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| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 3 | IPA1 functions as a downstream transcription factor repressed by D53 in strigolactone signaling in rice显示文摘Strigolactones (SL ) ,一组类胡萝卜素导出 terpenoid 内酯,是压制射击由禁止腋的芽的长出分叉的 root-to-shoot 植物激素。矮子 53 (D53 ) ,表明小径的 SL 的关键抑压者,被推测调整 SL 反应的下游的 transcriptional 网络。然而, D53 指向的下游的抄写因素还都没被报导。这里,我们报导那理想的植物体系结构 1 (IPA1 ) ,在米饭的植物体系结构的一个关键管理者,在调整 tiller 数字和导致 SL 的基因表示作为 D53 的一个直接下游的部件工作。我们证明 D53 在 vivo 并且在 vitro 与 IPA1 交往并且压制 IPA1 的 transcriptional 激活活动。我们进一步证明 IPA1 能直接绑在 D53 倡导者并且在导致 SL 的 D53 表示的反馈规定起一个关键作用。这些调查结果表明 IPA1 是可能的与 D53 行动到的长推测的抄写因素之一调停在米饭的调整 SL 的 tiller 发展。 | Xiaoguang Song Zefu Lu Hong Yu Gaoneng Shao Jinsong Xiong Xiangbing Meng Yanhui Jing Guifu Liu Guosheng Xiong Jingbo Duan Xue-Feng Yao Chun-Ming Liu Hongqing Li Yonghong Wang Jiayang Li | 2017 | Cell Research2017，27，9： | 48 |
| 4 | Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis B显示文摘瞄准:与长期的肝炎 B (CHB ) 在病人学习在肝炎 B (HBV ) DNA 层次和肝组织学之间的关系并且决定肝炎 B e 的流行和特征抗原(HBeAg )negative 病人。方法:有 CHB 的 213 个病人的一个总数被学习,并且浆液 HBV DNA 层次被 COBAS Amplicor HBV 监视器测量测试。所有病人根据 HBeAg 地位被划分成二个组。在浆液 HBV DNA 层次和肝损坏(肝组织学和生物化学) 之间的关联被探索。结果:有比 105 copies/mL 高的浆液 HBV DNA 层次的 213 个病人,(83.6%) 178 是 HBeAg 积极,(16.4%) 35 是 HBeAg 否定。浆液 HBV DNA 层次没在否定的 HBeAg 或 HBeAg 被相关到肝疾病的年龄, CHB 的历史,组织学的等级和阶段积极病人。在 HBV DNA 和丙氨酸 aminotransferanse (中高音) 的浆液层次之间没有关联,在 HBeAg 积极病人的 aspartate aminotrans-ferase (著名计算机生产厂商) 。在 HBeAg 否定病人,当浆液 DNA 层次与中高音相关时,在 HBV DNA 和著名计算机生产厂商的浆液层次之间没有关联(r = 0.351, P = 0.042 ) 。肝疾病的等级(G) 与中高音和著名计算机生产厂商相关(P <
0.05, r = 0.205, 0.327 分别地) 在 HBeAg 积极病人。在 HBeAg 否定病人,关联在中高音,著名计算机生产厂商和 G 之间被显示出(P <
0.01,并且 r = 0.862, 0.802 分别地) 。 HBeAg 否定病人更老( 35 +/- 9 年对 30 +/- 9 年, P <
0.05 )并且有 HBV 感染的更长的历史( 8 +/- 4 年对 6 +/- 4 年, P <
0.05 )并且更低的 HBV DNA 比 HBeAg 积极病人铺平( 8.4 +/- 1.7 木头 HBV DNA 对 9.8 +/- 1.3 木头 HBV DNA , P <
0.001 )。在在二个组之间的两性比率,中高音和著名计算机生产厂商层次和肝组织学没有有效差量。结论:浆液 HBV DNA 水平没与 HBV DNA 在 CHB 病人被相关到肝疾病的组织学的等级或舞台超过 105 copies/mL。比作 HBeAg 积极病人, HBeAg 否定病人更老并且有更低的 HBV DNA 水平和更长的 HBV 感染历史。在在二个组之间的两性比率,中高音和著名计算机生产厂商层次和肝组织学没有有效差量。 | Jie Shao Lai Wei Hao Wang Yan Sun Lan-Fang Zhang Jing Li Jian-Qiang Dong | 2007 | World Journal of Gastroenterology2007，13，14： | 35 |
| 5 | Polymorphisms in PPARD,PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions显示文摘Based on the theory of constitution of Traditional Chinese Medicine (TCM), the human population is divided into nine constitutions including one balanced constitution (Normality) and eight unbalanced constitutions (Yang-deficiency, Yin-deficiency, Phlegm-wetness, Qi-deficiency, Wetness-heat, Blood stasis, Depressed constitution, and Inherited special constitution). Different constitutions have specific metabolic features and different susceptibility to certain diseases. However, whether a genetic basis accounts for such constitution classifica-tion is yet to be determined. Here we performed a genetic study to assess the association between genetic variations of metabolic genes in-cluding PPARD, PPARG and APM1 and the constitutions. A total of 233 individuals of the Han population in China were classified into four groups, Normality, Yang-deficiency, Yin-deficiency and Phlegm-wetness with whom 23 single nucleotide polymorphisms (SNPs) in the three genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biased distri-bution of PPARD rs2267669 and rs2076167, APM1 rs7627128 and rs1063539 in Yang-deficiency, PPARG Pro12Ala in Yin-deficiency and PPARD rs2076167, APM1 rs266729 and rs7627128 in Phlegm-wetness were observed. The frequencies of Haplotype13 (Hap13) of PPARG in Yin-deficiency, Hap25 of APM1 in Yang-deficiency and Hap2 of PPARD and Hap14 of PPARG in Phlegm-wetness, were significantly different from those in Normality, suggesting those might be group-associated haplotypes. These results suggested that single SNP and hap-lotypes of PPARD, PPARG and APM1 may underlie the genetic basis of the constitutions classified in TCM. | Yanrui Wu Yina Cun Jing Dong Jingru Shao Shengjun Luo Shengjie Nie Haijing Yu Bingrong Zheng Qi Wang Chunjie Xiao | 2010 | Journal of Genetics and Genomics2010，37，6： | 36 |
| 6 | Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible. | Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO | 2005 | Cell Research2005，15，11： | 34 |
| 7 | Network Pharmacology Evaluation Method Guidance-Draft显示文摘Foreword Note:Some of the document contents may involve certain patents,the identification of which is not the responsibility of the institution that releases the document.Main drafting organizations:Tsinghua University,Specialty Committee of Network Pharmacology of World Federation of Chinese Medicine Societies(WFCMS). | Shao Li Yi-Tao Chen Qing-Yang Ding Jian-Ye Dai Xian-Chun Duan Yuan-Jia Hu Xin-Xing Lai Qing-Fei Liu Ming Niu Rong-Wu Xiang Zheng Xiang Hai-Yu Xu Xin Wang Hong-Jun Yang Kuo Yang Ming Yang Hai-Yang Yu Bo Zhang Peng Zhang Qian-Ru Zhang Hui-Hui Zhao Jing Zhao | 2021 | World Journal of Traditional Chinese Medicine2021，7，1： | 32 |
| 8 | Effect of intestinal lymphatic circulation blockage in two-hit rats显示文摘AIM: To study the effect of blocking intestinal lymphatic circulation in two-hit rats and explore the significance of intestinal lymphatic circulation in two-hit. METHODS: Wistar rats were divided equally into three groups: mesenteric lymph duct ligation group, non- ligation group and sham group. Mesenteric lymph was diverted by ligation of mesenteric lymph duct, and the two-hit model was established by hemorrhage and lipopolysaccharide (LPS) methods. All rats were sampled for serum pre-experiment and 24 h post- experiment. The organs including kidney, liver, lung and heart were collected for pathomorphologic observation and biochemical investigation. The nitric oxide (NO), malondialdehyde (MDA) and superoxide dismutase (SOD) were determined in serum and tissue homogenate. RESULTS: Pathomorphology study showed that the structures of kidney, lung, liver and heart tissues were normal in sham group; congestion, degeneration and necrosis in non-ligation group; but only mild lesions in ligation group. After two-hits, the contents of AST, ALT, BUN, Cr and LDH-1 in the serum of non-ligation group and ligation group were obviously higher than that in pre-experiment group and sham group, but obviously lower than that in non-ligation group. The contents of NO2-/NO3-, NOS, iNOS and MDA in the serum of non- ligation group were significantly increased, compared with pre-experiment and sham group, but SOD was significantly lower. These parameters were significantly different in ligation group compared with that in sham group, but NO2-/NO3-, iNOS and MDA in ligation group were significantly lower than that in non-ligation group. CONCLUSION: Ligation of mesenteric lymph duct could improve the disturbance of organic function and morphologic damage in two-hit rats; the lymphatic mechanism in two-hit should be emphasized. | Chun-Yu Niu Ji-Cheng Li Zi-Gang Zhao Jing Zhang Xue-Hui Shao | 2006 | World Journal of Gastroenterology2006，12，36： | 29 |
| 9 | Predictive factors improving survival after gastric and hepatic surgical treatment in gastric cancer patients with synchronous liver metastases显示文摘背景为有胃的癌症和同步的肝转移的病人的预后是很 poor.However ,标准治疗学的策略一直不是在为从胃的癌症遗体 controversial.Methods 的肝转移的肝的外科的治疗以后的临床的利益和预示的因素不管肝的外科的治疗经历了 gastrectomy 的 105 个病人记录的井 established.The 因为有在我们在 1995 和 2010 之间的中心的同步肝唯一的转移的胃的癌症 P 0.001 ) .However ,肝的外科的治疗不是为经历了 D1 lymphadenectomy 的病人的一个预示的因素(中部的幸存, 8 个 vs.8 月; P=0.495 ) .For 加肝的外科的治疗经历了 gastrectomy 的 35 个病人, D2 lymphadenectomy ( P 0.001 ),淋巴节点转移( P=-0.015 ),并且肝转移( H1 vs.H2 和 H3 )( P=-0.017 )的程度是独立重要预示的因素因为加肝的外科的治疗的 survival.Conclusions D2 lymphadenectomy 可以为 long-te | Liu Jing Li Jing-hui Zhai Ru-jun Wei Bo Shao Ming-zhe Chen Lin | 2012 | Chinese Medical Journal2012，，2： | 27 |
| 10 | Review of clinical investigation on recurrence of gastric cancer following curative resection显示文摘 | LI Jing-hui ZHANG Shi-wu LIU Jing SHAO Ming-zhe CHEN Lin | 2012 | Chinese Medical Journal2012，，8： | 22 |
| 11 | Farmland marginalization in the mountainous areas: Characteristics, influencing factors and policy implications显示文摘基于 SPOT-5 图象, 1:1 百万张地志的地图,到森林工程和重庆森林工程的回来的农田的地图,聚会和经济统计,等等,这份报纸识别影响农田 marginalization 的特征和因素。结果出现了:(1 ) 在 20022012 期间,农田 marginalization 的率是 16.18% ,它主要在北 Qiyao 山的高区域和南部的 Qiyao 山的中等高度的区域被发现。并且这农田 marginalization 将增加,与农村劳动者的 non-agriculturalization 和留下的劳动者的老化联系了。(2 ) 举起,来自村庄的距离半径和道路连接在农田 marginalization 上有大影响。农田 marginalization 率随举起的增加显示出一个增加的趋势,并且 60.88% 全部的农田 marginalization 区域在海水平上面在比 1000 m 大的高度被发现。marginalization 趋势也从分发网络与斜坡和距离增加。(3 ) 农田区域每劳动者和农场劳动者的平均年龄是驾驶农田 marginalization 的主要因素。农田转移和小农业机械集合关于管理和生产率效率影响农田 marginalization。(4 ) 有 comparative-disadvantage-dominated marginalization 的农田说明了 55.32% 全部的农田 marginalization 区域,由地点主导的 marginalization (33.80%) 列在后面。(5 ) 根据每种真实状况的细节,不同政策被建议减轻 marginalization。一条连续 marginalization 政策将在地面主导的 marginalization 鼓励农田的回来到森林。一条 anti-marginalization 政策被建议创造新农村住所并且改进农村道路系统抵抗地面主导的 marginalization。并且另一条 anti-marginalization 政策被计划改进管理并且为 comparative-disadvantage-dominated marginalization 微机械化。一个新想法被开发与调查信息集成高分辨率遥感和统计数据在多山的区域识别陆地 marginalization 和它的驱动力。 | SHAO Jing'an ZHANG Shichao LI Xiubin | 2015 | Journal of Geographical Sciences2015，25，6： | 22 |
| 12 | Electroacupuncture and moxibustion promote regeneration of injured sciatic nerve through Schwann cell proliferation and nerve growth factor secretion显示文摘Using electroacupuncture and moxibustion to treat peripheral nerve injury is highly efficient with low side effects. However, the electroacupuncture-and moxibustion-based mechanisms underlying nerve repair are still unclear. Here, in vivo and in vitro experiments uncovered one mechanism through which electroacupuncture and moxibustion affect regeneration after peripheral nerve injury. We first established rat models of sciatic nerve injury using neurotomy. Rats were treated with electroacupuncture or moxibustion at acupoints Huantiao(GB30) and Zusanli(ST36). Each treatment lasted 15 minutes, and treatments were given six times a week for 4 consecutive weeks. Behavioral testing was used to determine the sciatic functional index. We used electrophysiological detection to measure sciatic nerve conduction velocity and performed hematoxylin-eosin staining to determine any changes in the gastrocnemius muscle. We used immunohistochemistry to observe changes in the expression of S100—a specific marker for Schwann cells—and an enzyme-linked immunosorbent assay to detect serum level of nerve growth factor. Results showed that compared with the model-only group, sciatic functional index, recovery rate of conduction velocity, diameter recovery of the gastrocnemius muscle fibers, number of S100-immunoreactive cells, and level of nerve growth factor were greater in the electroacupuncture and moxibustion groups. The efficacy did not differ between treatment groups. The serum from treated rats was collected and used to stimulate Schwann cells cultured in vitro. Results showed that the viability of Schwann cells was much higher in the treatment groups than in the model group at 3 and 5 days after treatment. These findings indicate that electroacupuncture and moxibustion promoted nerve regeneration and functional recovery; its mechanism might be associated with the enhancement of Schwann cell proliferation and upregulation of nerve growth factor. | Lin-na Hu Jin-xin Tian Wei Gao Jing Zhu Fang-fang Mou Xiao-chun Ye Yu-pu Liu Ping-ping Lu Shui-jin Shao Hai-dong Guo | 2018 | Neural Regeneration Research2018，13，3： | 22 |
| 13 | Lithofacies palaeogeography of the Carboniferous and Permian in the Qinshui Basin, Shanxi Province, China显示文摘The Qinshui Basin in the southeastern Shanxi Province is an important area for coalbed methane(CBM) exploration and production in China, and recent exploration has revealed the presence of other unconventional types of gas such as shale gas and tight sandstone gas. The reservoirs for these unconventional types of gas in this basin are mainly the coals, mudstones, and sandstones of the Carboniferous and Permian; the reservoir thicknesses are controlled by the depositional environments and palaeogeography. This paper presents the results of sedimentological investigations based on data from outcrop and borehole sections, and basin-wide palaeogeographical maps of each formation were reconstructed on the basis of the contours of a variety of lithological parameters. The palaeogeographic units include the depositional environments of the fluvial channel, flood basin(lake), upper delta plain, lower delta plain, delta front, lagoon, tidal flat, barrier bar, and carbonate platform.The Benxi and Taiyuan Formations are composed mainly of limestones, bauxitic mudstones,siltstones, silty mudstones, sandstones, and economically exploitable coal seams, which were formed in delta, tidal flat, lagoon, and carbonate platform environments. The Shanxi Formation consists of sandstones, siltstones, mudstones, and coals; during the deposition of the formation, the northern part of the Qinshui Basin was occupied mainly by an upper delta plain environment, while the central and southern parts were mainly occupied by a lower delta plain environment and the southeastern part by a delta front environment. Thick coal zones occur in the central and southern parts, where the main depositional environment was a lower delta plain. The thick coal zones of the Taiyuan Formation evidently occur in the sandstone-rich belts, located mainly in the lower delta plain environment in the northern part of the basin and the barrier bar environments in the southeastern part of the basin. In contrast, the thick coal zones of the Shanxi Formation extend over the mudstone-rich belts, located in the areas of the lower delta plain environments of the central and southern parts of the Basin.The Xiashihezi, Shangshihezi, and Shiqianfeng Formations consist mainly of red mudstones with thick-interbedded sandstones. During the deposition of these formations, most areas of the basin were occupied by a fluvial channel, resulting in palaeogeographic units that include fluvial channel zones and flood basins. The fluvial channel deposits consist mainly of relatively-thick sandstones, which could have potential for exploration of tight sandstone gas. | Long-Yi Shao Zhi-Yu Yang Xiao-Xu Shang Zheng-Hui Xiao Shuai Wang Wen-Long Zhang Ming-Quan Zheng Jing Lu | 2015 | Journal of Palaeogeography2015，4，4： | 21 |
| 14 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 15 | MONOCULM 3,an Ortholog of WUSCHEL in Rice,Is Required for Tiller Bud Formation显示文摘WUSCHEL(WUS)plays an essential role for the maintenance of meristem activity in dicots,but its function is still elusive in monocots.We isolated a new monoculm mutant,monoculm 3(moc3),in which a point mutation causes the premature termination of rice O.sativa WUS(Os WUS).Morphological observation revealed that the formation of tiller buds was disrupted in moc3.MOC3 was localized in the nuclear and could interact with TOPLESS-RELATED PROTEINS(TPRs).The expression of MOC3 was induced by cytokinins and defection of MOC3 affected the expression of several two-component cytokinin response regulators,Os RRs and ORRs.Our results suggest that MOC3 is required for the formation of axillary buds and has a complex relationship with cytokinins. | Zefu Lu Gaoneng Shao Jinsong Xiong Yongqing Jiao Jing Wang Guifu Liu Xiangbing Meng Yan Liang Guosheng Xiong Yonghong Wang Jiayang Li | 2015 | Journal of Genetics and Genomics2015，42，2： | 17 |
| 16 | Degradation of Nitrobenzene-Containing Wastewater with O_3 and H_2O_2 by High Gravity Technology显示文摘Nitrobenzene-containing industrial wastewater was degraded in the presence of ozonecoupled with H2O2 by high gravity technology. The effect of high gravity factor, H2O2 concentration, pH value, liquid flow-rate, and reaction time on the efficiency for removal of nitrobenzene was investigated. The experimental results show that the high gravity technology enhances the ozone utilization efficiency with O3 /H2O2 showing synergistic effect. The degradation efficiency in terms of the COD removal rate and nitrobenzene removal rate reached 45.8% and 50.4%, respectively, under the following reaction conditions, viz.: a high gravity factor of 66.54, a pH value of 9, a H2O2 /O3 molar ratio of 1:1, a liquid flow rate of 140L/h, an ozone concentration of 40mg/L, a H2O2 multiple dosing mode of 6mL/h, and a reaction time of 4h. Compared with the performance of conventional stirred aeration mixers, the high gravity technology could increase the COD and nitrobenzene removal rate related with the nitrobenzene-containing wastewater by 22.9% and 23.3%, respectively. | Jiao Weizhou Liu Youzhi Liu Wenli Li Jing Shao Fan Wang Chaoran | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 16 |
| 17 | Paleo-fires and Atmospheric Oxygen Levels in the Latest Permian:Evidence from Maceral Compositions of Coals in Eastern Yunnan,Southern China显示文摘从三节在的晚二叠的煤的 Inertinite maceral 作文陆上并且东方云南的 paralic 背景被分析以便揭示 paleo 火事件和大气的氧层次在最近二叠。尽管在学习的节的 macerals 被 vitrinite 通常统治, inertinite 组完成一个可观的比例。它的内容从开始向上增加对二叠三叠纪的边界附近的煤缝接晚二叠。基于显微镜的特征和 inertinite 大部分是 paleo 火的一个副产品的占优势的理论,我们建议向上增加 inertinite 丰富在的趋势最近二叠能暗示晚二叠的 peatland 受不了经常的野火。自从点火并且烧取决于足够的氧,基于模型的计算建议 O2 层次接近 Wuchiapingian/Changhsingian 边界,二叠三叠纪的边界分别地是 27% 和 28% 。这产量把支持加到在时间的海洋、陆上的沉积做的另外的发现,并且质问为二叠三叠纪的边界危机作为机制倡导组织缺氧的理论。 | SHAO Longyi WANG Hao YU Xiaohui LU Jing ZHANG Mingquan | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 16 |
| 18 | Aspergillus fumigatus conidia upregulates NOD2 protein expression both in vitro and in vivo显示文摘瞄准:决定 NOD2 是否涉及曲霉属菌 fumigatus (Af ) 的主人识别 conidia。方法:Af conidia 肺的感染鼠科的模型被 Af onidia 暂停的 intranasal 接种建立。在肺织物的 NOD2 的蛋白质层次被免疫组织化学决定。激活的 THP-1 房间衬里的 A549 和 phorbol-12-myristate 13 醋酸盐(PMA ) 与杀死热的 Af conidia 被对待,然后,在这些房间线的 NOD2 蛋白质的存在被西方的弄污检测。muramyl dipeptide (MDP ) 的能力被连接酶的免疫吸着剂试金测量与杀死热的 Af conidia 在孵化以后导致 TNF-α 的分泌物。结果:在肺织物的 NOD2 蛋白质的表示在 Af conidia 感染以后增加了。杀死热的 Af conidia 显著地在在 A549 房间和激活 PMA 的 THP-1 房间的调整 NOD2 蛋白质表示上面。另外,在有 MDP 的 conjuction 的 Af conidia,显著地在 A549 房间和激活 PMA 的 THP-1 房间增加了 TNF-α 的分泌物。结论: Af conidia 在上面在 vitro 并且在 vivo 调整 NOD2 蛋白质表示。这些调查结果显示那 NOD2 蛋白质可以对 Af conidia 作出回应。 | Hui-jun ZHANG Jie-ming QU Chang-zhou SHAO Jing ZHANG Li-xian HE Zheng-hong YUAN | 2008 | Acta Pharmacologica Sinica2008，29，10： | 15 |
| 19 | MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ显示文摘 | Shuo Li Jing Li Bing-Yuan Fei Dan Shao Yue Pan Zhan-Hao MO Bao-Zhen Sun Dan Zhang Xiao Zheng Ming Zhang Xue-Wen Zhang Li Chen | 2015 | Chinese Medical Journal2015，，7： | 15 |
| 20 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
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