|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overview of China's Antarctic research progress 1984–2016显示文摘It is more than 30 years since the first Chinese National Antarctic Research Expedition(CHINARE) landed in Antarctica in 1984, representing China's initiation in polar research. This review briefly summarizes the Chinese Antarctic scientific research and output accomplished over the past 30 years. The developments and progress in Antarctic research and the enhancement of international scientific cooperation achieved through the implementation of the CHINARE program have been remarkable. Since the 1980 s, four permanent Chinese Antarctic research stations have been established successively and 33 CHINAREs have been completed. The research results have been derived from a series of spatiotemporal observations in association with various projects and multidisciplinary studies in the fields of oceanography, glaciology, geology, geophysics, geochemistry, atmospheric science, upper atmospheric physics, Antarctic astronomy, biology and ecology, human medicine, polar environment observation, and polar engineering. | CHEN Liqi LIU Xiaohan BIAN Lingen CHEN Bo HUANG Hongliang HU Hongqiao LUO Wei SHI Guitao SHI Jiuxin XU Chengli YANG Guang ZHAO Yue ZHANG Shaohua | 2017 | Advances in Polar Science2017，28，3： | 9 |
| 2 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 3 | Ultrabroad band microwave absorption from hierarchical MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)Tx hybrids via annealing treatment显示文摘Two-dimensional(2D)transition metal carbide MXene-based materials hold great potentials applied for new electromagnetic wave(EMW)absorbers.However,the application of MXenes in the field of electromagnetic wave absorption(EMA)is limited by the disadvantages of poor impedance matching,single loss mechanism,and easy oxidation.In this work,MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)T_(x)hybrids were prepared by the annealing-treated Mo_(2)TiC_(2)T_(x)MXene and uniform MoO_(3)and TiO_(2)oxides in-situ grew on Mo_(2)TiC_(2)T_(x)layers.At the annealing temperature of 300℃,the minimum reflection loss(RLmin)value of MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)T_(x)reaches-30.76 dB(2.3 mm)at 10.18 GHz with a significantly broadening effective absorption bandwidth(EAB)of 8.6 GHz(1.8 mm).The in-situ generated oxides creating numerous defects and heterogeneous interfaces enhance dipolar and interfacial polarizations and optimize the impedance matching of Mo_(2)TiC_(2)T_(x).Considering the excellent overall performance,the MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)T_(x)hybrids can be a promising candidate for EMA. | Feiyue HU Fan ZHANG Xiaohan WANG Yaya LI Hailong WANG Rui ZHANG Hongxia LI Bingbing FAN | 2022 | Journal of Advanced Ceramics2022，11，9： | 5 |
| 4 | SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk genetic epistasis in bipolar disorder显示文摘 | Xiaohan Hu Qiang Liu Zhao Zhang Zhiqiang Li Shilin Wang Lin He Yongyong Shi | 2010 | Cell Research2010，20，7： | 5 |
| 5 | Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus显示文摘The coordinated utilization of nitrogen(N)and phosphorus(P)is vital for plants to maintain nutrient balance and achieve optimal growth.Previously,we revealed a mechanism by which nitrate induces genes for phosphate utilization;this mechanism depends on NRT1.1B-facilitated degradation of cytoplasmic SPX4,which in turn promotes cytoplasmic-nuclear shuttling of PHR2,the central transcription factor of phosphate signaling,and triggers the nitrate-induced phosphate response(NIPR)and N-P coordinated utilization in rice.In this study,we unveiled a fine-tuning mechanism of NIPR in the nucleus regulated by Highly Induced by Nitrate Gene 1(HINGE1,also known as RLI1),a MYB-transcription factor closely related to PHR2.RLI1/HINGE1,which is transcriptionally activated by PHR2 under nitrate induction,can directly activate the expression of phosphate starvation-induced genes.More importantly,RLI1/HINGE1 competes with PHR2 for binding to its repressor proteins in the nucleus(SPX proteins),and consequently releases PHR2 to further enhance phosphate response.Therefore,RLI1/HINGE1 amplifies the phosphate response in the nucleus downstream of the cytoplasmic SPX4-PHR2 cascade,thereby enabling fine-tuning of N-P balance when nitrate supply is sufficient. | Zhihua Zhang Zhao Li Wei Wang Zhimin Jiang Liping Guo Xiaohan Wang Yangwen Qian Xiahe Huang Yongqiang Liu Xiujie Liu Yahong Liu Aifu Li Yu Yan Junpeng Xie Shouyun Cao Stanislav Kopriva Legong Li Fanjiang Kong Baohui Liu Yingchun Wang Bin Hu Chengcai Chu | 2021 | Molecular Plant2021，14，3： | 4 |
| 6 | New technologies accelerate the exploration of non-coding RNAs in horticultural plants显示文摘Non-coding RNAs(ncRNAs),that is,RNAs not translated into proteins,are crucial regulators of a variety of biological processes in plants.While protein-encoding genes have been relatively well-annotated in sequenced genomes,accounting for a small portion of the genome space in plants,the universe of plant ncRNAs is rapidly expanding.Recent advances in experimental and computational technologies have generated a great momentum for discovery and functional characterization of ncRNAs.Here we summarize the classification and known biological functions of plant ncRNAs,review the application of next-generation sequencing(NGS)technology and ribosome profiling technology to ncRNA discovery in horticultural plants and discuss the application of new technologies,especially the new genome-editing tool clustered regularly interspaced short palindromic repeat(CRISPR)/CRISPR-associated protein 9(Cas9)systems,to functional characterization of plant ncRNAs. | Degao Liu Ritesh Mewalal Rongbin Hu Gerald A Tuskan Xiaohan Yang | 2017 | Horticulture Research2017，4，1： | 4 |
| 7 | Resource optimization in wireless powered cooperative mobile edge computing systems显示文摘Mobile edge computing(MEC)meets the high-bandwidth and ultra-low-latency requirements of mobile networks and improves communication reliability by reducing the networks’load.In this study,we study a wireless powered MEC system,which includes an access point(AP)and two mobile devices.The endurance of mobile devices can be effectively enhanced using the wireless power transfer technology and user cooperation.However,during user cooperation,a closer user assists a farther user with forwarding tasks by sharing the same bandwidth,which causes interference.To overcome the interference issue,the closer user can instead assist other users in forwarding tasks by using a different bandwidth.We aim to minimize the power of the AP by joint power and bandwidth optimization while satisfying the delay and users’computational tasks.Simulation results show that the proposed user collaboration method can overcome user interference,reduce energy consumption,and improve user performance compared with the baseline policies. | Qibin YE Weidang LU Su HU Xiaohan XU | 2021 | Science China(Information Sciences)2021，64，8： | 3 |
| 8 | Bacterial outer membrane vesicles-based therapeutic platform eradicates triple-negative breast tumor by combinational photodynamic/chemo-/immunotherapy显示文摘Bacterial outer membrane vesicles(OMVs)are potent immuno-stimulating agents and have the potentials to be bioengineered as platforms for antitumor nanomedicine.In this study,OMVs are demonstrated as promising antitumor therapeutics.OMVs can lead to beneficial M2-to-M1 polarization of macrophages and induce pyroptosis to enhance antitumor immunity,but the therapeutic window of OMVs is narrow for its toxicity.We propose a bioengineering strategy to enhance the tumor-targeting ability of OMVs by macrophage-mediated delivery and improve the antitumor efficacy by co-loading of photosensitizer chlorin e6(Ce6)and chemotherapeutic drug doxorubicin(DOX)into OMVs as a therapeutic platform.We demonstrate that systemic injection of the DOX/Ce6-OMVs@M therapeutic platform,providing combinational photodynamic/chemo-/immunotherapy,eradicates triple-negative breast tumors in mice without side effects.Importantly,this strategy also effectively prevents tumor metastasis to the lung.This OMVs-based strategy with bioengineering may serve as a powerful therapeutic platform for a synergic antitumor therapy. | Yongjiang Li Junyong Wu Xiaohan Qiu Suhe Dong Jun He Jihua Liu Wenjie Xu Si Huang Xiongbin Hu Da-Xiong Xiang | 2023 | Bioactive Materials2023，，2： | 2 |
| 9 | Special interstitial route can transport nanoparticles to the brain bypassing the blood-brain barrier显示文摘Nowadays,nanoparticles(NPs)are considered to be ideal tools for bioimaging and drug delivery.Although increasing research has focused on NP biodistribution,transportation in the interstitial architecture has been neglected.The entire body is connected by the interstitial architecture,which can provide a long-range and direct pathway for NP biodistribution in a nonvascular system.In this study,we report that 10-nm gold NPs injected directly into the interstitial architecture of the tarsal tunnel of rats(intervaginal space injection(ISI))were delivered to the brain without crossing the blood-brain barrier.Furthermore,NaGdF4 nanoparticles were used to explore the transportation route by magnetic resonance imaging.The results demonstrated that,after ISI,the NaGdF4 nanoparticles were transported through the perivascular interstitial space of the carotid arteries and brain vessels to the brain.This is a special nonvascular transportation route like a stream based on the interstitial architecture that provides an alternative pathway for NP biodistribution. | Nan Hu Xiaoli Shi Qiang Zhang Wentao Liu Yuting Zhu Yuqing Wang Yi Hou Yinglu Ji Yupeng Cao Qian Zeng Zhuo Ao Quanmei Sun Xiaohan Zhou Xiaochun Wu Dong Han | 2019 | Nano Research2019，12，11： | 2 |
| 10 | Mapping of wheat stripe rust resistance gene Yr041133 by BSR-Seq analysis显示文摘Puccinia striiformis Westend. f. sp. tritici(Pst) pathotype CYR34 is widely virulent and prevalent in China.Here, we report identification of a strpie rust resistance(Yr) gene, designated Yr041133, in winter wheat line 041133. This line produced a hypersensitive reaction to CYR34 and conferred resistance to 13 other pathotypes. Resistance to CYR34 in line 041133 was controlled by a single dominant gene. Bulked segregant RNA sequencing(BSR-Seq) was performed on a pair of RNA bulks generated by pooling resistant and susceptible recombinant inbred lines. Yr041133 was mapped to a 1.7 c M genetic interval on the chromosome arm 7 BL that corresponded to a 0.8 Mb physical interval(608.9–609.7 Mb) in the Chinese Spring reference genome. Based on its unique physical location Yr041133 differred from the other Yr genes on this chromosome arm. | Yahui Li Ruiming Lin Jinghuang Hu Xiaohan Shi Dan Qiu Peipei Wu Gebremedhin Habteab Goitom Siqi Wang Hongjun Zhang Li Yang Hongwei Liu Qiuhong Wu Jingzhong Xie Yang Zhou Zhiyong Liu Hongjie Li | 2022 | The Crop Journal2022，10，2： | 1 |
| 11 | Superlensing effect in liquid surface waves显示文摘 | Hu Xinhua Shen Yifeng Liu Xiaohan | 2004 | Physical Review E-Statistical Nonlinear and Soft Matter Physics2004，69，31： | 1 |
| 12 | Superlensing effect in liquid surface waves显示文摘 | HU Xinhua SHEN Yinfeng LIU Xiaohan | 2004 | Physical Review E2004，69，03： | 1 |
| 13 | Wire-feed laser additive manufacturing of dissimilar metals via dual molten pool interface interlocking mechanism显示文摘Intermetallic compounds produced in laser additive manufacturing are the main factors restricting the joint performance of dissimilar metals.To solve this problem,a dual molten pool interface interlocking mechanism was proposed in this study.Based on a dual molten pool interface interlocking mechanism,the dissimilar metals,aluminum alloy and stainless steel,were produced as single-layer and multilayer samples,using the wire-feed laser additive manufacturing directed energy deposition technology.The preferred parameters for the dual molten pool interface interlocking mechanism process of the dissimilar metals,aluminum alloy and stainless steel,were obtained.The matching relationship between the interface connection of dissimilar metals and the process parameters was established.The results demonstrated excellent mechanical occlusion at the connection interface and no apparent intermetallic compound layer.Good feature size and high microhardness were observed under a laser power of 660 W,a wire feeding speed of 55 mm/s,and a platform moving speed of 10 mm/s.Molecular dynamics simulations demonstrated a faster rate of aluminum diffusion in the aluminum alloy substrate to stainless steel under the action of the initial contact force than without the initial contact force.Thus,the dual molten pool interface interlocking mechanism can effectively reduce the intermetallic compound layer when dissimilar metals are connected in the aerospace field. | HE Yi ZHANG XiaoHan ZHAO Zhe XU ShuoHeng XIA Min ZHANG Chen HU YaoWu | 2023 | Science China(Technological Sciences)2023，66，4： | 1 |
| 14 | First Chinese ultraviolet-visible hyperspectral satellite instrument implicating global air quality during the COVID-19 pandemic in early 2020显示文摘In response to the COVID-19 pandemic,governments worldwide imposed lockdown measures in early 2020,resulting in notable reductions in air pollutant emissions.The changes in air quality during the pandemic have been investigated in numerous studies via satellite observations.Nevertheless,no relevant research has been gathered using Chinese satellite instruments,because the poor spectral quality makes it extremely difficult to retrieve data from the spectra of the Environmental Trace Gases Monitoring Instrument(EMI),the first Chinese satellite-based ultraviolet–visible spectrometer monitoring air pollutants.However,through a series of remote sensing algorithm optimizations from spectral calibration to retrieval,we successfully retrieved global gaseous pollutants,such as nitrogen dioxide(NO2),sulfur dioxide(SO2),and formaldehyde(HCHO),from EMI during the pandemic.The abrupt drop in NO2 successfully captured the time for each city when effective measures were implemented to prevent the spread of the pandemic,for example,in January 2020 in Chinese cities,February in Seoul,and March in Tokyo and various cities across Europe and America.Furthermore,significant decreases in HCHO in Wuhan,Shanghai,Guangzhou,and Seoul indicated that the majority of volatile organic compounds(VOCs)emissions were anthropogenic.Contrastingly,the lack of evident reduction in Beijing and New Delhi suggested dominant natural sources of VOCs.By comparing the relative variation of NO2 to gross domestic product(GDP),we found that the COVID-19 pandemic had more influence on the secondary industry in China,while on the primary and tertiary industries in Korea and the countries across Europe and America. | Cheng Liu Qihou Hu Chengxin Zhang Congzi Xia Hao Yin Wenjing Su Xiaohan Wang Yizhou Xu Zhiguo Zhang | 2022 | Light(Science & Applications)2022，11，2： | 1 |
| 15 | Advances and perspectives in discovery and functional analysis of small secreted proteins in plants显示文摘Small secreted proteins(SSPs)are less than 250 amino acids in length and are actively transported out of cells through conventional protein secretion pathways or unconventional protein secretion pathways.In plants,SSPs have been found to play important roles in various processes,including plant growth and development,plant response to abiotic and biotic stresses,and beneficial plant–microbe interactions.Over the past 10 years,substantial progress has been made in the identification and functional characterization of SSPs in several plant species relevant to agriculture,bioenergy,and horticulture.Yet,there are potentially a lot of SSPs that have not been discovered in plant genomes,which is largely due to limitations of existing computational algorithms.Recent advances in genomics,transcriptomics,and proteomics research,as well as the development of new computational algorithms based on machine learning,provide unprecedented capabilities for genome-wide discovery of novel SSPs in plants.In this review,we summarize known SSPs and their functions in various plant species.Then we provide an update on the computational and experimental approaches that can be used to discover new SSPs.Finally,we discuss strategies for elucidating the biological functions of SSPs in plants. | Xiao-Li Hu Haiwei Lu Md Mahmudul Hassan Jin Zhang Guoliang Yuan Paul E.Abraham Him K.Shrestha Manuel I.Villalobos Solis Jin-Gui Chen Timothy J.Tschaplinski Mitchel J.Doktycz Gerald A.Tuskan Zong-Ming(Max)Cheng Xiaohan Yang | 2021 | Horticulture Research2021，8，1： | 1 |
| 16 | Multiscale structural engineering of carbon nitride for enhanced photocatalytic H2O2 production显示文摘Carbon nitride(C_(3)N_(4))holds great promise for photocatalytic H_(2)O_(2)production from oxygen reduction.In spite of great research efforts,they still suffer from low catalytic efficiency primarily limited by the fast recombination of photogenerated charge carriers.In this work,we report the multiscale structural engineering of C_(3)N_(4)to significantly improve its optoelectronic properties and consequently photocatalytic performance.The product consists of porous spheres with high surface areas,abundant nitrogen defects,and alkali metal doping.Under visible light irradiation,our catalyst shows a remarkable H_(2)O_(2)production rate of 3,080μmol·g^(−1)·h^(−1),which is more than 10 times higher than that of bulk C_(3)N_(4)and exceeds those of most other C_(3)N_(4)-based photocatalysts.Moreover,the catalyst exhibits great stability,and can continuously work for 15 h without obvious activity decay under visible light irradiation,eventually giving rise to a high H_(2)O_(2)concentration of ca.45 mM. | Qing He Bounxome Viengkeo Xuan Zhao Zhengyuan Qin Jie Zhang Xiaohan Yu Yongpan Hu Wei Huang Yanguang Li | 2023 | Nano Research2023，16，4： | 1 |
| 17 | Randomized controlled trials in surgery: Issues and problems显示文摘 | Robin S. McLeod James G. Wright Michael J. Solomon Xiaohan Hu Beverly C. Walters Al Lossing | 1996 | Surgery1996，，5： | 1 |
| 18 | Mn_(x)Co_(3-x)O_(4)Microtubules with Enhanced Catalytic Activity Towards Toluene Combustion:Effects of Redox Property and Oxygen Species显示文摘The redox property and oxygen species play an important role in the catalytic oxidation of volatile organic compounds(VOCs).In this paper,a series of Mn_(x)Co_(3-x)O_(4)catalysts with tubular structure were synthesized and applied for the catalytic combustion of toluene.Various characterization technologies were employed to reveal the relationship between the catalytic performance of the Mn_(x)Co_(3-x)O_(4)catalysts and Mn doping.The results of XRD,SEM and N2 adsorption-desorption analyses showed that the Mn doping had significant effects on the structure and morphology of the Mn_(x)Co_(3-x)O_(4)catalysts.The H2-TPR,O2-TPD,and XPS results proved that the strong interaction between Co and Mn resulted in the enhanced Olatt mobility,the richer active oxygen species,and the enhanced redox property in comparison with the pure Co_(3)O_(4)sample,which were crucial to the improvement of the catalytic activity of Co-Mn catalysts.The best catalyst,Co5-Mn5 sample,exhibited a good and stable activity to catalytically oxidize toluene at low temperatures even in the presence of water vapor,indicating that it is a potential material to be used in the commercialization of catalytic abatement of toluene. | Zhang Hanyu Hu Yue Zhang Xiaohan Sun Mengyao Liu Rui Qi Jian Jin Quan | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，4： | 1 |
| 19 | Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing显示文摘CRISPR/RfxCas13d(CasRx)editing system can specifically and precisely cleave single-strand RNAs,which is a promising treatment for various disorders by downregulation of related gene expression.Here,we tested this RNA-editing approach on Beethoven(Bth)mice,an animal model for human DFNA36 due to a point mutation in Tmc1.We first screened 30 sgRNAs in cell cultures and found that CasRx with sgRNA3 reduced the Tmc1^(Bth)transcript by 90.8%,and the Tmc1 wild type transcript(Tmc1^(+))by 44.3%.We then injected a newly developed AAV vector(AAV-PHP.eB)based CasRx into the inner ears of neonatal Bth mice,and we found that Tmc1^(Bth)was reduced by 70.2%in 2 weeks with few off-target effects in the whole transcriptome.Consistently,we found improved hair cell survival,rescued hair bundle degeneration,and reduced mechanoelectrical transduction current.Importantly,the hearing performance,measured in both ABR and DPOAE thresholds,was improved significantly in all ages over 8 weeks.We,therefore,have validated the CRISPR/CasRx-based RNA editing strategy in treating autosomal-dominant hearing loss,paving way for its further application in many other hereditary diseases in hearing and beyond. | Ziwen Zheng Guo Li Chong Cui Fang Wang Xiaohan Wang Zhijiao Xu Huiping Guo Yuxin Chen Honghai Tang Daqi Wang Mingqian Huang Zheng-Yi Chen Xingxu Huang Huawei Li Geng-Lin Li Xiaoxiang Hu Yilai Shu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 1 |
| 20 | Low genetic diversity in the endangered marine alga Silvetia siliquosa(Ochrophyta:Fucaceae)and the implication to conservation显示文摘Although signifi cant research eff orts have been targeted toward conservation and management of endangered terrestrial fl ora and fauna,attempts have been limited to conserve threatened seaweeds.Silvetia siliquosa is an ecologically and commercially vital brown alga that is uniquely distributed in the Yellow-Bohai Sea and along the southwest coast of Korea.A massive decline in its distribution range and biomass from the mid-1990s onward indicates that this species has become endangered.In the present study,we used nuclear internal transcribed spacer and concatenated mitochondrial cytochrome oxidase I subunit+intergenic spacer to estimate the genetic diversity,population connectivity,and degree of genetic diff erentiation of S.siliquosa in China and Korea.The molecular results exhibited strikingly low levels of haplotype/ribotype and nucleotide diversity in S.siliquosa populations,with only three mitochondrial haplotypes and nuclear ribotypes detected in 136 and 143 specimens,respectively.The analysis of molecular variance revealed 85%-95%of genetic variance among populations.Population diff erentiation coeffi cient(F_(ST))and gene fl ow(N_(m))suggested that two populations(JIN and GWA)along the southern coast of Korea are highly divergent from the others,with weak genetic exchange.No signifi cant genetic diff erentiation was observed among populations either in China or along the geographically proximate west coast of Korea.Thus,four independent management units were designated for sustainable management:the LII and RUS populations in China,the YEO and CHA populations along the west coast of Korea,and each of the GWA and JIN populations along the south coast of Korea.We suggest that artifi cial cultivation and transplantation of S.siliquosa are the eff ective approaches for restoration and conservation. | Yanshuo LIANG Jie ZHANG Xiaohan SONG Han-Gil CHOI Xu GAO Delin DUAN Zi-min HU | 2022 | Journal of Oceanology and Limnology2022，40，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员