intermediate in tricarboxylic acid circle in our body.The mutations of isocitrate dehydrogenase-1(IDH1) and isocitrate dehydrogenase-2(IDH2), however,will lead to the transformation of a-KA into 2-hydroxyglutarate(2-HG), which is confirmed to closely related to actue myeloid leukemia(AML). Therefore it is of great significance to detect a-KA level changes in serum. In this paper, a fluorescent 'off-on' probe CH for a-KA was designed based on naphthalimide fluorophore by introducing a hydrazine group for a-KA recognition and a long alkyl amino chain to enhance PET efficiency and water solubility. Cetyltrimethyl ammonium bromide(CTAB) was added toform self-assembly micelles for accelerating the recognition process. CH shows a 28-fold fluorescence enhancement((I - I_0)/I_0 at 550 nm) over other biological species by optimizing the chemical recognition process of CH with a-KA. Significantly, CH was successfully applied for thefluorescence discrimination of all kinds of blood cancer serum samples. This work would provide a potential method that is quick and convenient for sensing a-KA and may promote fluorescence detection in clinical diagnosis. | Yao Kang Jiangli Fan Qiang Jin Chenhui Shi Jianjun Du Xiaojun Peng | 2017 | Chinese Chemical Letters2017，28，10： | 0 |
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