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| 1 | Temperature and NaCl deposition dependent corrosion of SAC305 solder alloy in simulated marine atmosphere显示文摘The stable operation of electronic devices in marine atmospheric environment is affected by the corrosion deterioration of solder joints,and the effects by atmosphere temperature and chloride deposition are critical.In this work,NaCl deposition and temperature dependent corrosion of Pb-free SAC305 solder in simulated marine atmosphere has been investigated.The results indicate that higher NaCl deposition prolongs the surface wetting time and leads to the final thicker saturated electrolyte film for further corrosion.Higher temperature accelerates the evaporation and contributes to the final thinner saturated NaCl electrolyte film.Besides,the corrosion control process varies under the initially covered thicker NaCl electrolyte layer and under the final saturated much thinner NaCl electrolyte film as the evaporation proceeds.Moreover,the ready oxygen availability through the final thinner saturated NaCl electrolyte film facilitates the formation of corrosion product layer mainly of electrochemically stable SnO2,but higher temperature leads to the final corrosion product layer with smaller crystal size and large cracks.The findings clearly demonstrate the effects of NaCl deposition and temperature on corrosion evolution of SAC305 solder joints and are critical to the daily maintenance of electronic devices for longer service life in marine atmosphere. | Chuang Qiao Mingna Wang Long Hao Xiahe Liu Xiaolin Jiang Xizhong An Duanyang Li | 2021 | Journal of Materials Science & Technology2021，，16： | 3 |
| 2 | A global alfalfa diversity panel reveals genomic selection signatures in Chinese varieties and genomic associations with root development显示文摘Alfalfa(Medicago sativa L.) is an important forage crop worldwide. However, little is known about the effects of breeding status and different geographical populations on alfalfa improvement. Here, we sequenced 220 alfalfa core germplasms and determined that Chinese alfalfa cultivars form an independent group, as evidenced by comparisons of FSTvalues between different subgroups, suggesting that geographical origin plays an important role in group differentiation. By tracing the influence of geographical regions on the genetic diversity of alfalfa varieties in China, we identified 350 common candidate genetic regions and 548 genes under selection. We also defined 165 loci associated with 24 important traits from genome-wide association studies. Of those, 17 genomic regions closely associated with a given phenotype were under selection, with the underlying haplotypes showing significant differences between subgroups of distinct geographical origins. Based on results from expression analysis and association mapping,we propose that 6-phosphogluconolactonase(MsPGL) and a gene encoding a protein with NHL domains(MsNHL) are critical candidate genes for root growth. In conclusion, our results provide valuable information for alfalfa improvement via molecular breeding. | Lin Chen Fei He Ruicai Long Fan Zhang Mingna Li Zhen Wang Junmei Kang Qingchuan Yang | 2021 | Journal of Integrative Plant Biology2021，63，11： | 3 |
| 3 | Correlation between radiologic features on contrastenhanced CT and pathological tumor grades in pancreatic neuroendocrine neoplasms显示文摘Contrast-enhanced computed tomography(CT)contributes to the increasing detection of pancreatic neuroendocrine neoplasms(PNENs).Nevertheless,its value for differentiating pathological tumor grades is not well recognized.In this report,we have conducted a retrospective study on the relationship between the 2017 World Health Organization(WHO)classification and CT imaging features in 94 patients.Most of the investigated features eventually provided statistically significant indicators for discerning PNENs G3 from PNENs G1/G2,including tumor size,shape,margin,heterogeneity,intratumoral blood vessels,vascular invasion,enhancement pattern in both contrast phases,enhancement degree in both phases,tumor-to-pancreas contrast ratio in both phases,common bile duct dilatation,lymph node metastases,and liver metastases.Ill-defined tumor margin was an independent predictor for PNENs G3 with the highest area under the curve(AUC)of 0.906 in the multivariable logistic regression and receiver operating characteristic curve analysis.The portal enhancement ratio(PER)was shown the highest AUC of 0.855 in terms of quantitative features.Our data suggest that the traditional contrastenhanced CT still plays a vital role in differentiation of tumor grades and heterogeneity analysis prior to treatment. | Wenbin Xu Han Yan Lulu Xu Mingna Li Wentao Gao Kuirong Jiang Junli Wu Yi Miao | 2021 | The Journal of Biomedical Research2021，35，3： | 2 |
| 4 | Osteoprotegerin/RANK/RANKL axis and atrial remodeling in mitral valvular patients with atrial fibrillation显示文摘 | Hailong Cao Qingguo Li Mingna Li R?e OD Zhong Wu Qing Zhou Bin Cao Baojun Chen Yijiang Chen Dongjin Wang | 2013 | International Journal of Cardiology2013，，3： | 1 |
| 5 | Analsis and design of moving-magnet-type linear synchronous motor for electromagnetic launch system 显示文摘 | Li Liyi Ma Mingna Kou Baoquan | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
| 6 | Analysis and design of moving-magnet-type linear synchronous motor for electromagnetic launch system显示文摘 | Li Liyi Ma Mingna Kou Baoquan | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
| 7 | Quantitative trait locus mapping of yield and plant height in autotetraploid alfalfa(Medicago sativa L.)显示文摘Alfalfa(Medicago sativa L.)is the most widely grown forage legume crop worldwide.Yield and plant height are important agronomic traits influenced by genetic and environmental factors.The objective of this study was to identify quantitative trait loci(QTL)and molecular markers associated with alfalfa yield and plant height.To understand the genetic basis of these traits,a full-sib F1 population composed of 392 individuals was developed by crossing a low-yielding precocious alfalfa genotype(male parent)with a high-yielding latematuring alfalfa cultivar(female parent).The linkage maps were constructed with 3818 single-nucleotide polymorphism(SNP)markers on 64 linkage groups.QTL for yield and plant height were mapped using phenotypic data for three years.Sixteen QTL associated with yield and plant height were identified on chromosomes 1 to 8.Six QTL explained more than 10%of phenotypic variation,representing major loci controlling yield and plant height.One locus on chromosome 1 controlling yield traits had not been identified in previous studies.Three QTL co-located with other QTL(qyield-1 and qheight-7,qheight-5 and qyield-4,qheight-6,and qyield-6).With further validation,the markers closely linked with these QTL may be used for marker-assisted selection in breeding new alfalfa varieties with high yield. | Fei He Ruicai Long Tiejun Zhang Fan Zhang Zhen Wang Xijiang Yang Xueqian Jiang Changfu Yang Xuxin Zhi Mingna Li Longxi Yu Junmei Kang Qingchuan Yang | 2020 | The Crop Journal2020，8，5： | 1 |
| 8 | Analysis and design of moving-magnet-type linear synchronous motor for electro- magnetic launch system显示文摘 | Li Liyi Ma Mingna Kou Baoquan | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
| 9 | Genome Assembly of Alfalfa Cultivar Zhongmu-4 and Identification of SNPs Associated with Agronomic Traits显示文摘Alfalfa(Medicago sativa L.)is the most important legume forage crop worldwide with high nutritional value and yield.For a long time,the breeding of alfalfa was hampered by lacking reliable information on the autotetraploid genome and molecular markers linked to important agronomic traits.We herein reported the de novo assembly of the allele-aware chromosome-level genome of Zhongmu-4,a cultivar widely cultivated in China,and a comprehensive database of genomic variations based on resequencing of 220 germplasms.Approximate 2.74 Gb contigs(N50 of 2.06 Mb),accounting for 88.39%of the estimated genome,were assembled,and 2.56 Gb contigs were anchored to 32 pseudo-chromosomes.A total of 34,922 allelic genes were identified from the allele-aware genome.We observed the expansion of gene families,especially those related to the nitrogen metabolism,and the increase of repetitive elements including transposable elements,which probably resulted in the increase of Zhongmu-4 genome compared with Medicago truncatula.Population structure analysis revealed that the accessions from Asia and South America had relatively lower genetic diversity than those from Europe,suggesting that geography may influence alfalfa genetic divergence during local adaption.Genome-wide association studies identified 101 single nucleotide polymorphisms(SNPs)associated with 27 agronomic traits.Two candidate genes were predicted to be correlated with fall dormancy and salt response.We believe that the alleleaware chromosome-level genome sequence of Zhongmu-4 combined with the resequencing data of the diverse alfalfa germplasms will facilitate genetic research and genomics-assisted breeding in variety improvement of alfalfa. | Ruicai Long Fan Zhang Zhiwu Zhang Mingna Li Lin Chen Xue Wang Wenwen Liu Tiejun Zhang Long-Xi Yu Fei He Xueqian Jiang Xijiang Yang Changfu Yang Zhen Wang Junmei Kang Qingchuan Yang | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 1 |
| 10 | Penetrating Keratoplasty With Small-Diameter and Glycerin-Cryopreserved Grafts for Eccentric Corneal Perforations显示文摘 | Weiyun Shi Mingna Liu Hua Gao Suxia Li Ting Wang Lixin Xie | 2009 | Cornea2009，，6： | 1 |
| 11 | Design and control of deformable quadrotor with varying length arms显示文摘Deformable quadrotors can manipulate their specific structure for specialized tasks or excellent flight performance under diverse conditions.With added deformation mechanism,the quadrotor exhibits higher flexibility;however,this is accompanied by difficulties in modeling analysis and controller design,which are crucial issues.Here,a novel deformable quadrotor that can alter its arm's length is designed by combining the crank-slider mechanism and cross-configuration.The dynamics,including the attitude and position systems,are analyzed and the former is further described as switched linear parameter varying(SLPV)systems from a control-oriented perspective.In addition,a combined SLPV/proportion-integration-differentiation(PID)attitude controller is developed to handle different deformable quadrotor modes,which guarantees the stability of the closed-loop attitude system during the deformation process and achieves attitude tracking.Furthermore,together with the cascade PID position controller,the entire flight controller is constructed whose feasibility is verified via fixed-point hovering and trajectory tracking experiments. | SUN YiChong XIE MingNa LI YeHui NG WingYin ZHANG Heng LI Zheng | 2023 | Science China(Technological Sciences)2023，66，5： | 0 |
| 12 | Should they wait?Two children under 3 years old infected by HCV 1b successfully treated by ledipasvir/sofosbuvir:A report of two cases显示文摘Although direct-acting antivirals(DAAs)have notably increased the sustained virological response(SVR)rates in hepatitis C virus(HCV)-infected adolescent patients,the efficacy and safety for young children under 3 years old remain unclear.Currently,no guidelines recommend DAA therapy for this situation worldwide.Furthermore,the China National Medical Products Administration has not approved any DAA for treating children below 12 years old.Here,we described the characteristics of two children approximately 2 years old,who were infected by HCV genotype 1b and had significant clinical symptoms.Both received 12 weeks of ledipasvir/sofosbuvir(Case 1:45.00 mg/200 mg per day,weight 17 kg;Case 2:33.75 mg/150 mg per day,weight 12 kg).They achieved SVR at 12 weeks after treatment completion without obvious treatment-related adverse effects.Therefore,the safety and benefits of ledipasvir/sofosbuvir treatment in children under 3 years old seem to be confirmed.Our findings require further evaluation. | Mingna Li Kuerbannisa Wulayin Shutao Lin Chao Wu Lubiao Chen | 2023 | Liver Research2023，7，4： | 0 |
| 13 | GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease显示文摘Peripheral bacterial infections without impaired blood brain barrier integrity have been attributed to the pathogenesis of Parkinson's disease(PD).Peripheral infection promotes innate immune training in microglia and exacerbates neuroinflammation.However,how changes in the peripheral environment mediate microglial training and exacerbation of infection-related PD is unknown.In this study,we demonstrate that GSDMD activation was enhanced in the spleen but not in the CNS of mice primed with low-dose LPS.GSDMD in peripheral myeloid cells promoted microglial immune training,thus exacerbating neuroinflammation and neurodegeneration during PD in an IL-1R-dependent manner.Furthermore,pharmacological inhibition of GSDMD alleviated the symptoms of PD in experimental PD models.Collectively,these findings demonstrate that GSDMD-induced pyroptosis in myeloid cells initiates neuroinflammation by regulating microglial training during infection-related PD.Based on these findings,GSDMD may serve as a therapeutic target for patients with PD. | Bingwei Wang Yan Ma Sheng Li Hang Yao Mingna Gu Ying Liu You Xue Jianhua Ding Chunmei Ma Shuo Yang Gang Hu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 14 | The function of ubiquitin-specific protease 31 in intracerebral hemorrhage显示文摘Intracerebral hemorrhage(ICH)is the most serious type of stroke.High level of thrombin is found in the ICH.Ubiquitin-specific protease(USP)31,a member of deubiquitinating enzymes family,has been found to negatively regulate the NF-κB pathway.However,the function of USP31 in ICH remains largely unknown.In the present study,the mRNA and protein expression levels of USP31 were measured by real-time PCR and western blot.Flow cytometry was used to measure cell apoptosis and the level of reactive oxygen species(ROS).In the current study,we found the mRNA level of USP31 was decreased in peripheral blood mononuclear cells(PBMCs)from the patients with ICH.Thrombin stimulated cell apoptosis,and increased the ROS level,the productions of interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and monocyte chemoattractant protein-1(MCP-1),but it decreased the expression level of USP31 in BV-2 cells.In agreement,USP31 overexpressing could alleviate these effects caused by thrombin.USP31 partially reversed the thrombin induced increase of nuclear factor kappa B(NF-κB)localization.Further,NF-κB inhibitor could alleviate the effects induced by USP31 knockdown.In addition,USP31 decreased the ubiquitination level of IκBα,which might contribute to the depression of NF-κB activation.In conclusions,USP31 played a role in the ICH might via regulating NF-κB signaling pathway. | SUYING PU HUI ZHENG YUN TAO JING SHAO MINGNA YANG SHUNJUN LI | 2022 | BIOCELL2022，46，6： | 0 |
| 15 | Health Status and Food Intake Frequency of Elderly Residents During COVID-19 Community Closure—Jiangxia District,Wuhan City,China,2020显示文摘What is already known about this topic?Elderly persons are vulnerable to infectious diseases,and nutritional status and health conditions were important to evaluate for disease prevention and ability to recover for the elderly during the coronavirus disease 2019(COVID-19)pandemic.What is added by this report?In our study,a rapid assessment questionnaire was used to investigate the change of household life and dietary intake of the elderly(aged 60 years or more)during community closure.Food consumption frequency of aquatic food products,soybeans,and fresh fruits declined dramatically with reductions of 70.9%,70.9%,and 53.0%,respectively,and 49.6%of the elderly lived with chronic non-communicable diseases but had little knowledge of nutrition and health.What are the implications for public health practice?Community closure measures in Wuhan City have played a key role in cutting off the transmission route of COVID-19 and protecting vulnerable groups.As a high-risk population,the elderly should be advised to maintain and strengthen a balanced diet with proper nutrition through increasing intake of aquatic food products,soybeans,fruits,and vegetables,reducing total caloric intake,and decreasing oil and salt consumption.These measures will be significant for the elderly to reduce the risk of chronic disease complications and COVID-19 infection and to decrease the chance of critical illness. | Pengkun Song Cheng Li Ganyu Feng Jian Zhang Li Li Titi Yang Mingna Dong Ailing Liu Qi Zhang Yujing Liu Jinglei Wang Tanxi Ge Qing Yu Gangqiang Ding | 2020 | China CDC weekly2020，2，27： | 0 |
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