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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Climate sensitivities of two versions of FGOALS model to idealized radiative forcing显示文摘Projections of future climate change by climate system models depend on the sensitivities of models to specified greenhouse gases.To reveal and understand the different climate sensitivities of two versions of LASG/IAP climate system model FGOALS-g2 and FGOALS-s2,we investigate the global mean surface air temperature responses to idealized CO2 forcing by using the output of abruptly quadrupling CO2 experiments.The Gregory-style regression method is used to estimate the'radiative forcing'of quadrupled CO2 and equilibrium sensitivity.The model response is separated into a fast-response stage associated with the CO2 forcing during the first 20 years,and a slow-response stage post the first 20 years.The results show that the radiative forcing of CO2 is overestimated due to the positive water-vapor feedback and underestimated due to the fast cloud processes.The rapid response of water vapor in FGOALS-s2 is responsible for the stronger radiative forcing of CO2.The climate sensitivity,defined as the equilibrium temperature change under doubled CO2 forcing,is about 3.7 K in FGOALS-g2 and4.5 K in FGOALS-s2.The larger sensitivity of FGOALS-s2 is due mainly to the weaker negative longwave clear-sky feedback and stronger positive shortwave clear-sky feedback at the fast-response stage,because of the more rapid response of water vapor increase and sea-ice decrease in FGOALS-s2 than in FGOALS-g2.At the slow-response stage,similar to the fast-response stage,net negative clear-sky feedback is weaker in FGOALS-s2.Nevertheless,the total negative feedback is larger in FGOALS-s2 due to a larger negative shortwave cloud feedback that involves a larger response of total cloud fraction and condensed water path increase.The uncertainties of estimated forcing and net feedback mainly come from the shortwave cloud processes. | CHEN XiaoLong ZHOU TianJun GUO Zhun | 2014 | Science China Earth Sciences2014，57，6： | 19 |
| 3 | An improved diagnostic stratocumulus scheme based on estimated inversion strength and its performance in GAMIL2显示文摘Based on satellite data and the estimated inversion strength(EIS) derived by Wood et al.(2006), a feasible and uncomplicated stratocumulus scheme is proposed, referred to as EIS scheme. It improves simulation of cloud radiative forcing(CRF) in the Grid-point Atmospheric Model of IAP/LASG version 2(GAMIL2.0) model. When compared with the original lower troposphere stability(LTS) scheme, the EIS scheme reproduces more reasonable climatology distributions of clouds and CRF. The parameterization partly corrects CRF underestimation at mid and high latitudes and overestimation in the convective region. Such improvements are achieved by neglecting the effect of free-tropospheric stratification changes that follow a cooler moist adiabat at middle and high latitude, thereby improving simulated cloudiness. The EIS scheme also improves simulation of the CRF interannual variability. The positive net CRF and negative stratiform anomaly in the East Asian and western North Pacific monsoon regions(EAWNPMR) are well simulated. The EIS scheme is more sensitive to sea surface temperature anomalies(SSTA) than the LTS. Therefore, under the effect of a warmer SSTA in the EAWNPMR, the EIS generates a stronger negative stratiform response, which reduces radiative heating in the low and mid troposphere, in turn producing strong subsidence and negative anomalies of both moisture and cloudiness. Consequent decreases in cloud reflection and shading effects ultimately improve simulation of incoming surface shortwave radiative fluxes and CRF. Because of the stronger subsidence, a stronger anomalous anticyclone over the Philippines Sea is simulated by the EIS run, which leads to a better positive precipitation anomaly in eastern China during ENSO winter. | GUO Zhun ZHOU TianJun | 2014 | Science China Earth Sciences2014，57，11： | 11 |
| 4 | Climate Sensitivity and Feedbacks of a New Coupled Model CAMS-CSM to Idealized CO_2 Forcing: A Comparison with CMIP5 Models显示文摘Climate sensitivity and feedbacks are basic and important metrics to a climate system. They determine how large surface air temperature will increase under CO_2 forcing ultimately, which is essential for carbon reduction policies to achieve a specific warming target. In this study, these metrics are analyzed in a climate system model newly developed by the Chinese Academy of Meteorological Sciences(CAMS-CSM) and compared with multi-model results from the Coupled Model Comparison Project phase 5(CMIP5). Based on two idealized CO_2 forcing scenarios, i.e.,abruptly quadrupled CO_2 and CO_2 increasing 1% per year, the equilibrium climate sensitivity(ECS) and transient climate response(TCR) in CAMS-CSM are estimated to be about 2.27 and 1.88 K, respectively. The ECS is near the lower bound of CMIP5 models whereas the TCR is closer to the multi-model ensemble mean(MME) of CMIP5 due to compensation of a relatively low ocean heat uptake(OHU) efficiency. The low ECS is caused by an unusually negative climate feedback in CAMS-CSM, which is attributed to cloud shortwave feedback(λSWCL) over the tropical Indo-Pacific Ocean.The CMIP5 ensemble shows that more negative λSWCL is related to larger increase in low-level(925–700 hPa)cloud over the tropical Indo-Pacific under warming, which can explain about 90% of λSWCL in CAMS-CSM. Static stability of planetary boundary layer in the pre-industrial simulation is a critical factor controlling the low-cloud response and λSWCL across the CMIP5 models and CAMS-CSM. Evidently, weak stability in CAMS-CSM favors lowcloud formation under warming due to increased low-level convergence and relative humidity, with the help of enhanced evaporation from the warming tropical Pacific. Consequently, cloud liquid water increases, amplifying cloud albedo, and eventually contributing to the unusually negative λSWCL and low ECS in CAMS-CSM. Moreover, the OHU may influence climate feedbacks and then the ECS by modulating regional sea surface temperature responses. | Xiaolong CHEN Zhun GUO Tianjun ZHOU Jian LI Xinyao RONG Yufei XIN Haoming CHEN Jingzhi SU | 2019 | Journal of Meteorological Research2019，33，1： | 11 |
| 5 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 6 | Seasonal Variation and Physical Properties of the Cloud System over Southeastern China Derived from Cloud Sat Products显示文摘Based on the National Centers for Environmental Prediction(NCEP) and Climate Prediction Center(CPC) Merged Analysis of Precipitation(CMAP) data and Cloud Sat products, the seasonal variations of the cloud properties, vertical occurrence frequency, and ice water content of clouds over southeastern China were investigated in this study. In the Cloud Sat data, a significant alternation in high or low cloud patterns was observed from winter to summer over southeastern China. It was found that the East Asian Summer Monsoon(EASM) circulation and its transport of moisture leads to a conditional instability, which benefits the local upward motion in summer, and thereby results in an increased amount of high cloud. The deep convective cloud centers were found to coincide well with the northward march of the EASM, while cirrus lagged slightly behind the convection center and coincided well with the outflow and meridional wind divergence of the EASM. Analysis of the radiative heating rates revealed that both the plentiful summer moisture and higher clouds are effective in destabilizing the atmosphere. Moreover, clouds heat the mid-troposphere and the cloud radiative heating is balanced by adiabatic cooling through upward motion, which causes meridional wind by the Sverdrup balance. The cloud heating–forced circulation was observed to coincide well with the EASM circulation, serving as a positive effect on EASM circulation. | GUO Zhun ZHOU Tianjun | 2015 | Advances in Atmospheric Sciences2015，32，5： | 5 |
| 7 | A Robustness Analysis of CMIP5 Models over the East Asia-Western North Pacific Domain显示文摘 | Tianjun Zhou Xiaolong Chen Bo Wu Zhun Guo Yong Sun Liwei Zou Wenmin Man Lixia Zhang Chao He | 2017 | Engineering2017，3，5： | 4 |
| 8 | The Asymmetric Effects of El Ni?o and La Ni?a on the East Asian Winter Monsoon and Their Simulation by CMIP5 Atmospheric Models显示文摘El Ni?o–Southern Oscillation(ENSO) events significantly affect the year-by-year variations of the East Asian winter monsoon(EAWM). However, the effect of La Ni?a events on the EAWM is not a mirror image of that of El Ni?o events. Although the EAWM becomes generally weaker during El Ni?o events and stronger during La Ni?a winters, the enhanced precipitation over the southeastern China and warmer surface air temperature along the East Asian coastline during El Ni?o years are more significant. These asymmetric effects are caused by the asymmetric longitudinal positions of the western North Pacific(WNP) anticyclone during El Ni?o events and the WNP cyclone during La Ni?a events; specifically, the center of the WNP cyclone during La Ni?a events is westward-shifted relative to its El Ni?o counterpart. This central-position shift results from the longitudinal shift of remote El Ni?o and La Ni?a anomalous heating, and asymmetry in the amplitude of local sea surface temperature anomalies over the WNP.However, such asymmetric effects of ENSO on the EAWM are barely reproduced by the atmospheric models of Phase 5 of the Coupled Model Intercomparison Project(CMIP5), although the spatial patterns of anomalous circulations are reasonably reproduced. The major limitation of the CMIP5 models is an overestimation of the anomalous WNP anticyclone/cyclone, which leads to stronger EAWM rainfall responses. The overestimated latent heat flux anomalies near the South China Sea and the northern WNP might be a key factor behind the overestimated anomalous circulations. | Zhun GUO Tianjun ZHOU Bo WU | 2017 | Journal of Meteorological Research2017，31，1： | 3 |
| 9 | Seasonal variation analysis of atmospheric CH_4,N_2O and CO_2 in Tianjin offshore area显示文摘The concentrations of CH4, N2O and CO2 at the sea level were observed from November 2007 to August 2008 in order to study the greenhouse gases in the Tianjin offshore area of Bohai Sea. CH4 concentrations varied from 1.87 to 2.61 ppm with the highest value appearing in summer and the lowest in winter. The concentration range of N2O was 319.3 to 347.7 ppb, with the maximal value appearing in winter. CO2 was higher in the heating season than in non-heating season in this area. Concentrations of the three greenhouse gases in the study area exceeded the 2005 global background values. Backward trajectory model was used to analyze the sources. All three gases were influenced evidently by continental sources in the inshore area during the sampling periods. Every gas was compared with each other by correlation analysis, showing that the correlation of CO2 and N2O was more significant than to CH4 and their relationship with meteorological factors was consistent. It can be concluded these three greenhouse gases may be influenced by some similar sources, especially for CO2 and N2O. | KONG ShaoFei, LU Bing, HAN Bin, BAI ZhiPeng, XU Zhun, YOU Yan, JIN LiangMao, GUO XiaoYang & WANG Rui State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China | 2010 | Science China Earth Sciences2010，53，8： | 2 |
| 10 | Responses of Cloud-Radiative Forcing to Strong El Nino Events over the Western Pacific Warm Pool as Simulated by CAMS-CSM显示文摘Cloud-radiative forcing(CRF)at the top of the atmosphere(TOA)over the western Pacific warm pool(WP)shows unique characteristics in response to El Nino events.In this region,the responses of CRF to El Nino events have been a useful metric for evaluating climate models.Satellite data are used to analyze the CRF anomalies to El Nino events simulated by the new and old versions of the Climate System Model of the Chinese Academy of Meteorological Sciences(CAMS-CSM),which has participated in the Atmospheric Model Intercomparison Project(AMIP).Here,simulations for super El Nino years,El Nino years,and normal years are compared with observations.The results show that the mean values of both longwave CRF(LWCRF)and shortwave CRF(SWCRF)in CAMS-CSM are weaker than the observations for each category of El Nino events.Compared with the old version of CAMS-CSM,the decrease in LWCRF during El Nino events is well simulated by the new version of CAMS-CSM.However,both new and old models cannot reproduce the anomalous SWCRF in El Nino events.The biases in the CRF response to El Nino events are attributed to the biases in the cloud vertical structure because of a weaker crash of the Walker circulation in CAMS-CSM.Due to the modification of the conversion rate from cloud droplets to raindrops in the cumulus convection scheme,the new version of CAMS-CSM has better CRF skills in normal years,but biases in El Nino events still exist in the new version.Improving the response of the Walker circulation to El Nino events is key to higher skills in simulating the cloud radiative responses. | Baichao ZHANG Zhun GUO Xiaolong CHEN Tianjun ZHOU Xinyao RONG Jian LI | 2020 | Journal of Meteorological Research2020，34，3： | 2 |
| 11 | Long-term change in low-cloud cover in Southeast China during cold seasons显示文摘中国东南地区在冬春冷季节盛行低云,对局地能量平衡和水文循环有重要的作用.本研究使用多套数据和数值模拟结果,分析这一地区冷季节内低云云量在1980年至2017年的长期变化.结果表明,低云云量经历了先下降后上升的趋势变化,转折点出现在2008年左右.局地水汽通量输送在影响低云云量的变化中起着至关重要的作用,其在冬季和春季分别受到哈德莱环流和沃克环流的影响.CMIP6中的气候模式对水汽通量输送的模拟能力欠佳,影响了对低云云量的模拟结果. | Zhe Chen Minghuai Wang Haipeng Zhang Shuheng Lin Zhun Guo Yiquan Jiang Chen Zhou | 2022 | Atmospheric and Oceanic Science Letters2022，15，6： | 1 |
| 12 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 13 | Surface modification of mesoporous silica nanoparticle with 4-triethoxysilylaniline to enhance seawater desalination properties of thin-film nanocomposite reverse osmosis membranes显示文摘Mesoporous silica nanoparticles(MSN),with higher water permeability than NaA zeolite,were used to fabricate thin-film nanocomposite(TFN)reverse osmosis(RO)membranes.However,only aminoalkyl-modified MSN and low-pressure(less than 2.1 MPa)RO membrane were investigated.In this study,aminophenyl-modified MSN(AMSN)were synthesized and used to fabricate high-pressure(5.52 MPa)RO membranes.With the increasing of AMSN dosage,the crosslinking degree of the aromatic polyamide decreased,while the hydrophilicity of the membranes increased.The membrane morphology was maintained to show a ridge-and-valley structure,with only a slight increase in membrane surface roughness.At the optimum conditions(AMSN dosage of 0.25 g/L),when compared with the pure polyamide RO membrane,the water flux of the TFN RO membrane(55.67 L/m^2/h)was increased by about 21.6%,while NaCl rejection(98.97%)was slightly decreased by only 0.29%.However,the water flux of the membranes was much lower than expected.We considered that the enhancement of RO membrane permeability is attributed to the reduction of the effective thickness of the PA layer. | Jian Wang Qun Wang Xueli Gao Xinxia Tian Yangyang Wei Zhen Cao Chungang Guo Huifeng Zhang Zhun Ma Yushan Zhang | 2020 | Frontiers of Environmental Science & Engineering2020，14，1： | 1 |
| 14 | Oral pyroptosis nanoinhibitor for the treatment of inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)is an autoimmune gastrointestinal disease characterized by chronic relapsing inflammation of the intestine.Excessive pyroptosis that exists in the inflamed intestine can activate damage signals and aggravate local inflammation in IBD.Here,we designed an oral pyroptosis nanoinhibitor,DXMS@CuM@PPADT@PSS(DCMP),which can target intestinal lesions,and respond to reactive oxygen species(ROS)to release active sites and drugs at the lesion.DCMP can inhibit the activation of the nucleotide-binding domain and leucine-rich repeat family pyrin domain containing 3(NLRP3)inflammasomes by scavenging ROS,resulting in the down-regulation of gasdermin D(GSDMD)cleavage thus inhibiting pyroptosis.It also improved intestinal barrier function,decreased inflammatory cytokine levels,and increased the diversity of gut microbiota in mice with colitis.This work is believed to expand the biomedical application of nanomaterials for innate immunity modulation. | Zhenxing Zhu Dongtao Zhou Yi Yin Zhun Li Zhen Guo Yongchun Pan Yanfeng Gao Jingjing Yang Weiming Zhu Yujun Song Yi Li | 2024 | Nano Research2024，17，3： | 0 |
| 15 | Efficacy and safety of remimazolam-based sedation for intensive care unit patients undergoing upper gastrointestinal endoscopy:a cohort study显示文摘BACKGROUND:Remimazolam is a novel ultra-short-acting sedative,but its safety and adverse events(AEs)in high-risk patients in the intensive care unit(ICU)setting remain unknown.METHODS:This was a single-center,retrospective study that compared remimazolam to propofol and midazolam in patients undergoing upper gastrointestinal endoscopy.The primary outcome was the incidence of treatment-related AEs.The secondary outcomes were the time to extubation,the length of ICU stay,and the average cost of sedative per case.RESULTS:Of the 88 patients analyzed,47 were treated with remimazolam(mean dose,7.90±4.84mg),and 41 were treated with propofol(21.19±17.98 mg)or midazolam(3.08±2.17 mg).There was no statistically significant difference in the average duration of the endoscopic procedure(35.89±13.37 min vs.44.51±21.68 min,P=0.133)or the time to extubation(15.00±9.75 h vs.20.59±18.71 h,P=0.211)in the remimazolam group(group I)compared to the propofol or midazolam group(group II).ICU stays(5.40±2.93 d vs.4.63±3.31 d,P=0.072)and treatment-related AEs(48.61%vs.51.38%,P=0.056)were similar between groups.The average cost of sedative per case was significantly lower in the group I than in the group II(RMB 16.07±10.58 yuan vs.RMB 24.37±15.46 yuan,P=0.016).CONCLUSION:Remimazolam-based sedation was noninferior to the classic sedatives and had lower average cost per case,indicating that it may be used as a promising sedative for high-risk patients during endoscopic procedures in the ICU setting. | Yuan-rui Zhao Ke-sheng Huang Guo Hou Lan Yao Li-ping Lu Song Xu Ying-tao Lian Zhun Yao Zhui Yu | 2023 | World Journal of Emergency Medicine2023，14，1： | 0 |
| 16 | 金掺杂对碳负载钯催化还原性能的促进作用(英文)显示文摘在许多催化应用中双金属的Pd Au催化剂性能优于单金属催化剂.科研人员对具有可控纳米结构和高活性的Pd Au催化剂进行了广泛的研究,但该催化剂的制备需要多步且通常步骤复杂.本文仅通过浸渍和焙烧制得了Au掺杂的负载型Pd催化剂,所得Pd Au/C催化剂用于室温水相三氯乙烯加氢脱氯反应.当Pd和Au负载量分别为1.0 wt%和1.1 wt%时,在经过干燥、空气处理和H_2还原的过程后,所制得的Pd Au/C催化剂活性最高,初始转化频率(TOF)为34.0×10^(–2) mol_(TCE) mol^(–1)Pd s^(–1),是单金属1.0 wt%Pd/C催化剂TOF(2.2×10^(–2) mol_(TCE) mol^(–1)Pd s^(–1))的15倍以上.X射线吸收光谱结果表明,金的加入避免了400 oC焙烧时Pd的氧化.本文还提出了可能的催化剂纳米结构演变路径,以解释所观察到的催化现象. | Yu-lun Fang Kimberly N.Heck Zhun Zhao Lori A.Pretzer Neng Guo Tianpin Wu Jeffrey T.Miller Michael S.Wong | 2016 | Chinese Journal of Catalysis2016，37，10： | 0 |
| 17 | Summer Extreme Temperatures over East China during 1984-2004 Simulated by LASG/IAP Regional Climate Model CREM显示文摘The authors examine extreme summer temperatures over East China during 1984-2004 using a regional climate model named CREM(the Climate version of Regional Eta-coordinate Model),which was developed by LASG/IAP.The results show that the main features of the extreme summer temperatures over East China are reproduced well by CREM,and the skill for the minimum temperature is higher than that for the maximum temperature,especially along the Yangtze-Huai River Valley(YHV).The simulated extreme temperatures are lower than those of observation,especially for the maximum temperature.The bias of extreme temperatures is consistent with the cold bias of the climatological mean summer surface air temperature.The skill of the model in simulating the interannual variability of extreme temperatures increases from north to south.The simulated interannual variation of the minimum temperature is more reasonable than the maximum temperature.The underestimation of net solar radiation at the surface leads to a cold bias of the climatological mean temperature.Furthermore,the model underestimates the light and moderate rain,while overestimates heavy rain.It causes the simulated minimum temperature more reasonable than the maximum temperature. | ZENG Xian-Feng LIU Jing-Wei LI Bo GUO Zhun ZHOU Tian-Jun FENG Lei | 2012 | Atmospheric and Oceanic Science Letters2012，5，1： | 0 |
| 18 | Improved simulation of the East Asian winter monsoon interannual variation by IAP/LASG AGCMs显示文摘东亚冬季风的模拟性能一直是检验气候模式的重要指标。本文对比分析了LASG新旧两个版本大气环流模式对东亚冬季风年际变率的模拟性能。结果表明,GAMIL2模拟的东亚冬季风指数与观测的相关系数为0.71,相较于GAMIL1(0.37)有明显改进。主要原因是GAMIL2改进了云参数化方案,能够更合理的再现加热率对厄尔尼诺的响应,有助于激发菲律宾海反气旋,从而改进东亚冬季风的模拟。 | JIN Chen-Xi ZHOU Tian-Jun GUO Zhun WU Bo CHEN Xiao-Long | 2016 | Atmospheric and Oceanic Science Letters2016，9，3： | 0 |
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