|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor显示文摘 | Liu HQ Zhang WY Luo XT Ye Y Zhu XZ | 2006 | 中国生物学文摘2006，20，10： | 34 |
| 2 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 3 | Effect of nitroprusside (nitric oxide) on endogenous dopamine release from rat striatal slices显示文摘 | Zhu XZ Luo LG | | 0，，： | 1 |
| 4 | The cultural shaping of depression:Somatic symptoms in China,psychological symptoms in north American显示文摘 | Ryder AG Yang J Zhu XZ | | 0，，02： | 1 |
| 5 | Roles of p53, c-myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor显示文摘 | Zhu XZ | 1999 | Brain Res Mol Brain Res1999，71，2： | 1 |
| 6 | The influence of multivalent phosphate structure on the properties of ionieally cross-linked ehitosan films for controlled drug release 显示文摘 | SHU XZ ZHU KJ | 2002 | Eur J Pharm Biopharm2002，54，2： | 1 |
| 7 | Transplantation of adipose-derived stem cel s overexpressing hHGF into cardiac tissue显示文摘 | Zhu XY Zhang XZ Xu L | | 0，，04： | 1 |
| 8 | Transcriptome profiling, molecular biological, and physiological studies reveal a major role for ethylene in cotton fiber cell elongation显示文摘 | SHI YH ZHU SW MAO XZ | 2006 | Plant Cell2006，18，： | 1 |
| 9 | A novel approach to prepare tripolyphosphate/ ehitosan complex beads for controlled release drug delivery 显示文摘 | Shu XZ Zhu KJ | 2000 | Iht J Pharma2000，201，1： | 1 |
| 10 | Increased expression and nuclear accumulation ofbasic fibroblast growth factor in primary cultured astrocytes followingischemic-like insults显示文摘 | Liu X Zhu XZ | 1999 | Brain Res M ol1999，71，： | 1 |
| 11 | Laboratory Assessment of Lubricants for Wheel/Rail Lubrication显示文摘The antiwear properties of two wheel/rail lubricating oils were tested and compared on an Amsler machine. Under same testing conditions, oil A (developed by authors) showed much better wear resistance and higher load-carrying capacity than oil B (imported from abroad). The X-ray diffraction (XRD) analyses of the worn surfaces showed that different extreme pressure (EP) lubricating films were formed on the surfaces when the rollers were lubricated with different oils under boundary Iubrication condition. The EP film of oil A was a composite film containing three compounds, FeO, FeSx and FeP, while oil B formed only a simple EP film of FePO4. The composite EP film showed lower shear strength and better antiwear property than the simple EP film,which brought about different wear resistance of the two wheel/rail lubricating oils. | Zhao, XZ Liu, JJ Zhu, BL Wang, CY | 1997 | Journal of Materials Science & Technology1997，13，1： | 1 |
| 12 | Study of prognostic predictors for non- small cell lung cancer显示文摘 | Fu XL Zhu XZ Shi DR | 1999 | Lung Cancer1999，23，2： | 1 |
| 13 | A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery显示文摘 | Shu XZ Zhu KJ | 2000 | Int J Pharm2000，201，1： | 1 |
| 14 | Roles of p53,c-Myc,Bcl-2,Bax and caspases in serum deprivation-induced neuronal apoptosis:a possible neuroprotective mechanism of basic fibroblast growth factor显示文摘 | Liu X Zhu XZ | 1999 | Neuroreport1999，10，14： | 1 |
| 15 | Expression of angiopoietin - 2 and vascular endothelial growth factor in mice cerebral cortex after permanent focal cerebral ischemia 显示文摘 | Wang RG Zhu XZ | 2002 | Acta Pharmacol Sin2002，23，5： | 1 |
| 16 | Expression of angiopoietin-2 and vascular endothelial growth factor in mice cerebral cortex after permanent focal cerebral ischemia 显示文摘 | Wang RG Zhu XZ | 2002 | Acta Pharmacol Sin2002，23，5： | 1 |
| 17 | Roles of p53,c-Myc,Bcl-2,Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor显示文摘 | Liu X Zhu XZ | 1999 | Brain Res Mol Brain Res1999，71，2： | 1 |
| 18 | Protective effect of ginsen- oside Rgl on dopamine-induced apoptosis in PC12 cell 显示文摘 | Chen XC Zhu YG Wang XZ | 2001 | Ac- ta Phannacol Sin2001，22，8： | 1 |
| 19 | Role of NKG2D in cytokine-in- duced killer cells against multiple myeloma cells 显示文摘 | Lu XZ Zhu AS Cai XH | 2012 | Cancer Biol & Ther2012，13，8： | 1 |
| 20 | Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder显示文摘 | Hu XZ Lipsky RH Zhu G | 2006 | Am J Hum Genet2006，78，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员