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| 1 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 2 | Chinese expert consensus on the diagnosis and treatment of severely and critically ill patients with coronavirus disease 2019显示文摘The coronavirus disease 2019(COVID-19)threatens the health of humans worldwide,and at the time of this writing,there is no specifically targeted effective drug for COVID-19.The major initial symptoms of patients with COVID-19 are fever,dry cough,and fatigue,although some patients mainly experience vomiting,diarrhea,and other gastrointestinal symptoms.Other severe symptoms,namely chest tightness,dyspnea,and respiratory distress,usually appear one week later,with some patients rapidly developing acute respiratory distress syndrome(ARDS),septic shock,and possibly even death.A retrospective study of critically ill patients with COVID-19 has recently reported that 67.3%of patients presented with ARDS,28.9%with acute kidney injury,23.1%with heart injury,and 28.9%with abnormality in liver function.In addition,the 28-day mortality rate was up to 61.5%.[1] | Tong-Wen Sun Xi-Jing Zhang Zhui Yu You Shang | 2020 | Chinese Medical Journal2020，，24： | 2 |
| 3 | Production of cloned transgenic cow expressing omega-3 fatty acids显示文摘 | Xia Wu Hongsheng Ouyang Biao Duan Daxin Pang Li Zhang Ting Yuan Lian Xue Daibang Ni Lei Cheng Shuhua Dong Zhuying Wei Lin Li Ming Yu Qing-Yuan Sun Da-Yuan Chen Liangxue Lai Yifan Dai Guang-Peng Li | 2012 | Transgenic Research2012，，3： | 1 |
| 4 | Effects of 1,25-(OH)_2D_3 on Stimulation of Osteoclast-like Cells Formationand Expression of ODF mRNA in Murine Marrow Cells in Vitro显示文摘目的 :观察不同浓度的 1,2 5 - (OH) 2 D3 对破骨细胞形成及对骨髓细胞ODFmRNA表达的影响。进一步阐明骨吸收刺激因子在正畸牙周组织改建中的作用。方法 :应用不同浓度的 1,2 5 - (OH) 2 D3 (0、10 -10 、10 -8、10 -6mol/L)诱导大鼠骨髓细胞破骨样细胞的形成 ,采用体外破骨细胞溶骨模型 ,观察牙本质片上骨吸收陷窝数目 ,采用原位杂交技术检测骨髓基质细胞ODF的mRNA表达。结果 :随着 1,2 5 - (OH) 2 D3 浓度的增加 ,骨陷窝数明显增多 ,陷窝面积增大 ;ODFmRNA表达的阳性信号显著增强。结论 :在体外 ,1,2 5 - (OH) 2 D3 可以调节破骨细胞的骨吸收活性 。 | WANG Feng LIN Zhui LI Yong-ruing YU ANLu | 2004 | 口腔医学研究2004，20，4： | 1 |
| 5 | In vivo and in vitro development of Tibetan antelope(Pantholops hodgsonii)interspecific cloned embryos显示文摘The Tibetan antelope is endemic to the Tibetan Plateau,China,and is now considered an endangered species.As a possible rescue strategy,the development of embryos constructed by interspecies somatic cell nuclear transfer(iSCNT)was examined.Tibetan antelope fibroblast cells were transferred into enucleated bovine,ovine and caprine oocytes.These cloned embryos were then cultured in vitro or in the oviducts of intermediate animals.Less than 0.5%of the reconstructed antelope-bovine embryos cultured in vitro developed to the blastocyst stage.However,when the cloned antelope-bovine embryos were transferred to caprine oviducts,about 1.6%of the embryos developed to the blastocyst stage.In contrast,only 0.7%of the antelope-ovine embryos developed to the morula stage and none developed to blastocysts in ovine oviducts.The treatment of donor cells and bovine oocytes with trichostatin A did not improve the embryo development even when cultured in the oviducts of ovine and caprine.When the antelope-bovine embryos,constructed from oocytes treated with roscovitine or trichostatin A,were cultured in rabbit oviducts 2.3%and 14.3%developed to blastocysts,respectively.It is concluded that although some success was achieved with the protocols used,interspecies cloning of Tibetan antelope presents difficulties still to be overcome.The mechanisms resulting in the low embryo development need investigation and progress might require a deeper understanding of cellular reprogramming. | Guanghua SU Lei CHENG Yu GAO Kun LIU Zhuying WEI Chunling BAI Fengxia YIN Li GAO Guangpeng LI Shorgan BOU | 2014 | Frontiers of Agricultural Science and Engineering2014，1，1： | 1 |
| 6 | Efficacy and safety of remimazolam-based sedation for intensive care unit patients undergoing upper gastrointestinal endoscopy:a cohort study显示文摘BACKGROUND:Remimazolam is a novel ultra-short-acting sedative,but its safety and adverse events(AEs)in high-risk patients in the intensive care unit(ICU)setting remain unknown.METHODS:This was a single-center,retrospective study that compared remimazolam to propofol and midazolam in patients undergoing upper gastrointestinal endoscopy.The primary outcome was the incidence of treatment-related AEs.The secondary outcomes were the time to extubation,the length of ICU stay,and the average cost of sedative per case.RESULTS:Of the 88 patients analyzed,47 were treated with remimazolam(mean dose,7.90±4.84mg),and 41 were treated with propofol(21.19±17.98 mg)or midazolam(3.08±2.17 mg).There was no statistically significant difference in the average duration of the endoscopic procedure(35.89±13.37 min vs.44.51±21.68 min,P=0.133)or the time to extubation(15.00±9.75 h vs.20.59±18.71 h,P=0.211)in the remimazolam group(group I)compared to the propofol or midazolam group(group II).ICU stays(5.40±2.93 d vs.4.63±3.31 d,P=0.072)and treatment-related AEs(48.61%vs.51.38%,P=0.056)were similar between groups.The average cost of sedative per case was significantly lower in the group I than in the group II(RMB 16.07±10.58 yuan vs.RMB 24.37±15.46 yuan,P=0.016).CONCLUSION:Remimazolam-based sedation was noninferior to the classic sedatives and had lower average cost per case,indicating that it may be used as a promising sedative for high-risk patients during endoscopic procedures in the ICU setting. | Yuan-rui Zhao Ke-sheng Huang Guo Hou Lan Yao Li-ping Lu Song Xu Ying-tao Lian Zhun Yao Zhui Yu | 2023 | World Journal of Emergency Medicine2023，14，1： | 0 |
| 7 | Quality of life and influencing factors between local and itinerant populations during the COVID-19 pandemic显示文摘Objective:To determine the difference in quality of life and its influencing factors between local and itinerant populations in Nanjing during COVID-19.Methods:The quality of life questionnaire,which was based on the Brief Scale of WHO Quality of Life and redesigned by the research group,was used to randomly investigate 1150 people in 5 districts of Nanjing.Results:A total of 1112 valid questionnaires were collected(local population,n=558;itinerant population,n=554).The quality of life of the itinerant population was significantly lower than the local population.The itinerant population scores in physiology,psychology,social relationships,and environment were lower than the local population(all P values<0.05).COVID-19 had a greater impact on the itinerant population than on the local population,especially in medical assistance,enjoyment of life,and interpersonal relationships(all P values<0.05).Conclusion:The itinerant population had a lower quality of life than that of the local population during the prevention and control pandemic of COVID-19,thus more social support and help is warranted. | Han-Lu Cao Yi-Yang Cao Xie Wei Wen-Shu Zhao Yi Zhang Wen-Fei Kong Xiang-Ning Yang Wan-Xuan Li Ze-Han Yu Zhui Zhang Jing-Ning Zhao Xuan Han Cao Chen Ning Ding | 2022 | Psychosomatic Medicine Research2022，4，3： | 0 |
| 8 | The ecological adaptability of cloned sheep to free-grazing in the Tengger Desert of Inner Mongolia,China显示文摘Since the birth of the first cloned sheep,somatic cell nuclear transfer technology has been successfully used to clone a variety of mammals.Cloned livestock have no apparent health risks,and the quality and safety of the cloned animal products are similar to non-cloned animals.The social behavior and environmental adaptability of postnatal cloned animals,especially when used for grassland farm production purposes,is unknown.In the present study,the cloned Dorper sheep equipped with GPS location devices were free-grazed in a harsh natural environment similar to conditions commonly experienced by Mongolian sheep.The main findings of this research were as follows.(1)Under free-grazing conditions,the cloned sheep showed excellent climatic and ecological adaptability.In extreme temperature conditions ranging from–30 to 40°C,the cloned sheep maintained acceptable body condition and behaved as other sheep.(2)The cloned sheep quickly adapted from a herd feeding strategy to the harsh environment and quickly exhibited a grazing regimen as other free-grazing sheep.(3)The cloned sheep exhibited free-grazing patterns and social behavior as other sheep.(4)The cloned sheep in the harsh environment thrived and produced healthy lambs.Overall,the cloned Dorper sheep exhibited excellent ecological adaptation,which is an important consideration for breeding meat sheep by cloning.The Dorper sheep readily adapted to the free-grazing conditions on the Mongolian plateau grassland,which attests to their ability to withstand harsh environmental conditions. | Xinxin LI Huijuan WANG Guanghua SU Zhuying WEI Chunling BAI Wuni-MENGHE Yanhui HOU Changqing YU Shorgan BOU Guangpeng LI | 2014 | Frontiers of Agricultural Science and Engineering2014，1，3： | 0 |
| 9 | Apigenin as a promising myocyte protectant against damage and degradation显示文摘Myocytes power the movement of all organs in the body.Damage to and degradation of myocytes causes hypokinesia and muscle-related degenerative diseases.Apigenin,a kind of flavone,is being used to treat many disorders.It exerts a host of different pharmacological activities,such as anti-inflammatory,anti-mutagenic,cardioprotective,and antioxidant effects.Accordingly,apigenin is considered a promising candidate for myocyte protection.In this review,we introduced the characteristics of apigenin.The means of apigenin protection of myocytes as well as the mechanism were summarized and discussed.The protective effects can be classified into proliferation-promoting,anti-inflammatory,atrophy-preventing,metabolism-increasing,and antioxidative effects.Additionally,we provided some outlook on the valuable applications of apigenin in sports medicine,which eagerly require further fundamental research. | XIAO HUANG ZHIHAI YU LIJUAN NING YU LEI XUEFEI ZHANG ZHUYING WANG | 2022 | BIOCELL2022，46，2： | 0 |
| 10 | Expert consensus on management of analgesia and sedation for patients with severe coronavirus disease 2019显示文摘The coronavirus disease 2019(COVID-19)has been declared a global pandemic and is a major public health issue worldwide.COVID-19 is a systemic disease damaging multiple organs,including the lung as the main target organ. | Xiang-Hong Yang Bo Hu You Shang Jiao Liu Ming Zhong Xiu-Lling Shang Zhi-Xiong Wu Zhui Yu Ren-Hua Sun Hong-Liang Wang Ming-Yan Zhao Mei Meng Qiang-Hong Xu Xia Zheng De-Chang Chen | 2020 | Chinese Medical Journal2020，，18： | 0 |
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