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| 1 | The C_2H_2 -type Zinc Finger Protein ZFP182 is Involved in Abscisic Acid-Induced Antioxidant Defense in Rice显示文摘C2H2 -type zinc finger proteins (ZFPs) are thought to play important roles in modulating the responses of plants to drought, salinity and oxidative stress. However, direct evidence is lacking for the involvement of these ZFPs in abscisic acid (ABA)-induced antioxidant defense in plants. In this study, the role of the rice (Oryza sativa L. sub. japonica cv. Nipponbare) C 2 H 2 -type ZFP ZFP182 in ABA-induced antioxidant defense and the relationship between ZFP182 and two rice MAPKs, OsMPK1 and OsMPK5 in ABA signaling were investigated. ABA treatment induced the increases in the expression of ZFP182, OsMPK1 and OsMPK5, and the activities of superoxide dismutase (SOD) and ascorbate peroxidase (APX) in rice leaves. The transient gene expression analysis and the transient RNA interference (RNAi) analysis in protoplasts showed that ZFP182, OsMPK1 and OsMPK5 are involved in ABA-induced up-regulation in the activities of SOD and APX. Besides, OsMPK1 and OsMPK5 were shown to be required for the up-regulation in the expression of ZFP182 in ABA signaling, but ZFP182 did not mediate the ABA-induced up-regulation in the expression of OsMPK1 and OsMPK5. These results indicate that ZFP182 is required for ABA-induced antioxidant defense and the expression of ZFP182 is regulated by rice MAPKs in ABA signaling. | Hong Zhang Lan Ni Yanpei Liu Yunfei Wang Aying Zhang Mingpu Tan Mingyi Jiang | 2012 | Journal of Integrative Plant Biology2012，54，7： | 23 |
| 2 | An exact solution of unsteady Couette flow of generalized second grade fluid显示文摘The fractional calculus approach is introduced into the rheological constitutive model of a generalized second grade fluid. A constitutive model with fractional derivative is developed for the generalized second grade fluid. Unsteady Couette flow of the generalized second grade fluid is studied by using the method of the discrete inverse Laplace transform and generalized Mittag-Leffler function. And then an exact solution is obtained for this problem with arbitrary fractional derivative. This provides a new analytical tool for the study of viscoelastic fluid mechanics. | TAN Wenchang XIAN Feng WEI Lan | 2002 | Chinese Science Bulletin2002，47，21： | 17 |
| 3 | Intra-herb pharmacokinetics interaction between quercetin and isorhamentin显示文摘瞄准:橡黄素和 isorhamnetin 是一些植物摘录的普通成分,例如银杏叶子的摘录和 Hippophae rhamnoides L 的全部的黄酮。在 isorhamnetin 和橡黄素之间的 intra 植物 pharmacokinetics 相互作用在现在的学习被调查。方法:人的 MDR1 cDNA transfected MDCKII 房间被用来验证 isorhamnein 是否与 P-gp 交往了。Caco-2 运输试金并且一使随机化,在老鼠的 3 方法转线路 pharmacokinetics 学习被用来调查 pharmacokinetics 相互作用。HPLC 被用来决定房间运输样品。橡黄素和 isorhamnetin 的全部的血浆集中被处理被液体层析双人脚踏车团 spectrometry (LC-MS/MS ) 与 β-glucuronidase 和 sulfatase 决定。结果:越过人的 MDR1 cDNA transfected MDCKII 房间, Caco-2 房间和野类型的 MDCKII 房间的 isorhamnetin 的渗透比率(吸收性的 permeability/secretive 渗透) 分别地是 0.25 ± 0 .02, 0.74 ± 0 .05,和 1.41 ± 0 .06。这结果在 isorhamnetin 的房间流出证明了 P-gp 的角色。当越过 Caco-2 房间单层与对方一起共同搬运时, isorhamnetin 和橡黄素的渗透比率到 4.3 和 2.2 次增加了。在到老鼠的与对方一起的 coadministration 以后, C 72 h , 和 isorhamnetin 和橡黄素的 AUC 0 ∞
显著地与单个管理相比增加了的最大 , AUC 0。结论:上述结果证明了 intra 植物是在橡黄素和 isorhamentin 之间的 pharmacokinetics 相互作用。而另外的药流出抽, P-gp 可能起一个重要作用,例如多药抵抗伙伴蛋白质 2 并且乳癌抵抗蛋白质,可能被包含。除药植物相互作用以外,因此, intra 植物相互作用可能与草药底的疗法的宽使用被带进看法。 | Ke LAN Jian-lin HE Yang TIAN Fei TAN Xue-hua JIANG Ling WANG Li-ming YE | 2008 | Acta Pharmacologica Sinica2008，29，11： | 16 |
| 4 | Modelling operation parameters of UAV on spray effects at different growth stages of corns显示文摘Currently,unmanned aerial vehicles(UAVs)were widely applied to spray for pest and disease control.However,spray effect can be further improved by setting operation parameters more reasonably and scientifically.Therefore,this study attempts to derive the relationship between operation parameters and spray effect.Different growth stages were distinguished by various corn heights.A six-rotor UAV was operated at different heights and velocities to test pesticides spray effects for corns at different growth stages.Different plant canopy coverage rate and penetrating coefficients were obtained,according to which,the effects on droplet deposition rate caused by different UAVs’operation parameters were analyzed.Droplet penetrating coefficients were applied as indexes to evaluate and select UAVs operation parameters for corns at different growth stages respectively.Mathematical models of droplet penetrating coefficients with UAVs operation parameters were established for corns at all growth stages.The determination coefficients(R2)of all models were greater than 0.90 and average relative errors were within 20%,which asserted high forecasting accuracy of droplet penetrating rate.With the help of the models,parameters like operating height away from the bottom of corns and UAVs velocities were further analyzed,which guided the optimization of parameter settings and selection of spray methods for corns at different growth stages. | Zheng Yongjun Yang Shenghui Zhao Chunjiang Chen Liping Yubin Lan Tan Yu | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 13 |
| 5 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 6 | Selection of oocytes for in vitro maturation by brilliant cresyl blue staining: a study using the mouse model显示文摘选择是最可能的发展的卵母细胞是关键的为在 vitrofertilization 并且动物克隆。染色的灿烂的 cresyl 蓝色(BCB ) 在大型家畜被用于卵母细胞选举,但是它的更宽的用途需要推进评估。我们再划分进染色的那些(BCB+) 和那些的老鼠卵母细胞未沾污(BCB-) 根据他们的 ooplasm BCBcoloration。染色质配置,积云房间 apoptosis,细胞质的成熟和发展胜任在 BCB+ 和 BCB- 卵母细胞之间被比较。BCB+ 卵母细胞的胜任上的卵母细胞直径,性成熟和 gonadotropin 刺激的效果也被分析。在thelarge尺寸和中等尺寸的组,BCB+卵母细胞更大并且显示出更多的包围 nucleoli ( SN )染色质配置和早闭锁的更高的频率,并且他们也获得了更好细胞质的成熟(象细胞内部的 GSH 水平和 mitochondrialdistribution 的模式坚定)并且在试管内成熟( IVM )以后的更高发展的潜力比BCB卵母细胞。当没与 PMSG 告知时,成年老鼠比 prepubertal 老鼠与更高的胜任生产了更多的 BCB+ 卵母细胞。PMSG priming 增加了比例和 BCB+oocytes 的发展力量。在大尺寸的组的 BCB+ 卵母细胞在 medium-sizegroup 比他们的对应物显示出更多的 SN 染色质配置,更好细胞质的成熟和更高发展的潜力。染色的 BCB 能为卵母细胞选择被用作一个有效方法,这被结束,但是 BCB+ 卵母细胞的胜任可以与卵母细胞直径,动物性成熟和 gonadotropin 刺激变化。总起来说,这里描述的标准的系列将更好允许在为更好的开发选择卵母细胞的选择。 | Yan-Guang Wu Yong Liu Ping Zhou Guo-Cheng Lan Dong Han De-Qiang Miao Jing-He Tan | 2007 | Cell Research2007，17，8： | 11 |
| 7 | Executive Function Training for Children with Attention Deficit Hyperactivity Disorder显示文摘 | Lan Shuai David Daley Yu-Feng Wang Jin-Song Zhang Yan-Ting Kong Xin Tan Ning Ji | 2017 | Chinese Medical Journal2017，，5： | 10 |
| 8 | OsDMI3 Is a Novel Component of Abscisic Acid Signaling in the Induction of Antioxidant Defense in Leaves of Rice显示文摘Ca2+ 和 calmodulin (凸轮) 被看了抗氧化剂防卫到在 abscisic 酸(骆驼毛的织物) 的一个重要角色导致了的玩。然而, Ca2+/CaM-dependent 蛋白质 kinase (CCaMK ) 是否涉及这个过程,是未知的。在现在的学习,米饭 CCaMK 的角色, OsDMI3,在导致骆驼毛的织物的抗氧化剂,防卫在米饭(Oryza sativa ) 的叶子被调查植物。有骆驼毛的织物, H2O2,和聚乙烯乙二醇(木钉) 的处理导致了 OsDMI3 和 OsDMI3 的活动的表示,并且 H2O2 在水应力下面为表示和 OsDMI3 的活动的导致骆驼毛的织物的增加被要求。Subcellular 本地化分析证明 OsDMI3 位于原子核,细胞质,和血浆膜。在米饭原物和在米饭原物的 OsDMI3 的 silencing 显示出的 RNA 干扰(RNAi ) 的 OsDMI3 的短暂表示的分析那 OsDMI3 为表示和 superoxide dismutase (草皮) 和过氧化氢酶(猫) 的活动的导致骆驼毛的织物的增加被要求。进一步,氧化损坏由木钉的更高的集中导致了, H2O2 在 OsDMI3 的异种被加重。而且,在原物和 OsDMI3 的异种的 OsDMI3 的 RNAi silencing 的分析证明 H2O2 累积的高水平要求在骆驼毛的织物发信号的 OsDMI3 激活,而是起始的 H2O2 生产导致了由骆驼毛的织物不依赖于在米饭植物的叶子的 OsDMI3 的激活。我们的数据表明 OsDMI3 是在在米饭的导致骆驼毛的织物的抗氧化剂防卫的一个重要部件。 | Ben Shi Lan Ni Aying Zhang Jianmei Cao Hong Zhang Tingting Qin Mingpu Tan Jianhua Zhang Mingyi-Jiang | 2012 | Molecular Plant2012，5，6： | 10 |
| 9 | Efficacy of small-volume simethicone given at least 30 min before gastroscopy显示文摘AIM To evaluate the efficacy of 5 m L simethicone solution in decreasing gastric foam if given at least 30 min before gastroscopy.METHODS This was a randomized, placebo controlled, endoscopist blinded study performed at Changi General Hospital. Patients were at least 21 years old, had no prior sur-gical resection of the upper gastrointestinal tract, and scheduled for elective diagnostic gastroscopies. The primary outcome was the total mucosal visibility score(TMVS) which was evaluated using Mc Nally score. The sample size was calculated to be 24 per group(SD 2.4, 80% power, P < 0.05, 2-sample t test). RESULTS Fifty-four patients were randomised to receive either simethicone [1 m L liquid simethicone(100 mg) in 5 m L of water] or placebo(5 m L of water) at least 30 min before their gastroscopy. Six accredited consultants conductedthe gastroscopy, and the interobserver agreement of scoring TMVS was good with a Kappa statistic of 0.73. The simethicone group had significantly better mean TMVS compared to placebo(5.78 ± SD 1.65 vs 8.89 ± SD 1.97, P < 0.001). The improvement was statistically significant for the duodenum and the gastric antrum, angularis, body, and fundus. Percent 51.9 of patients in the simethicone group had a TMVS of 4(no bubbles at all) to 5(only 1 area with minimal bubbles), while in the placebo group 3.7% of patients had TMVS of 4 or 5. The number needed to treat was 2.1 to avoid a TMVS of 6 and more. The simethicone group also had a significantly shorter procedure time with less volume of additional flushes required during gastroscopy to clear away obscuring gastric foam.CONCLUSION With a premedication time of at least 30 min, 5 m L simethicone can significantly decrease gastric foam, decrease the volume of additional flushes, and shorten gastroscopy time. | Mingjun Song Andrew Boon Eu Kwek Ngai Moh Law Jeannie Peng Lan Ong Jessica Yi-Lyn Tan Prem Harichander Thurairajah Daphne Shih Wen Ang Tiing Leong Ang | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 10 |
| 10 | Type I natural killer T cells: naturally born for fighting显示文摘 | Jin-quan TAN Wei XIAO Lan WANG Yu-ling HE | 2010 | Acta Pharmacologica Sinica2010，31，9： | 9 |
| 11 | Anti-diabetic vanadyl complexes reduced Alzheimer's disease pathology independent of amyloid plaque deposition显示文摘Association of Alzheimer's disease(AD) with cerebral glucose hypometabolism, likely due to impairments of insulin signaling,has been reported recently, with encouraging results when additional insulin is provided to AD patients. Here, we tested the potential effects of the anti-diabetic vanadium, vanadyl(IV) acetylacetonate(VAC), on AD in vitro and in vivo models. The experimental results showed that VAC at sub-micromolar concentrations improved the viability of neural cells with or without increased β-amyloid(Aβ) burden; and in APP/PS1 transgenic mice, VAC treatment(0.1 mmol kg-1 d-1) preserved cognitive function and attenuated neuron loss, but did not reduce brain Aβ plaques. Further studies revealed that VAC attenuated Aβpathogenesis by(i) activation of the PPARγ-AMPK signal transduction pathway, leading to improved glucose and energy metabolism;(ii) up-regulation of the expression of glucose-regulated protein 75(Grp75), thus suppressing p53-mediated neuronal apoptosis under Aβ-related stresses; and(iii) decreasing toxic soluble Aβ peptides. Overall, our work suggested that vanadyl complexes may have great potential for effective therapeutic treatment of AD. | Yaqiong Dong TessANDra Stewart Yue Zhang Min Shi Chang Tan Xue Li Lan Yuan Aanchal Mehrotra Jing Zhang Xiaoda Yang | 2019 | Science China(Life Sciences)2019，62，1： | 8 |
| 12 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 13 | Recent progress on MOF-derived carbon materials for energy storage显示文摘Metal-organic frameworks(MOFs)are of quite a significance in the field of inorganic-organic hybrid crystals.Especially,MOFs have attracted increasing attention in recent years due to their large specific surface area,desirable electrical conductivity,controllable porosity,tunable geometric structure,and excellent thermal/chemical stability.Some recent studies have shown that carbon materials prepared by MOFs as precursors can retain the privileged structure of MOFs,such as large specific surface area and porous structure and,in contrast,realize in situ doping with heteroatoms(eg,N,S,P,and B).Moreover,by selecting appropriate MOF precursors,the composition and morphology of the carbon products can be easily adjusted.These remarkable structural advantages enable the great potential of MOF-derived carbon as high-performance energy materials,which to date have been applied in the fields of energy storage and conversion systems.In this review,we summarize the latest advances in MOF-derived carbon materials for energy storage applications.We first introduce the compositions,structures,and synthesis methods of MOF-derived carbon materials,and then discuss their applications and potentials in energy storage systems,including rechargeable lithium/sodium-ion batteries,lithium-sulfur batteries,supercapacitors,and so forth,in detail.Finally,we put forward our own perspectives on the future development of MOF-derived carbon materials. | Jincan Ren Yalan Huang He Zhu Binghao Zhang Hekang Zhu Shenghui Shen Guoqiang Tan Feng Wu Hao He Si Lan Xinhui Xia Qi Liu | 2020 | Carbon Energy2020，2，2： | 8 |
| 14 | Recovery of novel bacterial diversity from mangrove sediment显示文摘 | Liang JB Chen YQ Lan CY Tan NFY Zan QJ Huang LN | 2007 | 中国生物学文摘2007，21，7： | 7 |
| 15 | BiCuSeO as state-of-the-art thermoelectric materials for energy conversion:from thin films to bulks显示文摘BiCuSeO-based thermoelectric material has attracted great attention as state-of-the-art thermoelectric materials since it was first reported in 2010. In this review,we update the studies on the BiCuSeO thin films first.Then, we focus on the most recent progress of multiple approaches that enhance the thermoelectric performance including advanced synthesized technologies,notable mechanisms for higher power factor(optimizing carrier concentration, carrier mobility, Seebeck coefficient)and doping effects predicted by calculation. And finally,aiming at further enhancing the performance of these materials and ultimately commercial application, we give a brief discussion on the urgent issues to which should be paid close attention. | Rui Liu Xing Tan Yao-Chun Liu Guang-Kun Ren Jin-Le Lan Zhi-Fang Zhou Ce-Wen Nan Yuan-Hua Lin | 2018 | Rare Metals2018，37，4： | 7 |
| 16 | A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells显示文摘Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone)ethane (BBSKE),a novel TrxR inhibitor,were investigated on human leu-kemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. Apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlich's ascites carcinoma-bearing mice were used to inves-tigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors. | Zuo-fu PENG Lin-xiang LAN Fang ZHAO Jing LI Qiang TAN Han-wei YIN Hui-hui ZENG | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，1： | 7 |
| 17 | Preparation and Characterization of Microencapsulated Hexadecane Used for Thermal Energy Storage显示文摘Polyurea microcapsules about 2.5μm in diameter containing phase change material for thermal energy storage application were synthesized and characterized by interfacial polycondensation method with toluene-2,4-diisocyanate and ethylenediamine as monomers in an emulsion system. Hexadecane was used as a phase change material and OP, which is nonionic surfactant, and used as an emulsifier. The chemical structure and thermal behavior of the microcapsules were investigated by FTIR and thermal analysis respectively. The results show encapsulated hexadecane has a good potential as a solar energy storage material. | Guang Long ZOU Zhi Cheng TAN Xiao Zheng LAN Li Xian SUN Tao ZHANG | 2004 | Chinese Chemical Letters2004，15，6： | 7 |
| 18 | Promoting Bone Mesenchymal Stem Cells and Inhibiting Bacterial Adhesion of Acid-Etched Nanostructured Titanium by Ultraviolet Functionalization显示文摘Titanium(Ti) and its alloys are used extensively in orthopedic implants because of their excellent biocompatibility,mechanical properties and corrosion resistance. However,titanium-based implant materials face many severe complications,such as implant loosening due to poor osseointegration and bacterial infections,which may lead to implant failure. Hence,preparing a biomaterial surface,which enhances the interactions with host cells and inhibits bacterial adhesion,may be an optimal strategy to reduce the incidence of implant failure. This study aims to improve osseointegration and confer antibacterial properties on Ti through a combination of two surface modifications including nanostructuring generated by acid etching and ultraviolet(UV) light treatment.Our results showed that without UV treatment,the acid etching treatment of Ti surface was effective at both improving the adhesion of bone mesenchymal stem cells(BMSCs) and increasing bacterial adhesion. A further UV treatment of the acid-etched surface however,not only significantly improved the cell adhesion but also inhibited bacterial adhesion. The acid-etched nanostructured titanium with UV treatment also showed a significant enhancement on cell proliferation,alkaline phosphatase(ALP) activity and mineralization. These results suggest that such nanostructured materials with UV treatment can be expected to have a good potential in orthopedic applications. | Guobo Lan Mei Li Ying Tan Lihua Li Xiaoming Yang Limin Ma Qingshui Yin Hong Xia Yu Zhang Guoxin Tan Chengyun Ning | 2015 | Journal of Materials Science & Technology2015，31，2： | 7 |
| 19 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 20 | Transdermal permeation of Zanthoxylum bungeanum essential oil on TCM components with different lipophilicity显示文摘Objective:To investigate the percutaneous penetration enhancement effect of essential oil from Zanthoxylum bungeanum Maxim.(Z.bungeanum oil)on active components in externally-applied traditional Chinese medicines.Methods:Five model drugs,geniposide,puerarin,ferulic acid,tetramethylpyrazine,and osthole,were chosen based on their lipophilicity and tested using in vitro transdermal permeation studies consisting of Franz diffusion cells and full thickness rat abdominal skin.Scanning electron microscopy was employed to observe the morphological changes of rat skin tissue after treatment with Z.bungeanum oil.The molecular interactions between the oil and the polar head groups in stratum corneum(SC)lipids were monitored using molecular dynamic simulation,and the SC/vehicle partition coefficients and saturation solubilities of the selected model drugs treated with and without the oil were also determined to ascertain its mechanisms of action.Results:As oil concentration increased,the log ERflow trended toward a negative linear relationship with the lipophilicity of drugs.After treatment with Z.bungeanum oil,a mild lifting up and wrinkle on the SC surface were observed,and appeared to become more pronounced as oil concentration increased.There was no significant difference between the control and the Z.bungeanum oil at different concentrations in terms of saturation solubility of GP,while saturation solubilities of the 4 other drugs gradually increased as oil concentration increased.The oxygen-containing constituents in Z.bungeanum oil,such as terpinen-4-ol and 1,8-cineole,which accounted for 57.95%of total oil,could form stable hydrogen bonds with the polar head group of ceramide 3.Conclusion:Z.bungeanum oil facilitated transdermal permeation of drugs with different lipophilicity,including the extremely hydrophilic and lipophilic drugs,whereas it exhibited greater enhancement activity for strongly hydrophilic drugs.The mechanisms of transdermal permeation enhancement by the oil could be explained with SC/vehicle partition coefficient,saturation solubility,and the interactions with SC lipids. | Yi Lan Jingyan Wang Shuwang He Shuying Li Peng Tan Hongmei Lin Qing Wu | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，3： | 6 |
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