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| 1 | Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model显示文摘Background:Neuron-microglia communication plays a crucial role in the motor neurons(MNs)death in amyotrophic lateral sclerosis(ALS).Neurons can express chemokine(C-X3-C motif)ligand 1(CX3CL1),which mediates microglial activation via interacting with its sole receptor CX3CR1 in microglia.In the present study,we aimed to investigate the dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and MNs loss in SOD1G93A mouse model of ALS.Methods:qPCR,western blot and immunofluorescent staining were used to examine the mRNA and protein levels and localization of CX3CL1/CX3CR1 in the anterior horn region of spinal cord in both SOD1G93A mice and their agematched wild type(WT)littermates at 40,60,90 and 120 days of age.The M1/M2 microglial activation in the spinal cord tissues of SOD1G93A mice and WT mice were evaluated by immunofluorescent staining of M1/M2 markers and further confirmed by qPCR analysis of M1/M2-related cytokines.Results:The immunofluorescent staining revealed that CX3CL1 was predominately expressed in MNs,while CX3CR1 was highly expressed in microglia in the anterior horn region of spinal cord.Compared with age-matched WT mice,CX3CL1 mRNA level was elevated at 40 days but decreased at 90 and 120 days in the anterior horn region of spinal cords in ALS mice.Consistently,CX3CR1 mRNA level was increased at 90 and 120 days.Western blot assay further confirmed the dynamic changes of CX3CL1/CX3CR1 axis in ALS mice.Additionally,the levels of M1/M2 markers of microglia and their related cytokines in the anterior horn region of spinal cord in ALS mice were increased at 90 and 120 days.Moreover,while M1-related cytokines in ALS mice were persistently increased at 120 days,the upregulated M2-related cytokines started to decline at 120 days,suggesting an altered microglial activation.Conclusions:Our data revealed the dynamic changes of CX3CL1/CX3CR1 axis and an imbalanced M1/M2 microglial activation during ALS pathological progression.These findings may help identify potential molecular targets for ALS therapy. | Jingjing Zhang Yufei Liu Xinyao Liu Song Li Cheng Cheng Sheng Chen Weidong Le | 2018 | Translational Neurodegeneration2018，7，1： | 7 |
| 2 | Ultrafine Sn nanocrystals in a hierarchically porous N-doped carbon for lithium ion batteries显示文摘我们报导准备高效的一个简单方法,为锂离子电池(解放) 的基于 Sn 的阳极材料。增加的 H 2 到包含 Sn 2+ 和苯胺的一个水的答案的 O 2 导致苯胺的同时的聚合和 Sn 2+ 的氧化到导致的 SnO 2, 一同类 polyaniline 和 SnO 2 合成。上述合成收益的氢热减小有层次孔和同类地分布式的、极其细小的 Sn 粒子的做 N 的碳。nanocomposite 为锂离子电池作为阳极材料展出优秀性能,显示出 788 mAh 的一个高可逆的特定的能力吗? | Xinghua Chang Teng Wang Zhiliang Liu Xinyao Zheng Jie Zheng Xingguo Li | 2017 | Nano Research2017，10，6： | 5 |
| 3 | Prediction-based Manufacturing Center Self-adaptive Demand Side Energy Optimization in Cyber Physical Systems显示文摘Cyber physical systems(CPS)recently emerge as a new technology which can provide promising approaches to demand side management(DSM),an important capability in industrial power systems.Meanwhile,the manufacturing center is a typical industrial power subsystem with dozens of high energy consumption devices which have complex physical dynamics.DSM,integrated with CPS,is an effective methodology for solving energy optimization problems in manufacturing center.This paper presents a prediction-based manufacturing center self-adaptive energy optimization method for demand side management in cyber physical systems.To gain prior knowledge of DSM operating results,a sparse Bayesian learning based componential forecasting method is introduced to predict24-hour electric load levels for specific industrial areas in China.From this data,a pricing strategy is designed based on short-term load forecasting results.To minimize total energy costs while guaranteeing manufacturing center service quality,an adaptive demand side energy optimization algorithm is presented.The proposed scheme is tested in a machining center energy optimization experiment.An AMI sensing system is then used to measure the demand side energy consumption of the manufacturing center.Based on the data collected from the sensing system,the load prediction-based energy optimization scheme is implemented.By employing both the PSO and the CPSO method,the problem of DSM in the manufacturing center is solved.The results of the experiment show the self-adaptive CPSO energy optimization method enhances optimization by 5%compared with the traditional PSO optimization method. | SUN Xinyao WANG Xue WU Jiangwei LIU Youda | 2014 | Chinese Journal of Mechanical Engineering2014，27，3： | 4 |
| 4 | Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation显示文摘Parkinson’s disease(PD)is the second most common neurodegenerative disease,which manifests with both motor and non-motor symptoms.Circadian rhythm dysregulation,as one of the most challenging non-motor features of PD,usually appears long before obvious motor symptoms.Moreover,the dysregulated circadian rhythm has recently been reported to play pivotal roles in PD pathogenesis,and it has emerged as a hot topic in PD research.In this review,we briefly introduce the circadian rhythm and circadian rhythm-related genes,and then summarize recent research progress on the altered circadian rhythm in PD,ranging from clinical features to the possible causes of PD-related circadian disorders.We believe that future comprehensive studies on the topic may not only help us to explore the mechanisms of PD,but also shed light on the better management of PD. | Yufei Liu Long Niu Xinyao Liu Cheng Cheng Weidong Le | 2021 | Neuroscience Bulletin2021，37，7： | 4 |
| 5 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 6 | Short-term climatic impacts of afforestation in the East Asian monsoon region显示文摘The influence of changes in vegetation cover on short-term climate over the East Asian monsoon region is simulated using the Community Climate System Model Version 3.5.The results show the annual mean surface air temperature significantly decreases by 0.93°C in response to afforestation over the East Asian monsoon region.Also,surface air temperature decreases by 1.46 and 0.40°C in summer and winter,respectively.The cooling is caused by enhanced evapotranspiration(ET) produced by increased forest cover.Evapotranspiration is greater in summer than in winter,so summer cooling is greater than winter cooling.The annual mean precipitation increases in response to afforestation,with a maximum of 7% in April.Water vapor increases significantly because of greater latent heat flux release.Meanwhile,afforestation leads to higher surface roughness,which decreases surface wind speed and induces an ascending air motion.These factors can produce more clouds and precipitation.Moreover,the surface albedo and the reflective solar radiation are reduced in response to afforestation. | MA Di LIU ZhengYu Lü ShiHua MICHAEL Notaro RONG XinYao CHENG GuangShan WANG FuYao | 2013 | Chinese Science Bulletin2013，58，18： | 3 |
| 7 | Altered Motor Performance,Sleep EEG,and Parkinson’s Disease Pathology Induced by Chronic Sleep Deprivation in Lrrk2^(G2019S) Mice显示文摘Parkinson’s disease(PD)is a multifaceted disease in which environmental variables combined with genetic predisposition cause dopaminergic(DAergic)neuron loss in the substantia nigra pars compacta.The mutation of leucine-rich repeat kinase 2(Lrrk2)is the most common autosomal dominant mutation in PD,and it has also been reported in sporadic cases.A growing body of research suggests that circadian rhythm disruption,particularly sleep-wake abnormality,is common during the early phase of PD.Our present study aimed to evaluate the impact of sleep deprivation(SD)on motor ability,sleep performance,and PD pathologies in Lrrk2^(G2019S) transgenic mice.After two months of SD,Lrrk2^(G2019S) mice at 12 months of age showed an exacerbated PD-like phenotype with motor deficits,a reduced striatal DA level,degenerated DAergic neurons,and altered sleep structure and biological rhythm accompanied by the decreased protein expression level of circadian locomotor output cycles kaput Lrrk2 gene in the brain.All these changes persisted and were even more evident in 18-month-old mice after 6 months of follow-up.Moreover,a significant increase inα-synuclein aggregation was found in SD-treated transgenic mice at 18 months of age.Taken together,our findings indicate that sleep abnormalities,as a risk factor,may contribute to the pathogenesis and progression of PD.Early detection of sleep disorders and improvement of sleep quality may help to delay disease progression and provide long-term clinical benefits. | Xinyao Liu Hang Yu Yuanyuan Wang Song Li Cheng Cheng Murad Al-Nusaif Weidong Le | 2022 | Neuroscience Bulletin2022，38，10： | 3 |
| 8 | New approaches for rare earth-magnesium based hydrogen storage alloys显示文摘As the most possibility applied to the next generation negative electrode materials of Ni/ MH second battery,rare earth(RE)-magnesium(Mg) based alloys have been developed over the last few years. Recent advances about the RE-Mg based intermetallic compounds on the crystal structures, hydrogenation behaviors and electrochemical performances are reviewed in the paper. On the other hand, new results about the preparation and modification methods of the alloys are also covered in details. | Huaiwei Zhang Xinyao Zheng Xiao Tian Yang Liu Xingguo Li | 2017 | Progress in Natural Science:Materials International2017，27，1： | 2 |
| 9 | Loss-induced nonreciprocity显示文摘Nonreciprocity is important in both optical information processing and topological photonics studies.Conventional principles for realizing non reciprocity rely on magnetic fields,spatiotemporal modulation,or nonlinearity.Here we propose a generic principle for generating nonreciprocity by taking advantage of energy loss,which is usually regarded as harmful.The loss in a resonance mode induces a phase lag,which is independent of the energy transmission direction.When multichannel lossy resonance modes are combined,the resulting interference gives rise to nonreciprocity,with different coupling strengths for the forward and backward directions,and unidirectional energy transmission.This study opens a new avenue for the design of nonreciprocal devices without stringent requirements. | Xinyao Huang Cuicui Lu Chao Liang Honggeng Tao Yong-Chun Liu | 2021 | Light(Science & Applications)2021，10，2： | 2 |
| 10 | Probabilistic analysis for the response of nonlinear base isolation system under the ground excitation induced by high dam flood discharge显示文摘According to theoretical analysis,a general characteristic of the ground vibration induced by high dam flood discharge is that the dominant frequency ranges over several narrow frequency bands,which is verified by observations from the Xiangjiaba Hydropower Station.Nonlinear base isolation is used to reduce the structure vibration under ground excitation and the advantage of the isolation application is that the low-frequency resonance problem does not need to be considered due to its excitation characteristics,which significantly facilitate the isolation design.In order to obtain the response probabilistic distribution of a nonlinear system,the state space split technique is modified.As only a few degrees of freedom are subjected to the random noise,the probabilistic distribution of the response without involving stochastic excitation is represented by theδfunction.Then,the sampling property of theδfunction is employed to reduce the dimension of the Fokker-PlanckKolmogorov(FPK)equation and the low-dimensional FPK equation is solvable with existing methods.Numerical results indicate that the proposed approach is effective and accurate.Moreover,the response probabilistic distributions are more reasonable and scientific than the peak responses calculated by conventional time and frequency domain methods. | Liang Chao Zhang Jinliang Lian Jijian Liu Fang Li Xinyao | 2017 | Earthquake Engineering and Engineering Vibration2017，16，4： | 2 |
| 11 | Post COVID-19 burden:focus on the short-term condition显示文摘The catastrophic pandemic of the coronavirus disease 2019(COVID-19)has caused serious harm to human life and global social economy.As of June 13,2022,there were more than 530 million confirmed cases of COVID-19 and over 6.3 million deaths[1].During the past 2 years,global studies on prevention and therapies for COVID-19 have achieved a series of promising findings,including antiviral drugs(Remdesivir,Molnupiravir,Paxlovid)and monoclonal antibodies(Bamlanivimab and Etesevimab,Sotrovimab,Casirivimab and Imdevimab)[2]. | Fengwen Yang Bo Pang Xinyao Jin Zhe Chen Wentai Pang Qingquan Liu Junhua Zhang Boli Zhang | 2022 | Acupuncture and Herbal Medicine2022，2，3： | 2 |
| 12 | Cyanophage Pf-WMP4, a T7-1ike phage infecting the freshwater cyanobacterium Phormidium foveolarum: complete genome sequence and DNA translocation显示文摘 | LIU Xinyao SHI Miao KONG Shuanglei | 2007 | Virology2007，366，1： | 1 |
| 13 | Genomic analysis of freshwater cyanophage Pf-WMP3 infectingcyanobacterium Phormidium foveolarum: the conserved elements for a phage显示文摘 | LIU Xinyao KONG Shuanglei SHI Miao | 2008 | Microbial Ecology2008，56，67： | 1 |
| 14 | Peroxisome proliferator activated receptor-γ ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells显示文摘 | Jiajun Liu Huiling Lu Renwei Huang Dongjun Lin Xiangyuan Wu Qu Lin Xinyao Wu Jing Zheng Xianglin Pan Jun Peng Yuqin Song Maohong Zhang Ming Hou Feng Chen | 2005 | Cancer Chemotherapy and Pharmacology2005，，4： | 1 |
| 15 | Atmospheric Particle Hygroscopicity and the Influence by Oxidation State of Organic Aerosols in Urban Beijing显示文摘A hygroscopic tandem differentialmobility analyser(H-TDMA)was used to observe the sizeresolved hygroscopic characteristics of submicron particles in January and April 2018 in urban Beijing.The probability distribution of the hygroscopic growth factor(HGF-PDF)in winter and spring usually showed a bimodal pattern,with more hygroscopic mode(MH)being more dominant.The seasonal variation in particle hygroscopicity was related to the origin of air mass,which received polluted southerly air masses in spring and clean northwesterly air masses in winter.Particles showed stronger hygroscopic behaviour during heavy pollution episodes(HPEs)with elevated concentrations of secondary aerosols,especially higher mass fraction of nitrate,which were indicated using the PM2.5(particulate matter with diameter below 2.5μm)mass concentration normalised by CO mass concentration.The hygroscopic parameter(κ)values were calculated using H-TDMA(κhtdma)and chemical composition(κchem).The closure study showed thatκchem was overestimated in winter afternoon when compared withκhtdma,because the organic particle hygroscopic parameter(κorg)was overestimated in the calculations.It was influenced by the presence of a high concentration of hydrocarbon-like organic aerosol(HOA)with a weak water uptake ability.A positive relationship was observed betweenκorg and the ratio of oxygenated organic aerosol(OOA)and HOA,thereby indicating that the strong oxidation state enhanced the hygroscopicity of the particles.This study revealed the effect of local emission sources and secondary aerosol formation processes on particle hygroscopicity,which is of great significance for understanding the pollution formation mechanism in the North China Plain. | Sinan Zhang Xiaojing Shen Junying Sun Yangmei Zhang Xiaoye Zhang Can Xia Xinyao Hu Junting Zhong Jialing Wang Shuo Liu | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 16 | White up-conversion luminescence and highly-sensitive optical temperature sensing in Na_(3)La(VO_(4))_(2):Yb,Er,Tm,Ho phosphors显示文摘In this work,tunable white up-conversion luminescence was achieved in the Yb^(3+),Er^(3+),Tm^(3+),Ho^(3+) codoped Na_(3)La(VO_(4))_(2) phosphors under 980 nm excitation.The emissions of three primary colors are mainly attributed to the ~2H_(11/2)/~4S_(3/2)→~4I_(15/2) transitions of Er^(3+),~1G_(4)→~3H_6 transition of Tm^(3+),and_5F_5→~5I_8 transition of Ho^(3+).White luminescence characteristics and mechanisms of up-conversion system were investigated in detail.In addition,the temperature sensing behaviors of multiple levels emission combinations for Na_(3)La(VO_(4))_(2):Yb^(3+),Er^(3+),Tm^(3+),Ho^(3+) were analyzed by employing thermally coupled and non-thermally coupled energy levels.Based on the emissions of ~3F_(2,3)/~1G_(4) energy levels,the maximum relative and absolute sensitivities were obtained to be 2.20%/K and 0.279 K^(-1).The design of up-conversion luminescence materials with high-quality white luminescence and excellent sensitivity performance is critical in the field of optical applications. | Qi Xiao Xiumei Yin Lin Lv Xinyao Dong Na Zhou Kuichao Liu Xixian Luo | 2023 | Journal of Rare Earths2023，41，7： | 1 |
| 17 | Preparation of copper nano-particle powder by γ-irradiation显示文摘Copper nano-particles were prepared by 100 kGy room temperature γ-ray irradiation of CuSO4 aqueous solution added with surfactant and inactive agent.Effects of the surfactants and pH value on particle size and morphology of the Cu powder,and the storage stability,were investigated.Structure,morphology,particle size and melting point of the copper nano-particles were characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM),laser particle size analyzer and differential scanning calorimetry(DSC),respectively.The results show that the Cu nano-particles prepared with PCM as surfactant and N,N-bis-hydroxyethyl dodecyl amide as inactive agent,in pH=4.0-6.5 of the aqueous solution,can be stored in air for 140 days. | FU Junjie LIU Yajian TAN Yuanyuan ZHOU Xinyao XU Furong | 2012 | Nuclear Science and Techniques2012，23，3： | 1 |
| 18 | Screening non-noble metal oxides to boost the low-temperature combustion of polyethylene waste in air显示文摘Globally,the efficient utilization of polymer wastes is one of the most important issues for current sustainable development topics.Herein,a green and efficient low-temperature combustion approach is proposed to deal with polymer wastes and recover heat energy,simultaneously alleviating the environment and energy crisis.Non-noble metal oxides(Al_(2)O_(3),Fe_(2)O_(3),NiO_(2),ZrO_(2),La_(2)O_(3)and CeO_(2)) were prepared,characterized and screened to boost the low-temperature combustion of polyethylene waste at 300℃ in air.The mass change,heat release and CO_(x) formation were studied in details and employed to evaluate the combustion rate and efficiency.It was found that CeO_(2)significantly enhanced the combustion rate and efficiency,which was respectively 2 and 7 times that of non-catalytic case.An interesting phenomenon was observed that the catalytic performance of CeO_(2) in polyethylene low-temperature combustion was significantly improved by the 7-day storage in the room environment or water treatment.XPS analysis confirmed the co-existence of Ce^(3+) and Ce^(4+) in CeO_(2),and the 7-day storage and water treatment promoted the amount of Ce^(3+),which facilitated the formation of the oxygen vacancies.That may be the reason why CeO_(2) exhibited excellent catalytic performance in polyethylene low-temperature combustion. | Xinyao Sun Liu Zhao Xu Hou Hao Zhou Huimin Qiao Chenggong Song Jing Huang Enxian Yuan | 2023 | Chinese Journal of Chemical Engineering2023，58，6： | 1 |
| 19 | Enhancement of dendritic cell-tumor fusion vaccine potency by indoleamine-pyrrole 2,3-dioxygenase inhibitor, 1-MT显示文摘 | Xueling Ou Shaohui Cai Peng Liu Jun Zeng Yuwen He Xinyao Wu Jun Du | 2008 | Journal of Cancer Research and Clinical Oncology2008，，5： | 1 |
| 20 | Subsynchronous resonance and its mitigation for power system with unified power flow controller显示文摘Control strategy of unified power flow controller(UPFC)utilizing dq decoupling control is deduced in this paper,which can closely follow the control orders of the active and reactive power.The subsynchronous resonance(SSR)characteristics of a series compensated system equipped with UPFC are studied,and the results reveal that SSR characteristics of the system may vary significantly with UPFC in service or not.Consequently,supplementary subsynchronous damping controller(SSDC)for UPFC is proposed and investigated,and the effectiveness of the proposed SSDC is verified by damping torque analysis and time domain simulations. | Xinyao ZHU Meng JIN Xiangping KONG Jingbo ZHAO Jiankun LIU Qian ZHOU | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，1： | 1 |
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