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| 1 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 2 | Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis显示文摘 | Wei Li Baoyang Hu XuepengWang Tianda Li Tongtong Cui Dawei Yu Chao Liu Liyuan Jiang Guihai Feng Lei wang Rui Fu Xinxin Zhang Jie Hao Yukai Wang Liu Wang Qi Zhou | 2018 | Cell Research2018，28，1： | 2 |
| 3 | Research and Application on EngineeringCases based Three Stages Teaching Methodology 显示文摘 | Bihong Lu Yukai Li | 2013 | AdvancedMaterials Research2013，，： | 1 |
| 4 | Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro显示文摘Haploid pluripotent stem cells,such as haploid embryonic stem cells(haESCs),facilitate the genetic study of recessive traits.In vitro,fish haESCs maintain haploidy in both undifferentiated and differentiated states,but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested.Here,wereport thatmousehaESCs can differentiate in vitro into haploid epiblast stem cells(haEpiSCs),which maintain an intact haploid genome,unlimited self-renewal potential,and durable pluripotency to differentiate into various tissues in vitro and in vivo.Mechanistically,the maintenance of self-renewal potential depends on the Activin/bFGF pathway.We further show that haEpiSCs can differentiate in vitro into haploid progenitor-like cells.When injected into the cytoplasm of an oocyte,androgenetic haEpiSC(ahaEpiSCs)can support embryonic development until midgestation(E12.5).Together,these resultsdemonstrate durable pluripotency inmousehaESCs andhaEpiSCs,aswell asthe valuable potential of using these haploid pluripotent stem cells in high-throughput genetic screening. | Ling Shuai Yukai Wang Mingzhu Dong Xuepeng Wang Lisi Sang Mei Wang Haifeng Wan Guanzheng Luo Tiantian Gu Yan Yuan Chunjing Feng Fei Teng Wei Li Xiuying Liu Tianda Li Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2015 | Journal of Molecular Cell Biology2015，7，4： | 1 |
| 5 | Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells显示文摘Ubiquitin-specific peptidase 18(USP18)plays an important role in the development of CD11b^(+)dendritic cells(DCs)and Th17 cells,however,its role in the differentiation of other T cell subsets,especially in regulatory T(Treg)cells,is unknown.In our study,we used Usp18 K0 mice to study the loss of USP18 on the impact of Treg cell differentiation and function.We found that USP18 deficiency upregulates the differentiation of Treg cells,which may lead to disrupted homeostasis of peripheral T cells,and downregulates INF-y,IL-2,IL-17A producing CD4^(+)T cells and INF-γproducing CD8^(+)T cells.Mechanistically,we also found that the upre-gulation of Tregs is due to elevated expression of CD25 in Usp18 KO mice.Finally,we found that the suppressive function of Usp18 KO Tregs is downregulated.Altogether,our study was the first to identify the role of USP18 in Tregs differentiation and its suppressive function,which may provide a new reference for the treatment of Treg function in many autoimmune diseases,and USP18 can be used as a new therapeutic target for precise medical treatment. | Lu Yang Yukai Jing Danqing Kang Panpan Jiang Na Li Xinrong Zhou Yan Chen Lisa S.Westerberg Chaohong Liu | 2021 | Genes & Diseases2021，8，3： | 1 |
| 6 | Physical activity and cancer risk:a dose-response analysis for the Global Burden of Disease Study 2019显示文摘Objective Adopting a healthy lifestyle,including regular physical activity,is widely believed to decrease cancer risk.This study aimed to quantitatively establish the dose-response relationships between total physical activity and the risk of breast,colon,lung,gastric,and liver cancers.Methods A systematic review and dose-response analysis were conducted using PubMed and Embase from January 1,1980 to March 20,2023.Prospective cohort studies that examined the association between physical activity and the risks of any of the 5 outcomes were included.The search was confined to publications in the English language with a specific focus on human studies.Physical activity is standardized by using the data from US National Health and Nutrition Examination Surveys(NHANES)and the Global Burden of Disease 2019 database.Results A total of 98 studies,involving a combined population of 16,418,361 individuals,were included in the analysis.Among the included studies,57 focused on breast cancer,17 on lung cancer,23 on colon cancer,5 on gastric cancer,and 7 on liver cancer.Overall,elevated levels of physical activity exhibited an inverse correlation with the risk of cancer.The dose-response curve for lung cancer exhibited a non-linear pattern,with the greatest benefit risk reduction observed at 13,200 MET-minutes/week of physical activity,resulting in a 14.7%reduction in risk(relative risk 0.853,uncertainty interval 0.798 to 0.912)compared to the inactive population.In contrast,the dose-response curves for colon,gastric,breast,and liver cancers showed linear associations,indicating that heightened levels of total physical activity were consistently associated with reduced cancer risks.However,the increase in physical activity yielded a smaller risk reduction for colon and gastric cancers compared to breast and liver cancers.Compared to individuals with insufficient activity(total activity level<600 MET-minutes/week),individuals with high levels of activity(≥8,000 MET-minutes/week)experienced a 10.3%(0.897,0.860 to 0.934)risk reduction for breast cancer;5.9%(0.941,0.884 to 1.001)for lung cancer;7.1%(0.929,0.909 to 0.949)for colon cancer;5.1%(0.949,0.908 to 0.992)for gastric cancer;17.1%(0.829,0.760 to 0.903)for liver cancer.Conclusions This study demonstrated a significant inverse relationship between total physical activity and the risk of breast,gastric,liver,colon,and lung cancers. | Xiayao Diao Yudong Ling Yi Zeng Yueqian Wu Chao Guo Yukai Jin Xiaojiang Chen Shoucheng Feng Jianrong Guo Chao Ding Feiyu Diao Zhicheng Du Shanqing Li Haibo Qiu | 2023 | Cancer Communications2023，43，11： | 1 |
| 7 | Pathogenesis and preventive measures of environment-related cardiovascular disease in northern China显示文摘Cardiovascular diseases(CVDs)have been the top-ranked cause of human death in the world for years,according to the World Health Organization.Accumulating evidence from epidemiological data supports the view that the risk of CVDs is higher in northern China than in southern area.There is no doubt that living environment has become a crucial factor contributing to the occurrence and progression of CVDs in northern region.However,there have not been any clinical guidelines for the prevention strategy of environment-related CVDs,especially for cold exposure.Thus,there is an urgent need for better understanding of the clinical characteristics and underlying mechanisms of cold-induced CVDs in order to formulate and implement proper and effective measures for minimizing the risk of CVDs for people residing in low-temperature area.Cold exposure,air pollution,lack of sunlight and irrational diet are believed to be crucial factors responsible for environment-related CVDs,and preventive measures might be carried out accordingly to decrease the high risk of CVDs in northern China. | Yukai Cao Xuejie Han Xinbo Zhao Jiuxu Kan Yue Yuan Yue Li | 2022 | Frigid Zone Medicine2022，2，3： | 0 |
| 8 | Stability of unduloid bridges with free boundary in a Euclidean slab显示文摘We study the stability of unduloids with free boundary in the domain B between two parallel hyperplanes in R^(n+1). If the unduloid has one half of period in B and is sufficiently close to a cylinder, then for 2≤n≤10, it is unstable; while for n≥11, it is stable. If the unduloid has two or more halves of period in B and is sufficiently close to a cylinder, then for all n≥2, it is unstable. | Haizhong Li Yukai Xia Changwei Xiong | 2018 | Science China Mathematics2018，61，5： | 0 |
| 9 | Deformation monitoring of long-span railway bridges based on SBAS-InSAR technology显示文摘The deformation monitoring of long-span railway bridges is significant to ensure the safety of human life and property.The interferometric synthetic aperture radar(In SAR)technology has the advantage of high accuracy in bridge deformation monitoring.This study monitored the deformation of the Ganjiang Super Bridge based on the small baseline subsets(SBAS)In SAR technology and Sentinel-1A data.We analyzed the deformation results combined with bridge structure,temperature,and riverbed sediment scouring.The results are as follows:(1)The Ganjiang Super Bridge area is stable overall,with deformation rates ranging from-15.6 mm/yr to 10.7 mm/yr(2)The settlement of the Ganjiang Super Bridge deck gradually increases from the bridge tower toward the main span,which conforms to the typical deformation pattern of a cable-stayed bridge.(3)The sediment scouring from the riverbed cause the serious settlement on the bridge’s east side compared with that on the west side.(4)The bridge deformation negatively correlates with temperature,with a faster settlement at a higher temperature and a slow rebound trend at a lower temperature.The study findings can provide scientific data support for the health monitoring of long-span railway bridges. | Lv Zhou Xinyi Li Yuanjin Pan Jun Ma Cheng Wang Anping Shi Yukai Chen | 2024 | Geodesy and Geodynamics2024，15，2： | 0 |
| 10 | Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs显示文摘Introducing a combination of transcription factors such as Oct4,Sox2,Klf4 and c-Myc(OSKM)enables reprogramming which converts somatic cells into induced pluripotent stem cells(i PSCs)(Takahashi and Yamanaka,2006).i PSCs play an important role in clinical and regenerative medicine because they can be utilized to model a specific disease or differentiate into functional cells for transplantation.Enhancing the efficiency of induction | Xiaoyin Lu Yukai Wang Long Yan Libin Wang Wei Li Hongmei Wang | 2016 | Journal of Genetics and Genomics2016，43，10： | 0 |
| 11 | Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells显示文摘Epigenetic reprogramming of somatic cells into induced pluripotent stem cells(i PSCs)by overexpression of defined factors holds great promise for disease modeling and regenerative medicine(Takahashi and Yamanaka,2006;Robinton and Daley,2012).However,the stochastic reprogramming process often results in variable pluripotency levels of i PSC lines as measured by their in vivo developmental potential, | Zhikun Li Libin Wang Yukai Wang Lei Liu Liu Wang Wei Li Qi Zhou | 2015 | Journal of Genetics and Genomics2015，42，3： | 0 |
| 12 | Applications of intelligent computing in vehicular networks显示文摘Purpose–This paper aims to introduce vehicular network platform,routing and broadcasting methods and vehicular positioning enhancement technology,which are three aspects of the applications of intelligent computing in vehicular networks.From this paper,the role of intelligent algorithm in thefield of transportation and the vehicular networks can be understood.Design/methodology/approach–In this paper,the authors introduce three different methods in three layers of vehicle networking,which are data cleaning based on machine learning,routing algorithm based on epidemic model and cooperative localization algorithm based on the connect vehicles.Findings–In Section 2,a novel classification-based framework is proposed to efficiently assess the data quality and screen out the abnormal vehicles in database.In Section 3,the authors canfind when traffic conditions varied from freeflow to congestion,the number of message copies increased dramatically and the reachability also improved.The error of vehicle positioning is reduced by 35.39%based on the CV-IMM-EKF in Section 4.Finally,it can be concluded that the intelligent computing in the vehicle network system is effective,and it will improve the development of the car networking system.Originality/value–This paper reviews the research of intelligent algorithms in three related areas of vehicle networking.In thefield of vehicle networking,these research results are conducive to promoting data processing and algorithm optimization,and it may lay the foundation for the new methods. | Daxin Tian Weiqiang Gong Wenhao Liu Xuting Duan Yukai Zhu Chao Liu Xin Li | 2018 | Journal of Intelligent and Connected Vehicles2018，1，2： | 0 |
| 13 | Self-templating synthesis of biomass-based porous carbon nanotubes for energy storage and catalytic degradation applications显示文摘Dwindling energy sources and a worsening environment are huge global problems,and biomass wastes are an under-exploited source of material for both energy and material generation.Herein,self-template decoction dregs of Ganoderma lucidum-derived porous carbon nanotubes(ST-DDLGCs)were synthesized via a facile and scalable strategy in response to these challenges.ST-DDLGCs exhibited a large surface area(1731.51 m^(2)g^(-1))and high pore volume(0.76 cm^(3)g^(-1)),due to the interlacing tubular structures of precursors and extra-hierarchical porous structures on tube walls.In the ST-DDLGC/PMS system,the degradation efficiency of capecitabine(CAP)reached~97.3%within 120 min.Moreover,ST-DDLGCs displayed high catalytic activity over a wide pH range of 3–9,and strong anti-interference to these typical and ubiquitous anions in wastewater and natural water bodies(i.e.,H_(2)PO_(4)^(-),NO_(3)^(-),Cl^(-) and HCO_(3)^(-)),in which a ^(1)O_(2)-dominated oxidation was identified and non-radical mechanisms were deduced.Additionally,ST-DDLGC-based coin-type symmetrical supercapacitors exhibited outstanding electrochemical performance,with specific capacitances of up to 328.1 F g^(-1)at 0.5 A g^(-1),and cycling stability of up to 98.6%after 10,000 cycles at a current density of 2 A g^(-1).The superior properties of ST-DDLGCs could be attributed to the unique porous tubular structure,which facilitated mass transfer and presented numerous active sites.The results highlight ST-DDLGCs as a potential candidate for constructing inexpensive and advanced environmentally functional materials and energy storage devices. | Manman Xu Shiqi Fu Yukai Wen Wei Li Qiongfang Zhuo Haida Zhu Zhikeng Zheng Yuwen Chen Anqi Wang Kai Yan | 2024 | Green Energy & Environment2024，9，3： | 0 |
| 14 | SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism显示文摘The SARS-CoV-2 infection causes severe immune disruption.However,it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients.In our study,we have characterized the immunephe no type of B cells from 15 recovered COVID-19 patients,and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation,but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation.However,the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation.Interestingly,we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients.Moreover,the BCR signaling and early B-cell response were disrupted upon BCR stimulation.Mechanistically,we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism.In conclusion,we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhandng B-cell metabolism,which may provide a new intervention target to cure COVID-19. | Yukai Jing Li Luo Ying Chen Lisa S.Westerberg Peng Zhou Zhiping Xu Andres A.Herrada Chan-Sik Park Masato Kubo Heng Mei Yu Hu Pamela Pui-Wah Lee Bing Zheng Zhiwei Sui Wei Xiao Quan Gong Zhongxin Lu Chaohong Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 15 | The regulators of BCR signaling during B cell activation显示文摘B lymphocytes produce antibodies under the stimulation of specific antigens,thereby exerting an immune effect.B cells identify antigens by their surface B cell receptor(BCR),which upon stimulation,directs the cell to activate and differentiate into antibody generating plasma cells.Activation of B cells via their BCRs involves signaling pathways that are tightly controlled by various regulators.In this review,we will discuss three major BCR mediated signaling pathways(the PLC-g2 pathway,PI3K pathway and MAPK pathway)and related regulators,which were roughly divided into positive,negative and mutual-balanced regulators,and the specific regulators of the specific signaling pathway based on regulatory effects. | Yue Wen Yukai Jing Lu Yang Danqing Kang Panpan Jiang Na Li Jiali Cheng Jingwen Li Xingbo Li Zican Peng Xizi Sun Heather Miller Zhiwei Sui Quan Gong Boxu Ren Wei Yin Chaohong Liu | 2019 | Blood Science2019，1，2： | 0 |
| 16 | Investigation on occupant presence and appliance operation schedules for university campus in south China sub-tropical area显示文摘Building occupant presence during varying periods is crucial to the performance studies of buildings and city regions.However,the understanding of the building occupancies on the university campus remains limited.To address this gap,our study employs field measurements,payment records,course arrangements,and building access systems to depict the occupancy patterns of the canteen,dormitory,library,and teaching and lab buildings during weekdays and weekends.We found that the occupancy rates across different buildings are somehow interrelated,given that the total number of occupants on campus is generally constant.Notably,dormitory occupancy rates tend to be low during the morning and afternoon course hours,which inversely correlates with the high occupancy rates in the teaching and lab buildings during these periods.Similarly,canteens experience surges in occupancy during meal times,which coincide with a decrease in library usage.Moreover,we established appliance operation schedules for dormitories through surveys and on-site investigations.Water dispensers and electronic devices were identified as the primary energy consumers for both male and female occupants,with desk-top fans and hairdryers being significant energy users for male and female occupants,respectively.These findings are essential for energy studies within a campus setting,underlining the importance of considering occupant behaviors on a regional scale. | Siwei Lou Zhongyuan Lin Yukai Zou Dawei Xia Yu Huang Zhuohong Li Zhaowen Gu | 2024 | Building Simulation2024，17，2： | 0 |
| 17 | Frequency-tunable microwave quantum light source based on superconducting quantum circuits显示文摘A non-classical light source is essential for implementing a wide range of quantum information processing protocols,including quantum computing,networking,communication and metrology.In the microwave regime,propagating photonic qubits,which transfer quantum information between multiple superconducting quantum chips,serve as building blocks for large-scale quantum computers.In this context,spectral control of propagating single photons is crucial for interfacing different quantum nodes with varied frequencies and bandwidths.Here a deterministic microwave quantum light source was demonstrated based on superconducting quantum circuits that can generate propagating single photons,time-bin encoded photonic qubits and qudits.In particular,the frequency of the emitted photons can be tuned in situ as large as 200 MHz.Even though the internal quantum efficiency of the light source is sensitive to the working fre-quency,it is shown that the fidelity of the propagating photonic qubit can be well preserved with the time-bin encoding scheme.This work thus demonstrates a versatile approach to realizing a practical quantum light source for future distributed quantum computing. | Yan Li Zhiling Wang Zenghui Bao Yukai Wu Jiahui Wang Jize Yang Haonan Xiong Yipu Song Hongyi Zhang Luming Duan | 2023 | Chip2023，2，3： | 0 |
| 18 | Regulatory Effect of JAK2/STAT3 on the Immune Function of Endotoxin-tolerant Dendritic Cells and its Involvement in Acute Liver Failure显示文摘Background and Aims:Acute liver failure(ALF)is a potentially fatal clinical syndrome with no effective treatment.This study aimed to explore the role of Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)pathway in modulating the phenotype and immune function of endotoxin-tolerant dendritic cells(ETDCs).In addition,we explored the use of EDTCs in an experimental model of ALF and investigated the associated mechanisms.Methods:In the in vitro experiment,ETDCs were transfected with adenovirus to induce SOCS1^(+/+)ETDCs and SOCS1^(−/−)ETDCs.Thereafter,costimulatory molecules and mixed lymphocyte reaction were assessed.Experimental mice were randomly divided into normal control,ALF,ALF+mock-ETDCs,ALF+SOCS1^(+/+)ETDCs,ALF+AG490,and ALF+AG490+SOCS1^(+/+)ETDCs groups.We examined the therapeutic effect of adoptive cellular immunotherapy by tail-vein injection of target ETDCs 12 h before ALF modeling.AG490,a JAK2/STAT3 inhibitor,was used in the in vivo experiment to further explore the protective mechanism of SOCS1^(+/+)ETDCs.Results:Compared with control ETDCs,SOCS1^(+/+)ETDCs had lower expression of costimulatory molecules,weaker allostimulatory ability,lower levels of IL-6 and TNF-αexpression and higher IL-10 secretion.SOCS1^(−/−)ETDCs showed the opposite results.In the in vivo experiments,the ALF+SOCS1^(+/+)ETDCs and ALF+AG490+SOCS1^(+/+)ETDCs groups showed less pathological damage and suppressed activation of JAK2/STAT3 pathway.The changes were more pronounced in the ALF+AG490+SOCS1^(+/+)ETDCs group.Infusion of SOCS1^(+/+)ETDCs had a protective effect against ALF possibly via inhibition of JAK2 and STAT3 phosphorylation.Conclusions:The SOCS1 gene had an important role in induction of endotoxin tolerance.SOCS1^(+/+)ETDCs alleviated lipopolysaccharide/D-galactosamine-induced ALF by downregulating the JAK2/STAT3 signaling pathway. | Yukai Chen Chaochen Hou Naibin Yang Yanyan Yang Youran Chen Deyong Kong Yuchun Jiang Minghao Lin Sijie Zheng Shanshan Li Mingqin Lu | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 0 |
| 19 | One-step cell biomanufacturing platform:porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo显示文摘Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s disease.Transplantation of midbrain dopaminergic progenitor cells is a promising treatment for Parkinson’s disease.However,transplanted cells can be injured by mechanical damage during handling and by changes in the transplantation niche.Here,we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells.These beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion,effectively maintaining axonal integrity in vitro.Importantly,midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts.Overall,our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation. | Lin Feng Da Li Yao Tian Chengshun Zhao Yun Sun Xiaolong Kou Jun Wu Liu Wang Qi Gu Wei Li Jie Hao Baoyang Hu Yukai Wang | 2024 | Neural Regeneration Research2024，19，2： | 0 |
| 20 | An asymmetric catalytic multi-component reaction enabled the green synthesis of isoserine derivatives and semi-synthesis of paclitaxel显示文摘Paclitaxel(Taxol^(@))as a cornerstone of chemotherapy remains in high demand.The semi-synthesis of paclitaxel via coupling of Taxus leaf-produced baccatin III and manually synthesized isoserine(C-13 side chain)is one of the solutions to avoid environmental damage caused by the sacrifice of the whole Taxus brevifolia.A green synthesis of the C-13 side chain is pivotal to the green production of paclitaxel.We herein report a green synthesis of isoserine derivatives and the semi-synthesis of paclitaxel via a straightforward assembly of isoserines based on an Rh2(TPA)3(OAc)/CPA1 co-catalyzed asymmetric multi-component reaction of ethyl diazoacetate,triethyl silanol and N-(anthrancen-9-ylmethyl)benzaldimine.The method is featured by improved atom economy,effective mass yield,and environmental factors compared to our previous racemic method and BMS company's semi-synthesis method.And the method allows for rapid access to paclitaxel derivatives with varied C-13 side chains. | Taoda Shi Xinglin Li Yukai Li Xiang Fu Linna Wu Dengqing Wu Wenhao Hu | 2023 | Green Synthesis and Catalysis2023，4，1： | 0 |
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