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| 1 | Effects of freeze-thaw on soil erosion processes and sediment selectivity under simulated rainfall显示文摘The freeze-thaw(FT) processes affect an area of 46.3% in China. It is essential for soil and water conservation and ecological construction to elucidate the mechanisms of the FT processes and its associated soil erosion processes. In this research, we designed the control simulation experiments to promote the understanding of FT-water combined erosion processes. The results showed that the runoff of freeze-thaw slope(FTS) decreased by 8% compared to the control slope(CS), and the total sediment yield of the FTS was 1.10 times that of the CS. The sediment yield rate from the FTS was significantly greater than that from the CS after 9 min of runoff(P<0.01). Both in FTS and CS treatments, the relationships between cumulative runoff and sediment yield can be fitted well with power functions(R2>0.98, P<0.01). Significant differences in the mean weight diameter(MWD) values of particles were observed for washed particles and splashed particles between the CS and the FTS treatments in the erosion process(P<0.05). The mean MWD values under CS were smaller than those under FTS for both washed and splashed particles. The ratio of the absolute value of a regression coefficient between the CS and the FTS was 1.15, being roughly correspondent with the ratio of K between the two treatments. Therefore, the parameter a of the power function between cumulative runoff and sediment yield could be an acceptable indicator for expressing the soil erodibility. In conclusion, the FTS exhibited an increase in soil erosion compared to the CS. | WANG Tian LI Peng REN Zongping XU Guoce LI Zhanbin YANG Yuanyuan TANG Shanshan YAO Jingwei | 2017 | Journal of Arid Land2017，9，2： | 8 |
| 2 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 3 | Microstructure,tensile properties and thermal stability of AlMgSiScZr alloy printed by laser powder bed fusion显示文摘The new generation of Sc and Zr modified Al alloys has been attracted wide concerns in aerospace industry,owing to the excellent mechanical performances and superior thermal stability than other normal Al alloys.By microalloying with Sc and Zr,the Al3(Sc,Zr)particle forms as the grain refiner during the solidification,which is extremely beneficial for the laser powder bed fusion(LPBF)processed Al alloys.In this study,a new type Al-14.1 Mg-0.47 Si-0.31 Sc-0.17 Zr alloy was additively manufactured by LPBF,and the microstructure,tensile properties and thermal stability were studied in detail.By using a single melt-67°scanning strategy,the LPBF-processed specimen with a relative density of 99.4%and tensile strength of 487.7 MPa was obtained at 160 W-200 mm/s.And this AlMgSiScZr alloy can still exhibit an excellent tensile strength of 393.9 MPa at a moderate temperature of 473 K.After the aging treatment,the tensile properties further increased due to the precipitate hardening of Mg2Si and Al3(Sc,Zr),and the maximum value(580 MPa)was reached at an aging time of 10 h.The average crystal size was almost unchanged after aging treated at 325℃and 24 h,indicating this AlMgSiScZr alloy has an improved thermal stability.The AlMgSiScZr alloy is recommended to substitute some particular titanium alloys in aerospace field afterwards. | Jiang Bi Zhenglong Lei Yanbin Chen Xi Chen Ze Tian Nannan Lu Xikun Qin Jingwei Liang | 2021 | Journal of Materials Science & Technology2021，，10： | 4 |
| 4 | Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates显示文摘Huntington's disease(HD) is caused by abnormal CAG repeat expansion in the 5′-end of the Huntingtin(HTT) gene.In addition to the canonical C-terminal full-length huntingtin(htt) nuclear export signal,a cytoplasmic localization-related domain(CLRD) in the N-terminus of htt has recently been reported.Here,we analyzed this domain by introducing deletion and substitution mutations in a truncated N-terminal htt protein and subsequently monitored htt expression,aggregation and subcellular localization by immunocytochemistry and Western blot analysis.We demonstrated that Htt4-17 was the essential sequence for htt cytoplasmic localization.We also found that the subcellular distribution of htt was altered when Htt1-17 was mutated to contain amino acids of different charges,suggesting a structural requirement of Htt1-17 for the cytoplasmic localization of htt. Deletion of the first three amino acids did not affect its association with mitochondria.We observed that defective cytoplasmic localization resulted in a reduction of total htt aggregates and increased nuclear aggregates,indicating that the subcellular distribution of the protein might influence the aggregation process.These studies provide new insight into the molecular mechanism of htt aggregation in HD. | YAN YaPing PENG DanTao TIAN Jun CHI JingWei TAN JieQiong YIN XinZhen PU JiaLi XIA Kun ZHANG BaoRong | 2011 | Science China(Life Sciences)2011，54，4： | 4 |
| 5 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 6 | An improved least mean square/fourth direct adaptive equalizer for under-water acoustic communications in the Arctic显示文摘An improved least mean square/fourth direct adaptive equalizer(LMS/F-DAE)is proposed in this paper for underwater acoustic communication in the Arctic.It is able to process complex-valued baseband signals and has better equalization performance than LMS.Considering the sparsity feature of equalizer tap coefficients,an adaptive norm(AN)is incorporated into the cost function which is utilized as a sparse regularization.The norm constraint changes adaptively according to the amplitude of each coefficient.For small-scale coefficients,the sparse constraint exists to accelerate the convergence speed.For large-scale coefficients,it disappears to ensure smaller equalization error.The performance of the proposed AN-LMS/F-DAE is verified by the experimental data from the 9th Chinese National Arctic Research Expedition.The results show that compared with the standard LMS/F-DAE,AN-LMS/F-DAE can promote the sparse level of the equalizer and achieve better performance. | Yanan Tian Xiao Han Jingwei Yin Hongxia Chen Qingyu Liu | 2020 | Acta Oceanologica Sinica2020，39，9： | 1 |
| 7 | Guidelines for navigation-assisted spine surgery显示文摘Spinal surgery is a technically demanding and challenging procedure because of the complicated anatomical structures of the spine and its proximity to several important tissues.Surgical landmarks and fluoroscopy have been used for pedicle screw insertion but are found to produce inaccuracies in placement.Improving the safety and accuracy of spinal surgery has increasingly become a clinical concern.Computerassisted navigation is an extension and application of precision medicine in orthopaedic surgery and has significantly improved the accuracy of spinal surgery.However,no clinical guidelines have been published for this relatively new and fast-growing technique,thus potentially limiting its adoption.In accordance with the consensus of consultant specialists,literature reviews,and our local experience,these guidelines include the basic concepts of the navigation system,workflow of navigation-assisted spinal surgery,some common pitfalls,and recommended solutions.This work helps to standardize navigation-assisted spinal surgery,improve its clinical efficiency and precision,and shorten the clinical learning curve. | Wei Tian Bo Liu Da He Yajun Liu Xiaoguang Han Jingwei Zhao Mingxing Fan | 2020 | Frontiers of Medicine2020，14，4： | 1 |
| 8 | SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway显示文摘 | Haibo Zhu Libo Zou Jingwei Tian Guangying Du Yubai Gao | 2013 | European Journal of Pharmacology (-)2013，，1： | 1 |
| 9 | MicroRNA-610 inhibits the migration and invasion of gastric cancer cells by suppressing the expression of vasodilator-stimulated phosphoprotein显示文摘 | Jing Wang Jingwei Zhang Junzhu Wu Daji Luo Ke Su Wentao Shi Jian Liu Yihao Tian Lei Wei | 2011 | European Journal of Cancer2011，，12： | 1 |
| 10 | Neuroprotective Effects of Hydroxysafflor Yellow A: In Vivo and in Vitro Studies显示文摘 | Haibo Zhu Zhenhua Wang Chengjun Ma Jingwei Tian Fenghua Fu Changling Li Dean Guo E. Roeder Ke Liu | 2003 | Planta Med2003，，05： | 1 |
| 11 | ND-309,a novel compound,ameliorates cerebral infarction in rats by antioxidant action显示文摘 | Tian Jingwei Li Guisheng Liu Zhifeng | 2008 | Neurosci Lett2008，442，3： | 1 |
| 12 | Regression of atherosclerosis by Rosmarinic acid via regulating lipid metabolism and anti-inflammatory actions显示文摘 | Li Li Jingwei Tian Xuguo Liang | 2008 | Journal of Molecular and Cellular Cardiology2008，，4： | 1 |
| 13 | in vitro and in vivo anfifibrotic effects of rosmarinic acid on experimental liver fibrosis显示文摘 | LI Guisheng JIANG Wanglin TIAN Jingwei | 2010 | Phytomedicine2010，17，： | 1 |
| 14 | Ocotillol Enhanced the Antitumor Activity of Doxorubicin via p53-Dependent Apoptosis显示文摘 | Hongbo Wang Pengfei Yu Jing Bai Jianqiao Zhang Liang Kong Fangxi Zhang Guangying Du Shiqian Pei Lixia Zhang Yongtao Jiang Jingwei Tian Fenghua Fu Gautam Sethi | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 15 | Protec- tions of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury ameliora- tion in cerebral ischemia rats显示文摘 | Tian Jingwei Fu Fenghua Li Guisheng | 2009 | Journal Phytomedi- cine2009，16，： | 1 |
| 16 | A multifunctional optoelectronic device based on 2D material with wide bandgap显示文摘Low-dimensional materials exhibit unique quantum confinement effects and morphologies as a result of their nanoscale size in one or more dimensions,making them exhibit distinctive physical properties compared to bulk counterparts.Among all low-dimensional materials,due to their atomic level thickness,two-dimensional materials possess extremely large shape anisotropy and consequently are speculated to have large optically anisotropic absorption.In this work,we demonstrate an optoelectronic device based on the combination of two-dimensional material and carbon dot with wide bandgap.High-efficient luminescence of carbon dot and extremely large shape anisotropy(>1500)of two-dimensional material with the wide bandgap of>4 eV cooperatively endow the optoelectronic device with multi-functions of optically anisotropic blue-light emission,visible light modulation,wavelength-dependent ultraviolet-light detection as well as blue fluorescent film assemble.This research opens new avenues for constructing multi-function-integrated optoelectronic devices via the combination of nanomaterials with different dimensions. | Hongwei Xu Jingwei Liu Sheng Wei Jie Luo Rui Gong Siyuan Tian Yiqi Yang Yukun Lei Xinman Chen Jiahong Wang Gaokuo Zhong Yongbing Tang Feng Wang Hui-Ming Cheng Baofu Ding | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 17 | High carrier mobility and strong fluorescence emission: Toward highly sensitive single-crystal organic phototransistors显示文摘Organic single crystals(OSCs)offer a unique combination of both individual and collective properties of the employed molecules,but it remains highly challenging to achieve OSCs with both high mobilities and strong fluorescence emissions for their potential applications in multifunctional optoelectronics.Herein,we demonstrate the design and synthesis of two novel triphenylamine-functionalized thienoacenes-based organic semiconductors,4,8-distriphenylamineethynylbenzo[1,2-b:4,5-b′]dithiophene(4,8-DTEBDT)and 2,6-distriphenylamineethynylbenzo[1,2-b:4,5-b′]dithiophene(2,6-DTEBDT),with high-mobility and strong fluorescence emission.The two compounds show the maximum mobilities up to 0.25 and 0.06 cm^(2) V^(-1) s^(-1),the photoluminescence quantum yields(PLQYs)of 51% and 45%,and the small binding energies down to 55.13 and 58.79 meV.The excellent electrical and optical properties ensured the application of 4,8-DTEBDT and 2,6-DTEBDT single crystals in ultrasensitive UV phototransistors,achieving high photoresponsivity of 9.60×105 and 6.43×10^(4) AW^(-1),and detectivity exceeding 5.68×10^(17) and 2.99×10^(16) Jones. | Jingwei Tao Zhaoyang Liu Dan Liu Huanli Dong Jiangbo Jing Jiaxing Song Leijing Liu Bin Xu Wenjing Tian | 2023 | Aggregate2023，4，2： | 0 |
| 18 | Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons显示文摘The expression of linear DNA sequence is precisely regulated by the three-dimensional(3D)architecture of chromatin.Morphine-induced aberrant gene networks of neurons have been extensively investigated;however,how morphine impacts the 3D genomic architecture of neurons is still unknown.Here,we applied digestion-ligation-only high-throughput chromosome conformation capture(DLO Hi-C)technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons.After receiving continuous morphine administration for 90 days on rhesus monkeys,we discovered that morphine re-arranged chromosome territories,with a total of 391 segmented compartments being switched.Morphine altered over half of the detected topologically associated domains(TADs),most of which exhibited a variety of shifts,followed by separating and fusing types.Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops.Moreover,all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops,and were further validated for changed expression.Collectively,an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects.Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans. | Liang Wang Xiaojie Wang Chunqi Liu Wei Xu Weihong Kuang Qian Bu Hongchun Li Ying Zhao Linhong Jiang Yaxing Chen Feng Qin Shu Li Qinfan Wei Xiaocong Liu Bin Liu Yuanyuan Chen Yanping Dai Hongbo Wang Jingwei Tian Gang Cao Yinglan Zhao Xiaobo Cen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 19 | Empirical Analysis of Relationship between Farmers'Income Structure and Consumption in Guizhou Province in the Context of Large-scale Poverty Alleviation显示文摘Large-scale poverty alleviation is one of the three major strategic actions of Guizhou Province to plan for leapfrog development.Through building an econometric model,this paper made an empirical analysis of relationship between farmers'income structure and consumption in Guizhou Province in the context of large-scale poverty alleviation.The results show that the wage income and transfer income of rural residents in Guizhou Province have a significant impact on the promotion of their consumption,and the impact of income from household business operation is also significant,but the impact is relatively weak,while the contribution of farmers'property income to their consumption is insufficient.Finally,in view of the problems in the relationship between the income structure and consumption of farmers in Guizhou Province,it came up with policy recommendations including broadening the income channels,increasing farmers'income,improving the income structure,and promoting farmers'consumption. | Wuxu TIAN Jingwei LIU Zhentao WANG | 2020 | Asian Agricultural Research2020，12，9： | 0 |
| 20 | Advances in artificial intelligence techniques drive the application of radiomics in the clinical research of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)remains the most common malignancy to threaten public health globally.With advances in artificial intelligence techniques,radiomics for HCC management provides a novel perspective to solve unmet needs in clinical settings,and reveals pixel-level radiological information for medical imaging big data,correlating the radiological phenotype with targeted clinical issues.Conventional radiomics pipelines depend on handcrafted engineering features,and further deep learning-based radiomics pipelines are supplemented with deep features calculated via self-learning strategies.During the past decade,radiomics has been widely applied in accurate diagnoses and pathological or biological behavior evaluation,as well as in prognosis prediction.In this review,we systematically introduce the main pipelines of artificial intelligence-based radiomics and their efficacy in the clinical studies of HCC. | Jingwei Wei Meng Niu Ouyang Yabo Yu Zhou Xiaoke Ma Xue Yang Hanyu Jiang Hui Hui Hongyi Cao Binwei Duan Hongjun Li Dawei Ding Jie Tian | 2022 | iLIVER2022，1，1： | 0 |
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