|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson’s Disease Model Mouse显示文摘Modulating basal ganglia circuitry is of great signifcance in the improvement of motor function in Parkinson’s disease(PD).Here,for the frst time,we demonstrate that noninvasive ultrasound deep brain stimulation(UDBS)of the subthalamic nucleus(STN)or the globus pallidus(GP)improves motor behavior in a subacute mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP).Immunohistochemical c-Fos protein expression confrms that there is a relatively high level of c-Fos expression in the STN-UDBS and GP-UDBS group compared with sham group(both p<0.05).Furthermore,STN-UDBS or GPUDBS signifcantly increases the latency to fall in the rotarod test on day 9(p<0.05)and decreases the time spent climbing down a vertical rod in the pole test on day 12(p<0.05).Moreover,our results reveal that STN-UDBS or GP-UDBS protects the dopamine(DA)neurons from MPTP neurotoxicity by downregulating Bax(p<0.001),upregulating Bcl-2(p<0.01),blocking cytochrome c(Cyt C)release from mitochondria(p<0.05),and reducing cleaved-caspase 3 activity(p<0.01)in the ipsilateral substantia nigra(SN).Additionally,the safety of ultrasound stimulation is characterized by hematoxylin and eosin(HE)and Nissl staining;no hemorrhage or tissue damage is detected.Tese data demonstrate that UDBS enables modulation of STN or GP neural activity and leads to neuroprotection in PD mice,potentially serving as a noninvasive strategy for the clinical treatment of PD. | Hui Zhou Lili Niu Long Meng Zhengrong Lin Junjie Zou Xiangxiang Xia Xiaowei Huang Wei Zhou Tianyuan Bian Hairong Zheng | 2019 | Research2019，，1： | 9 |
| 2 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 3 | Magnesium Alloy for Repair of Lateral Tibial Plateau Defect in Minipig Model显示文摘Bone graft substitutes are widely-studied as alternatives to bone grafts in the clinic.The currently available products are mostly ceramics and polymers.Considerable progress has been made in the study of the biodegradable magnesium alloys,which possess the necessary attributions of a suitable substitute,including an excellent mechanical property.In the present study,a minipig model of a lateral tibial plateau defect was used to evaluate the effectiveness of a magnesium alloy in the repair of a critical-sized defect.The micro-arc oxidation(MAO)-coated ZK60 alloy tablets and medical-grade calcium sulfate pellets were used as the test and control materials,respectively.Bone morphology was monitored by computed tomography after the implantation for 2 and 4 months.It was found that the bone morphology in minipigs following magnesium treatment was similar to that of the normal bone,whereas an abnormal and concave morphology was displayed following the calcium sulfate treatment.The average bone healing rate for the magnesium-treated defects was higher than that of the calcium sulfate-treated defects at the first 4 months following the implantation.Overall,magnesium treatment appeared to improve the defect repair as compared with the calcium sulfate treatment.Thus,the MAO-coated ZK60 alloy appears to be a useful biocompatible bone graft substitute,and further research on its biological activity in vivo is needed. | Qiang Zhang Xiao Lin Zhengrong Qi Lili Tan Ke Yang Zhuangqi Hu Yan Wang | 2013 | Journal of Materials Science & Technology2013，29，6： | 5 |
| 4 | Noninvasive Ultrasound Stimulation of Ventral Tegmental Area Induces Reanimation from General Anaesthesia in Mice显示文摘Evidence in animals suggests that deep brain stimulation or optogenetics can be used for recovery from disorders of consciousness(DOC).However,these treatments require invasive procedures.This report presents a noninvasive strategy to stimulate central nervous system neurons selectively for recovery from DOC in mice.Through the delivery of ultrasound energy to the ventral tegmental area,mice were aroused from an unconscious,anaesthetized state in this study,and this process was controlled by adjusting the ultrasound parameters.The mice in the sham group under isoflurane-induced,continuous,steady-state general anaesthesia did not regain their righting reflex.On insonation,the emergence time from inhaled isoflurane anaesthesia decreased(sham.13.63±0.53 min,ultrasound.1.5±0.19 min,p<0.001).Further,the induction time(sham.12.0±0.6 min,ultrasound.17.88±0.64 min,p<0.001)and the concentration for 50%of the maximal effect(EC50)of isoflurane(sham.0.6%,ultrasound.0.7%)increased.In addition,ultrasound stimulation reduced the recovery time in mice with traumatic brain injury(sham.30.38±1.9 min,ultrasound.7.38±1.02 min,p<0.01).This noninvasive strategy could be used on demand to promote emergence from DOC and may be a potential treatment for such disorders. | Tianyuan Bian Wen Meng Meihong Qiu Zhigang Zhong Zhengrong Lin Junjie Zou Yibo Wang Xiaowei Huang Lisheng Xu Tifei Yuan Zhili Huang Lili Niu Long Meng Hairong Zheng | 2021 | Research2021，，1： | 2 |
| 5 | Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance显示文摘Ultrasound stimulation is an emerging noninvasive option in treating neuropsychiatric disorders. The present study investigates the behavioral alterations resulting from ultrasound stimulation on the nucleus accumbens(NAc) in freely moving mice. Our results show that an acute ultrasound stimulation on the NAc, rather than the visual cortex or auditory cortex, led to a pronounced avoidance behavior, while repeated NAc ultrasound stimulation resulted in an obvious conditioned place aversion with changes in synaptic protein(Glu A1/2 subunit) expression. Notably, NAc ultrasound stimulation suppressed the morphine-induced conditioned place preference. The results provide evidence that NAc ultrasound stimulation can be applied as a potential noninvasive therapeutic option in treating psychiatric disorders. | Lili Niu Yanchen Guo Zhengrong Lin Zhe Shi Tianyuan Bian Lin Qi Long Meng Anthony AGrace Hairong Zheng Ti-Fei Yuan | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 6 | Spleen-preserving splenic lymph node dissection in radical total gastrectomy显示文摘Radical gastrectomy has been recognized as the standard surgical treatment for advanced gastric cancer, and essentially applied in a wide variety of clinical settings. The thoroughness of lymph node dissection is an important prognostic factor for patients with advanced gastric cancer. Splenic lymph node dissection is required during D2 radical gastrectomy for upper stomach cancer. This is often accompanied by removal of the spleen in the past few decades. A growing number of investigators believe, however, that the spleen plays an important role as an immune organ, and thus they encourage the application of a spleen- preserving method for splenic hilum lymph node dissection. | Zhigang Jie Zhengrong Li Yi Cao Yi Liu Mengmeng Jiang Liangqing Lin Guoyang Zhang | 2013 | Chinese Journal of Cancer Research2013，25，4： | 1 |
| 7 | Montelukast plus budesonide in the treatment of children with cough variant asthma efficacy observation显示文摘 | Lin Chunyu Li Zhengrong Xu Xiufeng Mao-industry | 2009 | Chinese Journal of Practical Medicine2009，4，20： | 1 |
| 8 | Motion correction for MR cystography by an image processing approach显示文摘 | LIN Qin LIANG Zhengrong DUAN Chaijie | 2013 | IEEE Transactions on Biomedical Engineering2013，60，9： | 1 |
| 9 | Skin penetration of topically applied white mustard extract and its effects on epidermal Langerhans cells and cytokines显示文摘 | Xiucai Guo Haoyang Lu Yuanyuan Lin Bao Chen Chuanbin Wu Zhengrong Cui Yinping Wang Yuehong Xu | 2013 | International Journal of Pharmaceutics2013，，1： | 1 |
| 10 | Purification and characterization of a cellulose from Bacillus subtilis YJ1 显示文摘 | Yin Lijun Lin Hsinhung Xiao Zhengrong | 2010 | J Mar Sci Technol2010，18，3： | 1 |
| 11 | Integral approach to compacton solutions of Boussinesq-like B ( m , n ) equation with fully nonlinear dispersion显示文摘 | Zhengrong Liu Qingmei Lin Qixiu Li | 2003 | Chaos Solitons and Fractals2003，，5： | 1 |
| 12 | Extracting the Group Velocity of Rayleigh Waves from the Cross Correlation of the Ambient Seismic Noise Between Two Seismic Stations显示文摘This paper uses the 8 broad-band stations' microseism data recorded by the Seismic Monitoring Network of Fujian Province to calculate the vertical correlation coefficient between two stations at intervals of 5 minutes. According to the time intervals technique we obtain the different coefficients and then add the correlative coefficients. Depending on this, we extract the group velocity of Rayleigh waves from the cross correlation of the ambient seismic noise between two seismic stations and figure out the group velocity' spatial distribution. The results show that the signal noise ratio (SNR) increases proportionally to the superposition times, but the results from different days are similar to one another. Synchronously, the arrival-time is also stable and there is no obvious change when coming across typhoons. It is found the velocity of the surface wave is 2.9~3.1km/s in Fujian Province, which is close to the observationally attained value. | Jin Xing Li Jun Lin Shu Zhou Zhengrong Kang Lanchi Ou Yiping | 2008 | Earthquake Research in China2008，22，3： | 0 |
| 13 | Oral Sexual Behavior Among HIV-Infected Men Who Have Sex with Men--China,February 2021显示文摘Summary What is already known about this topic?Unprotected oral sex carries a risk of the transmission of sexually transmitted infections(STIs),especially if the individual has poor oral health.What is added by this report?Most human immunodeficiency virus(HIV)infected men who have sex with men(MSM)had never used a condom when giving oral sex(89.30%,718/804)or receiving oral sex(90.32%,709/785).Among MSM with detectable viral loads who had ever received oral sex without a condom,40.00%reported ejaculation in their partner’s mouth. | Leiwen Fu Jin Zhao Weiran Zheng Yinghui Sun Tian Tian Bingyi Wang Luoyao Yang Xinyi Zhou Yi-Fan Lin Zhengrong Yang Hui Li Huachun Zou | 2022 | China CDC weekly2022，4，25： | 0 |
| 14 | Research Progress on the Effect of Massage on Immune System Function in Children显示文摘As a traditional Chinese medicine treatment,massage has significant clinical effect.In recent years,a large number of clinical studies have shown that the mechanism of massage in the treatment of diseases is related to the regulation of immune function.In this article,we review the existing problems and prospects of massage on children with diarrhea,asthma and recurrent respiratory tract infection in relation to its effect on the regulation of immune function. | Yameng Xu Lin Wu Fangfang Yang Zhengrong Ye | 2021 | Proceedings of Anticancer Research2021，5，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员