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| 1 | Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration显示文摘Biomaterials as bone substitutes are always considered as foreign bodies that can trigger host immune responses.Traditional designing principles have been always aimed at minimizing the immune reactions by fabricating inert biomaterials.However,clinical evidence revealed that those methods still have limitations and many of which were only feasible in the laboratory.Currently,osteoimmunology,the very pioneering concept is drawing more and more attention-it does not simply regard the immune response as an obstacle during bone healing but emphasizes the intimate relationship of the immune and skeletal system,which includes diverse cells,cytokines,and signaling pathways.Properties of biomaterials like topography,wettability,surface charge,the release of cytokines,mediators,ions and other bioactive molecules can impose effects on immune responses to interfere with the skeletal system.Based on the bone formation mechanisms,the designing methods of the biomaterials change from immune evasive to immune reprogramming.Here,we discuss the osteoimmunomodulatory effects of the new modification strategies—adjusting properties of bone biomaterials to induce a favorable osteoimmune environment.Such strategies showed potential to benefit the development of bone materials and lay a solid foundation for the future clinical application. | Yajuan Xie Cheng Hu Yi Feng Danfeng Li Tingting Ai Yulei Huang Xiaodan Chen Lijia Huang Jiali Tan | 2020 | Regenerative Biomaterials2020，7，3： | 22 |
| 2 | Spatial and temporal distribution of MODIS and MISR aerosol optical depth over northern China and comparison with AERONET显示文摘Aerosol optical depths (AODs) from MODIS and MISR onboard the Terra satellite are assessed by comparison with measurements from four AERONET sites located in northern China for the period 2006-2009. The results show that MISR performs better than MODIS at the SACOL and Beijing sites. For the Xianghe and Xinglong sites, MODIS AOD retrievals are better than those of MISR. Overall, the relative error of the Angstrom exponent from MISR compared with AERONET is about 14%, but the MODIS error can reach 30%. Thus, it may be better to use the MISR Angstrom exponent to derive wavelength-dependent AOD values when calculating the aerosol radiative forcing in a radiative transfer model. Seasonal analysis of AOD over most of China shows two main areas with high aerosol loading: the Taklimakan Desert region and the southern part of North China and northern part of East China. The locations of these two areas of high aerosol loading do not change with season, but the AOD values have significant seasonal variation. The largest AOD value in the Taklimakan appears in spring when the Angstrom exponents are the lowest, which means the particle radii are relatively large. Over North and East China, the highest aerosol loading appears in summer. The aerosol particles are smallest in summer over both high-AOD areas. | QI YuLei GE JinMing HUANG JianPing | 2013 | Chinese Science Bulletin2013，58，20： | 19 |
| 3 | Comparative Analysis of Characteristics of the Coupled and Decoupled Parallel Mechanisms显示文摘The existence of coupling makes the parallel mechanism possess some special advantages over the serial mechanism, while it is just the coupling that brings about the parallel mechanism some limitations, such as complex workspace, high nonlinear relationship between input and output, difficulties in static and dynamic analysis, and the development of control system, which restricts its application fields. The decoupled parallel mechanism is currently one of the research focuses of the mechanism fields, while the study on the different characteristics between the decoupled and coupled parallel mechanisms has not been reported. Therefore, this paper performs the systematic comparative analysis of the 3-RPUR and the 3-CPR parallel mechanisms. The features of the two mechanisms are described and their movement forms are analyzed with screw theory. The inverse and forward displacement solutions are solved and the Jacobian matrices are obtained. According to the Jacobian matrices and by using the theory of physical model of the solution space, the workspace, dexterity, velocity, payload capability, and stiffness of the mechanisms are analyzed with plotting the indices atlases. The research results prove that the effects of the coupling on the parallel mechanism are double-side, and then the adoption of the decoupled parallel mechanism should be determined by the requirements of the concrete application situation. The contents of this paper should be useful for the type synthesis and practical application of the parallel mechanism. | ZENG Daxing HOU Yulei LU Wenjuan HUANG Zhen | 2010 | Chinese Journal of Mechanical Engineering2010，23，4： | 17 |
| 4 | Type Synthesis and Characteristic Analysis of a Family of 2-DOF Rotational Decoupled Parallel Mechanisms显示文摘It is widely used for the rotational parallel mechanism in the field of spatial orientation. While owing to the existence of coupling, the forward kinematic solution and the control of the general rotational parallel mechanism are especially difficult. If decoupling can be realized, the kinematic analysis of the mechanism will be very simple. Presently, the research of the parallel mechanism is focused on the inverse solution and structure optimization, and there is a lack of rotation decoupled parallel mechanisms (DPMs). So this paper proposes a family of 2 degree of freedom (DOF) rotational DPMs based on the four-bar linkage mechanism, and performs a characteristic analysis. This family of DPMs is composed of a moving platform, a fixed base and three limbs. Taking U__RRU__SPU DPM as an example, the motion feature of this DPM is analyzed with the constraint screw method, and its mobility is calculated by using the Modified Kutzbach-Grübler criterion. The inverse and forward displacement problems of the proposed parallel mechanism are solved. The decoupled feature of the proposed parallel mechanism is validated by the deduction of the expression of the Jacobian matrix. Three kinds of singularity conditions of this DPM are discussed, and the atlases of the output parameter concerning different geometric parameters are plotted with the theory of the physical model of the solution space. The proposition and characteristic analysis of the novel rotational DPMs in this paper should be useful for further research and application of the parallel mechanisms. | ZENG Daxing Hou Yulei HUANG Zhen LU Wenjuan | 2009 | Chinese Journal of Mechanical Engineering2009，22，6： | 14 |
| 5 | NCP-Type Pincer Iridium Complexes Catalyzed Transfer-Dehydrogenation of Alkanes and Heterocycles显示文摘A series of NCP-type pincer iridium complexes,(RNCCp)IrHCl(2a-2c)and(BQ-NCOP)IrHCl 3,have been studied for catalytic transfer alkane dehydrogenation.Complex 3 containing a rigid benzoquinoline backbone exhibits high activity and robustness in dehydrogenation of alkanes to form alkenes.Even more importantly,this catalyst system was also highly effective in the dehydrogenation of a wide range of heterocycles to furnish heteroarenes. | Yulei Wang Lu Qian Zhidao Huang Guixia Liu Zheng Huang | 2020 | Chinese Journal of Chemistry2020，38，8： | 2 |
| 6 | Transforming growth factor-β1 induces glutathione peroxidase-1 and protectsfrom H2O2-induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF-1αpathway显示文摘 | Ying Huang Wenfeng Fang Yulei Wang Wancai Yang Bin Xiong | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
| 7 | Continuous production of 1,2-propanediol by the selective hydrogenolysis of solvent-free glycerol under mild conditions 显示文摘 | Huang Long Zhu Yulei Zheng Hongyan | 2008 | J Chem Tecnnol Biotechnnol2008，83，12： | 1 |
| 8 | Direct conversion of glycerol into 1,3-propanediol over Cu-H4SiW12 O40/SiO2 in vapor phase 显示文摘 | Huang Long Zhu Yulei Zheng Hongyan | 2009 | Catal Lett2009，131，12： | 1 |
| 9 | Direct conversion of glycerol into 1,3-propanediol over Cu-H4SiWt204o/SiO: in vapor phase显示文摘 | Huang Long Zhu Yulei Zheng Hongyan | 2009 | Catal Lett2009，131，： | 1 |
| 10 | Continuous production of 1,2-propanediol by the selective hydrogenolysis of solvent-free glycerol under mild condition显示文摘 | Huang Long Zhu Yulei Zheng Hongyan | 2008 | Journal of Chemical Technology and Biotechnology2008，83，12： | 1 |
| 11 | Direct conversation of glycerol into 1,3-propanediol over Cu-H4SiW12O40/SiO2 in vapor phase显示文摘 | Huang Long Zhu Yulei Zheng Hongyan | 2009 | Catalysis Letters2009，131，： | 1 |
| 12 | Comparative Transcriptome Analysis of Heart Tissue in Response to Hypoxia in Silver Sillago (Sillago sihama)显示文摘Sillago sihama,commonly known as silver sillago,is considered as an economically important fish species in China.It is sensitive to hypoxia stress in the larval stage,and the mechanism has not been understood thoroughly.In this study,we investigated the transcriptome change in heart tissues under hypoxia stress.The fish were divided into four groups,including 1 h of hypoxia(hypoxia1h,dissolved oxygen(DO)=1.5±0.1 mg L^(−1)),4h of hypoxia(hypoxia4h,DO=1.5±0.1 mg L^(−1)),4h of reoxygen(reoxygen4h,DO=8.0±0.2 mg L^(−1))after 4h of hypoxia(DO=1.5 mg L^(−1))and normoxia or control(DO=8.0±0.2 mg L^(−1))groups.The results showed that a total of 3068 genes were identified as differentially expressed genes(DEGs)based on the criteria∣log2(Fold change)∣>1.0 and adjusted P-value<0.05.A total of 7761141 and 1151 DEGs were obtained from hypoxia1h,hypoxia4h and reoxygen4h groups,respectively.The enrichment pathway analysis showed that the DEGs were significantly enriched in ribosome biogenesis in eukaryotes,retinol metabolism,DNA replication and the oxidative phosphorylation(OXPHOS)pathways.Thirteen DEGs from the RNA-seq results were validated by quantitative real-time polymerase chain reaction(qRT-PCR).These candidate genes are considered as important regulatory factors involved in the hypoxia stress response in S.sihama. | SAETAN Wanida YE Minghui LIN Xinghua LIN Xiaozhan ZHANG Yulei HUANG Yang DU Tao LI Guangli TIAN Changxu | 2021 | Journal of Ocean University of China2021，20，4： | 1 |
| 13 | Direct conversion of glycerol into 1,3-propanediol over Cu-H4SiW12O40/ SiO2 in vapor phase显示文摘 | Huang Long Zhu Yulei Zheng Hongyan | 2009 | Catal Lett2009，131，： | 1 |
| 14 | Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential显示文摘 | Shengjuan Hu Xinning Guo Huahong Xie Yulei Du Yanglin Pan Yongquan Shi Jun Wang Liu Hong Shuang Han Dongtao Zhang Dawei Huang Kedong Zhang Feihu Bai Haiping Jiang Huihong Zhai Yongzhan Nie Kaichun Wu Daiming Fan | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
| 15 | A novel approach for preparing red phosphorus microcapsule by hydro- thermal method 显示文摘 | ZHAO Yajuan HUANG Xing TAI Yulei | 2010 | Int J Chem2010，2，2： | 1 |
| 16 | Adenovirus-Mediated Vector of siRNA against VEGFR-2 (KDR) Induced Gene Silencing and Suppressed Tumor Cell Growth in Vitro and in Vivo显示文摘 | Dawei Huang Yanglin Pan Liu Hong Kaichun Wu Lijun Sun Yulei Du Liping Yao Daiming Fan | 2005 | Journal of US-China Medical Science2005，2，4： | 1 |
| 17 | Study on Cu-Mn-Si catalysts for synthesis of cyclohexanone and 2- methylfuran through the coupling process显示文摘 | ZHENG Hongyan ZHU Yulei HUANG Long | 2008 | Catalysis Communications2008，9，3： | 1 |
| 18 | Transforming growth factor-β1 induces glutathione peroxidase-1 and protects from H2O2- induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF- 1 α pathway显示文摘 | Ying Huang Wenfeng Fang Yulei Wang | 2012 | International Journal of Molecular Medicine2012，29，5： | 1 |
| 19 | Experimental measurement of bipartite entanglement using parameterized quantum circuits显示文摘Entanglement in quantum systems plays a crucial role in various quantum information tasks. Measuring entanglement has been an important issue in both experiments and theories. In this work, we use parameterized quantum circuits(PQCs) to diagonalize density matrices of quantum states and obtain entanglement by only measuring the diagonal elements. With this method, full quantum state tomography can be bypassed, greatly reducing the number of measurements. A comprehensive characterization of entanglement was performed by using Rényi entropy and partially transposed moments. Mutual information, calculated from entropy is also used to characterize dynamical quantum phase transitions. We experimentally demonstrated the method on a four-qubit nuclear magnetic resonance quantum simulator. Our results agree with the theoretical descriptions. The measurement complexity of our PQC-based method grows linearly with the number of diagonal elements in the density matrix, a square root reduction over the full quantum tomography. The proposed method can have great potential in quantum systems with a large number of particles. | Shunzhong Xue Yulei Huang Dafa Zhao Chao Wei Jun Li Ying Dong Jiancun Gao Dawei Lu Tao Xin Gui-Lu Long | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 0 |
| 20 | A Transcriptome Analysis of Neural Tissue of Litopenaeus vannamei After Acute Exposure to Alexandrium pacificum显示文摘Alexandrium pacificum(A.pacificum)is a typical paralytic shellfish poisonous dinoflagellate.Harmful algal blooms(HABs)caused by this species can bring serious environmental problems and economic losses to the aquaculture industry.In this study,transcriptome sequencing and analyses were performed on the neural tissue of Litopenaeus vannamei(L.vannamei)after acute exposure to A.pacificum disrupted solution for 72 h,and differentially expressed genes(DEGs)were identified.The results showed that,compared with the control samples,300 DEGs were identified in the experimental group,of which 194 were up-regulated,and 106 down-regulated.The gene ontology(GO)functional enrichment analysis showed that DEGs were significantly enriched in the cortical cytoskeleton organization,troponin complex,amylo-alpha-1,6-glucosidase and thymidine phosphorylase.Kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis found that DEGs were mainly enriched in the oxidative phosphorylation process,intercellular tight junctions and mitophagy.The results showed that the proteoglycans,signaling pathways,and various metabolic processes that regulate cell proliferation,differentiation,and apoptosis all played an essential role in the response of L.vannamei to A.pacificum toxins. | YANG Huijie HUANG Xianghu MA Yukun HU Zhangxi ZHANG Ning LI Changling ZHANG Yulei | 2024 | Journal of Ocean University of China2024，23，2： | 0 |
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