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| 1 | Dust storms and loess accumulation on the Tibetan Plateau: A case study of dust event on 4 March 2003 in Lhasa显示文摘Whether the Tibetan Plateau is a significant dust source area is of great importance, because this is re-lated to the understanding of sources, accumulation and environmental effects of dusts on the Tibetan Plateau and in the Far East-Pacific Ocean regions as well as to the evolution of coupling of the Tibetan Plateau and atmosphere-ocean- continent exchange. Synoptic dynamics and remote sensing tracing of a dust storm on 3 to 5 March, 2003 in Lhasa on South Tibet demonstrate that the Tibetan Plateau possesses all factors and conditions of generating dust storms. Accom-panied with this dust storm is a strong ascending stream on the Plateau which has raised various sizes of dust particles into different levels. The lifted coarse particles were largely fallen down and accumulated as loess on the eastern Tibetan Plateau, and the fine particles were translated by the west-erly jet and subsided in the northern Pacific Ocean. The spa-tial-temporal distribution of dust-storms between years 1961 and 2000 on the Plateau shows that dust-storms mainly occur in winter and early spring with high frequency, and the path of dust storm moves gradually from south to north, which is closely coupled with the northward moving of the westerly jet from winter to spring over the Tibetan Plateau. Com-pared with other twelve dust source areas in China, the Ti-betan Plateau is one of the key dust source areas for the long-distance transport because its high occurring frequency and elevation cause fine particles easily to be lifted into the zone of the westerly jet. | FANG Xiaomin HAN Yongxiang MA Jinghui SONG Lianchun YANG Shengli ZHANG Xiaoye | 2004 | Chinese Science Bulletin2004，49，9： | 25 |
| 2 | Mapping the epigenetic modifications of DNA and RNA显示文摘Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,respectively.The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics.Developing chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their study.Here,we review the recent technological advances in this rapidly evolving field.We focus on high-throughput detection methods and biological findings for these modifications,and discuss questions to be addressed as well.We also summarize third-generation sequencing methods,which enable long-read and single-molecule sequencing of DNA and RNA modification. | Lin-Yong Zhao Jinghui Song Yibin Liu Chun-Xiao Song Chengqi Yi | 2020 | Protein & Cell2020，11，11： | 17 |
| 3 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 4 | Comparative studies on histological and ultra-structure of the pituitary of different ploidy level fishes显示文摘The histological and ultra-structure of the pituitary in diploid red crucian carp(Carassius auratus red var.),triploid crucian carp and allotetraploid hybrids within and after the breeding season were comparatively studied.The result showed that there were six endocrine cell types in the pituitary of these three kinds of fishes,and there was an obvious difference in cell size among different ploidy level fishes.As for the same type of pituitary cells,the cell size was increased gradually with the in- creasing ploidy level.In the breeding season,the allotetraploid hybrids had higher proportion of go- nadotropin cells(GTH)than triploids,and the triploids had higher proportion of GTH than diploids.The results were related to the earlier sexual maturity of allotetraploid hybrids and sterility of triploid cru- cian carp.On the other hand,among the three kinds of fishes,the proportion of somatotropin(STH) cells in triploids crucian carp was the highest,whereas that in allotetraploid hybrids was the lowest. The results might be connected with the faster growth rate of triploids and slower growth rate of al- lotetraploid hybrids.In addition,in GTH cells of meso-adenohypophysis after the breeding season, there were many endocrine particles in triploids,while those endocrine particles were released from the cells in allotetraploids and diploids.This result showed that the sterility of triploid crucian carp might be related to the hormone which was not released from the GTH cells.In a word,the present study indicated that the differences in the structure of pituitary among different ploidy level fishes contributed to their difference in the growth rate and gonadal development. | LONG Yu LIU Shaojun HUANG Weiren ZHANG Jian SUN Yuandong ZHANG Chun CHEN Song LIU Jinghui LIU Yun | 2006 | Science China(Life Sciences)2006，49，5： | 13 |
| 5 | Land Surface Displacement Geohazards Monitoring Using Multi-temporal InSAR Techniques显示文摘China has been affected by some of the world’s most serious geological disasters and experiences high economic damage every year.Geohazards occur not only in remote areas but also in highly populated cities.In the framework of the Dragon-432365 Project,this paper presents the main results and the major conclusions derived from an extensive exploitation of Sentinel-1,ALOS-2(Advanced Land Observing Satellite 2),GF-3(Gao Fen Satellite 3),and latest launched SAR(Synthetic Aperture Radar),together with methods that allow the evaluation of their importance for various geohazards.Therefore,in the scope of this project,the great benefits of recent remote sensing data(wide spatial and temporal coverage)that allow a detailed reconstruction of past displacement events and to monitor currently occurring phenomena are exploited to study different areas and geohazards problems,including:surface deformation of mountain slopes;identification and monitoring of ground movements and subsidence;landslides;ground fissure;and building inclination studies.Suspicious movements detected in the different study areas were cross validated with different SAR sensors and truth data. | Guang LIU Perski ZBIGNIEW Salvi STEFANO Thiebes BENNI Lixin WU Jinghui FAN Shibiao BAI Lianhuan WEI Shiyong YAN Rui SONG Bignami CHRISTIAN Tolomei CRISTIANO Stefan SCHNEIDERBAUER Joao Sousa JOAQUIM 无 | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 13 |
| 6 | Cu Partitioning Behavior and Its Effect on Microstructure and Mechanical Properties of 0.12C-1.33Mn-0.55Cu Q&P Steel显示文摘Cu, as an austenitic stable element, is added to steel in order to suppress the adverse effects of high content of C and Mn on welding. Based on C partitioning, Cu and Mn partitioning can further improve the stability of retained austenite in the intercritical annealing process. A sample of low carbon steel containing Cu was treated by the intercritical annealing, then quenching process(I&Q). Subsequently, another sample was treated by the intercritical annealing, subsequent austenitizing, then quenching and partitioning process(I&Q&P). The effects of element partitioning behavior in intercritical region on the microstructure and mechanical properties of the steel were studied. The results showed that after the I&Q process ferrite and martensite could be obtained, with C, Cu and Mn enriched in the martensite. When intercritically heated at 800 ℃, Cu and Mn were partitioned from ferrite to austenite, which was enhanced gradually as the heating time was increased. This partitioning effect was the most obvious when the sample was heated at 800 ℃ for 40 min. At the early stage of α→γ transformation, the formation of γ was controlled by the partitioning of carbon, while at the later stage, it was mainly affected by the partitioning of Cu and Mn. After the I&Q&P process, the partitioning effect of Cu and Mn element could be retained. C was assembled in retained austenite during the quenching and partitioning process. The strength and elongation of I&Q&P steel was increased by 5 305 MPa% compared with that subjected to Q&P process. The volume fraction of retained autensite was increased from 8.5% to 11.2%. Hence, the content of retained austenite could be improved significantly by Mn and Cu partitioning, which increased the elongation of steel. | 陈连生 HU Baojia XU Jinghui 田亚强 ZHENG Xiaoping SONG Jinying XU Yong | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，5： | 6 |
| 7 | Efficient Location-Aware Data Placement for Data-Intensive Applications in Geo-distributed Scientific Data Centers显示文摘Recent developments in cloud computing and big data have spurred the emergence of data-intensive applications for which massive scientific datasets are stored in globally distributed scientific data centers that have a high frequency of data access by scientists worldwide. Multiple associated data items distributed in different scientific data centers may be requested for one data processing task, and data placement decisions must respect the storage capacity limits of the scientific data centers. Therefore, the optimization of data access cost in the placement of data items in globally distributed scientific data centers has become an increasingly important goal.Existing data placement approaches for geo-distributed data items are insufficient because they either cannot cope with the cost incurred by the associated data access, or they overlook storage capacity limitations, which are a very practical constraint of scientific data centers. In this paper, inspired by applications in the field of high energy physics, we propose an integer-programming-based data placement model that addresses the above challenges as a Non-deterministic Polynomial-time(NP)-hard problem. In addition we use a Lagrangian relaxation based heuristics algorithm to obtain ideal data placement solutions. Our simulation results demonstrate that our algorithm is effective and significantly reduces overall data access cost. | Jinghui Zhang Jian Chen Junzhou Luo Aibo Song | 2016 | Tsinghua Science and Technology2016，21，5： | 3 |
| 8 | Evidence for a Dirac nodal-line semimetal in SrAs_3显示文摘Dirac nodal-line semimetals with the linear bands crossing along a line or loop, represent a new topological state of matter. Here, by carrying out magnetotransport measurements and performing first-principle calculations, we demonstrate that such a state has been realized in high-quality single crystals of SrAs_3.We obtain the nontrivial ∏ Berry phase by analysing the Shubnikov-de Haas quantum oscillations. We also observe a robust negative longitudinal magnetoresistance induced by the chiral anomaly.Accompanying first-principles calculations identifies that a single hole pocket enclosing the loop nodes is responsible for these observations. | Shichao Li Zhaopeng Guo Dongzhi Fu Xing-Chen Pan Jinghui Wang Kejing Ran Song Bao Zhen Ma Zhengwei Cai Rui Wang Rui Yu Jian Sun Fengqi Song Jinsheng Wen | 2018 | Science Bulletin2018，63，9： | 2 |
| 9 | Genome-wide Mapping of Cellular Protein–RNA Interactions Enabled by Chemical Crosslinking显示文摘RNA–protein interactions influence many biological processes. Identifying the binding sites of RNA-binding proteins(RBPs) remains one of the most fundamental and important challenges to the studies of such interactions. Capturing RNA and RBPs via chemical crosslinking allows stringent purification procedures that significantly remove the non-specific RNA and protein interactions. Two major types of chemical crosslinking strategies have been developed to date, i.e., UV-enabled crosslinking and enzymatic mechanism-based covalent capture. In this review, we compare such strategies and their current applications, with an emphasis on the technologies themselves rather than the biology that has been revealed. We hope such methods could benefit broader audience and also urge for the development of new methods to study RNA RBP interactions. | Xiaoyu Li Jinghui Song Chengqi Yi | 2014 | Genomics, Proteomics & Bioinformatics2014，12，2： | 1 |
| 10 | FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction显示文摘Dear Editor,Myocardial infarction(MI)is the irreversible cardiomyocyte death resulting from prolonged oxygen deprivation due to obstructed blood supply(ischemia),leading to contractile dysfunction and cardiac remodeling.In recent decades,stem cell transplantation has been extensively investigated for the repair of injured heart in animal studies and clinical trials(Kanelidis et al.,2017;Gyongyosi et al.,2018). | Jinghui Lei Si Wang Wang Kang Qun Chu Zunpeng Liu Liang Sun Yun Ji Concepcion Rodriguez Esteban Yan Yao Juan Carlos Izpisua Belmonte Piu Chan Guang-Hui Liu Weiqi Zhang Moshi Song Jing Qu | 2021 | Protein & Cell2021，12，2： | 1 |
| 11 | Expression of multidrug resistance 1 gene and C3435T genetic polymorphism in peripheral blood of patients with intractable epilepsy显示文摘BACKGROUND:Increased expression of multidrug resistance 1 (MDR1) mRNA in peripheral blood of pa-tients with intractable epilepsy is not due to epilepsy drugs,but epilepsy behavior. Monitoring MDR1 ex-pression in peripheral blood is a target for MDR1 gene evaluation. OBJECTIVE: To investigate the influence of antiepileptic drugs and seizures on MDR expression in intrac-table epilepsy,and to analyze the genetic polymorphisms of C3435T in the MDR1 gene. DESIGN,TIME AND SETTING: Factorial designs and comparative observations at the experimental cen-ter of the Affiliated Hospital of Qingdao Medical College,Qingdao University between October 2003 and October 2004. PARTICIPANTS: A total of 120 subjects were recruited from the epilepsy clinical department of the Affili-ated Hospital of Qingdao Medical College. Four groups (n=30) were classified according to statistical fac-torial design: intractable epilepsy,treatment response,no treatment,and normal control groups. METHODS: One-step semi-quantitative reverse-transcription polymerase chain reaction technology was used to test expressions of the MDR1 gene in 120 subjects. C3435T polymorphisms in intractable epilepsy group and normal control groups were analyzed by polymerase chain reaction-restriction fragment length polymorphism. MAIN OUTCOME MEASURES: Expression of MDR1 mRNA in the four groups,and C3435T genetic polymorphisms in intractable epilepsy and normal control groups. RESULTS: MDR1 gene expression was increased in the intractable epilepsy group,due to the factor sei-zures,but not the antiepileptic drugs. However,the interaction between the two factors was not statistically significant. Of the 30 subjects in the intractable epilepsy group,the following genotypes were exhibited: 3 (10%) C/C genotype,9 (30%) C/T genotype,and 18 (60%) T/T genotype at the site of C3435T,while 4 (13%),10 (33%),and 16 (53%) subjects were determined to express these genotypes in the normal control group,respectively. C and T allele frequency were 25% and 75% in the intractable epilepsy group,and 30% and 70% in the normal control group,respectively. However,there was no statistical difference between the groups. CONCLUSION: Results demonstrated that seizures,not antiepileptic drugs,induced MDR1 gene expres-sion in intractable epilepsy. Genetic polymorphisms of C3435T in the MDR1 gene did not contribute to the development of multidrug resistance in patients with intractable epilepsy. | Xueping Zheng Lan Tan Jinghui Song Yan Wang Yanping Sun | 2008 | Neural Regeneration Research2008，3，11： | 1 |
| 12 | Preparation of Er-doped YF3nanomaterials by microemulsion显示文摘 | Yan Jinghui Song Lihong Li Zhongtian | 2007 | Chin J InorgChem2007，8，： | 1 |
| 13 | Turning ZrTe_5 into a semiconductor through atom intercalation显示文摘In this study we successfully intercalated potassium(K) atoms into single ZrTe_5 crystals by liquid ammonia method, and found a semimetal-to-semiconductor transition at low temperatures in K-intercalated ZrTe_5. As the K concentration increased, the resistance anomalous peak was gradually suppressed until finally disappearing. Whilst, the corresponding Hall resistance measurements consistently showed a sign reversal. The semimetal-to-semiconductor transition can be attributed to a lattice expansion induced by atom intercalation, leading to a larger energy band gap. | QiYuan Li YangYang Lv JingHui Wang Song Bao Wei Shi Li Zhu WeiMin Zhao ChengLong Xue ZhenYu Jia LiBo Gao YanBin Chen JinSheng Wen YanFeng Chen ShaoChun Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，6： | 1 |
| 14 | Fault Analysis and Innovation in Slag Discharge System of 440-t/h CFB Boiler显示文摘CFB boilers have been widely used in China in recent years with their perfect performances in coal adaptability, load variation capability and lower pollutant emission. The No.3 135-MW CFB unit in Lianzhou Power Plant is the f irst 440-t/h series CFB unit in Guangdong Province. It f inished 72-hour trial operation in Feb. 2004 and was transferred to trial operation. During the trial operation and the next commercial operation, there were some problems happened in the boiler slag discharging system, seriously affecting the safe and reliable operation and the loading capability. After innovation, these problems have been completely solved. Hopefully the solutions may be used for reference to the units with similar problems. | Xu Qisheng and Song Jinghui Guangdong Electric Power Test and Research Institute Wang Ningling | 2009 | Electricity2009，20，1： | 0 |
| 15 | Electrosynthesis of ^(15)N-labeled amino acids from ^(15)N-nitrite and ketonic acids显示文摘^(15)N isotope-labeled amino acids(^(15)N-amino acids)are crucial in the fields of biology,medicine,and chemistry.^(15)N-amino acids are conventionally synthesized through microbial fermentation and chemical reductive amination of ketonic acids methodologies,which usually require complicated procedures,high temperatures,or toxic cyanide usage,causing energy and environmental concerns.Here,we report a sustainable pathway to synthesize ^(15)N-amino acids from readily available ^(15)N-nitrite(^(15)NO_(2)-)and biomass-derived ketonic acids under ambient conditions driven by renewable electricity.A mechanistic study demonstrates a ^(15)N-nitrite→^(15)NH_(2)OH→^(15)N-pyruvate oxime→^(15)N-alanine reaction pathway for ^(15)N-alanine synthesis.Moreover,this electrochemical strategy can synthesize six ^(15)N-amino acids with 68%–95%yields.Furthermore,a ^(15)N-labeled drug of ^(15)N-tiopronin,the most commonly used hepatitis treatment drug,is fabricated using ^(15)N-glycine as the building block.Impressively,^(15)N sources can be recycled by the electrooxidation of ^(15)NH4^(+) to ^(15)NO_(2)-with a method economy.This work opens an avenue for the green synthesis of ^(15)N-labeled compounds or drugs. | Yongmeng Wu Mengyang Li Tieliang Li Jinghui Zhao Ziyang Song Bin Zhang | 2023 | Science China Chemistry2023，66，6： | 0 |
| 16 | Comparison of Soil Nutritional Status between Different Muscat Hamburg Vineyards in Coastal Areas of Tianjin显示文摘To study the effects of different soil conditions on winter nutrient storage of Muscat Hamburg branches,this study compared the soil texture,bulk density,total salt content and soil K,Ca,Na,Mg and total Fe contents of Muscat Hamburg vineyards in Ninghe District and Hangu District,Binhai New Area of Tianjin and analyzed the soluble sugar and soluble protein contents in one-year-old vine branches. The results showed that the soil p H was lower,and the soil K,Ca and total salt( 0. 445%) contents were higher in the vineyard of Ninghe District than those in the vineyard of Hangu District. There were no significant differences in the soil Mg,Fe and Na contents between the vineyards in the two regions. The soil of the vineyard in Ninghe District is medium loam,and that in Hangu District is heavy loam. In short,all the soil indicators of the vineyard in Ninghe District were better than those in Hangu District except the indicator of soil salt content. The soluble sugar and soluble protein contents of one-year-old vine branches differed significantly between the two regions. | Xin HE Jinghui YANG Xin JIANG Ke SONG Bochao QIAO Bing LI | 2019 | Asian Agricultural Research2019，11，6： | 0 |
| 17 | Social-epigeneticmediators for racial disparities in pulmonary impairment among childhood cancer survivors显示文摘Dear Editor Previous research found that childhood cancer survivors of African ancestry have significantly higher morbidity and mortality than those of European ancestry[1].However,after adjusting for socio-economic factors,the magnitudes of racial health disparities are either substantially decreased or become statistically non-significant[1],suggesting that social and economic determinants may contribute to racial health disparities.Recently,we conducted epigenome-wide association studies(EWAS)for three key social determinants of health(SDOHs),namely,personal educational attainment,personal income,and neighborhood deprivation among survivors of childhood cancer,where 130 epigenome-wide significant SDOH-CpG associationswere identified among European ancestry survivors,and 25 of which were also validated in African ancestry survivors[2].Notably,many SDOH-associated CpG sites are also associated with tobacco use. | Nan Song Qian Dong Cheng Chen Qian Li Heather Mulder Emily Plyler John Easton Emily Walker Scott Olson Geoffrey Neale Kevin RKrull Deo Kumar Srivastava Kirsten K.Ness Jinghui Zhang Melissa M.Hudson Leslie L.Robison I-Chan Huang Zhaoming Wang | 2023 | Cancer Communications2023，43，2： | 0 |
| 18 | 通过靶向编辑长寿基因FOXO3产生优质的人类血管细胞移植物显示文摘文章简介FOXO3是一个在进化上高度保守的长寿基因。研究人员利用基因编辑技术成功置换了FOXO3基因上的两个AKT磷酸化位点,使FOXO3处于活性增强状态。此外,研究人员利用胚胎干细胞定向分化技术产生了FOXO3遗传激活的三种血管细胞,这三种血管细胞均表现出比野生型细胞更强的自我更新、抵抗氧化应激及延缓细胞衰老的能力。 | 颜鹏泽 李晴晴 Lixia Wang Ping Lu Keiichiro Suzuki Zunpeng Liu Jinghui Lei Wei Li Xiaojuan He Si Wang Jianjian Ding Piu Chan Weiqi Zhang Moshi Song Juan Carlos Izpisua Belmonte 曲静 汤富酬 刘光慧 | 2020 | 科学新闻2020，，2： | 0 |
| 19 | Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning显示文摘The alum-borneol nanoemulsion(ABN),which combines the mineral medicine alum and the botanical medicine borneol,has been applied for approximately 40 years in the clinical treatment of burns,scalds,radiation dermatitis and shingles,and has a good curative effect.However,the current formula and dosage form of ABN pose problems of low borneol content and ease of precipitation,which greatly affects the efficacy of the drug.In this study,polyvinylpyrrolidone(PVP)was selected as a carrier mixed with different proportions of alum and borneol to produce alum-borneol-PVP fibers(ABPF)by electrospinning.The results showed that the stable system with good drug dispersion was 2:3(alum:borneol).The dissolution content of borneol from the ABPF was about 80%in 4 h,which was much higher than that of the alum-borneol liquid(ABL)and ABN.The ABPF membrane showed a more significant inhibitory effect on Staphylococcus aureus than the ABL and ABN.The composite fiber markedly increased the drug content of borneol,which was 800 times of that in ABN.The fiber had a higher solubility than the nanoemulsion in vitro,which is of great importance for the development of new forms for the clinical application of alum and borneol. | HUANG Libing LIU Yueqi SANG Xinyu SONG Jinghui HU Ping LIU Yong | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 20 | Hardware-in the-loop Simulator for ABS based on MATLAB/Simulink显示文摘A method for building a Hardware-in the-loop Simulator of ABS base on MATLAB/Simulink is presented in this paper. In this method, the vehicle transmission model, the AT model and ABS algorithm is built in Simulink. This system can simulate a vehicle system in the Simulink environment. Further more, the Hardware-in the-loop Simulator system can be connected with the real ABS by I/O boards to observe the algorithm is reasonable or not. At the same time, user can simulate some different conditions by changing the parameter. The system help the user heightening the efficiency when developing the electronic device. Also, the system can be used as teaching demo software. | Pan,Wei Gao,Jinghui Zhou,Yafu Song,Zhenhuan | 2003 | 微计算机信息2003，19，12： | 0 |
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