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| 1 | Deactivation mechanism of beta-zeolite catalyst for synthesis of cumene by benzene alkylation with isopropanol显示文摘The alkylation of benzene with isopropanol over beta-zeolite is a more cost-effective solution to cumene production. During the benzene alkylation cycles, the cumene selectivity slowly increased, while the benzene conversion presented the sharp decrease due to catalyst deactivation. The deactivation mechanism of betazeolite catalyst was investigated by characterizing the fresh and used catalysts. The XRD, SEM and TEM results show that the crystalline and particle size of the beta-zeolite catalyst almost remained stable during the alkylation cycles. The drop in catalytic activity and benzene conversion could be explained by the TG, BET,NH_3-TPD and GC–MS results. The organic matters mainly consisted of ethylbenzene, p-xylene and 1-ethyl-3-(1-methyl) benzene produced in the benzene alkylation deposited in the catalyst, which strongly reduced the specific surface area of beta-zeolite catalyst. Moreover, during the reaction cycles, the amount of acidity also significantly decreased. As a result, the catalyst deactivation occurred. To maintain the catalytic performance,the catalyst regeneration was carried out by using ethanol rinse and calcination. The deactivated catalyst could be effectively regenerated by the calcination method and the good catalytic performance was obtained. | Yefei Liu Yang Zou Hong Jiang Huanxin Gao Rizhi Chen | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 4 |
| 2 | A Streptococcus suis serotype 2 caused streptococcal toxic shock syndrome(STSS) in a patient显示文摘Streptococcus suis(S.suis)is a Gram-positive,facultatively anaerobic coccus that has been implicated as the cause of a wide range of clinical disease syndromes in swine and other domestic animals.S.suis has also been implicated in disease in humans,especially among abattoir workers,swine and pork handlers.Here we report a case of streptococcal toxic shock syndrome(STSS)caused by S.suis in a 59-year-old man.Despite of intensive treatment,the patient died of shock with multiple organ failure 14 h after admission.One bacterial isolate obtained from blood culture was identified to the species level by biochemical tests and serological tests as S.suis serotype 2.Identification was confirmed by PCR amplification of genes encoding 16sRNA of S.suis and the capsule of S.suis serotype 2(cps 2J).Genes encoding virulence factors were also detected.An investigation to identify the source of S.suis revealed that several days before admission the affected man had been handling sick pigs or their meat.Transmission may occur through breaks in the skin of feet with tinea due to that no measures for personal protection was taken.This case should highten awareness of the potential for occupational exposure and human infection with S.suis. | Yefei Zhu Zhongmin Tan Lingyang Zhu Hongxing Pan Xuejun Zhang Lei Xu Huimin Qian Ling Gu Xun Ye Chen Dong Changjun Bao Rongqiang Zhu Fengcai Zhu Hua Wang | 2008 | Journal of Nanjing Medical University2008，22，5： | 3 |
| 3 | Violent offences of methamphetamine users and dilemmas of forensic psychiatric assessment显示文摘Methamphetamine(MA),an extremely addictive synthetic stimulant,has quickly spread to become the most frequently used illicit drug in China.People with a history of chronic and heavy MA use have a high possibility of exhibiting schizophrenia-like psychotic symptoms,mainly delusions of reference,auditory hallucinations and cognitive deficits.These emerging findings suggest MA use increases aggression and violence and that there is a correlation between MA use and violence.However,it is unclear how to assess the capacity of criminal responsibility in“MA-induced”psychosis and how to set clear boundaries between schizophrenia and MA-induced psychosis when only limited and inconsistent evidence is available.Furthermore,a final persuasive differential diagnostic method based on improved understanding of schizophrenia and MA-induced psychotic disorders has yet to be developed.This paper will evaluate the epidemiology,social harm,and forensic psychiatric assessment of MA users,propose a future direction for the differential diagnosis between MA-induced psychotic disorders and schizophrenia,and put forward some practical solutions to assess the capacity of criminal responsibility of defendants with drug-induced psychotic disorder. | Yi Liu Bo Hao Yanwei Shi Li Xue Xiaoguang Wang Yefei Chen Hu Zhao | 2017 | Forensic Sciences Research2017，2，1： | 3 |
| 4 | Tribological performance of hydrogenated diamond-like carbon coating deposited on superelastic 60NiTi alloy for aviation selflubricating spherical plain bearings显示文摘It is imperative to develop a novel matching of metallic substrate and self-lubricating coating for aircraft spherical plain bearing in a wide range of service conditions.As a new type of superelastic material,60NiTi alloy meets the performance requirements of aerospace bearing materials,but exhibits poor tribological performance,especially under the conditions of dry sliding friction.A Hydrogenated Diamond-Like Carbon(H-DLC)coating was deposited on the 60NiTi alloy to improve its tribological performance.The microstructure and mechanical behavior of the 60NiTi alloy and its H-DLC coating were explored.Results show that improvement of friction and wear performance of the H-DLC coating deposited on the 60NiTi substrate is mainly achieved by graphitization at the friction interface and the transfer film produced on the counterpart ball.The increased friction load leads to intensification of graphitization at the friction interface and formation of continuous and compact transfer film on the surface of the counterpart ball. | Yefei ZHOU Zhihao CHEN Zhonghui HU Lei LI Qingxiang YANG Xiaolei XING | 2022 | Chinese Journal of Aeronautics2022，35，12： | 2 |
| 5 | A systematic review of radiofrequency ablation versus percutaneous ethanol injection for small hepatocellular carcinoma up to 3 cm显示文摘 | Ai Shen Hua Zhang Chengyong Tang Yong Chen Yefei Wang Chao Zhang Zhongjun Wu | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 6 | Phenol hydrogenation to cyclohexanone over palladium nanoparticles loaded on charming activated carbon adjusted by facile heat treatment显示文摘Selective phenol hydrogenation is a green approach to produce cyclohexanone.It still remains a big challenge to prepare efficient supports of the catalysts for the phenol hydrogenation via a simple and cost-effective approach.Herein,a facile approach was developed,i.e.,direct calcination of activated carbon(AC)under argon at high temperature,to improve its structure and surface properties.The modified AC materials were supported with Pd nanoparticles(NPs)to fabricate the Pd/C catalysts.The as-prepared Pd/C600 catalyst exhibits superior catalytic performance in the phenol hydrogenation,and its turnover frequency(TOF)value is 199.2 h^-1,1.31 times to that of Pd/C-raw.The Pd/C600 catalyst presents both better hydrophobicity and more structural defects,contributing to the improved dispersibility in the reaction solution(phenol-cyclohexane),the better Pd dispersion and the smaller Pd size,which result in the enhancement of the catalytic performance.Furthermore,the as-prepared Pd/C600 catalyst shows a good recyclability. | Chunhua Zhang Guangxin Yang Hong Jiang Yefei Liu Rizhi Chen Weihong Xing | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 2 |
| 7 | The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients显示文摘 | Yefei Huang Weimin Wang Yansu Chen Yulin Huang Jianbing Zhang Song He Yongfei Tan Fulin Qiang Aiping Li Oluf Dimitri R?e Shouyu Wang Yan Zhou Jianwei Zhou | 2014 | Journal of Gastroenterology2014，，11： | 2 |
| 8 | Effect of yttrium on the cyclic oxidation behavior of HP40 heat-resistant steel at 1373K显示文摘 | Jingbo Yan Yimin Gao Long Liang Zhaozhong Ye Yefei Li Wei Chen Jianjun Zhang | 2011 | Corrosion Science2011，53，： | 1 |
| 9 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 10 | Zinc reverses glycine-dependent inactivation of NMDARs in cultured rat hippocampal neurons显示文摘In the presence of glutamate and co-agonists, e.g., glycine, the N-methyl-D-aspartate receptor (NMDAR) plays an important role in physiological and pathophysiological brain processes. Previous studies indicate glycine could inhibit NMDAR responses induced by high concentration of NMDA in hippocampal neurons. The mechanism underlying this inhibitory impact, how- ever, has been unclear. In this study, the whole-cell patch-clamp recording and Ca 2+ imaging with Fluo-3/AM under laser scanning confocal microscope were used to analyze the possible involvement of NMDAR subunits in this effect. We found that the peak current of NMDARs and Ca 2+ influx induced by high concentration of NMDA were reduced by treatment of glycine (0.03-10 mol L 1 ) in a dose-dependent manner, and that the glycine-dependent inhibition of NMDAR responses, which were induced at 300 mol L 1 NMDA, was reversed by ZnCl 2 through the blocking of the NR2A subunit of NMDARs, but was less influenced by ifenprodil, a NR2B inhibitor. Our results suggest that the glycine-dependent inactivation of NMDARs is potentially modulated by the regulatory subunit NR2A. | LI Xia CHEN ZhaoQin JIANG Zheng LI YeFei ZHANG YunFeng | 2012 | Science China(Life Sciences)2012，55，12： | 0 |
| 11 | Application of Stochastic Modeling Technique Constrained by Multilateral Horizontal Well显示文摘Introduction With the advancement of horizontal well drilling and completion techniques, horizontal well is widely used in the oilfield development and has brought enormous economic benefits. The GeoSteering technique | Zhao Mingzhang Yu Miao Xue Lei Chen Dongmei Chen Yefei | 2013 | China Oil & Gas2013，20，2： | 0 |
| 12 | A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys显示文摘Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural networks.However,few retro-grade AAV capsids have been shown to offer access to cor-tical projection neurons across different species and enable the manipulation of neural function in non-human primates(NHPs).Here,we report the development of a novel retro-grade AAV capsid,AAV-DJ8R,which efficiently labeled cortical projection neurons after local administration into the striatum of mice and macaques.In addition,intrastriatally injected AAV-DJ8R mediated opsin expression in the mouse motor cortex and induced robust behavioral alterations.Moreover,AAV-DJ8R markedly increased motor cortical neuron firing upon optogenetic light stimulation after viral delivery into the macaque putamen.These data demonstrate the usefulness of AAV-DJ8R as an efficient retrograde tracer for cortical projection neurons in rodents and NHPs and indicate its suitability for use in conducting functional interrogations. | Yefei Chen Jingyi Wang Jing Liu Jianbang Lin Yunping Lin Jinyao Nie Qi Yue Chunshan Deng Xiaofei Qi Yuantao Li Ji Dai Zhonghua Lu | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 13 | The Research for Surface Properties of Steel Slag Powder and High-Temperature Rheological Properties of Asphalt Mortar显示文摘In order to evaluate the feasibility of steel slag powder as filler,the coating properties of steel slag and limestone aggregate were compared by water boiling test,the micro morphology difierences between steel slag powder and mineral powder(limestone powder)were compared by scanning electron microscope(SEM),and the high-temperature rheological properties of asphalt mortar with difierent ratio of filler quality to asphalt quality(F/A)and difierent substitution rates of mineral powder(S/F)were studied by dynamic shear rheological test.The results show that the surface microstructure of steel slag powder is more abundant than that of mineral powder,and the adhesion of steel slag to asphalt is better than that of limestone.At the same temperature,the lower the ratio of S/F is,the greater the rutting factor and complex modulus will be.In addition,the complex modulus and rutting factor of the asphalt mortar increase with the increase of F/A,and the filler type and F/A have a negligible efiect on the phase angle. | WANG Yefei YUAN Yan YANG Lihong LIU Yong CHEN Yiwen | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，5： | 0 |
| 14 | Metastable hybridized structure transformation in amorphous carbon films during friction-A study combining experiments and MD simulation显示文摘Amorphous carbon films have attracted substantial interest due to their exceptional mechanical and tribological properties.Previous studies revealed that the amorphous carbon films exhibited lower coefficient of friction(COF)because of the transformation in bond structure from sp^(3)-C to sp^(2)-C during friction processes.However,the mechanism for such a transformation during friction is not well understood.This study is conducted to get an insight into the metastable transformation in amorphous carbon film during friction by means of experiments and molecular dynamics(MD)simulation.Relevant wear tests showed that wear of the film changed from an abrasive wear mode to a mixture of abrasion and adhesive wear,resulting in a decrease in growth rate of the wear rate after the running-in stage.It is worth noting that the sp^(3)-C atoms were increased during the running-in stage when the films contained lower sp^(3)/sp^(2) ratios.However,the formed sp^(3)-C atoms could only be short-lived and gradually transformed to sp^(2)-C atoms with the graphitization generated on the wearing surface of the films.The radial distribution function and translational order parameter indicated that the films'high sp^(3)/sp^(2) ratio led to an increased sp^(2)-C proportion on the wear scar after friction,which caused an increased structural ordering. | Yefei ZHOU Zhihao CHEN Tao ZHANG Silong ZHANG Xiaolei XING Qingxiang YANG Dongyang LI | 2023 | Friction2023，11，9： | 0 |
| 15 | Digestive tract reconstruction in pancreaticoduodenectomy in University Hospitals of China: a national questionnaire survey显示文摘Background Pancreaticoduodenectomy(PD)has been widely applied in general hospitals in China;however,there is still a lack of unified standards for each surgical technique and procedure.This survey is intended to investigate the current status of digestive tract reconstruction after PD in university hospitals in China.Method A cross-sectional survey was conducted among the members of the Young Elite Pancreatic Surgery Club of China by using the Questionnaire for Digestive Tract Reconstruction after Pancreaticoduodenectomy.The questionnaire was disseminated and collected by point-to-point communication via WeChat public platforms.Results A total of 73 valid questionnaires were returned from 65 university hospitals in 28 provincial divisions of China's Mainland.The respondents who performed PD surgery with an annual volume of over 100 cases accounted for 63%.Generally,laparoscopic PD was performed less often than open PD.Child and Whipple reconstructions accounted for 70%and 26%,respectively.The sequence of pancreatoenteric,biliary-enteric,and gastrointestinal reconstruction accounted for 84%of cases.In pancreatoenteric anastomosis,double-layer anastomosis is the most commonly employed type,accounting for approximately 67%,while single-layer anastomosis accounts for 30%.Of the double-layer anastomoses,duct-to-mucosa/dunking(94%/4%)PJ was performed with duct-mucosa using the Blumgart method(39%)and Cattel-Warren(29%),with continuous/interrupted sutures in the inner layer(69%/31%)and continuous/interrupted sutures in the outer layer(53%/23%).In single-layer anastomosis,continuous/interrupted sutures accounted for 41%/45%.In hepatojejunostomy,single-layer/double-layer suture accounted for 79%/4%,and continuous/interrupted suture accounted for 75%/9%.Forty-six percent of the responding units had not applied double-layer biliary-intestinal anastomosis in the last 3 years,75%of the responding surgeons chose the anastomosis method according to bile duct diameter,with absorbable/non-absorbable suture accounting for 86%/12%.PD/pylorus-preserving PD accounted for 79%/11%of GJ cases,the distance between GJ and HJ<30 cm,30-50 cm and>50 cm were 11%,75%,and 14%,respectively.Antecolic/retrocolic GJ accounted for 71%/23%of cases.Twenty-two percent of GJ cases employed Braun anastomosis,while 55%and 19%of GJ cases used linear cutting staplers/tube-type staplers,respectively;60%/14%were reinforced/not reinforced via manual suturing after stapler anastomosis.Manual anastomosis in GJ surgery employed absorbable/non-absorbable sutures(91%/9%).Significant differences in reconstruction techniques were detected between different volumes of PD procedures(<100/year and>100/year),regions with different economic development levels,and between north and south China.Conclusion Digestive tract reconstruction following PD exists heterogeneity in Chinese university hospitals.Corresponding prospective clinical studies are needed to determine the consensus on pancreatic surgery that meets the clinical reality in China. | Jishu Wei Qiang Xu Yuhua Zhang Jiabin Jin Xiaodong Tian Qiaofei Liu Zipeng Lu Zheng Wang Shanmiao Gou Song Gao Xianlin Han Yefei Rong Niandong Ji Ye Lin Guolin Li Shi Chen Feng Cao Hua Chen Wenming Wu Yupei Zhao the Young Elite Pancreatic Surgery Club of China | 2022 | Journal of Pancreatology2022，5，3： | 0 |
| 16 | Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme显示文摘The crucial role of intratumoral bacteria in the progression of cancer has been gradually recognized with the development of sequencing technology.Several intratumoral bacteria which have been identified as pathogens of cancer that induce progression,metastasis,and poor outcome of cancer,while tumor vascular networks and immunosuppressive microenvironment provide shelters for pathogens localization.Thus,the mutually-beneficial interplay between pathogens and tumors,named“pathogentumor symbionts”,is probably a potential therapeutic site for tumor treatment.Herein,we proposed a destroying pathogen-tumor symbionts strategy that kills intratumoral pathogens,F.nucleatum,to break the symbiont and synergize to kill colorectal cancer(CRC)cells.This strategy was achieved by a groundbreaking protein-supported copper single-atom nanozyme(BSA-Cu SAN)which was inspired by the structures of native enzymes that are based on protein,with metal elements as the active center.BSA-Cu SAN can exert catalytic therapy by generating reactive oxygen species(ROS)and depleting GSH.The in vitro and in vivo experiments demonstrate that BSA-Cu SAN passively targets tumor sites and efficiently scavenges F.nucleatum in situ to destroy pathogentumor symbionts.As a result,ROS resistance of CRC through elevated autophagy mediated by F.nucleatum was relieved,contributing to apoptosis of cancer cells induced by intracellular redox imbalance generated by BSA-Cu SAN.Particularly,BSA-Cu SAN experiences renal clearance,avoiding long-term systemic toxicity.This work provides a feasible paradigm for destroying pathogen-tumor symbionts to block intratumoral pathogens interplay with CRC for antitumor therapy and an optimized trail for the SAN catalytic therapy by the clearable protein-supported SAN. | Xinyue Wang Qian Chen Yefei Zhu Kairuo Wang Yongliang Chang Xiawei Wu Weichao Bao Tongcheng Cao Hangrong Chen Yang Zhang Huanlong Qin | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
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