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| 1 | Surface integrity and fatigue behavior when turning γ-TiAl alloy with optimized PVD-coated carbide inserts显示文摘This paper presents a comprehensive investigation on the effects of tool and turning parameters on surface integrity and fatigue behavior in turning c-Ti Al alloy. The wear of inserts surface, cutting forces, and surface roughness were studied to optimize PVD-coated carbide inserts.Surface topography, residual stresses, microhardness, and microstructure were analyzed to characterize the surfaces layer under different turning parameters. Surface integrity and fatigue life tests of c-Ti Al alloy were conducted under turning and turning-polishing processes. The results show that compared to CNMG120412-MF4, CNMG120408-SM is more suitable because it obtained low cutting force, surface roughness, and tool wear. With increasing the cutting speed and depth, the depths of the compressive residual stress layer, hardening layer, and plastic deformation layer increased. For turning and turning-polishing specimens, the compressive residual stress was relaxed by less than 20%–30% after 10~7 cycles. The fatigue life of a turning-polishing specimen with R_a= 0.15 mm has increased 3 times from that of a turning specimen with R_a= 0.43 mm. | Changfeng YAO Jiannan LIN Daoxia WU Junxue REN | 2018 | Chinese Journal of Aeronautics2018，31，4： | 9 |
| 2 | An Ensemble Approach for Emotion Cause Detection with Event Extraction and Multi-Kernel SVMs显示文摘In this paper, we present a new challenging task for emotion analysis, namely emotion cause extraction.In this task, we focus on the detection of emotion cause a.k.a the reason or the stimulant of an emotion, rather than the regular emotion classification or emotion component extraction. Since there is no open dataset for this task available, we first designed and annotated an emotion cause dataset which follows the scheme of W3 C Emotion Markup Language. We then present an emotion cause detection method by using event extraction framework,where a tree structure-based representation method is used to represent the events. Since the distribution of events is imbalanced in the training data, we propose an under-sampling-based bagging algorithm to solve this problem. Even with a limited training set, the proposed approach may still extract sufficient features for analysis by a bagging of multi-kernel based SVMs method. Evaluations show that our approach achieves an F-measure 7.04%higher than the state-of-the-art methods. | Ruifeng Xu Jiannan Hu Qin Lu Dongyin Wu Lin Gui | 2017 | Tsinghua Science and Technology2017，22，6： | 6 |
| 3 | Potent anti-angiogenesis and anti-tumor activity of a nove human anti-VEGF antibody, MIL60显示文摘 | Jing Yang Qun Wang Chunxia Qiao Zhou Lin Xinying Li Yifei Huang Tingting Zhou Yan Li Beifen Shen Ming Lv Jiannan Feng | 2014 | Cellular & Molecular Immunology2014，11，3： | 4 |
| 4 | Characterization of a Novel Anti-DR5 Monoclonal Antibody WD1 with the Potential to Induce Tumor Cell Apoptosis显示文摘TNF-related apoptosis-inducing ligand (TRAIL) is a TNF family member capable of inducing apoptosis. Death receptor 5 (DR 5) is a key receptor of TRAIL and plays an important role in TRAIL-induced apoptosis. To prepare monoclonal antibodies (mAbs) against DR5,cDNA encoding soluble DR5 (sDR5) was firstly amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) with specific primers,and then inserted into a prokaryotic expression vector pET-30a. The recombinant plasmid was expressed in Escherichia coli strain BL21 (DE3),and sDR5 was purified by nickel affinity chromatography. As an antigen,sDR5 was used to immunize mice. Hybridomas secreting antibodies against sDR5 were identified. One positive clone was selected to produce antibody,WD1. ELISA and immunofluorescence demonstrated that WD1 could bind recombinant sDR5 and membrane-bound DR5 (mDR5) on Jurkat and Molt-4 cells. ATPLite assays showed that Jurkat and Molt-4 cells were sensitive to the antibody in a dose dependent manner. The Annexin V/PI assays and Giemsa's staining both showed that WD1 could induce Jurkat cell apoptosis efficiently. Transient transfection of 293T cells and indirect immunofluorescence assay demonstrated that mAb (WD1) couldn't cross-react with DR4. Our findings indicated that the novel antibody,WD1 could act as a direct agonist,bind DR5 characteristically,and initiate efficient apoptotic signaling and tumor regression. Thus,WD1 would be a leading candidate for potential cancer therapeutics. | Jing Wang Zhou Lin Chunxia Qiao Ming Lv Ming Yu He Xiao Qingyang Wang Liyan Wang Jiannan Feng Beifen Shen Yuanfang Ma Yan Li | 2008 | Cellular & Molecular Immunology2008，5，1： | 4 |
| 5 | NMR assignments and characterization of the DNA-binding domain of Arabidopsis transcription factor WRKY11--Dedicated to Professor Xiuwen Han on the occasion of her 80th birthday显示文摘The WRKY proteins are a family of plant-specific transcription factors(TFs)that are widely involved in plant development and anti-stress responses.Arabidopsis WRKY11(AtWRKY11)functions in regulating plant defense against abiotic stress and belongs to the Ild subgroup of WRKY TFs.We herein report the expres sion,purification and preliminary structural characterization of AtWRKY11 DNA-binding domain(DBD)using solution NMR Almost complete backbone chemical shift assignments of AtWRKY11-DBD have been ob-tained.Chemical shift-based secondary structure analysis suggests that AtWRKY11-DBD may exhibit local conformational diferences from the X-ray structure of the C-terminal WRKY domain of AtWRKY1,particularly in the β1 and β5 strands.Our current study provides the basis for further structural and interactional studies. | Jiannan Wang Yaling Lin Qinjun Zhu Jingfeng Zhang Maili Liu Yunfei Hu | 2021 | Magnetic Resonance Letters2021，1，2： | 2 |
| 6 | Coordination of PSS and FACTS Damping Controllers to Improve Small Signal Stability of Large-scale Power Systems显示文摘This paper presents an approach for designing parameters of power system stabilizer(PSS)and FACTS damping controllers in a large scale practical power system.The objective is maximizing damping ratio of the target mode,and tracking technology(MTT)is used to avoid frequent alternations of target mode in optimization procedures.An improved planted growth simulation algorithm(IPGSA),which has high search efficiency and quick convergence speed,is proposed to optimize controller parameters coordinately.Based on case study of a large-scale power grid,and by using local and interregional low-frequency oscillation modes as target modes,simulation results verify proposed method in this paper.Furthermore,coordination optimization strategy adapted to multi-operating conditions demonstrates that the proposed approach is robust. | Guangzheng Yu Tao Lin Jiannan Zhang Ye Tian Xiu Yang | 2019 | CSEE Journal of Power and Energy Systems2019，5，4： | 2 |
| 7 | Heparin and magnesium sulfate cure advanced lung and heart disease combined caused to respiratory failure显示文摘 | LIN TIANSHUI CAO JIANNAN | 2002 | Chinese journal of practical internal medicine2002，22，6： | 1 |
| 8 | Properties of Natural Rubber Vulcanizates/Nanosiliea Composites Prepared Based on the Method of In-situ Generation and Coagulation显示文摘 | Yanfen Lin a Anqiang Zhang a Jiannan Sun | 2013 | Journal of Macromolecular Science Part B: Physics2013，52，11： | 1 |
| 9 | A Novel Human Antibody,HF,against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method显示文摘Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named 'HF,'which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases. | Chunxia Qiao Ming Lv Xinying Li Xiaoling Lang Shouqin Lv Mian Long Yan Li Shusheng Geng Zhou Lin Beifen Shen Jiannan Feng | 2021 | Engineering2021，7，11： | 0 |
| 10 | A common variant in AAK1 reduces risk of noise-induced hearing loss显示文摘Noise-induced hearing loss(NIHL)is one of the most common types of hearing loss and contributes to significant morbidity worldwide,as well as being the major cause of age-related hearing loss and tinnitus.The World Health Organization(WHO)estimates that 10%of the world's population is exposed to sound levels that could potentially cause NIHL[1].It has been widely accepted that NIHL is a multifactorial genetic disorder with estimated heritability of 36%to 40%[2].Ideally,identification of the modifying genetic variants would help protect individuals at high risk of NIHL.For decades,many geneticists have searched for genes that either predispose or protect from NIHL.Howeve r,the majority of genetic studies for NIHL were conducted in independent known candidate genes[3]. | Qixuan Wang Xueling Wang Tao Yang Lu Yang Huihui Liu Yihang Zheng Guixian Jiang Hongchao Liu Chenhui Huang Juan Chen Zhentao Wang Zhaoyan Wang Wei Zhao Jiannan Lin Xuejie Zhang Junbo Shi Kun Han Xingyu Le Yan Ren Yun Li Yingying Hong Wentao Shi Dongqi Cui Minfei Qian Jun Xu Xiaofei Zheng Yunge Gao Chen Li James Lin Zhiwu Huang Hao Wu | 2023 | National Science Review2023，10，7： | 0 |
| 11 | Multi-omics Analyses Provide Insight into the Biosynthesis Pathways of Fucoxanthin in Isochrysis galbana显示文摘Isochrysis galbana is considered an ideal bait for functional foods and nutraceuticals of humans because of its high fucoxanthin(Fx)content.However,multi-omics analysis of the regulatory networks for Fx biosynthesis in I.galbana has not been reported.In this study,we report a high-quality genome assembly of I.galbana LG007,which has a genome size of 92.73 Mb,with a contig N50 of 6.99 Mb and 14,900 protein-coding genes.Phylogenetic analysis confirmed the monophyly of Haptophyta,with I.galbana sister to Emiliania huxleyi and Chrysochromulina tobinii.Evolutionary analysis revealed an estimated divergence time between I.galbana and E.huxleyi of~133 million years ago.Gene family analysis indicated that lipid metabolism-related genes exhibited significant expansion,including IgPLMT,IgOAR1,and IgDEGS1.Metabolome analysis showed that the content of carotenoids in I.galbana cultured under green light for 7 days was higher than that under white light,andβ-carotene was the main carotenoid,accounting for 79.09%of the total carotenoids.Comprehensive multi-omics analysis revealed that the content ofβ-carotene,antheraxanthin,zeaxanthin,and Fx was increased by green light induction,which was significantly correlated with the expression of IgMYB98,IgZDS,IgPDS,IgLHCX2,IgZEP,IgLCYb,and IgNSY.These findings contribute to the understanding of Fx biosynthesis and its regulation,providing a valuable reference for food and pharmaceutical applications. | Duo Chen Xue Yuan Xuehai Zheng Jingping Fang Gang Lin Rongmao Li Jiannan Chen Wenjin He Zhen Huang Wenfang Fan Limin Liang Chentao Lin Jinmao Zhu Youqiang Chen Ting Xue | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 0 |
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