|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Urban Expansion and Its Influencing Factors in Natural Wetland Distribution Area in Fuzhou City,China显示文摘This paper principally focuses on land use dynamics,urban expansion and underlying driving forces in the Natural Wetland Distribution Area(NWDA)of Fuzhou City in the southeastern China.Based on time series Landsat TM/ETM+imageries and historical data,relationships between urban land expansion and its influencing factors from 1989 to 2009 were analyzed by using an integrated approach of remote sensing(RS)and geographic information system(GIS)techniques.The results showed that built-up land increased from 151.16 km2in 1989 to 383.76 km 2in 2009. Approximately 64.25%of the newly emerging built-up land was converted from cropland(29.47%),forest and shrub (25.78%),water(3.73%),wetland(4.61%),and bare land(0.66%)during 1989 and 2009.With a remarkable decrease in cropland,the proportion of non-agricultural population increased by 23.6%.Moreover,rapid development of infrastructures,facilities,industrial parks,and urban and rural settlements along the Minjiang River resulted in the eastward and southward expansion of built-up land.Additionally,the growth pattern of built-up land in the NWDA is highly correlated with socio-economic factors,including the gross domestic product(GDP),GDP per capita,and structure of industry.As a result,the observed environmental degradation such as loss of cropland and wetland due to heavy pressure of rapid urbanization have greatly impaired the carrying capacity of city.Thus,in addition to scientific and rational policies towards minimizing the adverse effects of urbanization,coordination between the administrative agencies should be urgently strengthened to balance the conflicts between urban development and ecological conservation to make sure the sustainable land use. | CAI Yuanbin ZHANG Hao PAN Wenbin CHEN Yanhong WANG Xiangrong | 2012 | Chinese Geographical Science2012，22，5： | 8 |
| 3 | Stratigraphy of the Triassic-Jurassic Boundary Successions of the Southern Margin of the Junggar Basin,Northwestern China显示文摘The Triassic-Jurassic(Tr-J) boundary marks a major extinction event,which(~200 Ma) resulted in global extinctions of fauna and flora both in the marine and terrestrial realms.There prevail great challenges in determining the exact location of the terrestrial Tr-J boundary,because of endemism of taxa and the scarcity of fossils in terrestrial settings leading to difficulties in linking marine and terrestrial sedimentary successions.Investigation based on palynology and bivalves has been carried out over a 1113 m thick section,which is subdivided into 132 beds,along the Haojiagou valley on the southern margin of the Junggar Basin of the northern Xinjiang,northwestern China.The terrestrial Lower Jurassic is conformably resting on the Upper Triassic strata.The Upper Triassic covers the Huangshanjie Formation overlaid by the Haojiagou Formation,while the Lower Jurassic comprises the Badaowan Formation followed by the Sangonghe Formation.Fifty six pollen and spore taxa and one algal taxon were identified from the sediments.Based on the key-species and abundance of spores and pollen,three zones were erected:the Late Triassic(Rhaetian) Aratrisporites-Alisporites Assemblage,the Early Jurassic(Hettangian) Perinopollenites-Pinuspollenites Assemblage,and the Sinemurian Perinopollenites-Cycadopites Assemblage.The Tr-J boundary is placed between bed 44 and 45 coincident with the boundary between the Haojiagou and Badaowan formations.Beds with Ferganoconcha(?),Unio-Ferganoconcha and Waagenoperna-Yananoconcha bivalve assemblages are recognized.The Ferganoconcha(?) bed is limited to the upper Haojiagou Formation, Unio-Ferganoconcha and Waagenoperna-Yananoconcha assemblages are present in the middle and upper members of the Badaowan Formation.The sedimentary succession is interpreted as terrestrial with two mainly lake deposit intervals within Haojiagou and Badaowan formations,yielding fresh water algae and bivalves.However,the presence of brackish water algae Tasmanites and the marine-littoral facies bivalve Waagenoperna from the Badaowan Formation indicate that the Junggar Basin was influenced by sea water caused by transgressions from the northern Tethys,during the Sinemurian. | SHA Jingeng Vivi VAJDA PAN Yanhong Linda LARSSON YAO Xiaogang ZHANG Xiaolin WANG Yaqiong CHENG Xiansheng JIANG Baoyu DENG Shenghui CHEN Siwei PENG Bo | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 7 |
| 4 | Emplacement Mechanism of the Akebasitao Pluton:Implications for Regional Tectonic Evolution of West Junggar,NW China显示文摘Late Carboniferous to Early Permian A-type granites are extensively distributed throughout the West Junggar region,NW China,and the Akebasitao pluton is extremely distinguished among these plutons.In this paper,we reported new anisotropy of magnetic susceptible(AMS) data combine with detailed field study and audio magnetotelluric(AMT) sounding to assess the three-dimensional shape and magmatic emplacement mechanism of the Akebasitao pluton.The geological features and the AMT sounding indicate that the pluton had a slightly oblique movement of magma from northwest to southeast,which was most likely to correspond to an asymmetrical torch with a laccolith-shaped upper part,and a lower part formed by sub-vertical 'root' that was located within its northwestern part,probably controlled by the NE-trending Anqi fault.The AMS fabrics of aU the specimens reveal a low P_j value(mean of 1.02) and a low T value(mean of-0.024),suggesting that the deformation of the AMS ellipsoid is relatively weak.The specimens exhibit both oblate and prolate shapes of the AMS ellipsoid.Magnetic lineations and foliations are randomly distributed throughout the pluton without any preferred orientation.These AMS patterns indicate that the pluton formed in a relatively stable structural environment with no regional extrusion.Therefore,we propose a complex emplacement process in which the magmas reached the shallower crust levels via deep-faults and subsequently occupied the room created by doming,accompanied by sloping near the pluton roof.Additionally,the regional tectonic setting was relatively stable during the emplacement of the Akebasitao pluton,indicating the termination of compressional orogeny during the late Late Carboniferous in the West Junggar region.This conclusion perfectly coincides with the regional tectonic paleogeography,magmatic system,and paleostress field. | ZHANG Pan WANG Guocan LI Yongtao ZHANG Shengye PENG Chao ZHAO Hongwei ZHA Yanhong | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 5 |
| 5 | Applications of chemical imaging techniques in paleontology显示文摘Chemical imaging techniques,based on a combination of microscopy and spectroscopy,are designed to analyse the composition and spatial distribution of heterogeneous chemical complexes within a sample.Over the last few decades,it has become an increasingly popular tool for characterizing trace elements,isotopic information and organic biomarkers(molecular biosignatures)found in fossils.Here,we introduce the analytical principle of each technique and the interpretation of the chemical signals,followed by a review of the main applications of these techniques in paleontology.We also demonstrate that each technique is associated with pros and cons,and the current limitations and obstacles associated with the use of each specific technique should be taken into account before being applied to fossil samples.Finally,we propose that,due to the rapid advances in the available technology and overall trends towards more multi-disciplinary studies in paleontology,chemical imaging techniques can be expected to have broader applications in paleontology in the near future. | Yanhong Pan Liang Hu Tao Zhao | 2019 | National Science Review2019，6，5： | 3 |
| 6 | Exceptional preservation of soft tissue in a new specimen of Eoconfuciusornis and its biological implications显示文摘We report on an exceptional specimen of Eoconfuciusornis preserving rare soft-tissue traces of the ovary and wing. Ovarian follicles preserve a greater hierarchy than observed in Jeholornis and enantiornithines,suggesting confuciusornithiforms evolved higher rates of yolk deposition in parallel with the neornithine lineage. The preserved soft tissues of the wing indicate the presence of a propatagium and postpatagium,whereas an alular patagium is absent. Preserved remnants of the internal support network of the propatagium bear remarkable similarity to that of living birds. Soft tissue suggests the confuciusornithiform propatagium could maintain a cambered profile and generate lift. The feathers of the wing preserve remnants of their original patterning; however, this is not strongly reflected by observable differences under scanning electron microscopy(SEM). The tail plumage lacks elongate rectrices, suggesting that the earliest known confuciusornithiforms were sexually dimorphic in their plumage. | Xiaoting Zheng Jingmai K. O'Connor Xiaoli Wang Yanhong Pan Yan Wang Min Wang Zhonghe Zhou | 2017 | National Science Review2017，4，3： | 3 |
| 7 | Effects of key growth conditions on endogenous hormone content in tillering stem bases,germination of lateral buds,and biomass allocation in Indocalamus decorus显示文摘Physiological responses and changes in growth of Indocalamus decorus Q.H.Dai under different ecological conditions are essential for further understanding growth regulation and adaptive mechanisms and establishing an evidence-based management system for optimal growth. In this study, the endogenous hormone content in tillering stem bases, germination of lateral buds, and biomass allocation of this bamboo species in different growth environments were investigated. Among the endogenous hormones in the basal stems of tillers, indole-3-pyruvic acid and zeatin riboside were highly correlated with lateral buds that germinated to form shoots, while gibberellic acid was highly correlated with lateral buds that germinated to form rhizomes. The best lateral bud germination characteristics were achieved with full sun, a density of six plantlets per pot, and watering every 6 days. I. decorus plantlets used different resource allocation strategies depending on treatment. Different ecological factors influenced endogenous hormones in the bamboo stem base,which affected lateral bud germination and biomass allocation. | Guibin Gao Hao Zhong Zhizhuang Wu Neng Li Zheke Zhong Yanhong Pan Liangru Wu | 2018 | Journal of Forestry Research2018，29，6： | 3 |
| 8 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 9 | Modeling of hemophilia A using patient-specific induced pluripotent stem cells derived from urine cells显示文摘 | Bei Jia Shen Chen Zhiju Zhao Pengfei Liu Jinglei Cai Dajiang Qin Juan Du Changwei Wu Qianyu Chen Xiujuan Cai Hui Zhang Yanhong Yu Duanqing Pei Mei Zhong Guangjin Pan | 2014 | Life Sciences2014，，： | 1 |
| 10 | Detection and Prevention of Environmental Hormone显示文摘The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental hormone pollution,such as reducing the use of goods and pesticide and the study of new substitutes and degradation technology are advanced. | Qili Chen Ling Pan Yanhong Xv Xuan Fu Hongzhen Sun Hongyan Li Pingping Liu | 2013 | Meteorological and Environmental Research2013，4，12： | 1 |
| 11 | Diagnostic efficacy of whole-body diffusion-weighted imaging in the detection of tumour recurrence and metastasis by comparison with 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography or computed tomography in patients with gastrointestinal cancer显示文摘Objective:The primary aim of this study was to assess the efficacy of whole-body diffusion-weighted imaging(WB-DWI)in detecting tumour recurrence and metastasis of gastrointestinal cancers by comparison with 18F-2-fluoro-2-deoxy-Dglucose positron emission tomography or computed tomography(18F-FDG-PET/CT).A secondary aim was to evaluate the change of apparent diffusion coefficient(ADC)value between metastases and normal tissues.Methods:Twenty-eight previously confirmed gastrointestinal cancer patients with suspected tumour recurrence or metastasis were recruited.WB-DWI and PET/CT images were evaluated by two radiologists and a nuclear medicine physician.Agreement between WB-DWI and PET/CT for detective efficacy was compared using kappa statistics.Additionally,diagnostic accuracy,sensitivity,specificity,negative predictive value(NPV),and positive predictive value(PPV)were also statistically analysed.ADC values between metastatic and normal tissues were compared.Results:There was no statistically significant difference(P>0.05)in the overall diagnostic performances of PET/CT(accuracy 98.9%;sensitivity 95.2%;specificity 99.8%;PPV 98.9%;NPV 98.9%)and WB-DWI(accuracy 95.9%;sensitivity 81.7%;specificity 99.1%;PPV 95.0%;NPV 96.1%).WB-DWI showed agreement with PET/CT(j=0.877)for detecting recurrence and distant metastases.A statistically significant difference in ADC value was observed between tissues of normal healthy volunteers and metastases in lymph nodes,liver and bones(P<0.05).Conclusions:WB-DWI is reliable in detecting tumour recurrence and metastasis of colorectal cancer and offers the same diagnostic performance as 18F-PET/CT without ionizing radiation.The quantitative value of ADC provides extra information to determine cancer metastasis. | Jiaying Gong Wuteng Cao Zhanwen Zhang Yanhong Deng Liang Kang Pan Zhu Zhengjun Liu Zhiyang Zhou | 2015 | Gastroenterology Report2015，3，2： | 1 |
| 12 | Analysis of prognostic factors of endoscopic optic nerve decompression in traumatic blindness显示文摘 | Yexun Song Heqing Li Yanhong Ma Wei Li Xiaowei Zhang Xueying Pan Guolin Tan | 2013 | Acta Oto-Laryngologica2013，，11： | 1 |
| 13 | Extraction,Optical Properties and Bio-Imaging of Fluorescent Composition From Moso Bamboo Shoots显示文摘A novel fluorescent composition was firstly isolated from natural winter fresh Moso bamboo shoots,and its optical properties were fully investigated by fluorescence spectroscopy.It could emit strong blue light both in solid and solution state,providing high fluorescence intensity in ethanol.The solution’s concentration and addition of water greatly affected the fluorescence intensity,high concentration and addition of much water could quench fluorescence.Apoptosis results showed that the fluorescent extract(0-25 mg/L)could not induce apoptosis of Hela cells.Confocal fluorescent microscopic imaging in human hepatocellular carcinoma cells(HepG2)was realized using the fluorescent extract,it could dye the whole cell well which was different from 4',6-diamidino-2-phenylindole(DAPI)only dying cell nucleus.The fluorescent extract may be candidate for future natural fluorescent bio-imaging agent. | Jinlai Yang Liangru Wu Yanhong Pan Hao Zhong | 2019 | Journal of Renewable Materials2019，7，11： | 1 |
| 14 | The sociolinguistics of exogamy: Dialect acquisition in a Zhuang village[Thank you ]显示文摘 | James N. Stanford Yanhong Pan | 2013 | J Sociolinguisti cs2013，，5： | 1 |
| 15 | Enhan- eing Electrochemical and Electrocatalytic Activities of Polyaniline via Co-doping whh Poly(styrene sulfonate) and Gold显示文摘 | Tang Yanhong Pan Kexue Wang Xiaojian | 2010 | Journal of Electroanalytieal Chemistry2010，639，12： | 1 |
| 16 | Development prospects of metal-based two-dimensional nanomaterials in lithium-sulfur batteries显示文摘A lithium-sulfur(Li-S)system is an important candidate for future lithium-ion system due to its low cost and high specific theoretical capacity(1675 m Ah/g,2600 Wh/kg),which is greatly hindered by the poor conductivity of sulfur,large volume change and dissolution of lithium polysulfides.Two-dimensional(2D)materials with monolayers or few-layers usually have peculiar structures and physical/chemical properties,which can resolve the critical issues in Li-S batteries.Especially,the metal-based 2D nanomaterials,including ferrum,cobalt or other metal-based composites with various anions,can provide high conductivity,large surface area and abundant reaction sites for restraining the diffusion for lithium polysulfides.In this mini-review,we will present an overview of recent developments on metal-based 2D nanomaterials with various anions as the electrode materials for Li-S batteries.Since the main bottleneck for the Li-S system is the shuttle of polysulfides,emphasis is placed on the structure and components,physical/chemical interaction and interaction mechanisms of the 2D materials.Finally,the challenges and prospects of metal-based 2D nanomaterials for Li-S batteries are discussed and proposed. | Yuxue Mo Liling Liao Dongyang Li Rongwu Pan Yanhong Deng Yanliang Tan Haiqing Zhou | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 17 | The brackish-water bivalve Waagenoperna from the Lower Jurassic Badaowan Formation of the Junggar Basin and its palaeoenvironmental and palaeogeographic significance显示文摘略有盐味水的瓣鳃类 WaagenopernaTokuyama, 1959 在四个地区从更低的侏罗记 Badaowan 形成被报导,沿着南部的边缘和 Junggar 盆的西方的边缘。在这块地里记录的 Taphonomic 特征显示它发生在本土或 parautochthonous 集合。Waagenoperna 的个体生态学因此在区域的 palaeoenvironment 上产出信息。到海洋、略有盐味水的背景的 Waagenoperna 的限制建议海水曾经在 Sinemurian 期间到达了这些区域。这份报纸讨论 palaeogeographic 含意并且从西方建议海水的 ingression 到 Junggar 盆的西方、南部的部分。另外,在 Junggar 盆从 Haojiagou 节收集的二 Waagenoperna 种分类地被记录。 | Yanhong Pan Jingeng Sha Yaqiong Wang Xiaolin Zhang Xiaogang Yao Bo Peng Xin Rao | 2013 | Geoscience Frontiers2013，4，1： | 1 |
| 18 | Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro显示文摘 | Wenjuan Li Xiaoling Li Wei Wan Mei Yi Yanhong Zhou Pan Zheng Wei Xiong Jianbo Yang Shuping Peng James B. McCarthy Bo Xiang Guiyuan Li | 2013 | International Journal of Biochemistry and Cell Biology2013，，： | 1 |
| 19 | Chromatin accessibility landscapes revealed the subgenome-divergent regulation networks during wheat grain development显示文摘Development of wheat(Triticum aestivum L.)grain mainly depends on the processes of starch synthesis and storage protein accumulation,which are critical for grain yield and quality.However,the regulatory network underlying the transcriptional and physiological changes of grain development is still not clear.Here,we combined ATAC-seq and RNA-seq to discover the chromatin accessibility and gene expression dynamics during these processes.We found that the chromatin accessibility changes are tightly associated with differential transcriptomic expressions,and the proportion of distal ACRs was increased gradually during grain development.Specific transcription factor(TF)binding sites were enriched at different stages and were diversified among the 3 subgenomes.We further predicted the potential interactions between key TFs and genes related with starch and storage protein biosynthesis and found different copies of some key TFs played diversified roles.Overall,our findings have provided numerous resources and illustrated the regulatory network during wheat grain development,which would shed light on the improvement of wheat yields and qualities. | Hongcui Pei Yushan Li Yanhong Liu Pan Liu Jialin Zhang Xueni Ren Zefu Lu | 2023 | aBIOTECH2023，4，1： | 1 |
| 20 | Bi-level Multi-leader Multi-follower Stackelberg Game Model for Multi-energy Retail Package Optimization显示文摘In the competitive energy market,energy retailers are facing the uncertainties of both energy price and demand,which requires them to formulate reasonable energy purchasing and selling strategies for improving their competitiveness in this market.Particularly,the attractive multi-energy retail packages are the key for retailers to increase their benefit.Therefore,combined with incentive means and price signals,five types of multi-energy retail packages such as peak-valley time-of-use(TOU)price package and day-night bundled price package are designed in this paper for retailers.The iterative interactions between retailers and end-users are modeled using a bi-level model of stochastic optimization based on multi-leader multi-follower(MLMF)Stackelberg game,in which retailers are leaders and end-users are followers.Retailers make decisions to maximize the profit considering the conditional value at risk(CVaR)while end-users optimize the satisfaction of both energy comfort and economy.Besides,a distributed algorithm is proposed to obtain the Nash equilibrium of above MLMF Stackelberg game model while the particle swarm optimization(PSO)algorithm and CPLEX solver are applied to solve the optimization model for each participant(retailer or end-user).Numeral results show that the designed retail packages can increase the overall profit of retailers,and the overall satisfaction of industrial users is the highest while that of residential users is the lowest after game interaction. | Hongjun Gao Hongjin Pan Rui An Hao Xiao Yanhong Yang Shuaijia He Junyong Liu | 2024 | Journal of Modern Power Systems and Clean Energy2024，12，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员