|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 2 | The levels, sources and reactivity of volatile organic compounds in a typical urban area of Northeast China显示文摘Air concentrations of volatile organic compounds(VOCs) were continually measured at a monitoring site in Shenyang from 20 August to 16 September 2017. The average concentrations of alkanes, alkenes, aromatics and carbonyls were 28.54, 6.30, 5.59 and9.78 ppbv, respectively. Seven sources were identified by the Positive Matrix Factorization model based on the measurement data of VOCs and CO. Vehicle exhaust contributed the most(36.15%) to the total propene-equivalent concentration of the measured VOCs,followed by combustion emission(16.92%), vegetation emission and secondary formation(14.33%), solvent usage(10.59%), petrochemical industry emission(9.89%), petrol evaporation(6.28%), and liquefied petroleum gas(LPG) usage(5.84%). Vehicle exhaust, solvent usage and combustion emission were found to be the top three VOC sources for O_3 formation potential, accounting for 34.52%, 16.55% and 11.94%, respectively. The diurnal variation of the total VOCs from each source could be well explained by their emission characteristics,e.g., the two peaks of VOC concentrations from LPG usage were in line with the cooking times for breakfast and lunch. Wind rose plots of the VOCs from each source could reveal the possible distribution of the sources around the monitoring site. The O_3 pollution episodes during the measurement period were found to be coincident with the elevation of VOCs, which was mainly due to the air parcel from the southeast direction where petrochemical industry emission was found to be dominant, suggesting that the petrochemical industry emission from the southeast was probably a significant cause of O_3 pollution in Shenyang. | Zhuobiao Ma Chengtang Liu Chenglong Zhang Pengfei Liu Can Ye Chaoyang Xue Di Zhao Jichen Sun Yiming Du Fahe Chai Yujing Mu | 2019 | Journal of Environmental Sciences2019，31，5： | 12 |
| 3 | Development of a polycaprolactone/poly(p-dioxanone)bioresorbable stent with mechanically self-reinforced structure for congenital heart disease treatment显示文摘Recent progress in bioresorbable stents(BRSs)has provided a promising alternative for treating coronary artery disease.However,there is still lack of BRSs with satisfied compression and degradation performance for pediatric patients with congenital heart disease,leading to suboptimal therapy effects.Here,we developed a mechanically self-reinforced composite bioresorbable stent(cBRS)for congenital heart disease application.The cBRS consisted of poly(p-dioxanone)monofilaments and polycaprolactone/poly(p-dioxanone)core-shell composite yarns.Interlacing points in cBRS structure were partially bonded,offering the cBRS with significantly higher compression force compared to typical braids and remained good compliance.The suitable degradation profile of the cBRS can possibly preserve vascular remodeling and healing process.In addition,the controllable structural organization provides a method to customize the performance of the cBRS by altering the proportion of different components in the braids.The in vivo results suggested the cBRS supported the vessel wall similar to that of metallic stent.In both abdominal aorta and iliac artery of porcine,cBRS was entirely endothelialized within 1 month and maintained target vessels with good patency in the 12-month follow-up.The in vivo degradation profile of the cBRS is consistent with static degradation results in vitro.It is also demonstrated that there is minimal impact of pulsatile pressure of blood flow and variation of radial force on the degradation rate of the cBRS.Moreover,the lumen of cBRS implanted vessels were enlarged after 6 months,and significantly larger than the vessels implanted with metallic stent in 12 months. | Fan Zhao Jing Sun Wen Xue Fujun Wang Martin W.King Chenglong Yu Yongjie Jiao Kun Sun Lu Wang | 2021 | Bioactive Materials2021，6，9： | 3 |
| 4 | An unexpected large continental source of reactive bromine and chlorine with significant impact on wintertime air quality显示文摘Halogen atoms affect the budget of ozone and the fate of pollutants such as hydrocarbons and mercury.Yet their sources and significances in polluted continental regions are poorly understood.Here we report the observation of unprecedented levels(averaging at 60 parts per trillion)of bromine chloride(BrCl)at a mid-latitude site in North China during winter.Widespread coal burning in rural households and a photo-assisted process were the primary source of BrCl and other bromine gases.BrCl contributed about 55%of both bromine and chlorine atoms.The halogen atoms increased the abundance of'conventional'tropospheric oxidants(OH,HO_(2) and RO_(2))by 26%-73%,and enhanced oxidation of hydrocarbon by nearly a factor of two and the net ozone production by 55%.Our study reveals the significant role of reactive halogen in winter atmospheric chemistry and the deterioration of air quality in continental regions where uncontrolled coal combustion is prevalent. | Xiang Peng Weihao Wang Men Xia Hui Chen A.R.Ravishankara Qinyi Li Alfonso Saiz-Lopez Pengfei Liu Fei Zhang Chenglong Zhang Likun Xue Xinfeng Wang Christian George Jinhe Wang Yujing Mu Jianmin Chen Tao Wang | 2021 | National Science Review2021，8，7： | 2 |
| 5 | The role of gut microbiota and its metabolites short-chain fatty acids in food allergy显示文摘Emerging evidence indicated that the increase in food allergy(FA)over the past few decades was associated with the abnormal compositional and metabolic changes of gut microbiota.Gut microbiota played a vital role in maintaining the homeostasis of the immune system and the dysbiosis of gut microbiota promoted the occurrence of FA.Recent research suggested that short-chain fatty acids(SCFAs),the main metabolites derived from gut microbiota,contributed to FA protection.Herein,we provided a comprehensive review on the relationship between gut microbiota and FA.The multifaceted mechanisms underlymg beneficial effects of gut microbiota composition/metabolites on the regulation of diverse cellular pathways in intestinal epithelial cells,dendritic cells,innate lymphoid cells,T cells,B cells and mast cells in the immune system were discussed systematically.These findings emphasized the positive function of gut microbiota in FA and provided novel ideas for the treatment or prevention of FA in the future. | Chen Chen Chenglong Liu Ke Zhang Wentong Xue | 2023 | Food Science and Human Wellness2023，12，3： | 2 |
| 6 | Experimental and modeling study of the auto-ignition of n -heptane/ n -butanol mixtures显示文摘 | Jiaxiang Zhang Shaodong Niu Yingjia Zhang Chenglong Tang Xue Jiang Erjiang Hu Zuohua Huang | 2013 | Combustion and Flame2013，，1： | 1 |
| 7 | Activity maintenance of the excised branches and a case study of NO_2 exchange between the atmosphere and P.nigra branches显示文摘The efficient maintenance of the activity of excised branches is the powerful guarantee to accurately determine gas exchange flux between the detached branches of tall trees and the atmosphere. In this study, the net photosynthetic rate(NPR) of the excised branches and branches in situ were measured simultaneously by using two photosynthetic instruments to characterize the activity of the excised branches of Phyllostachys nigra. The ratio of normalized NPR of excised branches to NPR in situ was used to assess the photosynthetic activity of detached branches. Based on photosynthetic activity, an optimal hydroponics protocol for maintaining activity of excised P. nigra branches was presented:1/8 times the concentration of Gamborg B5 vitamin mixture with p H = 6. Under the best cultivation protocol, photosynthetic activity of excised P. nigra branches could be maintained more than 90% within 6 hr in the light intensity range of 200–2000 μmol/(m2·sec) and temperature range of 13.4–28.7°C. The nitrogen dioxide(NO2) flux differences between in situ and in vitro branches and the atmosphere were compared using double dynamic chambers.Based on the maintenance method of excised branches, the NO2 exchange flux between the excised P. nigra branches and the atmosphere(from-1.01 to-2.72 nmol/(m2·sec) was basically consistent with between the branches in situ and the atmosphere(from-1.12 to-3.16 nmol/(m2 sec)) within 6 hr. Therefore, this study provided a feasible protocol for in vitro measurement of gas exchange between tall trees and the atmosphere for a period of time. | Chun Chen Yuzheng Wang Yuanyuan Zhang Xiaoxiu Lun Chengtang Liu Yujing Mu Chenglong Zhang Pengfei Liu Chaoyang Xue Min Song Can Ye Junfeng Liu | 2019 | Journal of Environmental Sciences2019，31，6： | 1 |
| 8 | Turning ZrTe_5 into a semiconductor through atom intercalation显示文摘In this study we successfully intercalated potassium(K) atoms into single ZrTe_5 crystals by liquid ammonia method, and found a semimetal-to-semiconductor transition at low temperatures in K-intercalated ZrTe_5. As the K concentration increased, the resistance anomalous peak was gradually suppressed until finally disappearing. Whilst, the corresponding Hall resistance measurements consistently showed a sign reversal. The semimetal-to-semiconductor transition can be attributed to a lattice expansion induced by atom intercalation, leading to a larger energy band gap. | QiYuan Li YangYang Lv JingHui Wang Song Bao Wei Shi Li Zhu WeiMin Zhao ChengLong Xue ZhenYu Jia LiBo Gao YanBin Chen JinSheng Wen YanFeng Chen ShaoChun Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，6： | 1 |
| 9 | The role of probiotics in prevention and treatment of food allergy显示文摘With the prevalence of food allergy increasing every year,food allergy has become a common public health problem.More and more studies have shown that probiotics can intervene in food allergy based on the intestinal mucosal immune system.Probiotics and their metabolites can interact with immune cells and gut microbiota to alleviate food allergy.This review outlines the relationship between the intestinal mucosal immune system and food allergy.This review also presents the clinical application and potential immunomodulation mechanisms of probiotics on food allergy.We aim at providing a reference for further studies to explore the key active substances and immunomodulation mechanisms of anti-allergic probiotics. | Shimin Gu Dong Yang Chenglong Liu Wentong Xue | 2023 | Food Science and Human Wellness2023，12，3： | 1 |
| 10 | Changes in wheat protein digestibility and allergenicity: role of Pediococcus acidilactici XZ31 and yeast during dough fermentation显示文摘Wheat flour,as the most important source of food globally,is one of the most common causative agents of food allergy.This study aimed to investigate the effects of fermentation on wheat protein digestibility and allergenicity.Protein digestibility were evaluated using the sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis and enzyme-linked immunosorbent assay.The effect of protein on intestinal permeability was investigated by Caco-2 cell monolayers.Co-culture fermentation with Pediococcus acidilactici XZ31 and yeast leads to improvement in digestibility of wheat protein compared to single strain fermentation.Fermentation leads to a decrease in albumin/globulin antigenicity and an increase in gluten R5 reactivity,with the most significant changes in the co-culture group.Digestion strengthen the decrease of protein antigenicity and counteracts the difference in antigenicity induced by fermentation between groups.However,pretreatment with P.acidilactici XZ31 reduces the amount of allergens across Caco-2 monolayer and attenuates the gluten-induced increase in permeability of Caco-2 cell monolayer by reducing actin polymerization and villous atrophy.Co-culture fermentation reduces gluten-induced cell monolayer damage to a greater extent than P.acidilactici XZ31 monoculture.These results gives valuable insight into the effects of P.acidilactici XZ31 fermentation on the allergenicity and toxicity of wheat proteins,which contribute to promoting the application of multi-strain leavening agent in hypoallergenic and gluten-free wheat products. | Wenhui Fu Chen Chen Chenglong Liu Sha Tao Wentong Xue | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
| 11 | MCC: A Message and Command Correlation Method for Identifying New Interactive Protocols via Session Analyses显示文摘Traffic classification is critical to effective network management. However, more and more proprietary, encrypted, and dynamic protocols make traditional traffic classification methods less effective. A Message and Command Correlation (MCC) method was developed to identify interactive protocols (such as P2P file sharing protocols and Instant Messaging (IM) protocols) by session analyses. Unlike traditional packet-based classification approaches, this method exploits application session information by clustering packets into application messages which are used for further classification. The efficacy and accuracy of the MCC method was evaluated with real world traffic,including P2P file sharing protocols Thunder and BitTorrent, and IM protocols QQ and GTalk. The tests show that the false positive rate is less than 3% and the false negative rate is below 8%, and that MCC only needs to check 8.7% of the packets or 0.9% of the traffic. Therefore, this approach has great potential for accurately and quickly discovering new types of interactive application protocols. | Chenglong Li Yibo Xue Yingfei Dong Dongsheng Wang | 2012 | Tsinghua Science and Technology2012，17，3： | 0 |
| 12 | Assessment of immune responses and intestinal flora in BALB/c mice model of wheat food allergy via different sensitization methods显示文摘Increasing incidences showed that food allergies have attracted more and more attention from researchers.BALB/c mice were sensitized with wheat gluten combined with aluminum hydroxide adjuvant via intraperitoneal injection,transdermal sensitization,and oral gavage sensitization route.Results showed that all the three sensitization methods could induce allergic symptoms;increase the serum antibody(total immunoglobulin E(IgE),specific IgE,IgG,IgA)and histamine content;promote the secretion of Th2 cytokines(interleukin(IL)-4,IL-5,IL-13)and inflammatory factors(IL-6,IL-17 A,IL-10);and inhibit the production of Th1 cytokines(IFN-γ,IL-2).However,the allergic symptoms of mice sensitized by intraperitoneal injection were the most obvious among the three models.The level of serum antibodies in intraperitoneal injection group was significantly higher than control.Subsequently,16 S rRNA sequencing technology was used to analyze the intestinal flora of mice.The results showed that the abundance of Firmicutes in the wheat protein sensitized group was lower than that in the normal group,while the abundance of Bacteroidetes was higher,and Lactobacillus was the difference marker in normal group.Bacterial species diversity analysis showed that the species richness and diversity of intestinal flora in mice were decreased,the difference between mice induced by intraperitoneal injection and normal control group mice was the most significant.Taken together,these results show that among three sensitization methods used to build a mouse model with aluminum hydroxide as adjuvant,intraperitoneal injection is the comparably best way to build a mouse sensitization mode. | Chenglong Liu Chen Chen Xingyu Yan Shimin Gu Xin Jia Wenhui Fu Xiao Meng Wentong Xue | 2023 | Food Science and Human Wellness2023，12，3： | 0 |
| 13 | Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts显示文摘Although most fishes are ectothermic,some,including tuna and billfish,achieve endothermy through specialized heat producing tissues that are modified muscles.How these heat producing tissues evolved,and whether they share convergent molecular mechanisms,remain unresolved.Here,we generated a high-quality genome from the mackerel tuna(Euthynnus affinis)and investigated the heat producing tissues of this fish by single-nucleus and bulk RNA sequencing.Compared with other teleosts,tuna-specific genetic variation is strongly associated with muscle differentiation.Single-nucleus RNA-seq revealed a high proportion of specific slow skeletal muscle cell subtypes in the heat producing tissues of tuna.Marker genes of this cell subtype are associated with the relative sliding of actin and myosin,suggesting that tuna endothermy is mainly based on shivering thermogenesis.In contrast,cross-species transcriptome analysis indicated that endothermy in billfish relies mainly on nonshivering thermogenesis.Nevertheless,the heat producing tissues of the different species do share some tissue-specific genes,including vascular-related and mitochondrial genes.Overall,although tunas and billfishes differ in their thermogenic strategies,they share similar expression patterns in some respects,highlighting the complexity of convergent evolution. | Baosheng Wu Xueli Gao Mingling Hu Jing Hu Tianming Lan Tingfeng Xue Wenjie Xu Chenglong Zhu Yuan Yuan Jiangmin Zheng Tao Qin Peidong Xin Ye Li Li Gong Chenguang Feng Shunping He Huan Liu Haimeng Li Qing Wang Zhenhua Ma Qiang Qiu Kun Wang | 2023 | Science China(Life Sciences)2023，66，11： | 0 |
| 14 | Highly Efficient Electroluminescent Materials with High Color Purity Based on Strong Acceptor Attachment onto B-N-Containing Multiple Resonance Frameworks显示文摘The development and enrichment of organic materials with narrowband emission in longer wavelength regions beyond 515 nm still remains a great challenge.Herein,a synthetic methodology for narrowband emission materials has been proposed to functionalize multiple resonance(MR)skeletons and generate a universal building block,namely,the key intermediate DtCzB-Bpin,which can be utilized to construct multifarious thermally activated delayed fluorescence(TADF)materials with high color purity through a simple one-step Suzuki coupling reaction.Based on this unique synthetic strategy,a series of efficient narrowband green TADF emitters has been constructed by localized attachment of 1,3,5-triazine and pyrimidine derivatives-based acceptors onto B–N-containing MR frameworks with 1,3-bis(3,6-di-tertbutylcarbazol-9-yl)benzene(DtCz)as the ligand.The precise modulation of the acceptor is an intelligent approach to achieve bathochromic shift and narrowband emission simultaneously.The DtCzB-TPTRZbased organic light-emitting diode(OLED)exhibits pure green emission with Commission Internationale de L’Eclairage(CIE)coordinates of(0.23,0.68),a maximum external quantum efficiency(EQE)of 30.6%,and relatively low efficiency roll-off. | Yincai Xu Chenglong Li Zhiqiang Li Jiaxuan Wang Jianan Xue Qingyang Wang Xinliang Cai Yue Wang | 2022 | CCS Chemistry2022，4，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员