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| 1 | Inflammasomes as therapeutic targets in human diseases显示文摘Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals.Inflammasome multiprotein complexes are composed of three parts:a sensor protein,an adaptor,and pro-caspase-1.Activation of the inflammasome leads to the activation of caspase-1,which cleaves pro-inflammatory cytokines such as IL-ip and IL-18,leading to pyroptosis.Effectors of the inflammasome not only provide protection against infectious pathogens,but also mediate control over sterile insults.Aberrant inflammasome signaling has been implicated in the development of cardiovascular and metabolic diseases,cancer,and neurodegenerative disorders.Here,we review the role of the inflammasome as a double-edged sword in various diseases,and the outcomes can be either good or bad depending on the disease,as well as the genetic background.We highlight inflammasome memory and the two-shot activation process.We also propose the M-and N-type inflammation model,and discuss how the inflammasome pathway may be targeted for the development of novel therapy. | Yangxin Li Hui Huang Bin Liu Yu Zhang Xiangbin Pan Xi-Yong Yu Zhenya Shen Yao-Hua Song | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 3 |
| 2 | Molecular Epidemiology of Klebsiella pneumoniae from Clinical Bovine Mastitis in Northern Area of China,2018–2019显示文摘Klebsiella pneumoniae(K.pneumonia,KpⅠ)is a predominate inducement of bovine mastitis,which is associated with high mortality and milk yield reduction.However,data is lacking on the molecular characteristics of bovine K.pneumoniae,limiting the risk assessment of its transmission through the food chain.Herein,we investigated the prevalence of K.pneumoniae in 6301 clinical mastitis(CM)milk samples from dairy cattle in northern area of China.In total,183 K.pneumoniae isolates were recovered,with detection rates of 3.0% and 2.8% in 2018 and 2019,respectively.Like human clinical K.pneumoniae,all CM K.pneumoniae isolates belonged to one of three phylogroups:KpⅠ(n=143),Klebsiella.quasipneumoniae subsp.similipneumoniae(KpⅡ-B)(n=37),and Klebsiella variicola(KpⅢ)(n=3).We detected the extendedspectrum β-lactamase-encoding genes bla_(SHV-2a),blac_(CTX-M-14),and bla_(CTX-M-15),as well as clpC,lpfA,lacI,lacZ,lacY,and the fecABDEIR operon in the KpⅠ isolates,which may contribute to their pathogenicity and host adaptability in cows.The high prevalence of KpⅠ in dairy farms may be problematic,as it showed relatively higher rates of antibiotic resistance and virulence gene carriage than the KpⅡ-B and KpⅢ isolates.Furthermore,we observed distinct differences in population structure between CM-and human infection-associated KpⅠ isolates,with the genes associated with invasive infection in humans rarely being observed in bovine isolates,indicating that few CM-associated K.pneumoniae isolates pose a threat to human health.Nevertheless,bovine KpⅡ-B isolates shared a high level of nucleotide sequence identity with isolates from human infections and frequently carried the nitrogen-fixation gene nif,suggesting an association between KpⅡ-B isolates from cattle and humans,and plant-derived bacteria. | Shikai Song Wenjuan He Dawei Yang Manar Benmouffok Yao Wang Jiyun Li Chengtao Sun Xiangbin Song Shizhen Ma Chang Cai Shuangyang Ding Congming Wu Zhangqi Shen Yang Wang | 2022 | Engineering2022，8，3： | 1 |
| 3 | Ribosome biogenesis in disease:new players and therapeutic targets显示文摘The ribosome is a multi-unit complex that translates mRNA into protein.Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation,differentiation,apoptosis,development,and transformation.The mTORC1,Myc,and noncoding RNA signaling pathways are the primary mediators that work jointly with RNA polymerases and ribosome proteins to control ribosome biogenesis and protein synthesis.Activation of mTORC1 is required for normal fetal growth and development and tissue regeneration after birth.Myc is implicated in cancer development by enhancing RNA Pol II activity,leading to uncontrolled cancer cell growth.The deregulation of noncoding RNAs such as microRNAs,long noncoding RNAs,and circular RNAs is involved in developing blood,neurodegenerative diseases,and atherosclerosis.We review the similarities and differences between eukaryotic and bacterial ribosomes and the molecular mechanism of ribosome-targeting antibiotics and bacterial resistance.We also review the most recent findings of ribosome dysfunction in COVID-19 and other conditions and discuss the consequences of ribosome frameshifting,ribosome-stalling,and ribosome-collision.We summarize the role of ribosome biogenesis in the development of various diseases.Furthermore,we review the current clinical trials,prospective vaccines for COVID-19,and therapies targeting ribosome biogenesis in cancer,cardiovascular disease,aging,and neurodegenerative disease. | Lijuan Jiao Yuzhe Liu Xi-Yong Yu Xiangbin Pan Yu Zhang Junchu Tu Yao-Hua Song Yangxin Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 1 |
| 4 | Structural, optical and electrical properties of ZnO: B thin films with different thickness for bifacial a-Si:H/c-Si heterojunction solar cells显示文摘 | Dong XU Sheng YIN Xiangbin ZENG Song YANG Xixing WEN | 2017 | Frontiers of Optoelectronics2017，10，1： | 1 |
| 5 | Basic Catalytic Performance of Amino and Acylamide Functionalized Metal-organic Framework in the Synthesis of Chloropropene Carbonate from CO2 Under Atmospheric Pressure显示文摘 | SONG Lili CHEN Chao CHEN Xiangbin ZHANG Ning | 2016 | Chemical Research in Chinese Universities2016，32，5： | 0 |
| 6 | Quantum light source devices of In(Ga)As semiconductor self-assembled quantum dots显示文摘A brief introduction of semiconductor self-assembled quantum dots (QDs) applied in single-photon sources is given. Single QDs in confined quantum optical microcavity systems are reviewed along with their optical properties and coupling characteristics. Subsequently, the recent progresses in In(Ga)As QDs systems are summarized including the preparation of quantum light sources, multiple methods for embedding single QDs into different microcavities and the scalability of single-photon emitting wavelength. Particularly, several In(Ga)As QD single-photon devices are surveyed including In(Ga)As QDs coupling with nanowires, InAs QDs coupling with distributed Bragg reflection microcavity and the In(Ga)As QDs coupling with micropillar microcavities. Furthermore, applications in the field of single QDs technology are illustrated, such as the entangled photon emission by spontaneous parametric down conversion, the single-photon quantum storage, the chip preparation of single-photon sources as well as the single-photon resonance-fluorescence measurements. | Xiaowu He Yifeng Song Ying Yu Ben Ma Zesheng Chen Xiangjun Shang Haiqiao Ni Baoquan Sun Xiuming Dou Hao Chen Hongyue Hao Tongtong Qi Shushan Huang Hanqing Liu Xiangbin Su Xinliang Su Yujun Shi Zhichuan Niu | 2019 | Journal of Semiconductors2019，40，7： | 0 |
| 7 | A New Format of Single Chain Tri-specific Antibody with Diminished Molecular Size Efficiently Induces Ovarian Tumor Cell Killing显示文摘 | Jing Liu Qi Zhao Baofeng Zhao Julong Cheng Xiangbin Wang Liping Song Zhang Zhong Qing Lin Hualiang Huang | 2006 | 中国生物学文摘2006，20，1： | 0 |
| 8 | Bright semiconductor single-photon sources pumped by heterogeneously integrated micropillar lasers with electrical injections显示文摘The emerging hybrid integrated quantum photonics combines the advantages of different functional components into a single chip to meet the stringent requirements for quantum information processing.Despite the tremendous progress in hybrid integrations of III-V quantum emitters with silicon-based photonic circuits and superconducting single-photon detectors,on-chip optical excitations of quantum emitters via miniaturized lasers towards single-photon sources(SPSs)with low power consumptions,small device footprints,and excellent coherence properties is highly desirable yet illusive.In this work,we present realizations of bright semiconductor SPSs heterogeneously integrated with on-chip electrically-injected microlasers.Different from previous one-by-one transfer printing technique implemented in hybrid quantum dot(QD)photonic devices,multiple deterministically coupled QD-circular Bragg Grating(CBG)SPSs were integrated with electrically-injected micropillar lasers at one time via a potentially scalable transfer printing process assisted by the wide-field photoluminescence(PL)imaging technique.Optically pumped by electrically-injected microlasers,pure single photons are generated with a high-brightness of a count rate of 3.8 M/s and an extraction efficiency of 25.44%.Such a high-brightness is due to the enhancement by the cavity mode of the CBG,which is confirmed by a Purcell factor of 2.5.Our work provides a powerful tool for advancing hybrid integrated quantum photonics in general and boosts the developments for realizing highly-compact,energy-efficient and coherent SPSs in particular. | Xueshi Li Shunfa Liu Yuming Wei Jiantao Ma Changkun Song Ying Yu Rongbin Su Wei Geng Haiqiao Ni Hanqing Liu Xiangbin Su Zhichuan Niu You-ling Chen Jin Liu | 2023 | Light(Science & Applications)2023，12，3： | 0 |
| 9 | A Rigid Nanoplatform for Precise and Responsive Treatment of Intracellular Multidrug-Resistant Bacteria显示文摘Antibiotic treatment failure against life-threatening bacterial pathogens is typically caused by the rapid emergence and dissemination of antibiotic resistance.The current lack of antibiotic discovery and development urgently calls for new strategies to combat multidrug-resistant(MDR)bacteria,especially those that survive in host cells.Functional nanoparticles are promising intracellular drug delivery systems whose advantages include their high biocompatibility and tunable surface modifications.Inspired by the fact that the rigidity of nanoparticles potentiates their cellular uptake,rigidity-functionalized nanoparticles(RFNs)coated with bacteria-responsive phospholipids were fabricated to boost endocytosis,resulting in the increased accumulation of intracellular antibiotics.Precise delivery and high antibacterial efficacy were demonstrated by the clearing of 99%of MDR bacteria in 4 h using methicillin-resistant Staphylococcus aureus(MRSA)and pathogenic Bacillus cereus as models.In addition,the subcellular distribution of the RFNs was modulated by altering the phospholipid composition on the surface,thereby adjusting the electrostatic effects and reprograming the intracellular behavior of the RFNs by causing them to accurately target lysosomes.Finally,the RFNs showed high efficacy against MRSA-associated infections in animal models of wound healing and bacteremia.These findings provide a controllable rigidity-regulated delivery platform with responsive properties for precisely reprograming the accumulation of cytosolic antibiotics,shedding light on precision antimicrobial therapeutics against intracellular bacterial pathogens in the future. | Shaoqi Qu Xiaoyong Huang Xiangbin Song Yifan Wu Xiaowei Ma Jianzhong Shen Kui Zhu | 2022 | Engineering2022，8，8： | 0 |
| 10 | Green Superhydrophobic Paper with Self-cleaning Properties Prepared via One-step Impregnation显示文摘In this study,a green and pollution-free multifunctional superhydrophobic paper-based material was prepared using a simple and efficient dipping method.The superhydrophobic paper with a water contact angle(WCA)of 160°was prepared by attaching micro-and nanocomposite particles,made of stearic acid-modified chitosan and two kinds of titanium dioxide(TiO_(2))nanoparticles of different sizes,to a paper substrate.The surface morphology,elemental composition,and wetting properties of the coatings were examined using scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectroscopy(FT-IR),and contact angle measurements.Additionally,superhydrophobic coatings exhibited good self-cleaning properties,liquid repellency,ease of repair,and antifouling properties in organic solutions. | Xiangbin Zhang Shanshan Gao Xiaoming Song Jiale Wang Xunqian Wu Fushan Chen Shiyuan Xie | 2023 | Paper And Biomaterials2023，8，4： | 0 |
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