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| 1 | Study on incisional implantation of tumor cells by carbon dioxide pneumoperitoneum in gastric cancer of a murine model显示文摘 | Wang H Zheng MH Zhang HB Zhu J He JR Lu AG Ji YB Zhang MJ Jiang Y Yu BM Li HW | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 2 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 3 | Intrapleural heparin or heparin combined with human recombinant DNase is not effective in the treatment of emphysema in a rabbit model显示文摘 | Dikensoy O Zhu Z Na MJ etc | 2006 | Respirology2006，11，： | 1 |
| 4 | Angiotensin II promotes smooth muscle cell proliferation and migration through release of heparin-binding epidermal growth factor and activation of EGF-receptor pathway显示文摘 | Yang X Zhu MJ Sreejayan N | 2005 | Mol Cells2005，20，2： | 1 |
| 5 | Age-associated differences in activation of Akt/GSK-313 signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart 显示文摘 | Zhu J Rebecehi MJ Tan M | 2010 | J Gerontol A Biol Sei Med Sei2010，65，6： | 1 |
| 6 | Three-color flow cytometry analysis of tricistronic expression of eBFP, eGFP, and eYFP using EMCV-IRES linkages 显示文摘 | Zhu J Musco ML Grace MJ | 1999 | Cytometry1999，37，： | 1 |
| 7 | Practical application of molecular genetic testing as an aid to the surgical pathologic diagnosis of sarcoma:a prospective study显示文摘 | Hill DA O'Sullivan MJ Zhu X | 2002 | Am J Surg Pathol2002，26，8： | 1 |
| 8 | Angiopoietin-like 4 protein elevates the prosurvival intracellular O2 -:H2O2 ratio and confers anoikis resistance to tumors显示文摘 | Zhu P Tan MJ Huang RL Tan CK Chong HC Pal M Lam CR Boukamp P Pan JY Tan SH Kersten S Li HY Ding JL Tan NS | | 0，，03： | 1 |
| 9 | Diet quality and obesity inwomen: the Framinghan nutrition studies显示文摘 | Wolongevicz DM Zhu L Pencina MJ | 2010 | BJ Nutr2010，10，3122： | 1 |
| 10 | Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology 显示文摘 | Zhu YI Stiller MJ | 2000 | Skin Pharmacol Appl Skin Physiol2000，13，： | 1 |
| 11 | Characterisation of a novel transporter from Cryptosporidium parvum显示文摘 | LaGier MJ ' Keithly JS Zhu G | 2002 | Int J Parasitol2002，32，7： | 1 |
| 12 | A novel function for a glucose analog of blood group H antigen as a mediator of leukocyte-endothelial adhesion via intracellular adhesion molecule 1显示文摘 | Zhu K Amin MA Kim MJ | 2003 | J Biol Chem2003，278，21： | 1 |
| 13 | Effects of germination conditions on ascorbic acid level and yield of soybean sprouts显示文摘 | Xu MJ Dong JF Zhu MY | 2005 | J Sci Food Agric2005，85，6： | 1 |
| 14 | Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases显示文摘 | Soon F F Ng L M Zhou X E West G M Kovach A Tan M H Suino-Powell KM He Y Xu Y Chalmers MJ Brunzelle JS Zhang H Yang H Jiang H Li J Yong EL Cutler S Zhu JK Griffin PR Melcher K Xu HE | 2012 | Science2012，335，6064： | 1 |
| 15 | AMP-activated protein kinase and adipogenesis in sheep fetal skeletal muscle and 3T3- Ll cells显示文摘 | TongJ Zhu MJ Underwood KR | 2008 | J Anim Sci2008，86，6： | 1 |
| 16 | Practical application of molecular genetic testing as an aid to the surgical pathologic diagnosis of sarcoma显示文摘 | Hill DA O'Sullivan MJ Zhu XP | 2002 | AmJ Surg Pathol2002，26，8： | 1 |
| 17 | Oral administration of allergen extracts from mugwort pollen desensitizes specific allergen-induced allergy in mice 显示文摘 | Ma WJ Bao MJ Zhu JP | 2012 | Vaccine2012，30，8： | 1 |
| 18 | Understanding the effect of foreign gene dosage on the physiology of Piehia pas/oris by transcriptional analysis of key genes显示文摘 | Zhu T C Guo MJ Zhuang Y P | 2011 | Appl Microbiol Biotechnol2011，89，4： | 1 |
| 19 | cDNA cloning of growth hormone from giant panda (Ailuropoda melanoleuca) and its expression in Escherichia coli显示文摘 | Liao MJ Zhu MY Zheng X | 2003 | Comparative Biochemistry and Physiology Part B2003，135，： | 1 |
| 20 | AMP-activated protein kinase en-hances the expression of muscle-specific ubiquitin ligases despiteits activation of IGF-1/Akt signaling in C2C12 myotubes显示文摘 | Tong JF Yan X Zhu MJ | 2009 | CellBiochem2009，108，2： | 1 |
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