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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | ERK1/2 mediates lung adenocarcinoma cell proliferation and autophagy induced by apelin-13显示文摘这研究的目的是在房间增长和肺腺癌的 autophagy 调查 apelin 的角色。在肺腺癌的 APJ 的在表示上被 immunohistochemistry 检测,当在肺癌症病人的血浆 apelin 水平被连接酶的 immunosorbent 试金测量时。我们的调查结果表明 apelin-13 显著地增加了 ERK1/2 的 phosphorylation, cyclin D1 的表示,联系微导管的蛋白质 1 轻链 3A/B (LC3A/B ) ,和 beclin1,并且证实 apelin-13 支持了 A549 房间增长并且经由 ERK1/2 发信号导致了 A549 房间 autophagy。而且,人的肺腺癌房间线 A549 的表面和光滑、光滑的 apelin-13 原因房间表面上有毛孔是在原子力量下面观察了显微镜学。这些结果建议 ERK1/2 发信号小径调停 apelin-13-induced 肺腺癌房间增长和 autophagy。在我们的试验性的条件下面,与 3-methyladenine 联系的 autophagy 不涉及房间增长。 | Li Yang Tao Su Deguan Lv FengXie Wei Liu Jiangang Cao Irshad Ali Sheikh Xuping Qin Lanfang Li Linxi Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 15 |
| 3 | Neuroprotective effects of Ginkgo biloba extract and GinkgoUde B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model显示文摘 | Xiaohan Yang Tiezheng Zheng Hao Hong Nan Cai Xiaofeng Zhou Changkai Sun Liying Wu Shuhong Liu Yongqi Zhao Lingling Zhu Ming Fan Xuezhong Zhou Fengxie Jin | 2018 | Frontiers of Medicine2018，12，3： | 12 |
| 4 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 5 | Transcriptome Analysis Reveals Clues into leaf-like flower mutant in Chinese orchid Cymbidium ensifolium显示文摘The floral morphology of Cymbidium ensifolium,a well-known orchid in China,has increasingly attracted horticultural and commercial attention.However,the molecular mechanisms that regulate flower development defects in C.ensifolium mutants are poorly understood.In this work,we examined a domesticated variety of C.ensifolium named‘CuiYuMuDan',or leaf-like flower mutant,which lacks typical characteristics of orchid floral organs but continues to produce sepal-to leaf-like structures along the inflorescence.We used comparative transcriptome analysis to identify 6234 genes that are differentially expressed between mutant and wild-type flowers.The majority of these differentially expre ssed genes are involved in membrane-building,anabolism regulation,and plant hormone signal transduction,implying that in the leaf-like mutant these processes play roles in the development of flower defects.In addition,we identified 152 differentially expre ssed transcription factors,including the bHLH,MYB,MIKC,and WRKY gene families.Moreover,we found 20 differentially expressed genes that are commonly involved in flower development,including MADS-box genes,CLAVATA3(CLV3),WUSCHEL(WUS),and PERIANTHIA(PAN).Among them,floral homeotic genes were further investigated by phylogenetic analysis and expression validation,which displayed distinctive spatial expression patterns and significant changes between the wild type and the mutant.This is the first report on the C.ensifolium leaf-like flower mutant transcriptome.Our results shed light on the molecular regulation of orchid flower development,and may improve our understanding of floral patterning regulation and advance molecular breeding of Chinese orchids. | Yonglu Wei Jianpeng Jin Xiani Yao Chuqiao Lu Genfa Zhu Fengxi Yang | 2020 | Plant Diversity2020，42，2： | 4 |
| 6 | An auxin‐responsive endogenous peptide regulates root development in Arabidopsis显示文摘Auxin plays critical roles in root formation and development. The components involved in this process,however, are not well understood. Here, we newly identified a peptide encoding gene, auxin‐responsive endogenous polypeptide 1(AREP1), which is induced by auxin, and mediates root development in Arabidopsis. Expression of AREP1 was specific to the cotyledon and to root and shoot meristem tissues. Amounts of AREP1 transcripts and AREP1‐green fluorescent protein fusion proteins were elevated in response to indoleacetic acid treatment. Suppression of AREP1 through RNAi silencing resulted in reduction of primary root length, increase of lateral root number, and expansion of adventitious roots, compared to the observations in wild‐type plants in the presence of auxin. By contrast, transgenic plants overexpressing AREP1 showed enhanced growth of the primary root under auxin treatment.Additionally, root morphology, including lateral root number and adventitious roots, differed greatly between transgenic and wild‐type plants. Further analysis indicated that the expression of auxin‐responsive genes, such as IAA3, IAA7, IAA17, GH3.2, GH3.3,and SAUR‐AC1, was significantly higher in AREP1 RNAi plants, and was slightly lower in AREP1 overexpressing plants than in wild‐type plants. These results suggest that the novel endogenous peptide AREP1 plays an important role in the process of auxin‐mediated root development. | Fengxi Yang Yu Song Hao Yang Zhibin Liu Genfa Zhu Yi Yang | 2014 | Journal of Integrative Plant Biology2014，56，7： | 2 |
| 7 | Large margin linear projection and face recognition显示文摘 | Song Fengxi Yang Jingyu Liu Shuhai | 2004 | Pattern Recognition2004，37，： | 1 |
| 8 | Overexpression of microRNA828 reduces anthocyanin accumulation in Arabidopsis显示文摘 | Fengxi Yang Jing Cai Yi Yang Zhibin Liu | 2013 | Plant Cell Tissue and Organ Culture (PCTOC)2013，，2： | 1 |
| 9 | A method for speeding up feature extraction based on KPCA显示文摘 | Yong Xu David Zhang Fengxi Song Jing-Yu Yang Zhong Jing Miao Li | 2006 | Neurocomputing2006，，4： | 1 |
| 10 | Orthogonalized Fisher discriminant显示文摘 | Song Fengxi Liu Shuhai Yang Jingyu | 2005 | Pattern Recognition2005，38，2： | 1 |
| 11 | Interleukin‐10 promoter polymorphisms are associated with the mode and sequel of HBeAg seroconversion in patients with chronic hepatitis B virus infection显示文摘 | Xiao MouPeng Yang SuHuang Hui HuiMa LinGu Qi FengXie Zhi LiangGao | 2006 | Liver International2006，，3： | 1 |
| 12 | A novel dimensionality-reduction approach for face recognition显示文摘 | Song Fengxi Zhang D Yang Jingyu | 2006 | Neurocomputing2006，39，： | 1 |
| 13 | Effect and safety of Kanglaite injection combined with chemotherapy in the treatment of advanced colorectal cancer:a systematic review and meta-analysis显示文摘Objective:To evaluate the clinical efficacy and safety of Kanglaite injection combined with chemotherapy and chemotherapy alone in the treatment of advanced colorectal cancer.Methods:PubMed,Cochrane library,CNKI,VIP,Wanfang database were systematically searched by inputting keywords to explore the efficacy of Kanglaite injection combined with chemotherapy in the treatment of advanced colorectal cancer.A random-effects model was selected to evaluate the treatment outcomes.The screening of literature,the extraction of data and the assessment of methodology were independently undertaken by two reviewers.Meta analysis was performed using Revman5.3 software and stata15.0 software.Results:A total of 12 RCTs were included,with 792 cases.Compared with chemotherapy alone,Metaanalysis suggested that Kanglaite injection combined with chemotherapy can improve clinical efficiency(RR=1.45,95%CI:1.21-1.74,P<0.0001)and improve patients'quality of life(RR=1.55,95%CI:1.32-1.82,P<0.00001),improve the patient's immune function(CD3+cells:SWD=1.42,95%CI:1.11-1.73;CD4+/CD8+cell ratio:SWD=0.95,95%CI:0.66-1.25;NK cell activity:SWD=3.24,95%CI:2.81-3.66,P<0.00001);Leukopenia rate(RR=0.63,95%CI:0.54-0.74,P<0.0001),incidence of gastrointestinal adverse reactions(RR=0.56,95%CI:0.48-0.66,P<0.00001),incidence of peripheral neurotoxicity(RR=0.79,95%CI:0.65-0.96,P=0.02)were lower than the chemotherapy alone group,the difference was statistically significant.In improving the hand-foot syndrome and oral mucositis after chemotherapy,there was some difference between the Kanglaite injection combined with chemotherapy group and the chemotherapy alone group,but the difference was not significant.Puber bias detection and sensitivity analysis were performed with clinically effective relative risk(RR)as indicators.The results suggested that the publication bias was not obvious.The results of this study are stable.Conclusion:Compared with chemotherapy alone group in the treatment of advanced colorectal cancer,Kanglaite injection combined with chemotherapy can improve the effective rate,quality of life,immune function of patients and reduce the incidence of leukopenia after chemotherapy,gastrointestinal adverse reactions and peripheral neurotoxicity. | Jinlin Wu Zhu Yang Fengxi Long Bing Yang Xun Liu Xianman Wei Dongxin Tang | 2019 | Asian Toxicology Tesearch2019，1，1： | 1 |
| 14 | Complete Genome Sequence Analysis of Guangdong Isolates of Cymbidium Mosaic Virus显示文摘[Objectives]The paper was to explore the genetic information and evolution of CymMV,and to provide an important scientific basis for monitoring and early warning of orchid virus disease and anti-virus genetic engineering of orchid in Guangdong Province.[Methods]RT-PCR and DASELISA were used to detect and identify CymMV from leaves with suspected virus disease of Cymbidium sinense collected from Guangzhou area.The genome sequence assembly,annotation,phylogeny and selection pressure analysis of CymMV isolates were performed with related molecular biology software.[Results]Two CymMV isolates(GZV013 and ZC29)were found in Guangdong Province for the first time in this study.The genome of both GZV013 and ZC29 were 6227 nt in length,encoding 5 functional proteins.The similarity analysis of the full sequence showed that the nucleotide sequence identity of GZV013 and Taiwan isolate M2 was 97.03% and that of ZC29 and Nanjing isolate NJ-1 was 97.11%.The complete genome sequence identity among CymMV isolates ranged from 86.85% to 98.31%,and the differentiation of diverse populations was closely related to host species and geographical isolation.Each region of CymMV genome was affected by negative selection and conformed to the neutral evolution model.The genes encoding RdRp,TGB1 and TGB2 had the highest mutation rates in the genome.[Conclusions]GZV013 was most closely related to Taiwan isolate M2,and ZC29 was most closely related to Nanjing isolate NJ-1,belonging to the same branch of a family. | Yonglu WEI Rui REN Jie GAO Weiping LIU Qi XIE Genfa ZHU Fengxi YANG | 2022 | Plant Diseases and Pests2022，13，3： | 0 |
| 15 | Literature on the law of Miao medicine in treating liver cancer显示文摘目的:通过苗族医学治疗肝癌药物文献整理分析,探讨苗族医学治疗肝癌的用药规律。方法:以《中华本草·苗药卷》为文献来源,拟定检索词对CNKI数据库、万方数据库建库至2018年5月苗族医药治疗肝癌的相关文献进行检索,符合条件的药物对其科属、药性、药味、归经及功效进行统计分析。结果:共纳入苗族医学治疗肝癌药物132味,高频科属为菊科、百合科、蔷薇科,共占22.8%;药性以冷药为主,占75.8%;药味以苦、辣、甜为主,共占75.5%;归经以热经、冷经为主,共占90.5%;功效以治毒药、补体药、通气散血药为主,共占80.4%。结论:苗族医学治疗肝癌谨守两纲理论之冷热辨证,在治毒的基础上合理运用补体药、通气散血药等标本兼顾。 | Huili Shui Zhu Yang Fengxi Long Wenqi Huang Bing Yang Zhen Zhang Dongxin Tang | 2018 | TMR Clinical Research2018，1，1： | 0 |
| 16 | Research Progress on the Bismuth Containing Complex Oxide in Photocatalystic Technology显示文摘The photocatalytic degradation on the bismuth containing complex oxide was revised in detail including the synthesis and classification of photocatalyts,and then the photocatalytic reaction,scavenger,and the mechanism of reaction. In particular,the perspectives of photocatalytic degradation on the bismuth containing oxide were analyzed in detail. | Miao Yingchun Yang Huiqiong Li Fengxi Liang Yiwei | 2015 | Meteorological and Environmental Research2015，6，5： | 0 |
| 17 | Genome-wide association analysis identified molecular markers and candidate genes for flower traits in Chinese orchid (Cymbidium sinense)显示文摘The orchid,the champagne of f lowers,brings luxury,elegance,and novelty to nature.Cymbidium sinense is a symbol of gigantic floral variability on account ofwavering shapes and sizes of f loral organs,althoughmarker-trait association(MTA)has not been studied for its f loral traits.We evaluated markers associated with 14 f loral traits of C.sinense through a genome-wide association study(GWAS)of 195 accessions.A total of 65318522 single-nucleotide polymorphisms(SNPs)and 3906176 insertion/deletion(InDel)events were identified through genotyping-by-sequencing.Among these,4694 potential SNPs and 477 InDelswere identified as MTAs at−log10 P>5.The genes related to these SNPs and InDels were largely associated with f loral regulators,hormonal pathways,cell division,and metabolism,playing essential roles in tailoring f loral morphology.Moreover,20 candidate SNPs/InDels linked to 11 genes were verified,8 of which were situated on exons,onewas located in the 5-UTR and twowere positioned in introns.Here,themultitepal trait-related gene RABBIT EARS(RBE)was found to be the most crucial gene.We analyzed the role of CsRBE in the regulation of flower-related genes via efficient transient overexpression in C.sinense protoplasts,and found that the floral homeotic genes CsAP3 and CsPI,as well as organ boundary regulators,including CsCUC and CsTCP genes,were regulated by CsRBE.Thus,we obtained key gene loci for important ornamental traits of orchids using genome-wide association analysis of populations with natural variation.The findings of this study can do a great deal to expedite orchid breeding programs for shape variability. | Fengxi Yang Yudi Guo Jie Li Chuqiao Lu Yonglu Wei Jie Gao Qi Xie Jianpeng Jin Genfa Zhu | 2023 | Horticulture Research2023，10，11： | 0 |
| 18 | Astragalus injection as an adjuvant treatment for colorectal cancer:a meta-analysis显示文摘Background:The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients.However,due to the uneven basic conditions and research indicators of these clinical trials,it is difficult to comprehensively evaluate the effect of Astragalus injection in the adjuvant treatment of colorectal cancer.This study aimed to systematically evaluate the efficacy and safety of Astragalus injection as an adjuvant treatment for colorectal cancer.Methods:The Cochrane Library,VIP database,Wanfang database,and Chinese Academic Journal Full Text database were searched for potentially eligible articles from inception to December 15,2018.Randomized controlled trials in which patients were diagnosed with colorectal cancer were included.Patients in the control group received chemotherapy alone or combined with other drugs,or chemotherapy combined with radiotherapy.Patients in the experimental group were treated with Astragalus injection combined with interventions in the control group.Results:A total of 8 articles were included.Compared with Western medicine alone,the Astragalus injection could improve the therapeutic effect(RR=1.18,95%CI(1.01,1.38),P=0.03),improved the quality of life of colorectal cancer patients(SMD=1.18,95%CI(0.86,1.50),P<0.001),inhibited leukopenia(RR=0.55,95%CI(0.42,0.71),P<0.001),reduced neurotoxicity(RR=0.43,95%CI(0.34,0.56),P<0.001),and reduced the incidence of nausea and vomiting(RR=0.67,95%CI(0.55,0.80),P<0.001).Conclusion:Astragalus injection can reduce the toxicity and improve the efficiency of the conventional Western medicine in the treatment of colorectal cancer. | Jia Wang Zhu Yang Fengxi Long Li Luo Jinlin Wu Ting Yu Dongxin Tang | 2020 | Traditional Medicine Research2020，5，1： | 0 |
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