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| 1 | Characterization of interspecific hybrids and backcross progenies from a cross between Oryza minuta and Oryza sativa显示文摘Oryza minuta, a tetraploid wild relative of cultivated rice, is an important source for the genetic improvement. Interspecific hybrids were obtained from the cross of O. sativa L. (IR24) and O. minuta (Acc. No. 101133) with 5.58% crossability, which ranged from 0.11% to 1.62% in the backcross generations. The chromosome numbers of the backcross progenies were 24 to 48. Seven yield-related traits of the parents, hybrid F1, and backcross progenies were evaluated. Simple sequence repeat markers analysis showed that the polymorphism ratio of SSR bands between IR24 and Acc. No. 101133 was 93.2%. The average donor segment number, length, donor genome size, and percentage of donor genome of 92 BC3F1 plants (2n=24) were 24.1, 17.8 cM, 438.4 cM and 26.2%, respectively. They were complex variation and uneven among the chromosomes. These introgression lines could be used to identify the favorable genes of O. minuta and provide a new platform for the genetic improvement of cultivated rice. | GUO SiBin, QIN FaLan, ZHANG DuanPin & LIN XingHua· National Key Laboratory of Crop Genetic Improvement, National Center of Crop Molecular Breeding, Huazhong Agricultural University, Wuhan 430070, China | 2009 | Science China(Life Sciences)2009，52，12： | 9 |
| 2 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 3 | Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats显示文摘Chronic stress models,established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone,once per day,were given a daily oral feeding of 50 mg/kg baicalin.The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed rats.Results showed that subcutaneous injection of corticosterone significantly decreased the total number of doublecortin-positive neurons in the hippocampus.The reduced cell Ⅰ number caused by corticosterone was mainly due to the decrease of class Ⅱ doublecortin-positive neurons,but the class doublecortin-positive neurons were unaffected.Baicalin treatment increased the number of both class Ⅰ and class Ⅱ doublecortin-positive neurons.In addition,doublecortin-positive neurons showed less complexity in dendritic morphology after corticosterone injection,and this change was totally reversed by baicalin treatment.These findings suggest that baicalin exhibits a beneficial effect on adult neurogenesis. | Xinghua Jiang Junmei Xu Dingquan Zou Lin Yang Yaping Wang | 2013 | Neural Regeneration Research2013，8，6： | 6 |
| 4 | Soil heavy metal pollution from Pb/Zn smelting regions in China and the remediation potential of biomineralization显示文摘Smelting activities pose serious environmental problems due to the local and regional heavy metal pollution in soils they cause. It is therefore important to understand the pollution situation and its source in the contaminated soils. In this paper, data on heavy metal pollution in soils resulting from Pb/Zn smelting(published in the last 10 years) in China was summarized. The heavy metal pollution was analyzed from a macroscopic point of view. The results indicated that Pb, Zn, As and Cd were common contaminants that were present in soils with extremely high concentrations. Because of the extreme carcinogenicity, genotoxicity and neurotoxicity that heavy metals pose, remediation of the soils contaminated by smelting is urgently required. The primary anthropogenic activities contributing to soil pollution in smelting areas and the progressive development of accurate source identification were performed. Due to the advantages of biominerals, the potential of biomineralization for heavy metal contaminated soils was introduced. Furthermore, the prospects of geochemical fraction analysis, combined source identification methods as well as several optimization methods for biomineralization are presented, to provide a reference for pollution investigation and remediation in smelting contaminated soils in the future. | Xinghua Luo Chuan Wu Yongcheng Lin Waichin Li Min Deng Jingqiang Tan Shengguo Xue | 2023 | Journal of Environmental Sciences2023，，3： | 5 |
| 5 | Identification of the varietal origin of processed loose-leaf tea based on analysis of a single leaf by SNP nanofluidic array显示文摘Tea is an important cash crop, representing a $40 billion-a-year global market. Differentiation of the tea market has resulted in increasing demand for tea products that are sustainably and responsibly produced. Tea authentication is important because of growing concerns about fraud involving premium tea products. Analytical technologies are needed for protection and value enhancement of high-quality brands. For loose-leaf teas, the challenge is that the authentication needs to be established on the basis of a single leaf, so that the products can be traced back to the original varieties. A new generation of molecular markers offers an ideal solution for authentication of processed agricultural products. Using a nanofluidic array to identify variant SNP sequences, we tested genetic identities using DNA extracted from single leaves of 14 processed commercial tea products. Based on the profiles of 60 SNP markers, the genetic identity of each tea sample was unambiguously identified by multilocus matching and ordination analysis. Results for repeated samples of multiple tea leaves from the same products(using three independent DNA extractions) showed 100% concordance, showing that the nanofluidic system is a reliable platform for generating tea DNA fingerprints with high accuracy. The method worked well on green, oolong, and black teas, and can handle a large number of samples in a short period of time. It is robust and cost-effective, thus showing high potential for practical application in the value chain of the tea industry. | Wanping Fang Lyndel W.Meinhardt Huawei Tan Lin Zhou Sue Mischke Xinghua Wang Dapeng Zhang | 2016 | The Crop Journal2016，4，4： | 4 |
| 6 | Progress of the injection laser system of SG-Ⅱ显示文摘A high power laser system was used to drive the ignition of inertial confinement fusion(ICF), of which the high energy,the uniform focal spot, the accurate laser waveform, and the synchronization between the laser beams are key parameters.To accomplish this, global laser characteristics control should be assured, which was the main purpose of the injection laser system. In this paper, the key technological progress involved in the improvement of the performance of the injection laser of SG-II is reported, including frequency domain control, time domain control, near-field spatial shaping, preamplifier technology, and the optical parametric chirped pulse amplification pump source. | Wei Fan Youen Jiang Jiangfeng Wang Xiaochao Wang Dajie Huang Xinghua Lu Hui Wei Guoyang Li Xue Pan Zhi Qiao Chao Wang He Cheng Peng Zhang Wenfa Huang Zhuli Xiao Shengjia Zhang Xuechun Li Jianqiang Zhu Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，2： | 3 |
| 7 | CYP2A6 Polymorphisms Associate with Outcome of S-1 Plus Oxaliplatin Chemotherapy in Chinese Gastric Cancer Patients显示文摘Gastric carcinoma is a heterogeneous malignant disease involving genetic factors. To identify predictive markers for gastric cancer treatment in Chinese patients, we evaluated the association between polymorphisms of the gene encoding cytochrome P450 2A6(CYP2A6) and outcomes of S-1 plus oxaliplatin(SOX) chemotherapy treatment. Clinical data on 60 consecutive gastric cancer patients receiving SOX regimen were collected prospectively. We sequenced all exons of CYP2A6 and a total of 22 different polymorphisms were detected in the present study. Comprehensive analyses of these genetic polymorphisms were performed to determine their association with both safety and efficacy of SOX regimen. Our results showed that polymorphisms of CYP2A6 were associated with the safety and efficacy of SOX treatment. Among them, missense mutations CYP2A6 rs60823196 and rs138978736 could be possible risk factors(P < 0.05) for severe diarrhea induced by SOX, whereas CYP2A6 rs138978736 could be a conceivable predictor for overall survival of patients treated with SOX adjuvant chemotherapy. Further large-scale randomized prospective studies are warranted to confirm these findings. | Lin Yang Shanshan Zou Chang Shu Yan Song Yong-Kun Sun Wen Zhang Aiping Zhou Xinghua Yuan Yi Yang Songnian Hu | 2017 | Genomics, Proteomics & Bioinformatics2017，15，4： | 2 |
| 8 | SEGR-and SEB-hardened structure with DSPSOI in power MOSFETs显示文摘Single event irradiation-hardened power MOSFET is the most important device for DC/DC converter in space environment application. Single event gate rupture(SEGR) and single event burnout(SEB), which will degrade the running safety and reliability of spacecraft, are the two typical failure modes in power MOSFETs. In this paper, based on recombination mechanism of interface between oxide and silicon, a novel hardened power MOSFETs structure for SEGR and SEB is proposed. The structure comprises double stagger partial silicon-on-insulator(DSPSOI) layers. Results show that the safety operation area(SOA) of a 130 V N-channel power MOSFET in single event irradiation environment is enhanced by up to 50% when the linear-energy-transfer value of heavy ion is a constant of 98 MeV·cm^2/mg in the whole incident track, and the other parameters are almost maintained at the same value. Thus this novel structure can be widely used in designing single event irradiation-hardened power MOSFETs. | Zhaohuan Tang Xinghua Fu Fashun Yang Kaizhou Tan Kui Ma Xue Wu Jiexing Lin | 2017 | Journal of Semiconductors2017，38，12： | 2 |
| 9 | Study on the Heat Conduction of Phase-Change Material Microcapsules显示文摘The 3ω approach was used to measure the effective thermal conductivity of phase-change material microcapsules (PCMMs) based on urea formaldehyde and sliced paraffin. The effective thermal conductivities of PCMMs with different densities were measured within the phase-change temperature range. The relationships between effective thermal conductivity, density and temperature were analysed. The effective thermal conductivity reached peak values within the phase-change temperature range and the temperature peak value was consistent with the peak value of the phase-change temperature. The effective thermal conductivity increased with increasing density due to the decreased porosity of samples and their increased solid-phase conduction. | Gangtao Zhao Xiaohui Xu Lin Qiu Xinghua Zheng Dawei Tang | 2013 | Journal of Thermal Science2013，22，3： | 2 |
| 10 | Comprehensive genomic analysis and expression profiling of cysteine-rich polycomb-like transcription factor gene family in tea tree显示文摘Cysteine-rich polycomb-like(CPP)is a small gene family in plants,which plays key role in plant development and stress response.Although CPP transcription factors have been characterized in several other plant species,a genome-wide characterization of the CPP gene family has been absent in Camellia sinensis.In this study,we totally identified 7,8,and 8 non-redundant CsCPP genes in three published genomes,including Camellia sinensis var.assamica cv.Yunkang-10(CSA-YK10),Camellia sinensis var.sinensis cv.Biyun(CSS-BY)and Camellia sinensis var.sinensis cv.Shuchazao(CSS-SCZ).CPP proteins from tea tree and other plant species were classified into three groups,which were further divided into four subgroups based on phylogenetic relationships.Most CPP genes in the same subgroup had similar gene structures and conserved motifs.The cis-acting elements analysis indicated that CPP genes might be involved in plant growth,development and stress responses.Analysis of gene expression using qRT-PCR experiments validated that CPP genes exhibited different expression patterns across the examined tissues.All the genes were expressed differentially in a range of tissues,indicating that CPPs were involved in a range of developmental and physiological processes.This study has obtained new insights into the evolution and function of the CPP gene family in the growth and development of tea plants,and also provide candidate genes for further functional characterization in tea tree. | Hong Nan Yanglei Lin Xinghua Wang Lizhi Gao | 2021 | Horticultural Plant Journal2021，7，5： | 2 |
| 11 | Child sexual abuse and its relationship with health risk behaviors among rural children and adolescents in Hunan, China显示文摘 | Danhua Lin Xiaoming Li Xinghua Fan Xiaoyi Fang | 2011 | Child Abuse & Neglect2011，，9： | 1 |
| 12 | Ionic-Liquid-Doped Polyaniline Inverse Opals: Preparation, Characterization, and Application for the Electrochemical Impedance Immunoassay of Hepatitis B Surface Antigen 显示文摘 | XingHua Li Lin Dai Yan Liu | 2009 | Advanced Functionl Materials2009，19，： | 1 |
| 13 | Simultaneous Measurements of Thermal Conductivity and Thermal Diffusivity of SiO_2 Nano-Powder Using 3ωMethod显示文摘 | ZHENG Xinghua QIU Lin SU Guoping | 2011 | Journal of Engineering Thermophysics2011，，： | 1 |
| 14 | Luminescence properties of Ca 3 Si 2 O 7 : Dy 3+ phosphor for white light-emitting diodes显示文摘 | Xinghua Zhang Zunming Lu Fanbin Meng Long Hu Xuewen Xu Jing Lin Chengchun Tang | 2012 | Materials Letters2012，，： | 1 |
| 15 | Note:Non-Destructive Measurement of Thermal Effusivity of a Solid and Liquid Using a Freestanding Serpentine Sensor-Based 3a; Technique 显示文摘 | QIU Lin ZHENG Xinghua ZHU Jie | 2011 | Review of Scientific Instruments2011，82，08： | 1 |
| 16 | Thermal Conductivity and Thermal Diffusivity of SiO2 Nanopowder 显示文摘 | ZHENG Xinghua QIU Lin SU Guoping | 2011 | Journal of Nanoparticle Rearch2011，13，12： | 1 |
| 17 | Enhanced ferro-/piezoelectric properties of tape-casting-derived Er^(3+)-doped Ba_(0.85)Ca_(0.15)Ti_(0.9)Zr_(0.1O3) optoelectronic thick films显示文摘Er^(3+)-doped Ba_(0.85)Ca_(0.15)Ti_(0.9)Zr_(0.1O3)(xEr-BCTZ,x=0,0.005,0.01,0.015)multifunctional thick films were prepared by the tape-casting method,using sol-gel-derived nano-sized powders as the matrix material.The surface morphologies,photoluminescence,and electrical properties were investigated.Dense microstructures with pure perovskite structure were obtained in the thick films.By doping an appropriate amount of Er^(3+),the samples exhibit superior up-conversion photoluminescence performance and simultaneously enhanced electrical performances.In addition,relatively higher texture fractions(with the largest value of 83.5%)were realized through introducing plate-like BaTiO_(3) templates to make the thick film grow by the[001]_(c) orientation.And the ferro-/piezoelectric properties of the thick films were further improved,showing potential in the applications of micro-optoelectronic devices. | Jie XU Qiling LU Jinfeng LIN Cong LIN Xinghua ZHENG Tengfei LIN Xiao WU | 2020 | Journal of Advanced Ceramics2020，9，6： | 1 |
| 18 | Comparative Transcriptome Analysis of Heart Tissue in Response to Hypoxia in Silver Sillago (Sillago sihama)显示文摘Sillago sihama,commonly known as silver sillago,is considered as an economically important fish species in China.It is sensitive to hypoxia stress in the larval stage,and the mechanism has not been understood thoroughly.In this study,we investigated the transcriptome change in heart tissues under hypoxia stress.The fish were divided into four groups,including 1 h of hypoxia(hypoxia1h,dissolved oxygen(DO)=1.5±0.1 mg L^(−1)),4h of hypoxia(hypoxia4h,DO=1.5±0.1 mg L^(−1)),4h of reoxygen(reoxygen4h,DO=8.0±0.2 mg L^(−1))after 4h of hypoxia(DO=1.5 mg L^(−1))and normoxia or control(DO=8.0±0.2 mg L^(−1))groups.The results showed that a total of 3068 genes were identified as differentially expressed genes(DEGs)based on the criteria∣log2(Fold change)∣>1.0 and adjusted P-value<0.05.A total of 7761141 and 1151 DEGs were obtained from hypoxia1h,hypoxia4h and reoxygen4h groups,respectively.The enrichment pathway analysis showed that the DEGs were significantly enriched in ribosome biogenesis in eukaryotes,retinol metabolism,DNA replication and the oxidative phosphorylation(OXPHOS)pathways.Thirteen DEGs from the RNA-seq results were validated by quantitative real-time polymerase chain reaction(qRT-PCR).These candidate genes are considered as important regulatory factors involved in the hypoxia stress response in S.sihama. | SAETAN Wanida YE Minghui LIN Xinghua LIN Xiaozhan ZHANG Yulei HUANG Yang DU Tao LI Guangli TIAN Changxu | 2021 | Journal of Ocean University of China2021，20，4： | 1 |
| 19 | Fine Mapping of Xa2, a Bacterial Blight Resistance Gene in Rice显示文摘 | Qi He Dongbo Li Yongsheng Zhu Mingpu Tan Duanpin Zhang Xinghua Lin | 2006 | Molecular Breeding2006，，1： | 1 |
| 20 | Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase and Risk of Pancreatic Cancer显示文摘 | Li Wang Xiaoping Miao Wen Tan Xinghua Lu Ping Zhao Xiaohang Zhao Yi Shan Hui Li Dongxin Lin | 2005 | Clinical Gastroenterology and Hepatology2005，，8： | 1 |
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